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Search results 1 to 100 out of 1164 for Pkd1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Thivierge C
Year: 2006
Journal: Mol Cell Biol
Title: Overexpression of PKD1 causes polycystic kidney disease.
Volume: 26
Issue: 4
Pages: 1538-48
Publication
First Author: Coxam B
Year: 2014
Journal: Cell Rep
Title: Pkd1 regulates lymphatic vascular morphogenesis during development.
Volume: 7
Issue: 3
Pages: 623-33
Publication
First Author: Nie X
Year: 2013
Journal: Mech Dev
Title: Pkd1 is required for male reproductive tract development.
Volume: 130
Issue: 11-12
Pages: 567-76
Publication
First Author: Wu Y
Year: 2016
Journal: J Cell Sci
Title: Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.
Volume: 129
Issue: 19
Pages: 3675-3684
Publication
First Author: Takakura A
Year: 2008
Journal: J Am Soc Nephrol
Title: Pkd1 inactivation induced in adulthood produces focal cystic disease.
Volume: 19
Issue: 12
Pages: 2351-63
Publication
First Author: Ahrabi AK
Year: 2007
Journal: J Am Soc Nephrol
Title: PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice.
Volume: 18
Issue: 6
Pages: 1740-53
Publication
First Author: Kurbegovic A
Year: 2013
Journal: Hum Mol Genet
Title: Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain.
Volume: 22
Issue: 12
Pages: 2361-75
Publication
First Author: Lakhia R
Year: 2022
Journal: Nat Commun
Title: PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.
Volume: 13
Issue: 1
Pages: 4765
Publication  
First Author: Garcia-Gonzalez MA
Year: 2010
Journal: PLoS One
Title: Pkd1 and Pkd2 are required for normal placental development.
Volume: 5
Issue: 9
Publication
First Author: Zhu M
Year: 2024
Journal: Cell Metab
Title: PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer.
Volume: 36
Issue: 8
Pages: 1711-1725.e8
Publication
First Author: Qiu N
Year: 2012
Journal: PLoS One
Title: Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease.
Volume: 7
Issue: 9
Pages: e46038
Publication
First Author: Xiao Z
Year: 2011
Journal: FASEB J
Title: Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.
Volume: 25
Issue: 7
Pages: 2418-32
Publication
First Author: Saigusa T
Year: 2016
Journal: FASEB J
Title: Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model.
Volume: 30
Issue: 1
Pages: 370-9
Publication
First Author: Dackowski WR
Year: 2002
Journal: Genomics
Title: Canine PKD1 is a single-copy gene: genomic organization and comparative analysis.
Volume: 80
Issue: 1
Pages: 105-12
Publication
First Author: Muñoz JJ
Year: 2020
Journal: Sci Rep
Title: Identification of housekeeping genes for microRNA expression analysis in kidney tissues of Pkd1 deficient mouse models.
Volume: 10
Issue: 1
Pages: 231
Publication
First Author: Wu G
Year: 2002
Journal: Hum Mol Genet
Title: Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease.
Volume: 11
Issue: 16
Pages: 1845-54
Publication
First Author: Parrot C
Year: 2019
Journal: Hum Mol Genet
Title: c-Myc is a regulator of the PKD1 gene and PC1-induced pathogenesis.
Volume: 28
Issue: 5
Pages: 751-763
Publication
First Author: Chau TCY
Year: 2022
Journal: Dev Dyn
Title: Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice.
Volume: 251
Issue: 2
Pages: 336-349
GXD Expression    
Probe: MGI:6180693
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191085
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Pkd1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6180693
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191085
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Pkd1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6180693
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191085
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Pkd1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6180693
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191085
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Pkd1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6180693
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191085
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Pkd1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6180693
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191085
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Pkd1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6180693
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191085
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Pkd1
Detected: true
Specimen Num: 7
Publication
First Author: Kurbegovic A
Year: 2010
Journal: Hum Mol Genet
Title: Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes.
Volume: 19
Issue: 7
Pages: 1174-89
Publication
First Author: Lu W
Year: 1997
Journal: Nat Genet
Title: Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation.
Volume: 17
Issue: 2
Pages: 179-81
Publication
First Author: Fitzgibbon WR
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade.
Volume: 314
Issue: 2
Pages: F210-F218
Publication
First Author: Xiao Z
Year: 2010
Journal: J Biol Chem
Title: Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation.
Volume: 285
Issue: 2
Pages: 1177-87
Publication
First Author: Lantinga-van Leeuwen IS
Year: 2004
Journal: Hum Mol Genet
Title: Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease.
Volume: 13
Issue: 24
Pages: 3069-77
Publication
First Author: Bastos AP
Year: 2009
Journal: J Am Soc Nephrol
Title: Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion.
Volume: 20
Issue: 11
Pages: 2389-402
Publication
First Author: Pritchard L
Year: 2000
Journal: Hum Mol Genet
Title: A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.
Volume: 9
Issue: 18
Pages: 2617-27
Publication
First Author: Hughes P
Year: 2006
Journal: Cell Death Differ
Title: Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.
Volume: 13
Issue: 7
Pages: 1123-7
Publication
First Author: Natoli TA
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.
Volume: 294
Issue: 1
Pages: F73-83
Publication
First Author: Piontek KB
Year: 2004
Journal: J Am Soc Nephrol
Title: A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.
Volume: 15
Issue: 12
Pages: 3035-43
Publication
First Author: Hassane S
Year: 2010
Journal: J Pathol
Title: Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease.
Volume: 222
Issue: 1
Pages: 21-31
Publication
First Author: Leuenroth SJ
Year: 2010
Journal: Nephrol Dial Transplant
Title: Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.
Volume: 25
Issue: 7
Pages: 2187-94
Publication
First Author: Guillaume R
Year: 2000
Journal: Mech Dev
Title: Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes.
Volume: 93
Issue: 1-2
Pages: 179-83
Publication
First Author: Boulter C
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene.
Volume: 98
Issue: 21
Pages: 12174-9
Publication  
First Author: Olsson PG
Year: 1996
Journal: Cytogenet Cell Genet
Title: A comparative clone map of the region containing the PKD1 gene in mouse
Volume: 72
Pages: 292 (Abstr.)
Publication
First Author: Zhang T
Year: 2015
Journal: J Biol Chem
Title: PKD1 protein is involved in reactive oxygen species-mediated mitochondrial depolarization in cooperation with protein kinase Cδ (PKCδ).
Volume: 290
Issue: 16
Pages: 10472-85
Publication
First Author: Muto S
Year: 2002
Journal: Hum Mol Genet
Title: Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.
Volume: 11
Issue: 15
Pages: 1731-42
Publication
First Author: Nishio S
Year: 2005
Journal: J Clin Invest
Title: Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation.
Volume: 115
Issue: 4
Pages: 910-8
Publication
First Author: Smithline ZB
Year: 2014
Journal: PLoS One
Title: Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.
Volume: 9
Issue: 12
Pages: e114403
Publication
First Author: Raphael KL
Year: 2009
Journal: Kidney Int
Title: Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells.
Volume: 75
Issue: 6
Pages: 626-33
Publication
First Author: Ohata S
Year: 2015
Journal: J Neurosci
Title: Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.
Volume: 35
Issue: 31
Pages: 11153-68
Publication  
First Author: Li S
Year: 2017
Journal: Sci Rep
Title: A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development.
Volume: 7
Pages: 40505
Publication
First Author: Guillaume R
Year: 1999
Journal: Dev Dyn
Title: Murine Pkd1 is a developmentally regulated gene from morula to adulthood: role in tissue condensation and patterning.
Volume: 214
Issue: 4
Pages: 337-48
Publication
First Author: Piontek KB
Year: 1999
Journal: Mamm Genome
Title: Murine Pkd1 introns 21 and 22 lack the extreme polypyrimidine bias present in human PKD1.
Volume: 10
Issue: 2
Pages: 194-6
Publication
First Author: Karcher C
Year: 2005
Journal: Differentiation
Title: Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia.
Volume: 73
Issue: 8
Pages: 425-32
Publication
First Author: Qiu N
Year: 2010
Journal: PLoS One
Title: Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis.
Volume: 5
Issue: 12
Pages: e15240
Publication
First Author: Lantinga-van Leeuwen IS
Year: 2007
Journal: Hum Mol Genet
Title: Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice.
Volume: 16
Issue: 24
Pages: 3188-96
Publication
First Author: Paul BM
Year: 2011
Journal: Dev Dyn
Title: Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.
Volume: 240
Issue: 6
Pages: 1493-501
Publication
First Author: Bhunia AK
Year: 2002
Journal: Cell
Title: PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2.
Volume: 109
Issue: 2
Pages: 157-68
Publication
First Author: Yang Y
Year: 2019
Journal: Aging (Albany NY)
Title: Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice.
Volume: 11
Issue: 22
Pages: 10016-10030
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Amaral AG
Year: 2022
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Disruption of polycystin-1 cleavage leads to cardiac metabolic rewiring in mice.
Volume: 1868
Issue: 6
Pages: 166371
Publication
First Author: Tan M
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.
Volume: 307
Issue: 11
Pages: F1179-86
Publication
First Author: Woodward OM
Year: 2010
Journal: PLoS One
Title: Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.
Volume: 5
Issue: 8
Pages: e12305
Publication
First Author: Yu S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure.
Volume: 104
Issue: 47
Pages: 18688-93
Publication
First Author: Kurbegovic A
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Acute kidney injury induces hallmarks of polycystic kidney disease.
Volume: 311
Issue: 4
Pages: F740-F751
Publication
First Author: Rowe I
Year: 2013
Journal: Nat Med
Title: Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.
Volume: 19
Issue: 4
Pages: 488-93
Publication
First Author: Kurbegovic A
Year: 2014
Journal: Mol Cell Biol
Title: Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease.
Volume: 34
Issue: 17
Pages: 3341-53
Publication
First Author: Walker RV
Year: 2023
Journal: Nat Commun
Title: Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis.
Volume: 14
Issue: 1
Pages: 6513
Publication
First Author: Schneider MC
Year: 1996
Journal: Mol Med Today
Title: Advances in polycystic kidney disease.
Volume: 2
Issue: 2
Pages: 70-5
Publication
First Author: Himmelbauer H
Year: 1992
Journal: Genomics
Title: Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1).
Volume: 13
Issue: 1
Pages: 35-8
Publication
First Author: Kwon M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.
Volume: 109
Issue: 52
Pages: 21462-7
Publication
First Author: Löhning C
Year: 1997
Journal: Mamm Genome
Title: The mouse homolog of PKD1: sequence analysis and alternative splicing.
Volume: 8
Issue: 5
Pages: 307-11
Publication
First Author: Shillingford JM
Year: 2010
Journal: J Am Soc Nephrol
Title: Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.
Volume: 21
Issue: 3
Pages: 489-97
Publication
First Author: Yanda MK
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and cyst growth in polycystic kidney disease.
Volume: 313
Issue: 4
Pages: F997-F1004
Publication
First Author: Takakura A
Year: 2009
Journal: Hum Mol Genet
Title: Renal injury is a third hit promoting rapid development of adult polycystic kidney disease.
Volume: 18
Issue: 14
Pages: 2523-31
Publication  
First Author: Podrini C
Year: 2018
Journal: Commun Biol
Title: Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways.
Volume: 1
Pages: 194
Publication
First Author: Rees S
Year: 2014
Journal: J Am Soc Nephrol
Title: Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.
Volume: 25
Issue: 2
Pages: 232-7
Publication
First Author: Fielitz J
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Requirement of protein kinase D1 for pathological cardiac remodeling.
Volume: 105
Issue: 8
Pages: 3059-63
Publication
First Author: Lee EJ
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease.
Volume: 117
Issue: 46
Pages: 29001-29012
Publication
First Author: Dooley R
Year: 2013
Journal: Mol Cell Endocrinol
Title: Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIIIβ trans Golgi signalling in M1 cortical collecting duct cells.
Volume: 372
Issue: 1-2
Pages: 86-95
Publication
First Author: Pose-Utrilla J
Year: 2017
Journal: Nat Commun
Title: Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Volume: 8
Issue: 1
Pages: 2275
Publication
First Author: Balbo BE
Year: 2016
Journal: Kidney Int
Title: Cardiac dysfunction in Pkd1-deficient mice with phenotype rescue by galectin-3 knockout.
Volume: 90
Issue: 3
Pages: 580-97
Publication
First Author: Kolpakova-Hart E
Year: 2008
Journal: Dev Biol
Title: Growth of cranial synchondroses and sutures requires polycystin-1.
Volume: 321
Issue: 2
Pages: 407-19
Publication
First Author: Sharif-Naeini R
Year: 2009
Journal: Cell
Title: Polycystin-1 and -2 dosage regulates pressure sensing.
Volume: 139
Issue: 3
Pages: 587-96
Publication
First Author: Cabrita I
Year: 2020
Journal: Nat Commun
Title: Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.
Volume: 11
Issue: 1
Pages: 4320
Publication    
First Author: Liu X
Year: 2018
Journal: Elife
Title: Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.
Volume: 7
Publication
First Author: Patel V
Year: 2012
Journal: J Am Soc Nephrol
Title: MicroRNAs regulate renal tubule maturation through modulation of Pkd1.
Volume: 23
Issue: 12
Pages: 1941-8
Publication
First Author: Allen E
Year: 2006
Journal: Hum Mol Genet
Title: Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.
Volume: 15
Issue: 1
Pages: 11-21
Publication
First Author: Kim K
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Polycystin 1 is required for the structural integrity of blood vessels.
Volume: 97
Issue: 4
Pages: 1731-6
Publication
First Author: Olsson PG
Year: 1996
Journal: Genomics
Title: The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene.
Volume: 34
Issue: 2
Pages: 233-5
Publication
First Author: Hassane S
Year: 2011
Journal: Lab Invest
Title: Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension.
Volume: 91
Issue: 1
Pages: 24-32
Publication
First Author: Leonhard WN
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.
Volume: 300
Issue: 5
Pages: F1193-202
Publication
First Author: Parnell SC
Year: 2018
Journal: Hum Mol Genet
Title: A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.
Volume: 27
Issue: 19
Pages: 3313-3324
Publication      
First Author: Ishimoto Y
Year: 2017
Journal: Mol Cell Biol
Title: Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease.