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Search results 1 to 100 out of 118 for Psenen

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Type Details Score
Gene
55851 | PSENEN
Type: gene
Organism: human
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Gene
455962 | PSENEN
Type: gene
Organism: chimpanzee
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Gene
493993 | PSENEN
Type: gene
Organism: cattle
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Gene
402810 | psenen
Type: gene
Organism: zebrafish
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Gene
100429005 | PSENEN
Type: gene
Organism: macaque, rhesus
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Gene
549090 | psenen
Type: gene
Organism: frog, western clawed
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Gene
121108876 | PSENEN
Type: gene
Organism: chicken
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Gene
292788 | Psenen
Type: gene
Organism: rat
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Gene
476479 | PSENEN
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1913590 | Psenen
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
     
Probe: MGI:6181477
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191157
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Psenen
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6181477
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191157
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Psenen
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6181477
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6191157
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Psenen
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6181477
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6191157
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Psenen
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6181477
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191157
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Psenen
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6181477
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191157
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Psenen
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6181477
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191157
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Psenen
Detected: false
Specimen Num: 7
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Publication
34964690 | J:327484
First Author: Klein M
Year: 2022
Journal: Autophagy
Title: Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system.
Volume: 18
Issue: 9
Pages: 2068-2085
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Publication
38072061 | J:344349
First Author: Serneels L
Year: 2024
Journal: J Biol Chem
Title: Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.
Volume: 300
Issue: 1
Pages: 105533
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Protein Coding Gene
MGP_CAROLIEiJ_G0029528 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032028 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031938 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032012 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031731 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1913590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032478 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031065 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031697 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0031849 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031806 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031930 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031842 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032506 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031175 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012762 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030624 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12660785 | J:284995
First Author: Takasugi N
Year: 2003
Journal: Nature
Title: The role of presenilin cofactors in the gamma-secretase complex.
Volume: 422
Issue: 6930
Pages: 438-41
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Publication
25736404 | J:318282
First Author: Chu Y
Year: 2015
Journal: Acta Biochim Biophys Sin (Shanghai)
Title: Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice.
Volume: 47
Issue: 4
Pages: 258-66
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2853323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2854023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10420
Specimen Label: GUDMAP:10420
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5001533
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542087
Age: embryonic day 15.5
Image: GUDMAP:10455
Specimen Label: GUDMAP:10455
Detected: true
Specimen Num: 2
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Publication
32961023 | J:326593
First Author: Bi HR
Year: 2021
Journal: CNS Neurosci Ther
Title: Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling.
Volume: 27
Issue: 2
Pages: 174-185
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Publication
33972402 | J:316901
First Author: Hou J
Year: 2021
Journal: J Neurosci
Title: Pen-2 Negatively Regulates the Differentiation of Oligodendrocyte Precursor Cells into Astrocytes in the Central Nervous System.
Volume: 41
Issue: 23
Pages: 4976-4990
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Publication
12522139 | J:297314
First Author: Luo WJ
Year: 2003
Journal: J Biol Chem
Title: PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
Volume: 278
Issue: 10
Pages: 7850-4
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Publication
34292306 | J:321625
 
First Author: Wouters R
Year: 2021
Journal: J Cell Biol
Title: Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
Volume: 220
Issue: 9
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Publication
16371134 | J:111897
First Author: Shiraishi H
Year: 2006
Journal: Genes Cells
Title: Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
Volume: 11
Issue: 1
Pages: 83-93
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Publication
20130175 | J:157933
First Author: Zhao G
Year: 2010
Journal: J Neurosci
Title: Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.
Volume: 30
Issue: 5
Pages: 1648-56
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Publication
15474363 | J:93093
First Author: Hébert SS
Year: 2004
Journal: Neurobiol Dis
Title: Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.
Volume: 17
Issue: 2
Pages: 260-72
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Publication
34385359 | J:326435
First Author: Wang H
Year: 2021
Journal: J Neurosci
Title: Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
Volume: 41
Issue: 39
Pages: 8163-8180
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Publication
16641999 | J:108398
First Author: Chen F
Year: 2006
Journal: Nature
Title: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Volume: 440
Issue: 7088
Pages: 1208-12
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Publication
21597003 | J:177000
First Author: Barthet G
Year: 2011
Journal: FASEB J
Title: Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.
Volume: 25
Issue: 9
Pages: 2937-46
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Publication
15274632 | J:320147
First Author: Fraering PC
Year: 2004
Journal: Biochemistry
Title: Purification and characterization of the human gamma-secretase complex.
Volume: 43
Issue: 30
Pages: 9774-89
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Publication
14717705 | J:97674
First Author: Culvenor JG
Year: 2004
Journal: Eur J Biochem
Title: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
Volume: 271
Issue: 2
Pages: 375-85
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Publication
10206645 | J:54336
First Author: De Strooper B
Year: 1999
Journal: Nature
Title: A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Volume: 398
Issue: 6727
Pages: 518-22
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Publication
25741723 | J:219929
First Author: Xia D
Year: 2015
Journal: Neuron
Title: Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Volume: 85
Issue: 5
Pages: 967-81
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Publication
27256505 | J:236499
 
First Author: Liu L
Year: 2016
Journal: Neuroscience
Title: Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.
Volume: 330
Pages: 236-46
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Publication
34990407 | J:321806
 
First Author: Dave JM
Year: 2022
Journal: J Clin Invest
Title: JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.
Volume: 132
Issue: 5
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Publication
35575074 | J:325764
 
First Author: Xia Y
Year: 2022
Journal: Development
Title: Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus.
Volume: 149
Issue: 10
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Publication
30692224 | J:273599
First Author: Cheng S
Year: 2019
Journal: J Neurosci
Title: Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors.
Volume: 39
Issue: 12
Pages: 2195-2207
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Journal: MGI Direct Data Submission
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First Author: Shanghai Model Organisms Center
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Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Journal: Database Download
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First Author: Wellcome Trust Sanger Institute
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Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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First Author: GUDMAP Consortium
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First Author: Mouse Genome Informatics Scientific Curators
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First Author: Mouse Genome Informatics Scientific Curators
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Title: MGI Sequence Curation Reference
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
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Journal: Database Download
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Journal: Nature
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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