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Search results 1 to 100 out of 702 for Prkaa2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5563 | PRKAA2
Type: gene
Organism: human
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Gene
100216099 | prkaa2
Type: gene
Organism: frog, western clawed
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Gene
78975 | Prkaa2
Type: gene
Organism: rat
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Gene
489571 | PRKAA2
Type: gene
Organism: dog, domestic
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Gene
741802 | PRKAA2
Type: gene
Organism: chimpanzee
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Gene
538954 | PRKAA2
Type: gene
Organism: cattle
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Gene
429110 | PRKAA2
Type: gene
Organism: chicken
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Gene
572074 | prkaa2
Type: gene
Organism: zebrafish
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Gene
717703 | PRKAA2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028783 | PRKAA2
Type: Domain
Description: 5'-AMP-activated protein kinase catalytic subunit alpha (PRKAA) is the catalytic subunit of the AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism []. There are two AMPK alpha-subunit isoforms in mammals: PRKAA1 and PRKAA2. They have an N-terminal Ser/Thr kinase domain followed by an ubiquitin-associated (UBA)-like AID and a C-terminal AMPK regulatory domain [].This entry represents the AID that is responsible for PRKAA autoinhibition. PRKAA2 has been associated with type 2 diabetes [, ].
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Protein Coding Gene
MGI:1336173 | Prkaa2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16505254 | -
First Author: Sun MW
Year: 2006
Journal: Diabetes
Title: Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.
Volume: 55
Issue: 3
Pages: 849-55
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Publication
17950019 | -
First Author: Keshavarz P
Year: 2008
Journal: Mol Genet Metab
Title: Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes.
Volume: 93
Issue: 2
Pages: 200-9
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Publication
17712357 | -
First Author: Hardie DG
Year: 2007
Journal: Nat Rev Mol Cell Biol
Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Volume: 8
Issue: 10
Pages: 774-85
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Publication
38016036 | J:345967
 
First Author: Liu H
Year: 2024
Journal: JCI Insight
Title: ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA.
Volume: 9
Issue: 1
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Protein
Q8BRK8
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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Publication
12766162 | J:86014
First Author: Xing Y
Year: 2003
Journal: J Biol Chem
Title: Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase.
Volume: 278
Issue: 31
Pages: 28372-7
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Publication
15811316 | J:97374
First Author: Musi N
Year: 2005
Journal: FEBS Lett
Title: Functional role of AMP-activated protein kinase in the heart during exercise.
Volume: 579
Issue: 10
Pages: 2045-50
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Publication
19188503 | J:166008
First Author: Wang Y
Year: 2009
Journal: Circulation
Title: AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin.
Volume: 119
Issue: 6
Pages: 835-44
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Publication
18955383 | J:176559
First Author: Zwetsloot KA
Year: 2008
Journal: J Physiol
Title: AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise.
Volume: 586
Issue: 24
Pages: 6021-35
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Publication
18845612 | J:176562
First Author: Dzamko N
Year: 2008
Journal: J Physiol
Title: AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.
Volume: 586
Issue: 23
Pages: 5819-31
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Publication
18812461 | J:144090
First Author: Lefort N
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: The alpha-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro.
Volume: 295
Issue: 6
Pages: E1447-54
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Publication
19654283 | J:159583
First Author: Maarbjerg SJ
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice.
Volume: 297
Issue: 4
Pages: E924-34
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Publication
29287725 | J:271761
First Author: Cates C
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Activated protein C protects against pressure overload-induced hypertrophy through AMPK signaling.
Volume: 495
Issue: 4
Pages: 2584-2594
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Publication
19188248 | J:176549
First Author: Rose AJ
Year: 2009
Journal: J Physiol
Title: A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions.
Volume: 587
Issue: Pt 7
Pages: 1547-63
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Publication
36001969 | J:328042
First Author: Wang T
Year: 2022
Journal: Cell Rep
Title: The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.
Volume: 40
Issue: 8
Pages: 111210
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Publication
19531644 | J:152498
First Author: Pehmøller C
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle.
Volume: 297
Issue: 3
Pages: E665-75
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Publication
18728234 | J:142467
First Author: Fujii N
Year: 2008
Journal: Diabetes
Title: Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.
Volume: 57
Issue: 11
Pages: 2958-66
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Publication
17513699 | J:126468
First Author: Röckl KS
Year: 2007
Journal: Diabetes
Title: Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift.
Volume: 56
Issue: 8
Pages: 2062-9
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Publication
21297178 | J:170922
First Author: Jeppesen J
Year: 2011
Journal: J Lipid Res
Title: Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent.
Volume: 52
Issue: 4
Pages: 699-711
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Publication
23918774 | J:215852
First Author: Brandauer J
Year: 2013
Journal: J Physiol
Title: AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle.
Volume: 591
Issue: 20
Pages: 5207-20
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Publication
16186119 | J:104111
First Author: Fujii N
Year: 2005
Journal: J Biol Chem
Title: AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle.
Volume: 280
Issue: 47
Pages: 39033-41
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Publication
38094249 | J:343426
First Author: Malawsky DS
Year: 2023
Journal: iScience
Title: Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells.
Volume: 26
Issue: 12
Pages: 108443
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Publication
28351867 | J:240023
First Author: Anderson CM
Year: 2017
Journal: Development
Title: Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites.
Volume: 144
Issue: 7
Pages: 1235-1241
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Publication
27827305 | J:246068
First Author: Momken I
Year: 2017
Journal: Biochem J
Title: A new leptin-mediated mechanism for stimulating fatty acid oxidation: a pivotal role for sarcolemmal FAT/CD36.
Volume: 474
Issue: 1
Pages: 149-162
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Publication
31292296 | J:278266
 
First Author: Vila IK
Year: 2019
Journal: JCI Insight
Title: A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity.
Volume: 4
Issue: 13
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Publication
16804075 | J:111858
First Author: Treebak JT
Year: 2006
Journal: Diabetes
Title: AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.
Volume: 55
Issue: 7
Pages: 2051-8
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Publication
30772465 | J:352911
 
First Author: Ducommun S
Year: 2019
Journal: Cell Signal
Title: Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates.
Volume: 57
Pages: 45-57
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Publication
30328345 | J:285728
First Author: McCallum ML
Year: 2018
Journal: Reproduction
Title: A functional role for AMPK in female fertility and endometrial regeneration.
Volume: 156
Issue: 6
Pages: 501-513
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Publication
28389470 | J:247101
First Author: Sylow L
Year: 2017
Journal: Diabetes
Title: Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise.
Volume: 66
Issue: 6
Pages: 1548-1559
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Publication
27965101 | J:241714
First Author: Matheny RW Jr
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Skeletal muscle PI3K p110β regulates expression of AMP-activated protein kinase.
Volume: 482
Issue: 4
Pages: 1420-1426
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Publication
19159696 | J:148739
First Author: Habets DD
Year: 2009
Journal: Biochim Biophys Acta
Title: Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes.
Volume: 1791
Issue: 3
Pages: 212-9
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Publication
30646747 | J:281960
First Author: Wu S
Year: 2019
Journal: Circulation
Title: Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.
Volume: 139
Issue: 16
Pages: 1913-1936
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Publication
20701589 | J:166169
First Author: Vichaiwong K
Year: 2010
Journal: Biochem J
Title: Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.
Volume: 431
Issue: 2
Pages: 311-20
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Publication
25552597 | J:253120
First Author: Kjøbsted R
Year: 2015
Journal: Diabetes
Title: Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.
Volume: 64
Issue: 6
Pages: 2042-55
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Publication
32900951 | J:297627
First Author: Brandão BB
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
Volume: 117
Issue: 38
Pages: 23932-23941
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Publication
17709097 | J:125174
First Author: Ho RC
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle.
Volume: 362
Issue: 2
Pages: 354-9
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Publication
26378152 | J:263568
First Author: Kim GE
Year: 2015
Journal: Cardiovasc Res
Title: LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.
Volume: 108
Issue: 1
Pages: 197-208
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Publication
28916822 | J:252248
First Author: Laker RC
Year: 2017
Journal: Nat Commun
Title: Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy.
Volume: 8
Issue: 1
Pages: 548
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Protein Coding Gene
MGP_CAROLIEiJ_G0026227 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028210 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1336173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028936 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027646 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028179 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028327 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028295 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028428 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028971 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027372 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028562 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027196 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15331533 | J:92074
First Author: Villena JA
Year: 2004
Journal: Diabetes
Title: Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit.
Volume: 53
Issue: 9
Pages: 2242-9
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Publication
11981757 | J:82537
First Author: Tannour-Louet M
Year: 2002
Journal: Hepatology
Title: A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver.
Volume: 35
Issue: 5
Pages: 1072-81
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Publication
25637528 | J:220329
First Author: Chen T
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Muscle-selective knockout of AMPKα2 does not exacerbate diet-induced obesity probably related to altered myokines expression.
Volume: 458
Issue: 3
Pages: 449-55
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Publication
26552864 | J:228068
First Author: McKay SE
Year: 2015
Journal: Am J Pathol
Title: Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness.
Volume: 185
Issue: 12
Pages: 3132-40
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Publication
23274086 | J:195092
First Author: Faubert B
Year: 2013
Journal: Cell Metab
Title: AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.
Volume: 17
Issue: 1
Pages: 113-24
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Publication
34843742 | J:323816
 
First Author: Eacret D
Year: 2022
Journal: Behav Brain Res
Title: Adenosine Monophosphate-activated Protein Kinase (AMPK) in serotonin neurons mediates select behaviors during protracted withdrawal from morphine in mice.
Volume: 419
Pages: 113688
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Publication
27217398 | J:254553
First Author: Omura J
Year: 2016
Journal: Circ Res
Title: Protective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice.
Volume: 119
Issue: 2
Pages: 197-209
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Publication
23370326 | J:196878
First Author: Ríos M
Year: 2013
Journal: Cancer Res
Title: AMPK activation by oncogenesis is required to maintain cancer cell proliferation in astrocytic tumors.
Volume: 73
Issue: 8
Pages: 2628-38
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Publication
12511592 | J:81120
First Author: Viollet B
Year: 2003
Journal: J Clin Invest
Title: The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.
Volume: 111
Issue: 1
Pages: 91-8
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Publication
25365359 | J:261267
First Author: Noda K
Year: 2014
Journal: PLoS One
Title: Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice.
Volume: 9
Issue: 11
Pages: e110446
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Publication
18838626 | J:281918
First Author: Zhang P
Year: 2008
Journal: Hypertension
Title: AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice.
Volume: 52
Issue: 5
Pages: 918-24
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Publication
31902862 | J:292456
First Author: Sun ZG
Year: 2019
Journal: J Nutr Sci Vitaminol (Tokyo)
Title: AMPKα2 Deficiency Does Not Affect the Exercise-Induced Improvements in Glucose Tolerance and Metabolic Disorders in Mice Fed a High-Fat Diet.
Volume: 65
Issue: 6
Pages: 491-497
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Publication
17327449 | J:122024
First Author: Athéa Y
Year: 2007
Journal: Diabetes
Title: AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function.
Volume: 56
Issue: 3
Pages: 786-94
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Publication
17337600 | J:125906
First Author: Carvajal K
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion.
Volume: 292
Issue: 6
Pages: H3136-47
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Publication
30992489 | J:278615
First Author: Horakova O
Year: 2019
Journal: Sci Rep
Title: Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport.
Volume: 9
Issue: 1
Pages: 6156
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Publication
18812163 | J:143091
First Author: Zarrinpashneh E
Year: 2008
Journal: Biochem Biophys Res Commun
Title: AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol.
Volume: 376
Issue: 4
Pages: 677-81
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Publication
23224579 | J:194618
First Author: Lee-Young RS
Year: 2013
Journal: Diabetologia
Title: AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle.
Volume: 56
Issue: 3
Pages: 608-17
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Publication
22561688 | J:187465
First Author: Wang S
Year: 2012
Journal: Nat Med
Title: Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo.
Volume: 18
Issue: 6
Pages: 902-10
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Publication
23048187 | J:208466
First Author: Meijer RI
Year: 2013
Journal: Diabetes
Title: Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db mice.
Volume: 62
Issue: 2
Pages: 590-8
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Publication
29753072 | J:295006
 
First Author: Wang H
Year: 2018
Journal: Free Radic Biol Med
Title: AMPKα2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction.
Volume: 121
Pages: 202-214
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Publication
21825219 | J:194448
First Author: Hu X
Year: 2011
Journal: Hypertension
Title: AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development.
Volume: 58
Issue: 4
Pages: 696-703
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Publication
20693347 | J:169618
First Author: Jelenik T
Year: 2010
Journal: Diabetes
Title: AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids.
Volume: 59
Issue: 11
Pages: 2737-46
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Publication
27230293 | J:284816
 
First Author: Domise M
Year: 2016
Journal: Sci Rep
Title: AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo.
Volume: 6
Pages: 26758
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Publication
18835932 | J:143302
First Author: Xie Z
Year: 2008
Journal: Diabetes
Title: Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes.
Volume: 57
Issue: 12
Pages: 3222-30
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Publication
17711995 | J:126759
First Author: Klein DK
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise.
Volume: 293
Issue: 5
Pages: E1242-9
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Publication
37298222 | J:353928
 
First Author: Zhang M
Year: 2023
Journal: Int J Mol Sci
Title: Exercise Training Attenuates Acute β-Adrenergic Receptor Activation-Induced Cardiac Inflammation via the Activation of AMP-Activated Protein Kinase.
Volume: 24
Issue: 11
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Publication
24713487 | J:229880
First Author: Chatterjee A
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork.
Volume: 55
Issue: 5
Pages: 3127-39
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Publication
28479394 | J:254903
 
First Author: King-Himmelreich TS
Year: 2017
Journal: Neuropharmacology
Title: AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids.
Volume: 124
Pages: 134-142
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Publication
15967841 | J:114474
First Author: Schulz E
Year: 2005
Journal: Circulation
Title: Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.
Volume: 111
Issue: 25
Pages: 3473-80
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Publication
26068068 | J:237694
First Author: Ma X
Year: 2015
Journal: PLoS One
Title: Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent.
Volume: 10
Issue: 6
Pages: e0129971
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Publication
23316058 | J:195424
First Author: Fassett JT
Year: 2013
Journal: Am J Physiol Heart Circ Physiol
Title: AMPK attenuates microtubule proliferation in cardiac hypertrophy.
Volume: 304
Issue: 5
Pages: H749-58
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Publication
28143904 | J:259532
 
First Author: Marin TL
Year: 2017
Journal: Sci Signal
Title: AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.
Volume: 10
Issue: 464
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