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Search results 1 to 100 out of 400 for Pkhd1

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Type Details Score
Gene
Type: gene
Organism: human
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Gene
Type: gene
Organism: frog, western clawed
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Gene
Type: gene
Organism: dog, domestic
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Gene
Type: gene
Organism: chimpanzee
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Gene
Type: gene
Organism: rat
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Gene
Type: gene
Organism: cattle
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Gene
Type: gene
Organism: macaque, rhesus
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Gene
Type: gene
Organism: chicken
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression      
Probe: MGI:8270533
Assay Type: Northern blot
Annotation Date: 2026-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:8273558
Age: postnatal adult
Specimen Label: Pkhd1
Detected: true
Specimen Num: 1
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Gene
Type: gene
Organism: human
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Publication
First Author: Williams SS
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Tissue-specific regulation of the mouse Pkhd1 (ARPKD) gene promoter.
Volume: 307
Issue: 3
Pages: F356-68
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Publication
First Author: Bakeberg JL
Year: 2011
Journal: J Am Soc Nephrol
Title: Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin.
Volume: 22
Issue: 12
Pages: 2266-77
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Publication
First Author: Yang C
Year: 2023
Journal: J Mol Med (Berl)
Title: Pkhd1(cyli/cyli) mice have altered renal Pkhd1 mRNA processing and hormonally sensitive liver disease.
Volume: 101
Issue: 9
Pages: 1141-1151
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GXD Expression      
Probe: MGI:8270536
Assay Type: Northern blot
Annotation Date: 2026-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:8273559
Age: postnatal adult
Specimen Label: Pkhd1
Detected: true
Specimen Num: 1
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Publication
First Author: Mai W
Year: 2005
Journal: Mol Biol Cell
Title: Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells.
Volume: 16
Issue: 9
Pages: 4398-409
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Publication
First Author: Hu B
Year: 2011
Journal: Exp Cell Res
Title: Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys.
Volume: 317
Issue: 2
Pages: 173-87
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Publication
First Author: Huang W
Year: 2018
Journal: J Immunol
Title: A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis.
Volume: 200
Issue: 1
Pages: 147-162
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Publication  
First Author: Ishimoto Y
Year: 2026
Journal: Nat Commun
Title: Deletion of ARPKD-associated Pkhd1 gene in mice results in decreased Tfap2b expression and eye abnormalities.
Volume: 17
Issue: 1
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Publication
First Author: Olson RJ
Year: 2019
Journal: J Am Soc Nephrol
Title: Synergistic Genetic Interactions between Pkhd1 and Pkd1 Result in an ARPKD-Like Phenotype in Murine Models.
Volume: 30
Issue: 11
Pages: 2113-2127
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Publication
First Author: Hiesberger T
Year: 2004
Journal: J Clin Invest
Title: Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice.
Volume: 113
Issue: 6
Pages: 814-25
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Publication
First Author: Fox JC
Year: 2024
Journal: iScience
Title: Defects of renal tubular homeostasis and cystogenesis in the Pkhd1 knockout.
Volume: 27
Issue: 4
Pages: 109487
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Publication
First Author: Hiesberger T
Year: 2005
Journal: J Biol Chem
Title: Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis.
Volume: 280
Issue: 11
Pages: 10578-86
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Publication
First Author: Zhang MZ
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells.
Volume: 101
Issue: 8
Pages: 2311-6
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Publication
First Author: Richards T
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Atmin modulates Pkhd1 expression and may mediate Autosomal Recessive Polycystic Kidney Disease (ARPKD) through altered non-canonical Wnt/Planar Cell Polarity (PCP) signalling.
Volume: 1865
Issue: 2
Pages: 378-390
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Publication
First Author: Trott JF
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis.
Volume: 315
Issue: 6
Pages: F1855-F1868
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Publication
First Author: Nishio S
Year: 2010
Journal: J Am Soc Nephrol
Title: Loss of oriented cell division does not initiate cyst formation.
Volume: 21
Issue: 2
Pages: 295-302
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Gene
Type: gene
Organism: dog, domestic
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Gene
Type: gene
Organism: chimpanzee
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Gene
Type: gene
Organism: rat
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Gene
Type: gene
Organism: cattle
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Gene
Type: gene
Organism: macaque, rhesus
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Publication
First Author: Kaimori JY
Year: 2007
Journal: Hum Mol Genet
Title: Polyductin undergoes notch-like processing and regulated release from primary cilia.
Volume: 16
Issue: 8
Pages: 942-56
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Publication
First Author: Gallagher AR
Year: 2008
Journal: Am J Pathol
Title: Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1.
Volume: 172
Issue: 2
Pages: 417-29
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Publication
First Author: Williams SS
Year: 2008
Journal: Pediatr Nephrol
Title: Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease.
Volume: 23
Issue: 5
Pages: 733-41
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Publication
First Author: Xiong H
Year: 2002
Journal: Genomics
Title: A novel gene encoding a TIG multiple domain protein is a positional candidate for autosomal recessive polycystic kidney disease.
Volume: 80
Issue: 1
Pages: 96-104
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Publication
First Author: Shan D
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Heterozygous Pkhd1(C642*) mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney.
Volume: 316
Issue: 3
Pages: F463-F472
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Publication
First Author: Moser M
Year: 2005
Journal: Hepatology
Title: A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD).
Volume: 41
Issue: 5
Pages: 1113-21
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Publication
First Author: Nagasawa Y
Year: 2002
Journal: J Am Soc Nephrol
Title: Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene.
Volume: 13
Issue: 9
Pages: 2246-58
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Publication
First Author: Belyea BC
Year: 2023
Journal: Clin Sci (Lond)
Title: Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype.
Volume: 137
Issue: 1
Pages: 35-45
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Publication
First Author: Wang S
Year: 2007
Journal: Mol Cell Biol
Title: Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.
Volume: 27
Issue: 8
Pages: 3241-52
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Publication  
First Author: Harafuji N
Year: 2023
Journal: Front Cell Dev Biol
Title: Differential regulation of MYC expression by PKHD1/Pkhd1 in human and mouse kidneys: phenotypic implications for recessive polycystic kidney disease.
Volume: 11
Pages: 1270980
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Publication
First Author: Kim I
Year: 2008
Journal: J Am Soc Nephrol
Title: Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.
Volume: 19
Issue: 3
Pages: 455-68
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Publication
First Author: Zhang YJ
Year: 2023
Journal: FASEB J
Title: Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells: A mechanistic connection between the kidney defects in cpk mice and human ARPKD.
Volume: 37
Issue: 7
Pages: e23008
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Publication
First Author: Boddu R
Year: 2014
Journal: J Mol Med (Berl)
Title: Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1.
Volume: 92
Issue: 10
Pages: 1045-56
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Publication
First Author: Gresh L
Year: 2004
Journal: EMBO J
Title: A transcriptional network in polycystic kidney disease.
Volume: 23
Issue: 7
Pages: 1657-68
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Publication
First Author: Garcia-Gonzalez MA
Year: 2007
Journal: Hum Mol Genet
Title: Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.
Volume: 16
Issue: 16
Pages: 1940-50
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Publication
First Author: Fabris L
Year: 2022
Journal: FASEB J
Title: Dysregulation of the Scribble/YAP/?-catenin axis sustains the fibroinflammatory response in a PKHD1(-/-) mouse model of congenital hepatic fibrosis.
Volume: 36
Issue: 6
Pages: e22364
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Publication
First Author: Patel V
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease.
Volume: 110
Issue: 26
Pages: 10765-70
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Publication
First Author: Hossain Z
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.
Volume: 104
Issue: 5
Pages: 1631-6
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Publication
First Author: Weisser I
Year: 2024
Journal: J Am Soc Nephrol
Title: Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease.
Volume: 35
Issue: 1
Pages: 41-55
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Publication
First Author: Fedeles SV
Year: 2011
Journal: Nat Genet
Title: A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.
Volume: 43
Issue: 7
Pages: 639-47
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
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Publication
First Author: Hiesberger T
Year: 2006
Journal: J Biol Chem
Title: Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C.
Volume: 281
Issue: 45
Pages: 34357-64
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Publication
First Author: Ishimoto Y
Year: 2023
Journal: Kidney Int
Title: A novel ARPKD mouse model with near-complete deletion of the Polycystic Kidney and Hepatic Disease 1 (Pkhd1) genomic locus presents with multiple phenotypes but not renal cysts.
Volume: 104
Issue: 3
Pages: 611-616
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Publication
First Author: Yanda MK
Year: 2023
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Ameliorating liver disease in an autosomal recessive polycystic kidney disease mouse model.
Volume: 324
Issue: 5
Pages: G404-G414
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Publication
First Author: Woollard JR
Year: 2007
Journal: Kidney Int
Title: A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation.
Volume: 72
Issue: 3
Pages: 328-36
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GXD Expression    
Probe: MGI:4365600
Assay Type: Western blot
Annotation Date: 2009-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:4365604
Age: postnatal adult
Image: 1
Specimen Label: MK
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:4365600
Assay Type: Western blot
Annotation Date: 2009-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:4365604
Age: postnatal adult
Image: 1
Specimen Label: Mli
Detected: true
Specimen Num: 2
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GXD Expression    
Probe: MGI:4365600
Assay Type: Western blot
Annotation Date: 2009-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:4365604
Age: postnatal adult
Image: 1
Specimen Label: MH
Detected: true
Specimen Num: 3
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GXD Expression    
Probe: MGI:4365600
Assay Type: Western blot
Annotation Date: 2009-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:4365604
Age: postnatal adult
Image: 1
Specimen Label: MLu
Detected: true
Specimen Num: 4
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GXD Expression      
Probe: MGI:4939238
Assay Type: RT-PCR
Annotation Date: 2011-03-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:4939437
Age: embryonic day 18.5
Specimen Label: Wild-type
Detected: true
Specimen Num: 1
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GXD Expression      
Probe: MGI:4939238
Assay Type: RT-PCR
Annotation Date: 2011-03-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:4939437
Age: embryonic day 18.5
Specimen Label: Vangl2Lp/Lp
Detected: true
Specimen Num: 2
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GXD Expression    
Probe: MGI:6883642
Assay Type: RT-PCR
Annotation Date: 2022-02-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6883650
Age: embryonic day 13.5
Image: 7
Specimen Label: Control
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:7574280
Assay Type: RT-PCR
Annotation Date: 2024-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737325
Stage: TS25
Assay Id: MGI:7574339
Age: embryonic day 17.5
Image: 4
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:7574280
Assay Type: RT-PCR
Annotation Date: 2024-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737325
Stage: TS25
Assay Id: MGI:7574339
Age: embryonic day 17.5
Image: 4
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:8187792
Age: embryonic day 14.5
Image: 7
Specimen Label: E14.5 WT
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:8187792
Age: embryonic day 14.5
Image: 7
Specimen Label: E14.5 Sp2/+
Detected: true
Specimen Num: 2
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737323
Stage: TS23
Assay Id: MGI:8187792
Age: embryonic day 15.5
Image: 7
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 3
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737323
Stage: TS23
Assay Id: MGI:8187792
Age: embryonic day 15.5
Image: 7
Specimen Label: E15.5 Sp2/+
Detected: true
Specimen Num: 4
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:8187781
Age: embryonic day 14.5
Image: S7
Specimen Label: E14.5 WT
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:8187781
Age: embryonic day 14.5
Image: S7
Specimen Label: E14.5 Sp2/+
Detected: true
Specimen Num: 2
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737323
Stage: TS23
Assay Id: MGI:8187781
Age: embryonic day 15.5
Image: S7
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 3
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737323
Stage: TS23
Assay Id: MGI:8187781
Age: embryonic day 15.5
Image: S7
Specimen Label: E15.5 Sp2/+
Detected: true
Specimen Num: 4
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737325
Stage: TS25
Assay Id: MGI:8187781
Age: embryonic day 17.5
Image: S7
Specimen Label: E17.5 WT
Detected: true
Specimen Num: 5
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737325
Stage: TS25
Assay Id: MGI:8187781
Age: embryonic day 17.5
Image: S7
Specimen Label: E17.5 Sp2/+
Detected: true
Specimen Num: 6
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:8187781
Age: postnatal day 0
Image: S7
Specimen Label: P0 WT
Detected: true
Specimen Num: 7
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GXD Expression    
Probe: MGI:8187559
Assay Type: RT-PCR
Annotation Date: 2025-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:8187781
Age: postnatal day 0
Image: S7
Specimen Label: P0 Sp2/+
Detected: true
Specimen Num: 8
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GXD Expression      
Probe: MGI:8270533
Assay Type: Northern blot
Annotation Date: 2026-01-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:8273556
Age: postnatal adult
Specimen Label: br
Detected: false
Specimen Num: 1
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GXD Expression      
Probe: MGI:8270533
Assay Type: Northern blot
Annotation Date: 2026-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:8273556
Age: postnatal adult
Specimen Label: ht
Detected: true
Specimen Num: 2
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GXD Expression      
Probe: MGI:8270533
Assay Type: Northern blot
Annotation Date: 2026-01-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:8273556
Age: postnatal adult
Specimen Label: lu
Detected: false
Specimen Num: 3
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GXD Expression      
Probe: MGI:8270533
Assay Type: Northern blot
Annotation Date: 2026-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:8273556
Age: postnatal adult
Specimen Label: li
Detected: true
Specimen Num: 4
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