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Search results 1 to 100 out of 246 for Polg

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5428 | POLG
Type: gene
Organism: human
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Gene
100488393 | polg
Type: gene
Organism: frog, western clawed
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Gene
85472 | Polg
Type: gene
Organism: rat
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Gene
467754 | POLG
Type: gene
Organism: chimpanzee
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Gene
533090 | POLG
Type: gene
Organism: cattle
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Gene
100856383 | POLG
Type: gene
Organism: dog, domestic
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Gene
404292 | POLG
Type: gene
Organism: chicken
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Gene
100150924 | polg
Type: gene
Organism: zebrafish
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Gene
699750 | POLG
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1196389 | Polg
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
119545629 | POLG-DT
Type: gene
Organism: human
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Gene
125316803 | POLGARF
Type: gene
Organism: human
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Publication
29109127 | J:316083
First Author: Nikkanen J
Year: 2018
Journal: EMBO Mol Med
Title: A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions.
Volume: 10
Issue: 1
Pages: 13-21
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Publication
24722488 | J:215087
First Author: Hauser DN
Year: 2014
Journal: PLoS One
Title: Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.
Volume: 9
Issue: 4
Pages: e94646
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Publication
29875308 | J:264412
First Author: Faraci C
Year: 2018
Journal: Reproduction
Title: Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.
Volume: 156
Issue: 2
Pages: 185-194
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Publication
26212336 | J:270683
 
First Author: Ni T
Year: 2015
Journal: Sci Rep
Title: MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice.
Volume: 5
Pages: 12049
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Publication
26464968 | J:229612
 
First Author: Hauser DN
Year: 2015
Journal: eNeuro
Title: The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.
Volume: 2
Issue: 1
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Publication
22225879 | J:303120
First Author: Ahlqvist KJ
Year: 2012
Journal: Cell Metab
Title: Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.
Volume: 15
Issue: 1
Pages: 100-9
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Publication
21109200 | J:168109
First Author: Williams SL
Year: 2010
Journal: Cell Metab
Title: The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.
Volume: 12
Issue: 6
Pages: 675-82
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Publication
30240410 | J:266732
First Author: Faraci C
Year: 2018
Journal: PLoS One
Title: Calorie restriction does not influence oocyte quality in oocytes from POLG mitochondrial mutator mice.
Volume: 13
Issue: 9
Pages: e0204373
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Publication
40057508 | J:369461
First Author: Bond ST
Year: 2025
Journal: Nat Commun
Title: Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle.
Volume: 16
Issue: 1
Pages: 2338
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Publication
38928146 | J:350078
 
First Author: Trease AJ
Year: 2024
Journal: Int J Mol Sci
Title: Mitochondrial DNA Instability Supersedes Parkin Mutations in Driving Mitochondrial Proteomic Alterations and Functional Deficits in Polg Mutator Mice.
Volume: 25
Issue: 12
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Publication
28158260 | J:252031
First Author: Someya S
Year: 2017
Journal: PLoS One
Title: Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.
Volume: 12
Issue: 2
Pages: e0171159
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Publication
26294258 | J:232253
First Author: Clark-Matott J
Year: 2015
Journal: Neurobiol Aging
Title: Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
Volume: 36
Issue: 11
Pages: 2972-2983
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Publication
32119683 | J:286178
First Author: Maclaine KD
Year: 2020
Journal: PLoS One
Title: Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging.
Volume: 15
Issue: 3
Pages: e0226860
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Publication
16619054 | J:127895
First Author: Kasahara T
Year: 2006
Journal: Mol Psychiatry
Title: Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes.
Volume: 11
Issue: 6
Pages: 577-93, 523
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Publication
17122057 | J:116179
First Author: Kubota M
Year: 2006
Journal: J Neurosci
Title: Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects.
Volume: 26
Issue: 47
Pages: 12314-24
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Publication
9465903 | J:45383
First Author: Zullo SJ
Year: 1997
Journal: Cytogenet Cell Genet
Title: Localization by fluorescence in situ hybridization (FISH) of human mitochondrial polymerase gamma (POLG) to human chromosome band 15q24-->q26, and of mouse mitochondrial polymerase gamma (Polg) to mouse chromosome band 7E, with confirmation by direct sequence analysis of bacterial artificial chromosomes (BACs).
Volume: 78
Issue: 3-4
Pages: 281-4
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Publication
29950568 | J:266489
First Author: Nissanka N
Year: 2018
Journal: Nat Commun
Title: The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.
Volume: 9
Issue: 1
Pages: 2491
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Publication
31621839 | J:286789
First Author: Ma H
Year: 2020
Journal: Biol Reprod
Title: Deleterious mtDNA mutations are common in mature oocytes.
Volume: 102
Issue: 3
Pages: 607-619
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Publication
39742470 | J:364856
First Author: Li-Harms X
Year: 2025
Journal: Sci Adv
Title: Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis.
Volume: 11
Issue: 1
Pages: eads8489
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Publication
30040856 | J:267870
First Author: Ma H
Year: 2018
Journal: PLoS One
Title: Germline and somatic mtDNA mutations in mouse aging.
Volume: 13
Issue: 7
Pages: e0201304
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Publication
26124126 | J:223723
First Author: Wall CE
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice.
Volume: 112
Issue: 28
Pages: 8714-9
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Publication
34975341 | J:322271
First Author: Wang P
Year: 2022
Journal: Int J Biol Sci
Title: DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53.
Volume: 18
Issue: 1
Pages: 409-425
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Publication
25106705 | J:220113
 
First Author: Kolesar JE
Year: 2014
Journal: Free Radic Biol Med
Title: Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice.
Volume: 75
Pages: 241-51
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Publication
23935986 | J:204458
First Author: Joseph AM
Year: 2013
Journal: PLoS One
Title: Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.
Volume: 8
Issue: 7
Pages: e69327
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Publication
17363114 | J:140916
First Author: Someya S
Year: 2008
Journal: Neurobiol Aging
Title: The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.
Volume: 29
Issue: 7
Pages: 1080-92
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Publication
17310215 | J:122507
First Author: Lewis W
Year: 2007
Journal: Lab Invest
Title: Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.
Volume: 87
Issue: 4
Pages: 326-35
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Publication
21332926 | J:217048
First Author: Kong YX
Year: 2011
Journal: Aging Cell
Title: Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury.
Volume: 10
Issue: 4
Pages: 572-83
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Publication
40393978 | J:366852
First Author: VanPortfliet JJ
Year: 2025
Journal: Nat Commun
Title: Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease.
Volume: 16
Issue: 1
Pages: 4640
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Publication
30990467 | J:294375
 
First Author: Woodall BP
Year: 2019
Journal: JCI Insight
Title: Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.
Volume: 5
Issue: 10
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Publication
15888483 | J:99794
First Author: Hance N
Year: 2005
Journal: Hum Mol Genet
Title: Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis.
Volume: 14
Issue: 13
Pages: 1775-83
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HT Experiment
E-GEOD-55188 | RNA-Seq of Aged Polg Mutator Mouse Brains
Series Id: GSE55188
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGP_CAROLIEiJ_G0029880 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
ENSMUSG00200034576 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00195013608 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00220036682 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00180013122 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00175020848 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1196389 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00215017344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSTCUG00005004099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00210023850 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00185045173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00205014117 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00230011304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSUMUG00000014365 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00190018435 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00225041336 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSLUMG00010016784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSIUOG00005020758 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013102 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
ENSMSPG00010022215 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11058962 | J:65559
First Author: Mott JL
Year: 2000
Journal: DNA Cell Biol
Title: Genomic structure of murine mitochondrial DNA polymerase-gamma.
Volume: 19
Issue: 10
Pages: 601-5
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Publication
15164064 | J:91077
First Author: Trifunovic A
Year: 2004
Journal: Nature
Title: Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Volume: 429
Issue: 6990
Pages: 417-23
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Publication
26095671 | J:343123
 
First Author: Macao B
Year: 2015
Journal: Nat Commun
Title: The exonuclease activity of DNA polymerase ? is required for ligation during mitochondrial DNA replication.
Volume: 6
Pages: 7303
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Publication
18232733 | J:131839
First Author: Stewart JB
Year: 2008
Journal: PLoS Biol
Title: Strong purifying selection in transmission of mammalian mitochondrial DNA.
Volume: 6
Issue: 1
Pages: e10
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Publication
39552337 | J:376826
 
First Author: Baindoor S
Year: 2024
Journal: Dis Model Mech
Title: Distinct fingerprints of tRNA-derived small non-coding RNA in animal models of neurodegeneration.
Volume: 17
Issue: 11
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Publication
23418460 | J:199416
First Author: Mito T
Year: 2013
Journal: PLoS One
Title: Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.
Volume: 8
Issue: 2
Pages: e55789
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Publication
37020546 | J:345241
 
First Author: Limper CB
Year: 2023
Journal: Front Immunol
Title: Effective differentiation of double negative thymocytes requires high fidelity replication of mitochondrial DNA in an age dependent manner.
Volume: 14
Pages: 1128626
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Publication
26686024 | J:232814
First Author: Wiley CD
Year: 2016
Journal: Cell Metab
Title: Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
Volume: 23
Issue: 2
Pages: 303-14
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Publication
23965628 | J:205430
First Author: Ross JM
Year: 2013
Journal: Nature
Title: Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.
Volume: 501
Issue: 7467
Pages: 412-5
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Publication
30217445 | J:272110
First Author: McLaughlin KL
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart.
Volume: 504
Issue: 4
Pages: 742-748
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Publication
34143518 | J:314532
First Author: Lv M
Year: 2021
Journal: FASEB J
Title: Adipose-derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy.
Volume: 35
Issue: 7
Pages: e21709
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Publication
32107436 | J:291764
First Author: McLaughlin KL
Year: 2020
Journal: Sci Rep
Title: Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase.
Volume: 10
Issue: 1
Pages: 3603
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Publication
22988144 | J:203020
First Author: Yamada T
Year: 2012
Journal: J Physiol
Title: Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice.
Volume: 590
Issue: 23
Pages: 6187-97
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Publication
19656491 | J:151969
First Author: Edgar D
Year: 2009
Journal: Cell Metab
Title: Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
Volume: 10
Issue: 2
Pages: 131-8
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Publication
23042113 | J:190382
First Author: Freyer C
Year: 2012
Journal: Nat Genet
Title: Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
Volume: 44
Issue: 11
Pages: 1282-5
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Publication
42669151 | J:393367
First Author: Khan NA
Year: 2026
Journal: Cell Rep
Title: NAD(+) precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria.
Volume: 45
Issue: 9
Pages: 117849
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Publication
29601571 | J:261916
First Author: Forslund JME
Year: 2018
Journal: PLoS Genet
Title: The presence of rNTPs decreases the speed of mitochondrial DNA replication.
Volume: 14
Issue: 3
Pages: e1007315
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Publication
38397399 | J:345960
 
First Author: Ross JM
Year: 2024
Journal: Biomolecules
Title: Mitochondrial Dysfunction and Protein Homeostasis in Aging: Insights from a Premature-Aging Mouse Model.
Volume: 14
Issue: 2
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Publication
16332961 | J:104391
First Author: Trifunovic A
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
Volume: 102
Issue: 50
Pages: 17993-8
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Publication
18311139 | J:134475
First Author: Vermulst M
Year: 2008
Journal: Nat Genet
Title: DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.
Volume: 40
Issue: 4
Pages: 392-4
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Publication
23850316 | J:202707
First Author: Xu X
Year: 2013
Journal: Cell Metab
Title: Mitochondrial regulation in pluripotent stem cells.
Volume: 18
Issue: 3
Pages: 325-32
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Publication
24985350 | J:302961
First Author: Li L
Year: 2014
Journal: Diabetes
Title: Defects in ?-cell Ca2+ dynamics in age-induced diabetes.
Volume: 63
Issue: 12
Pages: 4100-14
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Publication
28699890 | J:256955
   
First Author: Brandt T
Year: 2017
Journal: Elife
Title: Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.
Volume: 6
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Publication
24915468 | J:302956
 
First Author: Baines HL
Year: 2014
Journal: Mech Ageing Dev
Title: Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans.
Volume: 139
Pages: 22-30
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Publication
21455489 | J:332742
First Author: Ameur A
Year: 2011
Journal: PLoS Genet
Title: Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.
Volume: 7
Issue: 3
Pages: e1002028
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Publication
17662273 | J:145126
First Author: Niu X
Year: 2007
Journal: Exp Cell Res
Title: Somatic mtDNA mutations cause progressive hearing loss in the mouse.
Volume: 313
Issue: 18
Pages: 3924-34
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Publication
35243258 | J:370264
First Author: Marti Gutierrez N
Year: 2022
Journal: iScience
Title: Horizontal mtDNA transfer between cells is common during mouse development.
Volume: 25
Issue: 3
Pages: 103901
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Publication
39277581 | J:354229
First Author: Landoni JC
Year: 2024
Journal: Nat Commun
Title: Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation.
Volume: 15
Issue: 1
Pages: 8066
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Publication
16870370 | J:119971
First Author: Yamasoba T
Year: 2007
Journal: Hear Res
Title: Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss.
Volume: 226
Issue: 1-2
Pages: 185-93
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Publication
40595506 | J:369478
First Author: Korotkevich E
Year: 2025
Journal: Nat Commun
Title: Selfish mutations promote age-associated erosion of mtDNA integrity in mammals.
Volume: 16
Issue: 1
Pages: 5435
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Publication
41946679 | J:385579
 
First Author: Wu Y
Year: 2026
Journal: Bone Res
Title: Periosteal mitochondria DNA structures drive aging-associated poor skeletal repair.
Volume: 14
Issue: 1
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Publication
22345551 | J:187490
First Author: Fox RG
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption.
Volume: 302
Issue: 9
Pages: G914-24
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Publication
34652935 | J:370551
First Author: Lim EW
Year: 2021
Journal: Sci Adv
Title: Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in Polg(D257A) mice.
Volume: 7
Issue: 42
Pages: eabj4077
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Publication
21368114 | J:170832
First Author: Safdar A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice.
Volume: 108
Issue: 10
Pages: 4135-40
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Publication
31344454 | J:293498
 
First Author: Kim MJ
Year: 2019
Journal: Exp Gerontol
Title: Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.
Volume: 125
Pages: 110675
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Publication
33193604 | J:308311
 
First Author: Kuroki R
Year: 2020
Journal: Front Genet
Title: Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition.
Volume: 11
Pages: 519206
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Publication
31992827 | J:294597
First Author: Geurts J
Year: 2020
Journal: Sci Rep
Title: Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features.
Volume: 10
Issue: 1
Pages: 1296
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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