|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 156 for Rad17

<< First    < Previous  |  Next >    Last >>
0.056s
Type Details Score
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: This entry represents Rad17 from budding yeast (the homologue of human and S. pombe Rad1). Rad17 is a component of the checkpoint clamp complex (Ddc1/Mec3/Rad17) involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes [, , ]. In S. cerevisiae, the Ddc1-Mec3-Rad17 complex associates with sites of DNA damage and modulates the Mec1 signaling pathway and the activation of Rad53 in response to DNA damage at phase G1 []. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA []. Contrary to its human counterpart, the 9-1-1 complex, the checkpoint clamp complex shows no detectable exonuclease activity []. It's worth noting that the name, Rad17, has been used for a different protein in human and S. pombe. The homologue of the human and S. pombe Rad17 in budding yeast is Rad24.
Publication
First Author: Budzowska M
Year: 2004
Journal: EMBO J
Title: Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.
Volume: 23
Issue: 17
Pages: 3548-58
Publication
First Author: von Deimling F
Year: 1999
Journal: Hum Genet
Title: Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma.
Volume: 105
Issue: 1-2
Pages: 17-27
Publication
First Author: Bluyssen HA
Year: 1999
Journal: Genomics
Title: Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Volume: 55
Issue: 2
Pages: 219-28
Publication
First Author: Bao S
Year: 1998
Journal: Cell Growth Differ
Title: The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint.
Volume: 9
Issue: 12
Pages: 961-7
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Paciotti V
Year: 1998
Journal: EMBO J
Title: Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.
Volume: 17
Issue: 14
Pages: 4199-209
Publication
First Author: Lydall D
Year: 1995
Journal: Science
Title: Yeast checkpoint genes in DNA damage processing: implications for repair and arrest.
Volume: 270
Issue: 5241
Pages: 1488-91
Publication
First Author: Sabbioneda S
Year: 2005
Journal: J Biol Chem
Title: The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.
Volume: 280
Issue: 46
Pages: 38657-65
Publication
First Author: Siede W
Year: 1996
Journal: Nucleic Acids Res
Title: Cloning and characterization of RAD17, a gene controlling cell cycle responses to DNA damage in Saccharomyces cerevisiae.
Volume: 24
Issue: 9
Pages: 1669-75
Publication
First Author: Kondo T
Year: 1999
Journal: Mol Cell Biol
Title: Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway.
Volume: 19
Issue: 2
Pages: 1136-43
Publication
First Author: Majka J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.
Volume: 100
Issue: 5
Pages: 2249-54
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:7412812
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7412903
Age: embryonic day 18.0
Image: 2
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7412812
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7412903
Age: postnatal month 2
Image: 2
Specimen Label: 2 months
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7412812
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691016
Stage: TS16
Assay Id: MGI:7412903
Age: embryonic day 10.0
Image: 2
Specimen Label: E10
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3487163
Assay Type: RT-PCR
Annotation Date: 2004-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3487255
Age: embryonic day 8.5
Specimen Label: +/5'delta
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3487163
Assay Type: RT-PCR
Annotation Date: 2004-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3487255
Age: embryonic day 8.5
Specimen Label: 5' delta/5' delta
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3487163
Assay Type: RT-PCR
Annotation Date: 2004-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3487255
Age: embryonic day 8.5
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3487257
Assay Type: Western blot
Annotation Date: 2004-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3487258
Age: embryonic day 8.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3487257
Assay Type: Western blot
Annotation Date: 2004-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3487258
Age: embryonic day 8.5
Specimen Label: +/5' delta
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3487257
Assay Type: Western blot
Annotation Date: 2004-11-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3487258
Age: embryonic day 8.5
Specimen Label: 5' delta/5' delta
Detected: false
Specimen Num: 3
Publication
First Author: Udell CM
Year: 1998
Journal: Nucleic Acids Res
Title: HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene.
Volume: 26
Issue: 17
Pages: 3971-6
Publication
First Author: Kumar A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.
Volume: 107
Issue: 16
Pages: 7491-6
Publication
First Author: Chesnokova V
Year: 2009
Journal: Endocrinology
Title: Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence.
Volume: 150
Issue: 6
Pages: 2603-10
Publication
First Author: Derradji H
Year: 2008
Journal: Dev Biol
Title: Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects.
Volume: 322
Issue: 2
Pages: 302-13
Publication  
First Author: Akagawa R
Year: 2021
Journal: Front Cell Dev Biol
Title: Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.
Volume: 9
Pages: 753175
Publication
First Author: Koss M
Year: 2012
Journal: Dev Cell
Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Volume: 22
Issue: 5
Pages: 913-26
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication
First Author: Post S
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.
Volume: 98
Issue: 23
Pages: 13102-7
Publication
First Author: Post SM
Year: 2003
Journal: Nucleic Acids Res
Title: The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.
Volume: 31
Issue: 19
Pages: 5568-75
GO Term
Publication
First Author: Bao S
Year: 1999
Journal: Cancer Res
Title: HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma.
Volume: 59
Issue: 9
Pages: 2023-8
Protein
Organism: Mus musculus
Length: 229  
Fragment?: false
UniProt Feature
Begin: 1
Description: Cell cycle checkpoint protein RAD17
Type: chain
End: 688
Publication
First Author: Venclovas C
Year: 2000
Journal: Nucleic Acids Res
Title: Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes.
Volume: 28
Issue: 13
Pages: 2481-93
Protein
Organism: Mus musculus
Length: 688  
Fragment?: false
Publication
First Author: Grushcow JM
Year: 1999
Journal: Genetics
Title: Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice.
Volume: 153
Issue: 2
Pages: 607-20
Allele    
Name: RAD17 checkpoint clamp loader component; wild type
Allele  
Name: RAD17 checkpoint clamp loader component; gene trap OST201553, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: RAD17 checkpoint clamp loader component; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: RAD17 checkpoint clamp loader component; targeted mutation 1, Alex Maas
Allele Type: Targeted
Attribute String: Null/knockout
Allele  
Name: RAD17 checkpoint clamp loader component; gene trap OST122844, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: RAD17 checkpoint clamp loader component; gene trap OST296068, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: RAD17 checkpoint clamp loader component; gene trap OST85074, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: RAD17 checkpoint clamp loader component; gene trap OST426300, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: RAD17 checkpoint clamp loader component; gene trap OST230347, Lexicon Genetics
Allele Type: Gene trapped
Publication
First Author: Yong W
Year: 2007
Journal: J Biol Chem
Title: Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.
Volume: 282
Issue: 20
Pages: 14690-4