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Search results 1 to 100 out of 220 for Pappa

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0.043s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Pappalysin-1 (also known as pregnancy-associated plasma protein-A (PAPP-A); MERIOPS identifier M43.004) is a metalloendopeptidase that belongs to the MEROPS peptidase family M43B. It was first found in high concentrations in the blood of pregnant women. Later, it was identified as a proteinase responsible for cleavage of insulin-like growth factor binding protein (IGFBP)-4, an inhibitor of IGF action that mediates cell growth and survival signals. PAPP-A is expressed by different cell types, and thus no longer could be considered to be just "pregnancy-associated"[]. It is involved in rapid yet strictly controlled growth and development, including wound healing, bone remodelling, folliculogenesis, placental development, and atherosclerosis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication    
First Author: Pappa CN
Year: 2000
Journal: GenBank Submission
Title: Mus musculus BM88 antigen mRNA, complete cds
Pages: AF243130
Protein
Organism: Mus musculus/domesticus
Length: 1624  
Fragment?: false
Publication
First Author: Boldt HB
Year: 2007
Journal: Growth Horm IGF Res
Title: Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs.
Volume: 17
Issue: 1
Pages: 10-8
Publication
First Author: Pappa S
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: PHF2 histone demethylase prevents DNA damage and genome instability by controlling cell cycle progression of neural progenitors.
Volume: 116
Issue: 39
Pages: 19464-19473
Publication  
First Author: Rojas-Rodriguez R
Year: 2020
Journal: Sci Transl Med
Title: PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans.
Volume: 12
Issue: 571
Publication
First Author: Vallejo AN
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A.
Volume: 106
Issue: 27
Pages: 11252-7
Publication
First Author: Nyegaard M
Year: 2010
Journal: Biol Reprod
Title: Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility.
Volume: 82
Issue: 6
Pages: 1129-38
Publication
First Author: Conover CA
Year: 2004
Journal: Development
Title: Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development.
Volume: 131
Issue: 5
Pages: 1187-94
Publication
First Author: Tanner SJ
Year: 2008
Journal: J Bone Miner Res
Title: Impact of pregnancy-associated plasma protein-a deletion on the adult murine skeleton.
Volume: 23
Issue: 5
Pages: 655-62
Publication
First Author: Conover CA
Year: 2010
Journal: J Gerontol A Biol Sci Med Sci
Title: Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A.
Volume: 65
Issue: 6
Pages: 590-9
Publication  
First Author: Conover CA
Year: 2016
Journal: Exp Gerontol
Title: Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice.
Volume: 80
Pages: 36-42
Publication  
First Author: Clifton KB
Year: 2015
Journal: Bone
Title: Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone.
Volume: 81
Pages: 413-6
Publication
First Author: Conover CA
Year: 2008
Journal: J Endocrinol
Title: Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype.
Volume: 198
Issue: 3
Pages: 599-605
Publication
First Author: Resch ZT
Year: 2006
Journal: Endocrinology
Title: Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury.
Volume: 147
Issue: 12
Pages: 5634-40
Publication
First Author: Conover CA
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet.
Volume: 305
Issue: 9
Pages: E1145-53
Publication
First Author: Miller BS
Year: 2007
Journal: J Endocrinol
Title: Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice.
Volume: 192
Issue: 3
Pages: 505-13
Publication  
First Author: Kashyap S
Year: 2020
Journal: JCI Insight
Title: Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis.
Volume: 5
Issue: 4
Publication
First Author: Bale LK
Year: 2005
Journal: J Endocrinol
Title: Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A.
Volume: 186
Issue: 2
Pages: 325-31
Publication
First Author: Austin K
Year: 2015
Journal: Endocrinology
Title: IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine.
Volume: 156
Issue: 2
Pages: 429-36
Publication
First Author: Ning Y
Year: 2008
Journal: Mol Endocrinol
Title: Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo.
Volume: 22
Issue: 5
Pages: 1213-25
Publication
First Author: Li W
Year: 2015
Journal: J Gerontol A Biol Sci Med Sci
Title: Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.
Volume: 70
Issue: 3
Pages: 263-72
Publication
First Author: Harrington SC
Year: 2007
Journal: Circ Res
Title: Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet.
Volume: 100
Issue: 12
Pages: 1696-702
Publication
First Author: Dominick G
Year: 2017
Journal: Aging Cell
Title: mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.
Volume: 16
Issue: 1
Pages: 52-60
Publication
First Author: Swindell WR
Year: 2010
Journal: Exp Gerontol
Title: In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene.
Volume: 45
Issue: 5
Pages: 366-74
Publication  
First Author: Wagner PK
Year: 2010
Journal: Reprod Biol Endocrinol
Title: Altered placental expression of PAPPA2 does not affect birth weight in mice.
Volume: 8
Pages: 90
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Søe R
Year: 2002
Journal: Eur J Biochem
Title: Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity.
Volume: 269
Issue: 8
Pages: 2247-56
Publication
First Author: Hourvitz A
Year: 2002
Journal: Endocrinology
Title: The regulated expression of the pregnancy-associated plasma protein-A in the rodent ovary: a proposed role in the development of dominant follicles and of corpora lutea.
Volume: 143
Issue: 5
Pages: 1833-44
Publication
First Author: Van Leuven F
Year: 1993
Journal: FEBS Lett
Title: Isolation, characterization and partial sequencing of Pregnancy Associated Mouse Protein PAMP1 identifies it as a novel female specific protein, unrelated to the alpha-2-macroglobulin family of proteinase inhibitors.
Volume: 322
Issue: 3
Pages: 219-22
Publication
First Author: Tomlinson E
Year: 2002
Journal: Endocrinology
Title: Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.
Volume: 143
Issue: 5
Pages: 1741-7
Publication
First Author: Conover CA
Year: 2013
Journal: Endocrinology
Title: Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response.
Volume: 154
Issue: 8
Pages: 2734-8
Publication
First Author: Bale LK
Year: 2017
Journal: Aging Cell
Title: Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span.
Volume: 16
Issue: 4
Pages: 895-897
Publication  
First Author: Ramakrishna A
Year: 2020
Journal: Endocrinology
Title: Genetic and Pharmacological Inhibition of PAPP-A Protects Against Visceral Obesity in Mice.
Volume: 161
Issue: 10
Publication
First Author: Bale LK
Year: 2014
Journal: Endocrinology
Title: Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice.
Volume: 155
Issue: 4
Pages: 1184-7
Publication      
First Author: Zhang Z
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for untersuchen.
Publication      
First Author: Zhang Z
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Maennel.
Publication      
First Author: Zhang Z
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for maennelein.
Publication      
First Author: Zhang Z
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for caer.
Publication
First Author: Qin X
Year: 2006
Journal: Endocrinology
Title: Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo.
Volume: 147
Issue: 12
Pages: 5653-61
Publication
First Author: Glerup S
Year: 2007
Journal: J Biol Chem
Title: Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor.
Volume: 282
Issue: 3
Pages: 1769-78
Publication
First Author: Mikkelsen JH
Year: 2008
Journal: J Biol Chem
Title: Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding.
Volume: 283
Issue: 24
Pages: 16772-80
Publication
First Author: Boldt HB
Year: 2013
Journal: Endocrinology
Title: Effects of mutated pregnancy-associated plasma protein-a on atherosclerotic lesion development in mice.
Volume: 154
Issue: 1
Pages: 246-52
Publication
First Author: Mohrin M
Year: 2021
Journal: Aging Cell
Title: Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells.
Volume: 20
Issue: 3
Pages: e13313
Publication  
First Author: Wang G
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Suppression of PAPP-A mitigates atherosclerosis by mediating macrophage polarization via STAT3 signaling.
Volume: 543
Pages: 29-37
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: k
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: h
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: li
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914327
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: f
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914227
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: t
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: b
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768127
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: c
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: lu
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: k
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: h
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: li
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914327
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: f
Detected: false
Specimen Num: 12
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914227
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: t
Detected: false
Specimen Num: 13
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: b
Detected: false
Specimen Num: 14
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768127
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: c
Detected: false
Specimen Num: 15
GXD Expression    
Probe: MGI:3844225
Assay Type: RT-PCR
Annotation Date: 2009-05-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:3844233
Age: postnatal newborn
Image: 1
Specimen Label: lu
Detected: false
Specimen Num: 16
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:5302810
Age: embryonic day 18.5
Specimen Label: Placenta
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185826
Stage: TS26
Assay Id: MGI:5302810
Age: embryonic day 18.5
Specimen Label: Fetal head
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185726
Stage: TS26
Assay Id: MGI:5302810
Age: embryonic day 18.5
Specimen Label: Fetal body
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768128
Stage: TS28
Assay Id: MGI:5302810
Age: postnatal week 8
Specimen Label: Calvaria
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1928728
Stage: TS28
Assay Id: MGI:5302810
Age: postnatal week 8
Specimen Label: Prostate
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:5302810
Age: postnatal week 8
Specimen Label: Colon
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5302810
Age: postnatal week 8
Specimen Label: Lung
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5302810
Age: postnatal week 8
Specimen Label: Ovaries
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914228
Stage: TS28
Assay Id: MGI:5302810
Age: postnatal week 8
Specimen Label: Tibia
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5302807
Assay Type: RT-PCR
Annotation Date: 2012-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5302810
Age: postnatal week 8
Specimen Label: Brain
Detected: true
Specimen Num: 10