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Search results 1 to 100 out of 166 for Rbbp8

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
5932 | RBBP8
Type: gene
Organism: human
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Gene
100380142 | rbbp8
Type: gene
Organism: frog, western clawed
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Gene
291787 | Rbbp8
Type: gene
Organism: rat
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Gene
455333 | RBBP8
Type: gene
Organism: chimpanzee
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Gene
480175 | RBBP8
Type: gene
Organism: dog, domestic
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Gene
512977 | RBBP8
Type: gene
Organism: cattle
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Gene
421071 | RBBP8
Type: gene
Organism: chicken
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Gene
503536 | rbbp8
Type: gene
Organism: zebrafish
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Gene
677718 | RBBP8
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033594 | RBBP8
Type: Family
Description: Retinoblastoma-binding protein 8 (RBBP8), also known as CtIP, is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends [, ]. CtIP interacts with the BRCA1 tumour suppressor []. BRCA1 and CtIP are required to recruit Dna2 at DSBs in homologous recombination, ensuring robust DSB resection []. CtIP it is not a tumuor suppressor itself, instead, it can promote tumourigenesis. This is probably related to its role in the formation of chromosomal rearrangements through the microhomology-mediated end joining (MMEJ) pathway, a relatively error-prone pathway of DSB repair [].
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Protein Coding Gene
MGI:2442995 | Rbbp8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27058754 | J:252618
First Author: Reczek CR
Year: 2016
Journal: Oncotarget
Title: The DNA resection protein CtIP promotes mammary tumorigenesis.
Volume: 7
Issue: 22
Pages: 32172-83
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Publication
23712259 | J:197743
First Author: Reczek CR
Year: 2013
Journal: J Cell Biol
Title: The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.
Volume: 201
Issue: 5
Pages: 693-707
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Protein
Q05CC7
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: true
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Protein
A0A3Q4L2U0
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
A0A3Q4EGK0
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: false
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Protein
A0A3Q4EGL1
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
Q80YR6
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
Q8VE67
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: true
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Gene
140893 | RBBP8NL
Type: gene
Organism: human
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Gene
100420552 | RBBP8P1
Type: gene
Organism: human
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Gene
100420607 | RBBP8P2
Type: gene
Organism: human
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Publication
25909997 | -
First Author: Hoa NN
Year: 2015
Journal: PLoS One
Title: BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.
Volume: 10
Issue: 4
Pages: e0124495
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Publication
25558984 | -
First Author: Davies OR
Year: 2015
Journal: Nat Struct Mol Biol
Title: CtIP tetramer assembly is required for DNA-end resection and repair.
Volume: 22
Issue: 2
Pages: 150-157
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Gene
101927571 | RBBP8-AS1
Type: gene
Organism: human
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Publication
17965729 | -
First Author: Sartori AA
Year: 2007
Journal: Nature
Title: Human CtIP promotes DNA end resection.
Volume: 450
Issue: 7169
Pages: 509-14
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Publication
16093251 | J:105074
First Author: Darakhshan F
Year: 2006
Journal: Carcinogenesis
Title: Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.
Volume: 27
Issue: 2
Pages: 311-8
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Protein Coding Gene
MGP_CAROLIEiJ_G0021998 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024153 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024082 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024114 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023881 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2442995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024559 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023358 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023947 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024065 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023976 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024605 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018736 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022913 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
38067190 | J:343329
 
First Author: Wu-Baer F
Year: 2023
Journal: Cells
Title: ATM/ATR Phosphorylation of CtIP on Its Conserved Sae2-like Domain Is Required for Genotoxin-Induced DNA Resection but Dispensable for Animal Development.
Volume: 12
Issue: 23
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Publication
16249056 | J:103616
First Author: Chinnadurai G
Year: 2006
Journal: Biochim Biophys Acta
Title: CtIP, a candidate tumor susceptibility gene is a team player with luminaries.
Volume: 1765
Issue: 1
Pages: 67-73
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Publication
16581787 | J:107424
First Author: Liu F
Year: 2006
Journal: Mol Cell Biol
Title: CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.
Volume: 26
Issue: 8
Pages: 3124-34
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GXD Expression
GXD Expression
     
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: p53-/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: Bard1-/-; p53-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: Brca1-/-; p53-/-
Detected: true
Specimen Num: 3
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Publication
32989150 | J:296722
First Author: Wang XS
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.
Volume: 117
Issue: 41
Pages: 25700-25711
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Publication
31097467 | J:310934
First Author: Liu X
Year: 2019
Journal: J Exp Med
Title: CtIP is essential for early B cell proliferation and development in mice.
Volume: 216
Issue: 7
Pages: 1648-1663
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Publication
24837676 | J:215245
First Author: Makharashvili N
Year: 2014
Journal: Mol Cell
Title: Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.
Volume: 54
Issue: 6
Pages: 1022-33
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Publication
25582120 | J:219278
First Author: Badie S
Year: 2015
Journal: EMBO J
Title: BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Volume: 34
Issue: 3
Pages: 410-24
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Publication
15831459 | J:97648
First Author: Chen PL
Year: 2005
Journal: Mol Cell Biol
Title: Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency.
Volume: 25
Issue: 9
Pages: 3535-42
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Publication
21160476 | J:167994
First Author: Helmink BA
Year: 2011
Journal: Nature
Title: H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Volume: 469
Issue: 7329
Pages: 245-9
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Publication
34521752 | J:310613
 
First Author: Wang XS
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.
Volume: 118
Issue: 38
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Publication
12832489 | J:84329
First Author: McCarthy EE
Year: 2003
Journal: Mol Cell Biol
Title: Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability.
Volume: 23
Issue: 14
Pages: 5056-63
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Publication
23254285 | J:194603
First Author: Bothmer A
Year: 2013
Journal: J Exp Med
Title: Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
Volume: 210
Issue: 1
Pages: 115-23
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Publication
24842372 | J:213733
First Author: Polato F
Year: 2014
Journal: J Exp Med
Title: CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
Volume: 211
Issue: 6
Pages: 1027-36
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Publication
38554279 | J:348335
First Author: Georgieva D
Year: 2024
Journal: Cell Rep
Title: BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks.
Volume: 43
Issue: 4
Pages: 114006
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Publication
30657944 | J:319683
First Author: Mohiuddin M
Year: 2019
Journal: Nucleic Acids Res
Title: CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.
Volume: 47
Issue: 6
Pages: 2966-2980
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Publication
29709199 | J:320083
 
First Author: Syed A
Year: 2018
Journal: Annu Rev Biochem
Title: The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
Volume: 87
Pages: 263-294
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Publication
18171670 | J:319979
First Author: Chen L
Year: 2008
Journal: J Biol Chem
Title: Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.
Volume: 283
Issue: 12
Pages: 7713-20
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Publication
19654328 | J:156979
First Author: Snow JW
Year: 2009
Journal: J Biol Chem
Title: Translational isoforms of FOG1 regulate GATA1-interacting complexes.
Volume: 284
Issue: 43
Pages: 29310-9
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Publication
22369660 | J:320080
First Author: Wang B
Year: 2012
Journal: Cell Biosci
Title: BRCA1 tumor suppressor network: focusing on its tail.
Volume: 2
Issue: 1
Pages: 6
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Publication
32548123 | J:299723
 
First Author: Kafer GR
Year: 2020
Journal: Front Cell Dev Biol
Title: A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.
Volume: 8
Pages: 416
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Publication
22645310 | J:186644
First Author: Nakamura K
Year: 2012
Journal: Mol Cell Biol
Title: Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.
Volume: 32
Issue: 15
Pages: 2966-78
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Publication
37725078 | J:358060
   
First Author: Iskusnykh IY
Year: 2023
Journal: Elife
Title: Lmx1a is a master regulator of the cortical hem.
Volume: 12
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Publication
27100196 | J:253278
First Author: Greig LC
Year: 2016
Journal: Neuron
Title: Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex.
Volume: 90
Issue: 2
Pages: 261-77
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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