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Search results 1 to 100 out of 152 for Rasgrf2

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0.048s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Family
Description: RasGRF2 belongs to the RasGRF family. It is a dual Ras/Rac guanine nucleotide exchange factor (GEF) that has been shown to be necessary for long-term potentiation in situ [, ]. It is also involved in T-cell signalling responses through Ras GTPases []. RasGRF2 has been linked to alcoholism [].RasGRF is a Ras family guanine nucleotide exchange factor sharing homology with Saccharomyces cerevisiae Cdc25 that stimulates nucleotide exchange on S. cerevisiae RAS []. RasGRF N-terminal region contains a Dbl homology (DH) domain which is generally present in GEFs for the Rho family of small G proteins, whereas the C-terminal Cdc25-related domain is linked to Ras GTPase signalling []. The presence of regulatory domains for Rho and Ras GTPases implicates the role of RasGRF in the control of the both pathways []. Two RasGRF, RasGRF1 and 2, have been identified in mammals []. Their function can be inhibited by its interaction with Cdc42 in its inactive GDP bound form. Reciprocally, the effects of Cdc42 on cytoskeletal dynamics can be inhibited by RasGRF1/2 [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Schwechter B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission.
Volume: 110
Issue: 35
Pages: 14462-7
Publication
First Author: Ruiz S
Year: 2007
Journal: Mol Cell Biol
Title: RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.
Volume: 27
Issue: 23
Pages: 8127-42
Publication
First Author: Fam NP
Year: 1997
Journal: Mol Cell Biol
Title: Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras.
Volume: 17
Issue: 3
Pages: 1396-406
Gene
Type: gene
Organism: human
Publication  
First Author: Easton AC
Year: 2014
Journal: Brain Res Bull
Title: Rasgrf2 controls dopaminergic adaptations to alcohol in mice.
Volume: 109
Pages: 143-50
Publication
First Author: Easton AC
Year: 2014
Journal: Psychopharmacology (Berl)
Title: Rasgrf2 controls noradrenergic involvement in the acute and subchronic effects of alcohol in the brain.
Volume: 231
Issue: 21
Pages: 4199-209
Publication
First Author: Jimeno D
Year: 2016
Journal: J Cell Sci
Title: RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.
Volume: 129
Issue: 4
Pages: 729-42
Publication
First Author: Stacey D
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release.
Volume: 109
Issue: 51
Pages: 21128-33
Publication
First Author: Ruiz S
Year: 2009
Journal: PLoS One
Title: The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.
Volume: 4
Issue: 12
Pages: e8229
Publication
First Author: Ma X
Year: 2014
Journal: J Biol Chem
Title: βArrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility.
Volume: 289
Issue: 19
Pages: 13638-50
GXD Expression      
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191192
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Rasgrf2
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191192
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Rasgrf2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191192
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Rasgrf2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191192
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Rasgrf2
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191192
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Rasgrf2
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191192
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Rasgrf2
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191192
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Rasgrf2
Detected: true
Specimen Num: 7
Publication
First Author: Fan WT
Year: 1998
Journal: Curr Biol
Title: The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways.
Volume: 8
Issue: 16
Pages: 935-8
Publication
First Author: Cen H
Year: 1993
Journal: Mol Cell Biol
Title: Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor.
Volume: 13
Issue: 12
Pages: 7718-24
Publication
First Author: Crespo P
Year: 2011
Journal: Bioarchitecture
Title: Ras and Rho GTPases on the move: The RasGRF connection.
Volume: 1
Issue: 4
Pages: 200-204
Publication
First Author: Fernández-Medarde A
Year: 2011
Journal: Biochim Biophys Acta
Title: The RasGrf family of mammalian guanine nucleotide exchange factors.
Volume: 1815
Issue: 2
Pages: 170-88
Protein
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1189  
Fragment?: false
Publication      
First Author: Zeng H
Year: 2013
Journal: MGI Direct Data Submission
Title: Generation of an inducible Rasgrf2-cre knockin allele
Publication
First Author: Calvo F
Year: 2011
Journal: Nat Cell Biol
Title: RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Volume: 13
Issue: 7
Pages: 819-26
Publication
First Author: Bethge P
Year: 2017
Journal: PLoS One
Title: An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.
Volume: 12
Issue: 6
Pages: e0179460
Publication    
First Author: Suzuki M
Year: 2021
Journal: Elife
Title: Double-μPeriscope, a tool for multilayer optical recordings, optogenetic stimulations or both.
Volume: 10
Publication
First Author: Gilad A
Year: 2018
Journal: Neuron
Title: Behavioral Strategy Determines Frontal or Posterior Location of Short-Term Memory in Neocortex.
Volume: 99
Issue: 4
Pages: 814-828.e7
Publication
First Author: Rumyantsev OI
Year: 2020
Journal: Nature
Title: Fundamental bounds on the fidelity of sensory cortical coding.
Volume: 580
Issue: 7801
Pages: 100-105
Publication
First Author: Banerjee A
Year: 2020
Journal: Nature
Title: Value-guided remapping of sensory cortex by lateral orbitofrontal cortex.
Volume: 585
Issue: 7824
Pages: 245-250
Publication
First Author: Bernardi RE
Year: 2019
Journal: J Neurosci
Title: The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.
Volume: 39
Issue: 32
Pages: 6325-6338
Publication
First Author: Kim TH
Year: 2016
Journal: Cell Rep
Title: Long-Term Optical Access to an Estimated One Million Neurons in the Live Mouse Cortex.
Volume: 17
Issue: 12
Pages: 3385-3394
Publication
First Author: Gallero-Salas Y
Year: 2021
Journal: Neuron
Title: Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-Term Memory.
Volume: 109
Issue: 1
Pages: 135-148.e6
Publication
First Author: ElGrawani W
Year: 2024
Journal: Cell Rep
Title: BDNF-TrkB signaling orchestrates the buildup process of local sleep.
Volume: 43
Issue: 7
Pages: 114500
Publication    
First Author: Karimi Abadchi J
Year: 2023
Journal: Elife
Title: Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice.
Volume: 12
Publication      
First Author: Matteucci G
Year: 2022
Journal: Neuron
Title: Cortical sensory processing across motivational states during goal-directed behavior.
Publication
First Author: Suzuki M
Year: 2020
Journal: Cell
Title: General Anesthesia Decouples Cortical Pyramidal Neurons.
Volume: 180
Issue: 4
Pages: 666-676.e13
Publication
First Author: Xie H
Year: 2024
Journal: Nat Biomed Eng
Title: Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution.
Volume: 8
Issue: 6
Pages: 740-753
Publication
First Author: Kauvar IV
Year: 2020
Journal: Neuron
Title: Cortical Observation by Synchronous Multifocal Optical Sampling Reveals Widespread Population Encoding of Actions.
Volume: 107
Issue: 2
Pages: 351-367.e19
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Fam NP
Year: 1997
Journal: Genomics
Title: Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene.
Volume: 39
Issue: 1
Pages: 118-20
Publication  
First Author: Jimeno D
Year: 2023
Journal: Cells
Title: GRF2 Is Crucial for Cone Photoreceptor Viability and Ribbon Synapse Formation in the Mouse Retina.
Volume: 12
Issue: 21
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_07
Specimen Label: euxassay_009649_07
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_08
Specimen Label: euxassay_009649_08
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_16
Specimen Label: euxassay_009649_16
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_17
Specimen Label: euxassay_009649_17
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_11
Specimen Label: euxassay_009649_11
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_12
Specimen Label: euxassay_009649_12
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_13
Specimen Label: euxassay_009649_13
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_14
Specimen Label: euxassay_009649_14
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_15
Specimen Label: euxassay_009649_15
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_08
Specimen Label: euxassay_009649_08
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_09
Specimen Label: euxassay_009649_09
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_10
Specimen Label: euxassay_009649_10
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_11
Specimen Label: euxassay_009649_11
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_12
Specimen Label: euxassay_009649_12
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_14
Specimen Label: euxassay_009649_14
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_15
Specimen Label: euxassay_009649_15
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_16
Specimen Label: euxassay_009649_16
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_17
Specimen Label: euxassay_009649_17
Detected: true
Specimen Num: 11
Publication
First Author: Zhao Z
Year: 2023
Journal: Cell
Title: Two-photon synthetic aperture microscopy for minimally invasive fast 3D imaging of native subcellular behaviors in deep tissue.
Volume: 186
Issue: 11
Pages: 2475-2491.e22
Publication
First Author: Zhang Y
Year: 2024
Journal: Cell
Title: Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ.
Volume: 187
Issue: 21
Pages: 6104-6122.e25
Publication
First Author: Jacobs EAK
Year: 2020
Journal: Curr Biol
Title: Cortical State Fluctuations during Sensory Decision Making.
Volume: 30
Issue: 24
Pages: 4944-4955.e7
Publication
First Author: Li S
Year: 2006
Journal: J Neurosci
Title: Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.
Volume: 26
Issue: 6
Pages: 1721-9
Publication
First Author: Arai JA
Year: 2009
Journal: J Neurosci
Title: Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.
Volume: 29
Issue: 5
Pages: 1496-502
Publication
First Author: Li S
Year: 2006
Journal: Curr Biol
Title: The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.
Volume: 16
Issue: 23
Pages: 2303-13
Publication  
First Author: Gómez C
Year: 2017
Journal: Mol Cell Neurosci
Title: Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus.
Volume: 85
Pages: 127-147
Publication
First Author: Chen L
Year: 1993
Journal: Dev Genet
Title: A murine CDC25/ras-GRF-related protein implicated in Ras regulation.
Volume: 14
Issue: 5
Pages: 339-46
Publication
First Author: Dipoppa M
Year: 2018
Journal: Neuron
Title: Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex.
Volume: 98
Issue: 3
Pages: 602-615.e8
Publication
First Author: Zolnik TA
Year: 2020
Journal: Cell Rep
Title: Layer 6b Is Driven by Intracortical Long-Range Projection Neurons.
Volume: 30
Issue: 10
Pages: 3492-3505.e5
Publication
First Author: Fernández-Medarde A
Year: 2002
Journal: Mol Cell Biol
Title: Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.
Volume: 22
Issue: 8
Pages: 2498-504