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Search results 1 to 100 out of 2900 for Pdx1

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Hits by Category

Type Details Score
Gene
key_980053 | Pdx1
Type: gene
Organism: Not Specified
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Gene
3651 | PDX1
Type: gene
Organism: human
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Gene
538927 | PDX1
Type: gene
Organism: cattle
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Gene
771348 | PDX1
Type: gene
Organism: chicken
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Gene
30721 | pdx1
Type: gene
Organism: zebrafish
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Gene
710936 | PDX1
Type: gene
Organism: macaque, rhesus
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Gene
100490648 | pdx1
Type: gene
Organism: frog, western clawed
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Gene
29535 | Pdx1
Type: gene
Organism: rat
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Gene
493994 | PDX1
Type: gene
Organism: dog, domestic
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Gene
452507 | PDX1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:102851 | Pdx1
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:3820908
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826040
Age: embryonic day 14.5
Image: Additional file 4 Pdx1
Specimen Label: Additional file 4 Pdx1
Detected: true
Specimen Num: 1
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Gene
100861550 | PLUT
Type: gene
Organism: human
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GXD Expression
GXD Expression
   
Probe: MGI:7492310
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7492350
Age: embryonic day 11.5
Specimen Label: S1 PDX1 E11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7492310
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7492350
Age: embryonic day 15.5
Specimen Label: S1 PDX1 E15.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7492310
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7492350
Age: embryonic day 10.5
Specimen Label: S1 PDX1 E10.5
Detected: true
Specimen Num: 1
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Publication
26657766 | J:229014
First Author: Marty-Santos L
Year: 2016
Journal: Development
Title: Pdx1 regulates pancreas tubulogenesis and E-cadherin expression.
Volume: 143
Issue: 1
Pages: 101-12
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Publication
21852533 | J:174673
First Author: Yang YP
Year: 2011
Journal: Genes Dev
Title: Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.
Volume: 25
Issue: 16
Pages: 1680-5
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Publication
28017717 | J:241963
First Author: Yamamoto Y
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Preserving expression of Pdx1 improves β-cell failure in diabetic mice.
Volume: 483
Issue: 1
Pages: 418-424
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Publication
28087712 | J:238701
First Author: Roy N
Year: 2016
Journal: Genes Dev
Title: PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
Volume: 30
Issue: 24
Pages: 2669-2683
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Publication
26887806 | J:250031
 
First Author: Kodama S
Year: 2016
Journal: Sci Rep
Title: Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice.
Volume: 6
Pages: 21211
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Publication
12145169 | J:78086
First Author: Lee CS
Year: 2002
Journal: Diabetes
Title: Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.
Volume: 51
Issue: 8
Pages: 2546-51
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Publication
11994408 | J:76408
First Author: Kushner JA
Year: 2002
Journal: J Clin Invest
Title: Pdx1 restores beta cell function in Irs2 knockout mice.
Volume: 109
Issue: 9
Pages: 1193-201
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Publication
28580283 | J:301635
First Author: Bastidas-Ponce A
Year: 2017
Journal: Mol Metab
Title: Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells.
Volume: 6
Issue: 6
Pages: 524-534
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Publication
20558340 | J:161931
First Author: Galbo T
Year: 2010
Journal: Eur J Histochem
Title: Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels.
Volume: 54
Issue: 2
Pages: e19
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Publication
19855005 | J:154661
First Author: Sachdeva MM
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.
Volume: 106
Issue: 45
Pages: 19090-5
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Publication
29351489 | J:262148
First Author: Kropp PA
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability.
Volume: 314
Issue: 4
Pages: E308-E321
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Publication
19656489 | J:151308
First Author: Gauthier BR
Year: 2009
Journal: Cell Metab
Title: PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.
Volume: 10
Issue: 2
Pages: 110-8
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Publication
17403901 | J:122333
First Author: Wiebe PO
Year: 2007
Journal: Mol Cell Biol
Title: Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.
Volume: 27
Issue: 11
Pages: 4093-104
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Publication
24658302 | J:229796
First Author: Ren D
Year: 2014
Journal: Diabetes
Title: Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency.
Volume: 63
Issue: 8
Pages: 2744-50
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Publication
24506867 | J:210652
First Author: Gao T
Year: 2014
Journal: Cell Metab
Title: Pdx1 maintains β cell identity and function by repressing an α cell program.
Volume: 19
Issue: 2
Pages: 259-71
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Publication
27292642 | J:238301
First Author: Henley KD
Year: 2016
Journal: Cell Rep
Title: Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.
Volume: 15
Issue: 12
Pages: 2637-2650
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Publication
16126192 | J:103522
First Author: Hale MA
Year: 2005
Journal: Dev Biol
Title: The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas.
Volume: 286
Issue: 1
Pages: 225-37
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Publication
22135308 | J:183312
First Author: Chen C
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice.
Volume: 302
Issue: 4
Pages: G407-19
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Publication
17158802 | J:118281
First Author: Johnson JD
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
Volume: 103
Issue: 51
Pages: 19575-80
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Publication
24029239 | J:204080
First Author: Nishimura W
Year: 2013
Journal: Endocrinology
Title: Quantitative assessment of Pdx1 promoter activity in vivo using a secreted luciferase reporter system.
Volume: 154
Issue: 11
Pages: 4388-95
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Publication
12488434 | J:80826
First Author: Kitamura T
Year: 2002
Journal: J Clin Invest
Title: The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
Volume: 110
Issue: 12
Pages: 1839-47
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Publication
25801033 | J:316508
First Author: McKenna B
Year: 2015
Journal: Cell Rep
Title: Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells.
Volume: 10
Issue: 12
Pages: 2032-42
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Publication
15677506 | J:105152
First Author: Li Y
Year: 2005
Journal: Diabetes
Title: beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.
Volume: 54
Issue: 2
Pages: 482-91
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Publication
19654319 | J:155712
First Author: Fujimoto K
Year: 2009
Journal: J Biol Chem
Title: Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
Volume: 284
Issue: 40
Pages: 27664-73
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Publication
26085571 | J:247099
First Author: Soleimanpour SA
Year: 2015
Journal: Diabetes
Title: Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells.
Volume: 64
Issue: 10
Pages: 3475-84
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Publication
29723041 | J:272409
First Author: Ikeguchi E
Year: 2018
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice.
Volume: 315
Issue: 2
Pages: G272-G282
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Publication
12869553 | J:128796
First Author: Suzuki R
Year: 2003
Journal: J Biol Chem
Title: Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
Volume: 278
Issue: 44
Pages: 43691-8
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Publication
25040025 | J:215612
First Author: Fernández-Pérez A
Year: 2014
Journal: Biochem J
Title: Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells.
Volume: 463
Issue: 2
Pages: 287-96
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Publication
17056599 | J:117676
First Author: Deramaudt TB
Year: 2006
Journal: J Biol Chem
Title: The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter.
Volume: 281
Issue: 50
Pages: 38385-95
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Publication
25251389 | J:218424
First Author: Templin AT
Year: 2014
Journal: Mol Endocrinol
Title: Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response.
Volume: 28
Issue: 11
Pages: 1820-30
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Publication
31240701 | J:280914
First Author: Horiguchi M
Year: 2019
Journal: FEBS Lett
Title: Senescence caused by inactivation of the homeodomain transcription factor Pdx1 in adult pancreatic acinar cells in mice.
Volume: 593
Issue: 16
Pages: 2226-2234
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Publication
23775765 | J:208954
First Author: Guo L
Year: 2013
Journal: Diabetes
Title: PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation.
Volume: 62
Issue: 10
Pages: 3459-68
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Publication
22771330 | J:186237
First Author: Chen C
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice.
Volume: 424
Issue: 3
Pages: 549-53
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Publication
20811152 | J:165268
First Author: Claiborn KC
Year: 2010
Journal: J Clin Invest
Title: Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice.
Volume: 120
Issue: 10
Pages: 3713-21
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Publication
21042537 | J:166709
First Author: Mazur PK
Year: 2010
Journal: PLoS One
Title: Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo.
Volume: 5
Issue: 10
Pages: e13578
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Publication
19141476 | J:143476
First Author: Gao N
Year: 2008
Journal: Genes Dev
Title: Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
Volume: 22
Issue: 24
Pages: 3435-48
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Publication
19487809 | J:152582
First Author: Oliver-Krasinski JM
Year: 2009
Journal: J Clin Invest
Title: The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
Volume: 119
Issue: 7
Pages: 1888-98
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Publication
27993987 | J:238418
First Author: Yang YP
Year: 2017
Journal: Development
Title: The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation.
Volume: 144
Issue: 2
Pages: 248-257
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Publication
29910119 | J:264987
     
First Author: Malenczyk K
Year: 2018
Journal: Mol Metab
Title: Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification.
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Publication
27406855 | J:253778
 
First Author: Guo C
Year: 2016
Journal: Sci Rep
Title: Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model.
Volume: 6
Pages: 29396
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Publication
16148004 | J:102900
First Author: Iguchi H
Year: 2005
Journal: J Biol Chem
Title: SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.
Volume: 280
Issue: 45
Pages: 37669-80
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Publication
25713082 | J:338772
First Author: Maganti AV
Year: 2015
Journal: J Biol Chem
Title: Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
Volume: 290
Issue: 15
Pages: 9812-22
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Publication
26440894 | J:273053
First Author: Shih HP
Year: 2015
Journal: Cell Rep
Title: A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.
Volume: 13
Issue: 2
Pages: 326-36
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Publication
16794995 | J:110137
First Author: Holland AM
Year: 2006
Journal: Genesis
Title: A mouse carrying the green fluorescent protein gene targeted to the Pdx1 locus facilitates the study of pancreas development and function.
Volume: 44
Issue: 6
Pages: 304-7
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Publication
16123346 | J:101742
First Author: Holland AM
Year: 2005
Journal: Diabetes
Title: Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas.
Volume: 54
Issue: 9
Pages: 2586-95
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Publication
28705881 | J:245178
First Author: Spaeth JM
Year: 2017
Journal: Diabetes
Title: Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning.
Volume: 66
Issue: 11
Pages: 2830-2839
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Publication
16418487 | J:104617
First Author: Fujitani Y
Year: 2006
Journal: Genes Dev
Title: Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.
Volume: 20
Issue: 2
Pages: 253-66
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Publication
16962573 | J:119565
First Author: Boyer DF
Year: 2006
Journal: Dev Biol
Title: Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.
Volume: 298
Issue: 2
Pages: 616-31
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Publication
19808654 | J:155907
First Author: Chen C
Year: 2009
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells.
Volume: 297
Issue: 6
Pages: G1126-37
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Publication
18347078 | J:137140
First Author: Hald J
Year: 2008
Journal: J Histochem Cytochem
Title: Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development.
Volume: 56
Issue: 6
Pages: 587-95
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Gene
771963 | PCIF1
Type: gene
Organism: chicken
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HT Experiment
E-MTAB-127 | Transcription profiling of the islets from Pdx1+/- mice compared to islets isolated from Pdx1 +/+ littermates
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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GXD Expression
GXD Expression
Probe: MGI:6361200
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6361315
Age: embryonic day 10.5
Image: S1G
Note: The antibody used recognized the truncated Pdx1 protein expressed in the Pdx1;Sox9 mutant allele.
Specimen Label: S1G
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
Probe: MGI:6361200
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1654817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6361315
Age: embryonic day 10.5
Image: 6G
Note: The antibody used recognized the truncated Pdx1 protein expressed in the Pdx1;Sox9 mutant allele.
Specimen Label: 6G
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
Probe: MGI:6361200
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1706717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6361315
Age: embryonic day 10.5
Image: 6F
Note: The antibody used recognized the truncated Pdx1 protein expressed in the Pdx1 null allele.
Specimen Label: 6F
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:6361200
Assay Type: Immunohistochemistry
Annotation Date: 2019-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706716
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:6361503
Age: embryonic day 9.5
Image: S3D
Note: The antibody used recognized the truncated Pdx1 protein expressed in the Pdx1 null allele.
Specimen Label: S3D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:6361200
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6361315
Age: embryonic day 10.5
Image: S1F
Note: The antibody used recognized the truncated Pdx1 protein expressed in the Pdx1 null allele.
Specimen Label: S1F
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
Probe: MGI:6361200
Assay Type: Immunohistochemistry
Annotation Date: 2019-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702116
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:6361503
Age: embryonic day 9.5
Image: S3C
Note: The antibody used recognized the truncated Pdx1 protein expressed in the Pdx1 null allele.
Specimen Label: S3C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750320
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6695725
Age: embryonic day 12.5
Image: 3E (left)
Note: Considerably smaller dorsal pancreatic remnant than Pdx1 null embryos at same stage, while displaying a similar structure.
Specimen Label: 3E (left)
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6361425
Age: embryonic day 10.5
Image: 3O
Note: With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
Specimen Label: 3O
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6361425
Age: embryonic day 10.5
Image: 3S
Note: With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
Specimen Label: 3S
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6361425
Age: embryonic day 12.5
Image: 3T
Note: With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
Specimen Label: 3T
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:6361200
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1636317
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6361315
Age: embryonic day 10.5
Image: 6G
Note: Loss of both Pdx1 and Sox9 results in ectopic Cdx2 expression. There was extensive overlap between the Pdx1 and Cdx2 domains.
Specimen Label: 6G
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6361425
Age: embryonic day 12.5
Image: 3P
Note: With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
Specimen Label: 3P
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6361425
Age: embryonic day 10.5
Image: 3Q
Note: With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
Specimen Label: 3Q
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6361425
Age: embryonic day 12.5
Image: 3R
Note: With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
Specimen Label: 3R
Detected: true
Specimen Num: 10
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ncRNA Gene
MGI:1917397 | Plut
Type: lncRNA_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:5588713
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Widespread
Stage: TS22
Assay Id: MGI:7510122
Age: embryonic day 14.5
Image: S4D
Note: Expressed in all pancreatic epithelial cells, albeit at much higher levels in beta-cells. Almost complete overlap between Foxa2 and Pdx1 expression. Most of the Pdx1 highly expressed cells did not display the highest levels of Foxa2, indicating that Foxa2 highly positive cells did not correspond to beta-cells.
Specimen Label: S4D
Detected: true
Specimen Num: 1
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HT Sample
Pdx1 +/- Mouse 2
 
Organism Name: mouse, laboratory
Sex: Male
Age: postnatal week 8-10
Stage: 28
Structure . Name: islets of Langerhans
Curation Status: Curated
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HT Sample
Pdx1 +/- Mouse 3
 
Organism Name: mouse, laboratory
Sex: Male
Age: postnatal week 8-10
Stage: 28
Structure . Name: islets of Langerhans
Curation Status: Curated
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HT Sample
Pdx1 +/- Mouse 4
 
Organism Name: mouse, laboratory
Sex: Male
Age: postnatal week 8-10
Stage: 28
Structure . Name: islets of Langerhans
Curation Status: Curated
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Publication
11784003 | J:72023
First Author: Gannon M
Year: 2001
Journal: Dev Biol
Title: Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.
Volume: 238
Issue: 1
Pages: 185-201
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Publication
31682591 | J:295434
First Author: Trojanowski BM
Year: 2020
Journal: J Endocrinol
Title: Elevated β-cell stress levels promote severe diabetes development in mice with MODY4.
Volume: 244
Issue: 2
Pages: 323-337
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Publication
11973276 | J:76095
First Author: Gu G
Year: 2002
Journal: Development
Title: Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.
Volume: 129
Issue: 10
Pages: 2447-57
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Publication
32165492 | J:291485
 
First Author: Baumann D
Year: 2020
Journal: Development
Title: Role of nutrient-driven O-GlcNAc-post-translational modification in pancreatic exocrine and endocrine islet development.
Volume: 147
Issue: 7
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Publication
34735515 | J:312867
First Author: Walcheck MT
Year: 2021
Journal: PLoS One
Title: Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice.
Volume: 16
Issue: 11
Pages: e0259245
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Publication
36623733 | J:337682
First Author: Wong A
Year: 2023
Journal: J Biol Chem
Title: Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion.
Volume: 299
Issue: 2
Pages: 102878
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Publication
9637677 | J:48516
First Author: Ahlgren U
Year: 1998
Journal: Genes Dev
Title: beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.
Volume: 12
Issue: 12
Pages: 1763-8
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Publication
28922976 | J:257633
First Author: Jiang FX
Year: 2017
Journal: Stem Cells Dev
Title: Transient Impairment of Islet Architectural Development in Pancreas-Specific Bmpr1a-Deleted Prenatal Mice Involves Reduced Expression of E-Cadherin.
Volume: 26
Issue: 23
Pages: 1706-1714
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Publication
20802254 | J:169727
First Author: Wicksteed B
Year: 2010
Journal: Diabetes
Title: Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
Volume: 59
Issue: 12
Pages: 3090-8
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Publication
19619492 | J:151981
First Author: Spence JR
Year: 2009
Journal: Dev Cell
Title: Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.
Volume: 17
Issue: 1
Pages: 62-74
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Publication
16611688 | J:108521
First Author: Heiser PW
Year: 2006
Journal: Development
Title: Stabilization of beta-catenin impacts pancreas growth.
Volume: 133
Issue: 10
Pages: 2023-32
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Publication
27137932 | J:340178
First Author: Sun J
Year: 2016
Journal: J Biol Chem
Title: Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak.
Volume: 291
Issue: 26
Pages: 13529-34
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Publication
32547704 | J:311561
First Author: Asai A
Year: 2020
Journal: Oncotarget
Title: Hereditary pancreatitis model by blastocyst complementation in mouse.
Volume: 11
Issue: 22
Pages: 2061-2073
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