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Search results 1 to 100 out of 1521 for Rb1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
5925 | RB1
Type: gene
Organism: human
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Gene
386582 | RB1
Type: gene
Organism: chicken
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Gene
777733 | rb1
Type: gene
Organism: zebrafish
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Gene
704871 | RB1
Type: gene
Organism: macaque, rhesus
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Gene
100493114 | rb1
Type: gene
Organism: frog, western clawed
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Gene
452715 | RB1
Type: gene
Organism: chimpanzee
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Gene
534712 | RB1
Type: gene
Organism: cattle
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Gene
key_37832 | RB1
Type: gene
Organism: rabbit, European
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Gene
key_18957 | RB1
Type: gene
Organism: sheep
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Gene
key_36926 | RB1
Type: gene
Organism: orangutan, Bornean
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Gene
key_20114 | RB1
Type: gene
Organism: goat
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Gene
key_36925 | RB1
Type: gene
Organism: gorilla, western
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Gene
24708 | Rb1
Type: gene
Organism: rat
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Gene
476915 | RB1
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:97874 | Rb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
100862704 | RB1-DT
Type: gene
Organism: human
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GXD Expression
GXD Expression
   
Probe: MGI:5907625
Assay Type: RT-PCR
Annotation Date: 2017-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:5907670
Age: postnatal adult
Image: 4
Specimen Label: RB1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5907625
Assay Type: RT-PCR
Annotation Date: 2017-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:5907673
Age: embryonic day 14.0
Image: 4
Specimen Label: RB1
Detected: true
Specimen Num: 1
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Gene
9821 | RB1CC1
Type: gene
Organism: human
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Gene
100420130 | LOC100420130
Type: gene
Organism: human
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Publication
23687339 | J:199120
First Author: Gonzalez-Vasconcellos I
Year: 2013
Journal: Cancer Res
Title: Rb1 haploinsufficiency promotes telomere attrition and radiation-induced genomic instability.
Volume: 73
Issue: 14
Pages: 4247-55
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Publication
21478154 | J:173499
First Author: Hosoyama T
Year: 2011
Journal: J Biol Chem
Title: Rb1 gene inactivation expands satellite cell and postnatal myoblast pools.
Volume: 286
Issue: 22
Pages: 19556-64
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Publication
22300525 | J:198100
First Author: Andreeva V
Year: 2012
Journal: Gene Expr Patterns
Title: Rb1 mRNA expression in developing mouse teeth.
Volume: 12
Issue: 3-4
Pages: 130-5
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Publication
27571409 | J:236979
First Author: Jones RA
Year: 2016
Journal: J Clin Invest
Title: RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.
Volume: 126
Issue: 10
Pages: 3739-3757
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Publication
16449662 | J:105548
First Author: Sun H
Year: 2006
Journal: Mol Cell Biol
Title: An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.
Volume: 26
Issue: 4
Pages: 1527-37
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Publication
21187395 | J:169702
First Author: Sun H
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo.
Volume: 108
Issue: 2
Pages: 704-9
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Publication
8361753 | J:14191
First Author: Zacksenhaus E
Year: 1993
Journal: Oncogene
Title: Molecular cloning and characterization of the mouse RB1 promoter.
Volume: 8
Issue: 9
Pages: 2343-51
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Publication
12839925 | J:84345
First Author: Flesken-Nikitin A
Year: 2003
Journal: Cancer Res
Title: Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium.
Volume: 63
Issue: 13
Pages: 3459-63
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Publication
28169375 | J:275276
 
First Author: Gonzalez-Vasconcellos I
Year: 2017
Journal: Sci Rep
Title: The Rb1 tumour suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression.
Volume: 7
Pages: 42056
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Publication
29304157 | J:257024
First Author: Freytsis M
Year: 2018
Journal: PLoS One
Title: Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation.
Volume: 13
Issue: 1
Pages: e0190623
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Publication
19341623 | J:149842
First Author: Liu Y
Year: 2009
Journal: Cell Stem Cell
Title: Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.
Volume: 4
Issue: 4
Pages: 336-47
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Publication
23015754 | J:200265
First Author: Donovan SL
Year: 2012
Journal: Mol Biol Cell
Title: Retinal horizontal cells lacking Rb1 sustain persistent DNA damage and survive as polyploid giant cells.
Volume: 23
Issue: 22
Pages: 4362-72
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Publication
27001308 | J:236189
First Author: Chinnam M
Year: 2016
Journal: Mol Cell Biol
Title: Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.
Volume: 36
Issue: 11
Pages: 1621-7
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Publication
24959378 | J:336134
First Author: Lu Y
Year: 2014
Journal: Am J Cancer Res
Title: Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model.
Volume: 4
Issue: 3
Pages: 234-44
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Publication
15968549 | J:103000
First Author: Watanabe R
Year: 2005
Journal: Virchows Arch
Title: Rb1cc1 is critical for myoblast differentiation through Rb1 regulation.
Volume: 447
Issue: 3
Pages: 643-8
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Publication
28553932 | J:251276
First Author: Harlander S
Year: 2017
Journal: Nat Med
Title: Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.
Volume: 23
Issue: 7
Pages: 869-877
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GXD Expression
GXD Expression
   
Probe: MGI:7467355
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-01
Strength: Present
Sex: Female
Emaps: EMAPS:1796521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7467371
Age: embryonic day 13.5
Specimen Label: 1A XX RB1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7467355
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7467371
Age: embryonic day 13.5
Note: Expression is seen in a few somatic cells.
Specimen Label: 1A XY RB1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7467355
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7467371
Age: embryonic day 13.5
Specimen Label: 1A XY RB1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7467355
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-01
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7467371
Age: embryonic day 13.5
Note: Expression is seen in a few somatic cells.
Specimen Label: 1A XX RB1
Detected: true
Specimen Num: 2
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Publication
14522252 | J:86077
First Author: Meuwissen R
Year: 2003
Journal: Cancer Cell
Title: Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.
Volume: 4
Issue: 3
Pages: 181-9
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Publication
28059767 | J:237907
First Author: Ku SY
Year: 2017
Journal: Science
Title: Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.
Volume: 355
Issue: 6320
Pages: 78-83
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Publication
32568216 | J:309362
First Author: Cochrane CR
Year: 2020
Journal: J Clin Invest
Title: Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.
Volume: 130
Issue: 8
Pages: 4006-4018
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Publication
15716956 | J:96202
First Author: Carreira S
Year: 2005
Journal: Nature
Title: Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression.
Volume: 433
Issue: 7027
Pages: 764-9
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Publication
18832169 | J:143449
First Author: Kucherlapati MH
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.
Volume: 105
Issue: 40
Pages: 15493-8
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Publication
21665149 | J:173560
First Author: Sutherland KD
Year: 2011
Journal: Cancer Cell
Title: Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung.
Volume: 19
Issue: 6
Pages: 754-64
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Publication
20027616 | J:158408
First Author: Xiao H
Year: 2010
Journal: Genesis
Title: Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse.
Volume: 48
Issue: 2
Pages: 121-6
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Publication
25092376 | J:222396
 
First Author: Rosemann M
Year: 2014
Journal: Mol Cancer
Title: A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.
Volume: 13
Pages: 182
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Publication
17173065 | J:122890
First Author: Loffler KA
Year: 2007
Journal: Oncogene
Title: Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice.
Volume: 26
Issue: 27
Pages: 4009-17
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Publication
20234817 | J:162038
First Author: Tonks ID
Year: 2010
Journal: Neoplasia
Title: Dual loss of rb1 and Trp53 in the adrenal medulla leads to spontaneous pheochromocytoma.
Volume: 12
Issue: 3
Pages: 235-43
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Publication
26317218 | J:243021
First Author: Filtz EA
Year: 2015
Journal: PLoS One
Title: Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice.
Volume: 10
Issue: 8
Pages: e0136729
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Publication
21464947 | J:171665
First Author: Pratt CH
Year: 2011
Journal: PLoS One
Title: Mitotic defects lead to pervasive aneuploidy and accompany loss of RB1 activity in mouse LmnaDhe dermal fibroblasts.
Volume: 6
Issue: 3
Pages: e18065
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Publication
21788502 | J:175625
First Author: Lin W
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Volume: 108
Issue: 33
Pages: 13379-86
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GXD Expression
GXD Expression
   
Probe: MGI:6181962
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191194
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Rb1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6181962
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191194
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Rb1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6181962
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191194
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Rb1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6181962
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191194
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Rb1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6181962
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191194
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Rb1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6181962
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191194
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Rb1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6181962
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191194
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Rb1
Detected: true
Specimen Num: 7
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Publication
36343919 | J:341738
 
First Author: Li Y
Year: 2022
Journal: Mol Metab
Title: Rb1 negatively regulates bone formation and remodeling through inhibiting transcriptional regulation of YAP in Glut1 and OPG expression and glucose metabolism in male mice.
Volume: 66
Pages: 101630
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Publication
25583987 | J:251068
First Author: Zhao H
Year: 2015
Journal: J Biol Chem
Title: Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.
Volume: 290
Issue: 9
Pages: 5797-809
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Publication
30373918 | J:271180
First Author: Oser MG
Year: 2019
Journal: Cancer Discov
Title: Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.
Volume: 9
Issue: 2
Pages: 230-247
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Publication
24371144 | J:316984
First Author: Liu Y
Year: 2014
Journal: J Biol Chem
Title: The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression.
Volume: 289
Issue: 7
Pages: 4116-25
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Publication
19703998 | J:153996
First Author: El-Naggar S
Year: 2009
Journal: Mol Cell Biol
Title: Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.
Volume: 29
Issue: 21
Pages: 5710-7
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Publication
29610306 | J:261430
First Author: McBrayer SK
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.
Volume: 115
Issue: 16
Pages: E3741-E3748
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Gene
477876 | RB1CC1
Type: gene
Organism: dog, domestic
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Gene
464173 | RB1CC1
Type: gene
Organism: chimpanzee
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Gene
539858 | RB1CC1
Type: gene
Organism: cattle
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Gene
421116 | RB1CC1
Type: gene
Organism: chicken
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Gene
710330 | RB1CC1
Type: gene
Organism: macaque, rhesus
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Gene
100127640 | rb1cc1
Type: gene
Organism: frog, western clawed
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Publication
16091739 | J:104415
First Author: Xiao H
Year: 2005
Journal: Oncogene
Title: The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes.
Volume: 24
Issue: 55
Pages: 8105-13
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Publication
1594621 | J:90477
First Author: te Riele H
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.
Volume: 89
Issue: 11
Pages: 5128-32
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Publication
9150384 | J:39767
First Author: Jiang Z
Year: 1997
Journal: Oncogene
Title: The retinoblastoma gene family is differentially expressed during embryogenesis.
Volume: 14
Issue: 15
Pages: 1789-97
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HT Experiment
GSE149223 | Single-Cell Transcriptome Analysis of Rb1 Conditional Knockout Prospermatogonia
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
16369533 | J:106133
First Author: Takahashi C
Year: 2006
Journal: Nat Genet
Title: Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor.
Volume: 38
Issue: 1
Pages: 118-23
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Publication
21764851 | J:174756
First Author: Dooley AL
Year: 2011
Journal: Genes Dev
Title: Nuclear factor I/B is an oncogene in small cell lung cancer.
Volume: 25
Issue: 14
Pages: 1470-5
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Publication
26314709 | J:226505
First Author: Váraljai R
Year: 2015
Journal: Genes Dev
Title: Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells.
Volume: 29
Issue: 17
Pages: 1817-34
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Publication
23145321 | J:206777
 
First Author: Costa C
Year: 2012
Journal: Sci Rep
Title: A novel tumor suppressor network in squamous malignancies.
Volume: 2
Pages: 828
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Publication
28972075 | J:252311
First Author: Xu XL
Year: 2017
Journal: Cancer Res
Title: SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells.
Volume: 77
Issue: 24
Pages: 6838-6850
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Publication
8957005 | J:37145
First Author: Zacksenhaus E
Year: 1996
Journal: Genes Dev
Title: pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.
Volume: 10
Issue: 23
Pages: 3051-64
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Publication
15653467 | J:96345
First Author: Sage C
Year: 2005
Journal: Science
Title: Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein.
Volume: 307
Issue: 5712
Pages: 1114-8
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Publication
26176933 | J:228839
First Author: Yang QE
Year: 2015
Journal: PLoS Genet
Title: Inactivation of Retinoblastoma Protein (Rb1) in the Oocyte: Evidence That Dysregulated Follicle Growth Drives Ovarian Teratoma Formation in Mice.
Volume: 11
Issue: 7
Pages: e1005355
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Publication
24177421 | J:207630
First Author: Fu M
Year: 2013
Journal: J Clin Invest
Title: Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.
Volume: 123
Issue: 12
Pages: 5152-64
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Publication
19020086 | J:142357
First Author: Gutierrez GM
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice.
Volume: 105
Issue: 47
Pages: 18402-7
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Publication
21397855 | J:169931
First Author: Chow LM
Year: 2011
Journal: Cancer Cell
Title: Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain.
Volume: 19
Issue: 3
Pages: 305-16
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Publication
19966802 | J:155967
First Author: Wang H
Year: 2010
Journal: Nat Genet
Title: Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.
Volume: 42
Issue: 1
Pages: 83-8
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Publication
22890321 | J:198014
First Author: Costa C
Year: 2013
Journal: Oncogene
Title: E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis.
Volume: 32
Issue: 24
Pages: 2937-51
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Publication
25959802 | J:303198
First Author: Tanaka T
Year: 2015
Journal: J Reprod Dev
Title: The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage.
Volume: 61
Issue: 4
Pages: 305-16
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Publication
32286280 | J:287097
First Author: Chung PED
Year: 2020
Journal: Nat Commun
Title: Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.
Volume: 11
Issue: 1
Pages: 1825
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Publication
16809444 | J:113662
First Author: Donangelo I
Year: 2006
Journal: Endocrinology
Title: Pituitary tumor transforming gene overexpression facilitates pituitary tumor development.
Volume: 147
Issue: 10
Pages: 4781-91
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Publication
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