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Search results 1 to 100 out of 1674 for Ptk2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5747 | PTK2
Type: gene
Organism: human
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Gene
733890 | ptk2
Type: gene
Organism: frog, western clawed
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Gene
25614 | Ptk2
Type: gene
Organism: rat
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Gene
475108 | PTK2
Type: gene
Organism: dog, domestic
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Gene
464422 | PTK2
Type: gene
Organism: chimpanzee
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Gene
506270 | PTK2
Type: gene
Organism: cattle
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Gene
396416 | PTK2
Type: gene
Organism: chicken
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Gene
700634 | PTK2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:95481 | Ptk2
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
     
Probe: MGI:6181582
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191164
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ptk2
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6181582
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191164
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ptk2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6181582
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191164
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ptk2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6181582
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191164
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ptk2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6181582
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191164
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ptk2
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6181582
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191164
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ptk2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6181582
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191164
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ptk2
Detected: true
Specimen Num: 5
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Publication
31171046 | J:279711
First Author: Fenelon JC
Year: 2019
Journal: Zygote
Title: Focal adhesion kinase PTK2 autophosphorylation is not required for the activation of sodium-hydrogen exchange by decreased cell volume in the preimplantation mouse embryo.
Volume: 27
Issue: 3
Pages: 173-179
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Publication
7726850 | J:24213
First Author: Ilic D
Year: 1995
Journal: Biochem Biophys Res Commun
Title: Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells.
Volume: 209
Issue: 1
Pages: 300-9
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Publication
19201755 | J:148809
First Author: Park AY
Year: 2009
Journal: J Biol Chem
Title: Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis.
Volume: 284
Issue: 14
Pages: 9418-25
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Publication
11731413 | J:73153
First Author: McLean GW
Year: 2001
Journal: Cancer Res
Title: Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis.
Volume: 61
Issue: 23
Pages: 8385-9
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Publication
23799510 | J:205728
 
First Author: Kostourou V
Year: 2013
Journal: Nat Commun
Title: FAK-heterozygous mice display enhanced tumour angiogenesis.
Volume: 4
Pages: 2020
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Publication
21154724 | J:226147
First Author: Tavora B
Year: 2010
Journal: EMBO Mol Med
Title: Endothelial FAK is required for tumour angiogenesis.
Volume: 2
Issue: 12
Pages: 516-28
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Publication
25079333 | J:217095
First Author: Tavora B
Year: 2014
Journal: Nature
Title: Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy.
Volume: 514
Issue: 7520
Pages: 112-6
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Publication
34877929 | J:329045
   
First Author: Olivera GC
Year: 2021
Journal: Elife
Title: Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries.
Volume: 10
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Publication
18669633 | J:142317
First Author: Ding Q
Year: 2008
Journal: J Biol Chem
Title: Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner.
Volume: 283
Issue: 40
Pages: 26839-49
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Publication
39884384 | J:363584
 
First Author: Patrick R
Year: 2025
Journal: Microvasc Res
Title: Focal adhesion kinase mediates microvascular leakage and endothelial barrier dysfunction in ischemia-reperfusion injury.
Volume: 159
Pages: 104791
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Publication
21159635 | J:167604
First Author: Lee J
Year: 2010
Journal: Cancer Res
Title: Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma.
Volume: 70
Issue: 24
Pages: 10131-40
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Publication
15914540 | J:99022
First Author: Tilghman RW
Year: 2005
Journal: J Cell Sci
Title: Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells.
Volume: 118
Issue: Pt 12
Pages: 2613-23
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Publication
38824643 | J:363284
First Author: Akhter MZ
Year: 2024
Journal: Cell Rep
Title: FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity.
Volume: 43
Issue: 6
Pages: 114297
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Publication
17440961 | J:142495
First Author: Hayasaka H
Year: 2007
Journal: J Cell Biochem
Title: Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene.
Volume: 102
Issue: 4
Pages: 947-54
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Publication
23499373 | J:195344
First Author: Ding Q
Year: 2013
Journal: Am J Pathol
Title: FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.
Volume: 182
Issue: 5
Pages: 1572-84
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Publication
20522532 | J:185929
First Author: Ma H
Year: 2010
Journal: J Am Soc Nephrol
Title: Inhibition of podocyte FAK protects against proteinuria and foot process effacement.
Volume: 21
Issue: 7
Pages: 1145-56
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Publication
36222505 | J:348828
First Author: Roberts E
Year: 2022
Journal: Vasc Biol
Title: Cell contractility and focal adhesion kinase control circumferential arterial stiffness.
Volume: 4
Issue: 1
Pages: 28-39
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Publication
42503231 | J:392731
First Author: Ham E
Year: 2026
Journal: Mol Carcinog
Title: Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma.
Volume: 65
Issue: 10
Pages: 1209-1225
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Publication
20664055 | J:166470
First Author: Vemula S
Year: 2010
Journal: Blood
Title: Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Volume: 116
Issue: 20
Pages: 4103-15
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Publication
27064283 | J:234939
First Author: Haemmerle M
Year: 2016
Journal: J Clin Invest
Title: FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.
Volume: 126
Issue: 5
Pages: 1885-96
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Publication
19147559 | J:143710
First Author: Luo M
Year: 2009
Journal: Cancer Res
Title: Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.
Volume: 69
Issue: 2
Pages: 466-74
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Publication
28444899 | J:243594
First Author: Alexopoulou AN
Year: 2017
Journal: J Pathol
Title: Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice.
Volume: 242
Issue: 3
Pages: 358-370
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Publication
25536210 | J:322869
First Author: McGinnis LK
Year: 2015
Journal: Mol Reprod Dev
Title: Role of focal adhesion kinase in oocyte-follicle communication.
Volume: 82
Issue: 2
Pages: 90-102
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Publication
22105351 | J:178938
First Author: Li XY
Year: 2011
Journal: J Cell Biol
Title: Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.
Volume: 195
Issue: 5
Pages: 729-38
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Publication
21887232 | J:176155
First Author: Owen KA
Year: 2011
Journal: PLoS One
Title: FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing.
Volume: 6
Issue: 8
Pages: e23123
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Publication
18845837 | J:141117
First Author: Provenzano PP
Year: 2008
Journal: Am J Pathol
Title: Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.
Volume: 173
Issue: 5
Pages: 1551-65
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Publication
27677358 | J:259560
 
First Author: Shang N
Year: 2016
Journal: Sci Rep
Title: FAK deletion accelerates liver regeneration after two-thirds partial hepatectomy.
Volume: 6
Pages: 34316
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Publication
28283477 | J:241577
First Author: Wheaton AK
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis.
Volume: 312
Issue: 5
Pages: L722-L730
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Publication
25280866 | J:317777
First Author: Shelef MA
Year: 2014
Journal: Arthritis Res Ther
Title: Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis.
Volume: 16
Issue: 5
Pages: 464
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Publication
30001432 | J:264095
First Author: Heim JB
Year: 2018
Journal: PLoS One
Title: FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis.
Volume: 13
Issue: 7
Pages: e0200558
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Publication
21982831 | J:180092
First Author: Qin Y
Year: 2011
Journal: Am J Pathol
Title: Focal adhesion kinase signaling mediates acute renal injury induced by ischemia/reperfusion.
Volume: 179
Issue: 6
Pages: 2766-78
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Publication
38702347 | J:348051
First Author: Dahiya S
Year: 2024
Journal: Nat Commun
Title: Acinar to ?-like cell conversion through inhibition of focal adhesion kinase.
Volume: 15
Issue: 1
Pages: 3740
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Publication
38516563 | J:350683
 
First Author: Jia C
Year: 2024
Journal: Neurobiol Stress
Title: Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice.
Volume: 30
Pages: 100621
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Publication
24446483 | J:208263
First Author: Jean C
Year: 2014
Journal: J Cell Biol
Title: Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function.
Volume: 204
Issue: 2
Pages: 247-63
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Publication
14634134 | J:118569
First Author: Vial D
Year: 2003
Journal: J Immunol
Title: Alterations in granule matrix and cell surface of focal adhesion kinase-deficient mast cells.
Volume: 171
Issue: 11
Pages: 6178-86
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Publication
25242698 | J:217505
First Author: Tavora B
Year: 2014
Journal: Genesis
Title: Generation of point-mutant FAK knockin mice.
Volume: 52
Issue: 11
Pages: 907-15
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Publication
19561112 | J:151655
First Author: Kasorn A
Year: 2009
Journal: J Immunol
Title: Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.
Volume: 183
Issue: 2
Pages: 1032-43
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Publication
32493400 | J:297901
First Author: Paul R
Year: 2020
Journal: Breast Cancer Res
Title: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.
Volume: 22
Issue: 1
Pages: 59
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Publication
22264731 | J:180123
First Author: Chen XL
Year: 2012
Journal: Dev Cell
Title: VEGF-induced vascular permeability is mediated by FAK.
Volume: 22
Issue: 1
Pages: 146-57
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Publication
23832665 | J:201836
First Author: Luo M
Year: 2013
Journal: Cancer Res
Title: Distinct FAK activities determine progenitor and mammary stem cell characteristics.
Volume: 73
Issue: 17
Pages: 5591-602
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Publication
23028449 | J:191876
First Author: Castillo AB
Year: 2012
Journal: PLoS One
Title: Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo.
Volume: 7
Issue: 9
Pages: e43291
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Publication
18056629 | J:141541
First Author: Lahlou H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.
Volume: 104
Issue: 51
Pages: 20302-7
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Publication
22498697 | J:203602
First Author: Cai EP
Year: 2012
Journal: Diabetes
Title: In vivo role of focal adhesion kinase in regulating pancreatic ?-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.
Volume: 61
Issue: 7
Pages: 1708-18
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Publication
15601818 | J:94680
First Author: McLean GW
Year: 2004
Journal: Genes Dev
Title: Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.
Volume: 18
Issue: 24
Pages: 2998-3003
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Publication
34702049 | J:362556
First Author: Jeong K
Year: 2021
Journal: Circ Res
Title: FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes.
Volume: 129
Issue: 12
Pages: e215-e233
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Publication
19587216 | J:154139
First Author: Petzold T
Year: 2009
Journal: Am J Physiol Cell Physiol
Title: Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.
Volume: 297
Issue: 4
Pages: C814-22
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Publication
32910808 | J:301773
 
First Author: Weng Y
Year: 2020
Journal: JCI Insight
Title: Liver epithelial focal adhesion kinase modulates fibrogenesis and hedgehog signaling.
Volume: 5
Issue: 20
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Publication
7766995 | J:22801
First Author: Fiedorek FT Jr
Year: 1995
Journal: Mamm Genome
Title: Mapping of the focal adhesion kinase (Fadk) gene to mouse chromosome 15 and human chromosome 8.
Volume: 6
Issue: 2
Pages: 123-6
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Publication
16247468 | J:107206
First Author: Essayem S
Year: 2006
Journal: Oncogene
Title: Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK.
Volume: 25
Issue: 7
Pages: 1081-9
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Publication
35702047 | J:350155
First Author: Jia C
Year: 2022
Journal: J Cereb Blood Flow Metab
Title: Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition.
Volume: 42
Issue: 10
Pages: 1961-1974
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Publication
36270275 | J:331104
First Author: Foster DS
Year: 2022
Journal: Cancer Cell
Title: Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin.
Volume: 40
Issue: 11
Pages: 1392-1406.e7
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Publication
14657279 | J:87891
First Author: Ili? D
Year: 2004
Journal: J Cell Sci
Title: FAK promotes organization of fibronectin matrix and fibrillar adhesions.
Volume: 117
Issue: Pt 2
Pages: 177-87
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Publication
41616055 | J:378810
First Author: Mitchell DK
Year: 2026
Journal: Sci Adv
Title: Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis.
Volume: 12
Issue: 5
Pages: eady8382
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Publication
37527611 | J:372610
 
First Author: Murphy JM
Year: 2023
Journal: Atherosclerosis
Title: Nuclear FAK in endothelium: An intrinsic inhibitor of NF-?B activation in atherosclerosis.
Volume: 379
Pages: 117189
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Publication
25753414 | J:228192
First Author: Mui KL
Year: 2015
Journal: Cell Rep
Title: N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells.
Volume: 10
Issue: 9
Pages: 1477-1486
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Publication
28722198 | J:245518
 
First Author: He Y
Year: 2017
Journal: Genesis
Title: Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene.
Volume: 55
Issue: 9
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Publication
19880522 | J:159965
First Author: Lim ST
Year: 2010
Journal: J Biol Chem
Title: Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.
Volume: 285
Issue: 3
Pages: 1743-53
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Publication
22872087 | J:316187
First Author: Chac?n MR
Year: 2012
Journal: Development
Title: Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
Volume: 139
Issue: 17
Pages: 3200-10
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Publication
24080910 | J:202456
First Author: Perricone AJ
Year: 2013
Journal: J Am Heart Assoc
Title: Conditional knockout of myocyte focal adhesion kinase abrogates ischemic preconditioning in adult murine hearts.
Volume: 2
Issue: 5
Pages: e000457
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Publication
38631549 | J:349884
First Author: Ding LY
Year: 2024
Journal: Am J Pathol
Title: Stromal Rigidity Stress Accelerates Pancreatic Intraepithelial Neoplasia Progression and Chromosomal Instability via Nuclear Protein Tyrosine Kinase 2 Localization.
Volume: 194
Issue: 7
Pages: 1346-1373
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Publication
30408465 | J:273619
 
First Author: Jia C
Year: 2019
Journal: Exp Neurol
Title: Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF.
Volume: 312
Pages: 20-32
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Publication
17925492 | J:130102
First Author: Hitchcock IS
Year: 2008
Journal: Blood
Title: Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.
Volume: 111
Issue: 2
Pages: 596-604
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Publication
22155722 | J:191529
First Author: Lu J
Year: 2012
Journal: Exp Hematol
Title: Fak depletion in both hematopoietic and nonhematopoietic niche cells leads?to?hematopoietic stem cell expansion.
Volume: 40
Issue: 4
Pages: 307-17.e3
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Publication
21640103 | J:174314
First Author: Shen CJ
Year: 2011
Journal: Exp Cell Res
Title: Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner.
Volume: 317
Issue: 13
Pages: 1860-71
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Publication
18391070 | J:134671
First Author: Weis SM
Year: 2008
Journal: J Cell Biol
Title: Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.
Volume: 181
Issue: 1
Pages: 43-50
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Publication
7478517 | J:29978
First Author: Furuta Y
Year: 1995
Journal: Oncogene
Title: Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.
Volume: 11
Issue: 10
Pages: 1989-95
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Publication
19136609 | J:146540
First Author: Manso AM
Year: 2009
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration.
Volume: 296
Issue: 3
Pages: H627-38
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Publication
17568820 | J:168135
First Author: Glodek AM
Year: 2007
Journal: Leukemia
Title: Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.
Volume: 21
Issue: 8
Pages: 1723-32
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Publication
28348210 | J:242026
First Author: Heim JB
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.
Volume: 114
Issue: 15
Pages: 3933-3938
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Publication
32499572 | J:293349
First Author: Lechertier T
Year: 2020
Journal: Nat Commun
Title: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Volume: 11
Issue: 1
Pages: 2810
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Publication
23771883 | J:231253
First Author: Schmidt TT
Year: 2013
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities.
Volume: 305
Issue: 4
Pages: L291-300
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Publication
22555221 | J:317064
First Author: O'Neill TJ 4th
Year: 2012
Journal: J Mol Cell Cardiol
Title: Germline deletion of FAK-related non-kinase delays post-natal cardiomyocyte mitotic arrest.
Volume: 53
Issue: 2
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