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Search results 1 to 100 out of 104 for Ptpa

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0.043s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Wang J
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology.
Volume: 116
Issue: 25
Pages: 12500-12505
Publication  
First Author: Meeusen B
Year: 2021
Journal: Cancer Lett
Title: PPP2R4 dysfunction promotes KRAS-mutant lung adenocarcinoma development and mediates opposite responses to MEK and mTOR inhibition.
Volume: 520
Pages: 57-67
Publication
First Author: Sents W
Year: 2017
Journal: Cancer Res
Title: PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.
Volume: 77
Issue: 24
Pages: 6825-6837
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823698
Age: embryonic day 10.5
Image: Ppp2r4_a40_E10.5a_RF_JL
Specimen Label: Ppp2r4_a40_E10.5a_RF_JL
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823698
Age: embryonic day 10.5
Image: Ppp2r4_a40_E10.5b_RF_JL
Specimen Label: Ppp2r4_a40_E10.5b_RF_JL
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823698
Age: embryonic day 10.5
Image: Ppp2r4_a40_E10.5c_RF_3JUNE2013
Specimen Label: Ppp2r4_a40_E10.5c_RF_3JUNE2013
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Uniform
Stage: TS19
Assay Id: MGI:5823698
Age: embryonic day 11.5
Image: Ppp2r4_a40_E11.5a_RF_JL
Specimen Label: Ppp2r4_a40_E11.5a_RF_JL
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Uniform
Stage: TS19
Assay Id: MGI:5823698
Age: embryonic day 11.5
Image: Ppp2r4_a40_E11.5b_RF_JL
Specimen Label: Ppp2r4_a40_E11.5b_RF_JL
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823698
Age: embryonic day 10.5
Image: Ppp2r4_a40_E10.5a_JL
Specimen Label: Ppp2r4_a40_E10.5a_JL
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823698
Age: embryonic day 10.5
Image: Ppp2r4_a40_E10.5b_JL
Specimen Label: Ppp2r4_a40_E10.5b_JL
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823698
Age: embryonic day 10.5
Image: Ppp2r4_a40_E10.5c_3JUNE2013
Specimen Label: Ppp2r4_a40_E10.5c_3JUNE2013
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Widespread
Stage: TS19
Assay Id: MGI:5823698
Age: embryonic day 11.5
Image: Ppp2r4_a40_E11.5a_JL
Specimen Label: Ppp2r4_a40_E11.5a_JL
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:5811455
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Widespread
Stage: TS19
Assay Id: MGI:5823698
Age: embryonic day 11.5
Image: Ppp2r4_a40_E11.5b_JL
Specimen Label: Ppp2r4_a40_E11.5b_JL
Detected: true
Specimen Num: 10
Protein
Organism: Mus musculus
Length: 382  
Fragment?: false
Publication
First Author: Wang Q
Year: 2016
Journal: Biochem J
Title: A ternary complex comprising FAK, PTPα and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts.
Volume: 473
Issue: 4
Pages: 397-410
Publication
First Author: Ortega-Gutiérrez S
Year: 2008
Journal: PLoS One
Title: Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.
Volume: 3
Issue: 7
Pages: e2486
Publication        
First Author: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Year: 2001
Title: GenBank Record Derived Information
Publication
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
Publication
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
Publication      
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
Publication      
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Protein Domain
Type: Homologous_superfamily
Description: Phosphotyrosyl phosphatase activator (PTPA, also known as protein phosphatase 2A activator) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. It also reactivates the serine/threonine phosphatase activity of an inactive form of PP2A. The specific biological role of PTPA is unknown. PTPA has been suggested to play a role in the insertion of metals to the PP2A catalytic subunit (PP2Ac) active site, to act as a chaperone, and more recently, to have peptidyl prolyl cis/trans isomerase activity that specifically targets human PP2Ac [, , , , , ]. Together, PTPA and PP2A constitute an ATPase and it has been suggested that PTPA alters the relative specificity of PP2A from phosphoserine/phosphothreonine substrates to phosphotyrosine substrates in an ATP-hydrolysis-dependent manner. Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1 [].PTPA as a multihelical structure fold.
Publication
First Author: Van Hoof C
Year: 2005
Journal: Biochem J
Title: Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.
Volume: 386
Issue: Pt 1
Pages: 93-102
Protein Domain
Type: Family
Description: Phosphotyrosyl phosphatase activator (PTPA, also known as protein phosphatase 2A activator) proteins stimulate the phosphotyrosylphosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. It also reactivates the serine/threonine phosphatase activity of an inactive form of PP2A. The specific biological role of PTPA is unknown. PTPA has been suggested to play a role in the insertion of metals to the PP2A catalytic subunit (PP2Ac) active site, to act as a chaperone, and more recently, to have peptidyl prolyl cis/trans isomerase activity that specifically targets human PP2Ac [, , , , , ]. Together, PTPA and PP2A constitute an ATPase and it has been suggested that PTPA alters the relative specificity of PP2A from phosphoserine/phosphothreonine substrates to phosphotyrosine substrates in an ATP-hydrolysis-dependent manner. Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1 [].
Protein
Organism: Mus musculus
Length: 323  
Fragment?: false
Publication
First Author: Wang J
Year: 2017
Journal: Nat Commun
Title: The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.
Volume: 8
Issue: 1
Pages: 244
Publication
First Author: Luo Y
Year: 2013
Journal: Biochim Biophys Acta
Title: PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.
Volume: 1833
Issue: 5
Pages: 1235-43
Publication
First Author: Fellner T
Year: 2003
Journal: Genes Dev
Title: A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.
Volume: 17
Issue: 17
Pages: 2138-50
Protein
Organism: Mus musculus
Length: 61  
Fragment?: false
Protein
Organism: Mus musculus
Length: 126  
Fragment?: true
Protein
Organism: Mus musculus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus
Length: 281  
Fragment?: false
Protein
Organism: Mus musculus
Length: 104  
Fragment?: false
Protein
Organism: Mus musculus
Length: 323  
Fragment?: false
Publication
First Author: Chao Y
Year: 2006
Journal: Mol Cell
Title: Structure and mechanism of the phosphotyrosyl phosphatase activator.
Volume: 23
Issue: 4
Pages: 535-46
Publication
First Author: Leulliot N
Year: 2006
Journal: Mol Cell
Title: Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Volume: 23
Issue: 3
Pages: 413-24
Publication
First Author: Magnusdottir A
Year: 2006
Journal: J Biol Chem
Title: The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.
Volume: 281
Issue: 32
Pages: 22434-8
Publication
First Author: Jordens J
Year: 2006
Journal: J Biol Chem
Title: The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase.
Volume: 281
Issue: 10
Pages: 6349-57
Publication
First Author: Janssens V
Year: 2001
Journal: Biochem J
Title: Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.
Volume: 353
Issue: Pt 3
Pages: 417-39
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus