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Search results 1 to 100 out of 1096 for Ptprc

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5788 | PTPRC
Type: gene
Organism: human
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Gene
100493434 | ptprc
Type: gene
Organism: frog, western clawed
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Gene
24699 | Ptprc
Type: gene
Organism: rat
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Gene
490255 | PTPRC
Type: gene
Organism: dog, domestic
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Gene
457607 | PTPRC
Type: gene
Organism: chimpanzee
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Gene
407152 | PTPRC
Type: gene
Organism: cattle
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Gene
386580 | PTPRC
Type: gene
Organism: chicken
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Gene
559154 | ptprc
Type: gene
Organism: zebrafish
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Gene
712657 | PTPRC
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR016335 | Ptprc
Type: Family
Description: Receptor-type tyrosine-protein phosphatase C, also known as CD45, is a tyrosine-protein phosphatase required for T-cell activation through the antigen receptor []. It acts as a positive regulator of T-cell co-activation upon binding to DPP4 (CD26) [].
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Protein Coding Gene
MGI:97810 | Ptprc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q05C79
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Gene
139281668 | PTPRC-AS1
Type: gene
Organism: human
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Publication
2845400 | J:22340
First Author: Charbonneau H
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.
Volume: 85
Issue: 19
Pages: 7182-6
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Gene
108281163 | LOC108281163
Type: gene
Organism: human
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Publication
38697553 | J:352108
 
First Author: Ryan CE
Year: 2024
Journal: Mol Cell Probes
Title: Single-tube Ptprc SNP genotyping of JAXBoy (CD45.1) and C57BL/6J (CD45.2) mice by endpoint PCR and gel electrophoresis.
Volume: 75
Pages: 101962
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GXD Expression
GXD Expression
 
Probe: MGI:952870
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4827525
Age: embryonic day 14.5
Note: Expression is present in single cells in which the intercellular distance between stained cells is approximately equal to the cell diameter of an individual cell. A thumbnail photo of the staining is contained in the table.
Specimen Label: Table S9 - Ptprc
Detected: true
Specimen Num: 1
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Protein
P06800
Organism: Mus musculus/domesticus
Length: 1293  
Fragment?: false
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Protein
S4R1M0
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
Q8C6Q7
Organism: Mus musculus/domesticus
Length: 879  
Fragment?: true
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Protein
Q3U382
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
A0A0A6YXM4
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
Q64730
Organism: Mus musculus/domesticus
Length: 1343  
Fragment?: false
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Publication
11593028 | -
First Author: Ishii T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO.
Volume: 98
Issue: 21
Pages: 12138-43
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191166
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ptprc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191166
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ptprc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191166
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ptprc
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191166
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ptprc
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191166
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ptprc
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191166
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ptprc
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191166
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ptprc
Detected: true
Specimen Num: 7
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Protein
Q5XFY7
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: true
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Publication
8954783 | J:36984
First Author: Bruyns E
Year: 1996
Journal: Genomics
Title: Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.
Volume: 38
Issue: 1
Pages: 79-83
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Publication
- | J:265143
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Half_measure.
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Publication
- | J:152064
     
First Author: Siggs OM
Year: 2009
Journal: MGI Direct Data Submission
Title: Record for belittle, updated 17 Aug 2009 (Accessed 3 September 2009)
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Publication
- | J:254899
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for guotie2
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Publication
24068938 | J:214487
First Author: Caignard G
Year: 2013
Journal: PLoS Pathog
Title: Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.
Volume: 9
Issue: 9
Pages: e1003637
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Publication
30820040 | J:295283
First Author: Kresinsky A
Year: 2019
Journal: Oncogene
Title: Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation.
Volume: 38
Issue: 24
Pages: 4773-4787
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Publication
38017180 | J:358634
First Author: Laubreton D
Year: 2023
Journal: Lab Anim (NY)
Title: Generation of a C57BL/6J mouse strain expressing the CD45.1 epitope to improve hematopoietic stem cell engraftment and adoptive cell transfer experiments.
Volume: 52
Issue: 12
Pages: 324-331
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Publication
20505149 | J:161440
First Author: Wu Z
Year: 2010
Journal: J Immunol
Title: Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.
Volume: 185
Issue: 1
Pages: 231-8
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Publication
22724066 | J:225105
First Author: Andrews TD
Year: 2012
Journal: Open Biol
Title: Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
Volume: 2
Issue: 5
Pages: 120061
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Publication
34001904 | J:332772
First Author: Jin H
Year: 2021
Journal: Nat Commun
Title: Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.
Volume: 12
Issue: 1
Pages: 2863
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Publication
21423172 | J:171925
First Author: Siggs OM
Year: 2011
Journal: Nat Immunol
Title: The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.
Volume: 12
Issue: 5
Pages: 434-40
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Protein Coding Gene
MGP_CAROLIEiJ_G0014660 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016528 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016493 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016488 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016314 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97810 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016287 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016393 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016392 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016464 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027896 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015467 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
2944116 | J:8412
First Author: Saga Y
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA.
Volume: 83
Issue: 18
Pages: 6940-4
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Publication
1822988 | J:12548
First Author: Zebedee SL
Year: 1991
Journal: Dev Immunol
Title: Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles.
Volume: 1
Issue: 4
Pages: 243-54
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Publication
3037546 | J:8781
First Author: Saga Y
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages.
Volume: 84
Issue: 15
Pages: 5364-8
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Publication
3211131 | J:9538
First Author: Saga Y
Year: 1988
Journal: Mol Cell Biol
Title: Organization of the Ly-5 gene.
Volume: 8
Issue: 11
Pages: 4889-95
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Publication
3864163 | J:8080
First Author: Shen FW
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: Cloning of Ly-5 cDNA.
Volume: 82
Issue: 21
Pages: 7360-3
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Publication
2948186 | J:8545
First Author: Raschke WC
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages.
Volume: 84
Issue: 1
Pages: 161-5
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Publication
2955416 | J:8780
First Author: Thomas ML
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: B-cell variant of mouse T200 (Ly-5): evidence for alternative mRNA splicing.
Volume: 84
Issue: 15
Pages: 5360-3
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Publication
16356861 | J:113310
First Author: Hermiston ML
Year: 2005
Journal: Immunity
Title: The juxtamembrane wedge negatively regulates CD45 function in B cells.
Volume: 23
Issue: 6
Pages: 635-47
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Publication
23315077 | J:193323
First Author: Nobrega C
Year: 2013
Journal: J Immunol
Title: T cells home to the thymus and control infection.
Volume: 190
Issue: 4
Pages: 1646-58
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Publication
32978280 | J:303626
First Author: Daly CA
Year: 2020
Journal: J Immunol
Title: B Cell Subsets Differentially Contribute to the T Cell-Independent Memory Pool.
Volume: 205
Issue: 9
Pages: 2362-2374
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Publication
16517710 | J:129514
First Author: Dawes R
Year: 2006
Journal: J Immunol
Title: Combinations of CD45 isoforms are crucial for immune function and disease.
Volume: 176
Issue: 6
Pages: 3417-25
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Publication
18448457 | J:136717
First Author: Salmond RJ
Year: 2008
Journal: Int Immunol
Title: CD4+ T cell hyper-responsiveness in CD45 transgenic mice is independent of isoform.
Volume: 20
Issue: 7
Pages: 819-27
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Publication
16771860 | J:111956
First Author: Piercy J
Year: 2006
Journal: Immunology
Title: CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.
Volume: 118
Issue: 2
Pages: 250-6
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Publication
11342624 | J:106732
First Author: Martin SM
Year: 2001
Journal: J Immunol
Title: Development of intestinal intraepithelial lymphocytes, NK cells, and NK 1.1+ T cells in CD45-deficient mice.
Volume: 166
Issue: 10
Pages: 6066-73
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Publication
16856204 | J:113135
First Author: Montoya M
Year: 2006
Journal: Eur J Immunol
Title: CD45 is required for type I IFN production by dendritic cells.
Volume: 36
Issue: 8
Pages: 2150-8
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Publication
12393487 | J:115557
First Author: Virts EL
Year: 2003
Journal: Blood
Title: A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency.
Volume: 101
Issue: 3
Pages: 849-55
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Publication
11201744 | J:78884
First Author: Irie-Sasaki J
Year: 2001
Journal: Nature
Title: CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
Volume: 409
Issue: 6818
Pages: 349-54
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Publication
17277109 | J:143998
First Author: Falahati R
Year: 2007
Journal: J Immunol
Title: Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development.
Volume: 178
Issue: 4
Pages: 2056-64
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Publication
19269962 | J:149759
First Author: Panchal RG
Year: 2009
Journal: J Biol Chem
Title: Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.
Volume: 284
Issue: 19
Pages: 12874-85
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Publication
9190928 | J:110662
First Author: Stone JD
Year: 1997
Journal: J Immunol
Title: Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.
Volume: 158
Issue: 12
Pages: 5773-82
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Publication
15302847 | J:91960
First Author: Tchilian EZ
Year: 2004
Journal: Int Immunol
Title: Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice.
Volume: 16
Issue: 9
Pages: 1323-32
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Publication
18941197 | J:140741
First Author: Falahati R
Year: 2008
Journal: J Immunol
Title: Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.
Volume: 181
Issue: 9
Pages: 6082-91
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Publication
21273420 | J:168546
First Author: Zhu Y
Year: 2011
Journal: J Neurosci
Title: CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice.
Volume: 31
Issue: 4
Pages: 1355-65
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Publication
33990399 | J:307958
First Author: Alborzian Deh Sheikh A
Year: 2021
Journal: J Immunol
Title: The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells.
Volume: 206
Issue: 11
Pages: 2544-2551
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Publication
16505159 | J:129251
First Author: Dawes R
Year: 2006
Journal: J Med Genet
Title: Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection.
Volume: 43
Issue: 8
Pages: 678-84
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Publication
12902479 | J:84808
First Author: Ogilvy S
Year: 2003
Journal: J Immunol
Title: Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice.
Volume: 171
Issue: 4
Pages: 1792-800
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Publication
10970857 | J:64671
First Author: Baker M
Year: 2000
Journal: EMBO J
Title: Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.
Volume: 19
Issue: 17
Pages: 4644-54
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Publication
17719247 | J:125225
First Author: McNeill L
Year: 2007
Journal: Immunity
Title: The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.
Volume: 27
Issue: 3
Pages: 425-37
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Publication
15557316 | J:94797
First Author: López MC
Year: 2005
Journal: Int Immunol
Title: Phenotypical and functional alterations in the mucosal immune system of CD45 exon 9 KO mice.
Volume: 17
Issue: 1
Pages: 15-25
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Publication
19683682 | J:282686
First Author: Panchal RG
Year: 2009
Journal: Cell Host Microbe
Title: Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection.
Volume: 6
Issue: 2
Pages: 162-73
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Publication
38933266 | J:360394
 
First Author: Firdessa-Fite R
Year: 2024
Journal: Front Immunol
Title: Soluble antigen arrays provide increased efficacy and safety over free peptides for tolerogenic immunotherapy.
Volume: 15
Pages: 1258369
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Publication
8334701 | J:13163
First Author: Kishihara K
Year: 1993
Journal: Cell
Title: Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice.
Volume: 74
Issue: 1
Pages: 143-56
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Publication
16627620 | J:109462
First Author: Hesslein DG
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production.
Volume: 103
Issue: 18
Pages: 7012-7
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Publication
22135465 | J:180527
First Author: Zikherman J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.
Volume: 109
Issue: 1
Pages: E3-12
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Publication
15823427 | J:104929
First Author: Nakahara J
Year: 2005
Journal: Neurosci Lett
Title: Involvement of CD45 in central nervous system myelination.
Volume: 379
Issue: 2
Pages: 116-21
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Publication
15294970 | J:92653
First Author: Fleming HE
Year: 2004
Journal: J Immunol
Title: CD45-deficient mice accumulate Pro-B cells both in vivo and in vitro.
Volume: 173
Issue: 4
Pages: 2542-51
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Publication
9197241 | J:114804
First Author: Roach T
Year: 1997
Journal: Curr Biol
Title: CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion.
Volume: 7
Issue: 6
Pages: 408-17
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Publication
8551241 | J:78888
First Author: Benatar T
Year: 1996
Journal: J Exp Med
Title: Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.
Volume: 183
Issue: 1
Pages: 329-34
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