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Search results 1 to 100 out of 203 for Polg

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0.041s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Nikkanen J
Year: 2018
Journal: EMBO Mol Med
Title: A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions.
Volume: 10
Issue: 1
Pages: 13-21
Publication
First Author: Hauser DN
Year: 2014
Journal: PLoS One
Title: Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.
Volume: 9
Issue: 4
Pages: e94646
Publication  
First Author: Ni T
Year: 2015
Journal: Sci Rep
Title: MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice.
Volume: 5
Pages: 12049
Publication
First Author: Faraci C
Year: 2018
Journal: Reproduction
Title: Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.
Volume: 156
Issue: 2
Pages: 185-194
Publication  
First Author: Hauser DN
Year: 2015
Journal: eNeuro
Title: The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.
Volume: 2
Issue: 1
Publication
First Author: Williams SL
Year: 2010
Journal: Cell Metab
Title: The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.
Volume: 12
Issue: 6
Pages: 675-82
Publication
First Author: Ahlqvist KJ
Year: 2012
Journal: Cell Metab
Title: Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.
Volume: 15
Issue: 1
Pages: 100-9
Publication
First Author: Faraci C
Year: 2018
Journal: PLoS One
Title: Calorie restriction does not influence oocyte quality in oocytes from POLG mitochondrial mutator mice.
Volume: 13
Issue: 9
Pages: e0204373
Publication
First Author: Clark-Matott J
Year: 2015
Journal: Neurobiol Aging
Title: Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
Volume: 36
Issue: 11
Pages: 2972-2983
Publication
First Author: Someya S
Year: 2017
Journal: PLoS One
Title: Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.
Volume: 12
Issue: 2
Pages: e0171159
Publication
First Author: Maclaine KD
Year: 2020
Journal: PLoS One
Title: Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging.
Volume: 15
Issue: 3
Pages: e0226860
Publication
First Author: Kubota M
Year: 2006
Journal: J Neurosci
Title: Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects.
Volume: 26
Issue: 47
Pages: 12314-24
Publication
First Author: Kasahara T
Year: 2006
Journal: Mol Psychiatry
Title: Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes.
Volume: 11
Issue: 6
Pages: 577-93, 523
Publication
First Author: Zullo SJ
Year: 1997
Journal: Cytogenet Cell Genet
Title: Localization by fluorescence in situ hybridization (FISH) of human mitochondrial polymerase gamma (POLG) to human chromosome band 15q24-->q26, and of mouse mitochondrial polymerase gamma (Polg) to mouse chromosome band 7E, with confirmation by direct sequence analysis of bacterial artificial chromosomes (BACs).
Volume: 78
Issue: 3-4
Pages: 281-4
Publication
First Author: Nissanka N
Year: 2018
Journal: Nat Commun
Title: The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.
Volume: 9
Issue: 1
Pages: 2491
Publication
First Author: Ma H
Year: 2018
Journal: PLoS One
Title: Germline and somatic mtDNA mutations in mouse aging.
Volume: 13
Issue: 7
Pages: e0201304
Publication
First Author: Ma H
Year: 2020
Journal: Biol Reprod
Title: Deleterious mtDNA mutations are common in mature oocytes.
Volume: 102
Issue: 3
Pages: 607-619
Publication
First Author: Wall CE
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice.
Volume: 112
Issue: 28
Pages: 8714-9
Publication  
First Author: Kolesar JE
Year: 2014
Journal: Free Radic Biol Med
Title: Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice.
Volume: 75
Pages: 241-51
Publication
First Author: Joseph AM
Year: 2013
Journal: PLoS One
Title: Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.
Volume: 8
Issue: 7
Pages: e69327
Publication
First Author: Someya S
Year: 2008
Journal: Neurobiol Aging
Title: The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.
Volume: 29
Issue: 7
Pages: 1080-92
Publication
First Author: Wang P
Year: 2022
Journal: Int J Biol Sci
Title: DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53.
Volume: 18
Issue: 1
Pages: 409-425
Publication
First Author: Lewis W
Year: 2007
Journal: Lab Invest
Title: Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.
Volume: 87
Issue: 4
Pages: 326-35
Publication
First Author: Kong YX
Year: 2011
Journal: Aging Cell
Title: Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury.
Volume: 10
Issue: 4
Pages: 572-83
Publication    
First Author: Woodall BP
Year: 2019
Journal: JCI Insight
Title: Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.
Volume: 5
Publication
First Author: Hance N
Year: 2005
Journal: Hum Mol Genet
Title: Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis.
Volume: 14
Issue: 13
Pages: 1775-83
HT Experiment
Series Id: GSE55188
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Mott JL
Year: 2000
Journal: DNA Cell Biol
Title: Genomic structure of murine mitochondrial DNA polymerase-gamma.
Volume: 19
Issue: 10
Pages: 601-5
Publication
First Author: Stewart JB
Year: 2008
Journal: PLoS Biol
Title: Strong purifying selection in transmission of mammalian mitochondrial DNA.
Volume: 6
Issue: 1
Pages: e10
Publication
First Author: Vermulst M
Year: 2007
Journal: Nat Genet
Title: Mitochondrial point mutations do not limit the natural lifespan of mice.
Volume: 39
Issue: 4
Pages: 540-3
Publication
First Author: Dai DF
Year: 2011
Journal: Circ Res
Title: Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.
Volume: 108
Issue: 7
Pages: 837-46
Publication
First Author: Mito T
Year: 2013
Journal: PLoS One
Title: Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.
Volume: 8
Issue: 2
Pages: e55789
Publication
First Author: Trifunovic A
Year: 2004
Journal: Nature
Title: Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Volume: 429
Issue: 6990
Pages: 417-23
Publication
First Author: Wiley CD
Year: 2016
Journal: Cell Metab
Title: Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
Volume: 23
Issue: 2
Pages: 303-14
Publication
First Author: Kujoth GC
Year: 2005
Journal: Science
Title: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
Volume: 309
Issue: 5733
Pages: 481-4
Publication  
First Author: Kim MJ
Year: 2019
Journal: Exp Gerontol
Title: Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.
Volume: 125
Pages: 110675
Publication
First Author: Hämäläinen RH
Year: 2015
Journal: Cell Rep
Title: mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling.
Volume: 11
Issue: 10
Pages: 1614-24
Publication  
First Author: Kuroki R
Year: 2020
Journal: Front Genet
Title: Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition.
Volume: 11
Pages: 519206
Publication
First Author: Dobson PF
Year: 2020
Journal: Sci Rep
Title: Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss.
Volume: 10
Issue: 1
Pages: 11643
Publication
First Author: Yang L
Year: 2020
Journal: Aging Cell
Title: Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox.
Volume: 19
Issue: 9
Pages: e13206
Publication
First Author: Hiona A
Year: 2010
Journal: PLoS One
Title: Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.
Volume: 5
Issue: 7
Pages: e11468
Publication
First Author: Geurts J
Year: 2020
Journal: Sci Rep
Title: Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features.
Volume: 10
Issue: 1
Pages: 1296
Publication
First Author: Yamasoba T
Year: 2007
Journal: Hear Res
Title: Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss.
Volume: 226
Issue: 1-2
Pages: 185-93
Publication
First Author: Crawley BK
Year: 2011
Journal: Hear Res
Title: Effects of mitochondrial mutations on hearing and cochlear pathology with age.
Volume: 280
Issue: 1-2
Pages: 201-8
Publication
First Author: Fox RG
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption.
Volume: 302
Issue: 9
Pages: G914-24
Publication
First Author: Safdar A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice.
Volume: 108
Issue: 10
Pages: 4135-40
Publication
First Author: Mito T
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.
Volume: 456
Issue: 4
Pages: 933-7
Publication
First Author: Ross JM
Year: 2013
Journal: Nature
Title: Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.
Volume: 501
Issue: 7467
Pages: 412-5
Publication
First Author: Freyer C
Year: 2012
Journal: Nat Genet
Title: Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
Volume: 44
Issue: 11
Pages: 1282-5
Publication
First Author: Li L
Year: 2014
Journal: Diabetes
Title: Defects in β-cell Ca2+ dynamics in age-induced diabetes.
Volume: 63
Issue: 12
Pages: 4100-14
Publication
First Author: Wanrooij S
Year: 2012
Journal: EMBO Rep
Title: In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.
Volume: 13
Issue: 12
Pages: 1130-7
Publication
First Author: Ameur A
Year: 2011
Journal: PLoS Genet
Title: Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.
Volume: 7
Issue: 3
Pages: e1002028
Publication
First Author: Niu X
Year: 2007
Journal: Exp Cell Res
Title: Somatic mtDNA mutations cause progressive hearing loss in the mouse.
Volume: 313
Issue: 18
Pages: 3924-34
Publication
First Author: Xu X
Year: 2013
Journal: Cell Metab
Title: Mitochondrial regulation in pluripotent stem cells.
Volume: 18
Issue: 3
Pages: 325-32
Publication
First Author: Forslund JME
Year: 2018
Journal: PLoS Genet
Title: The presence of rNTPs decreases the speed of mitochondrial DNA replication.
Volume: 14
Issue: 3
Pages: e1007315
Publication
First Author: Lv M
Year: 2021
Journal: FASEB J
Title: Adipose-derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy.
Volume: 35
Issue: 7
Pages: e21709
Publication
First Author: Yamada T
Year: 2012
Journal: J Physiol
Title: Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice.
Volume: 590
Issue: 23
Pages: 6187-97
Publication    
First Author: Brandt T
Year: 2017
Journal: Elife
Title: Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.
Volume: 6
Publication
First Author: McLaughlin KL
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart.
Volume: 504
Issue: 4
Pages: 742-748
Publication
First Author: Trifunovic A
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
Volume: 102
Issue: 50
Pages: 17993-8
Publication  
First Author: Baines HL
Year: 2014
Journal: Mech Ageing Dev
Title: Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans.
Volume: 139
Pages: 22-30
Publication
First Author: Vermulst M
Year: 2008
Journal: Nat Genet
Title: DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.
Volume: 40
Issue: 4
Pages: 392-4
Publication
First Author: Edgar D
Year: 2009
Journal: Cell Metab
Title: Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
Volume: 10
Issue: 2
Pages: 131-8
Publication
First Author: McLaughlin KL
Year: 2020
Journal: Sci Rep
Title: Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase.
Volume: 10
Issue: 1
Pages: 3603
Publication
First Author: Koczor CA
Year: 2013
Journal: Lab Invest
Title: Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis.
Volume: 93
Issue: 2
Pages: 151-8
Publication  
First Author: Macao B
Year: 2015
Journal: Nat Commun
Title: The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication.
Volume: 6
Pages: 7303
Publication
First Author: Zhang D
Year: 2000
Journal: Genomics
Title: Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis.
Volume: 69
Issue: 2
Pages: 151-61
Publication
First Author: Kasahara T
Year: 2008
Journal: PLoS One
Title: A marked effect of electroconvulsive stimulation on behavioral aberration of mice with neuron-specific mitochondrial DNA defects.
Volume: 3
Issue: 3
Pages: e1877
Publication
First Author: Kelly RD
Year: 2012
Journal: Nucleic Acids Res
Title: Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A.
Volume: 40
Issue: 20
Pages: 10124-38