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Search results 1 to 100 out of 134 for Rbbp8

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Retinoblastoma-binding protein 8 (RBBP8), also known as CtIP, is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends [, ]. CtIP interacts with the BRCA1 tumour suppressor []. BRCA1 and CtIP are required to recruit Dna2 at DSBs in homologous recombination, ensuring robust DSB resection []. CtIP it is not a tumuor suppressor itself, instead, it can promote tumourigenesis. This is probably related to its role in the formation of chromosomal rearrangements through the microhomology-mediated end joining (MMEJ) pathway, a relatively error-prone pathway of DSB repair [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Reczek CR
Year: 2013
Journal: J Cell Biol
Title: The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.
Volume: 201
Issue: 5
Pages: 693-707
Publication
First Author: Reczek CR
Year: 2016
Journal: Oncotarget
Title: The DNA resection protein CtIP promotes mammary tumorigenesis.
Volume: 7
Issue: 22
Pages: 32172-83
Protein
Organism: Mus musculus
Length: 118  
Fragment?: true
Protein
Organism: Mus musculus
Length: 612  
Fragment?: false
Protein
Organism: Mus musculus
Length: 247  
Fragment?: false
Protein
Organism: Mus musculus
Length: 706  
Fragment?: true
Protein
Organism: Mus musculus
Length: 893  
Fragment?: false
Protein
Organism: Mus musculus
Length: 822  
Fragment?: true
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Hoa NN
Year: 2015
Journal: PLoS One
Title: BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.
Volume: 10
Issue: 4
Pages: e0124495
Publication
First Author: Davies OR
Year: 2015
Journal: Nat Struct Mol Biol
Title: CtIP tetramer assembly is required for DNA-end resection and repair.
Volume: 22
Issue: 2
Pages: 150-157
Publication
First Author: Sartori AA
Year: 2007
Journal: Nature
Title: Human CtIP promotes DNA end resection.
Volume: 450
Issue: 7169
Pages: 509-14
Publication
First Author: Darakhshan F
Year: 2006
Journal: Carcinogenesis
Title: Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.
Volume: 27
Issue: 2
Pages: 311-8
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Chinnadurai G
Year: 2006
Journal: Biochim Biophys Acta
Title: CtIP, a candidate tumor susceptibility gene is a team player with luminaries.
Volume: 1765
Issue: 1
Pages: 67-73
Publication
First Author: Liu F
Year: 2006
Journal: Mol Cell Biol
Title: CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.
Volume: 26
Issue: 8
Pages: 3124-34
GXD Expression      
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: p53-/-
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: Bard1-/-; p53-/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: Brca1-/-; p53-/-
Detected: true
Specimen Num: 3
Publication
First Author: Wang XS
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.
Volume: 117
Issue: 41
Pages: 25700-25711
Publication
First Author: Badie S
Year: 2015
Journal: EMBO J
Title: BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Volume: 34
Issue: 3
Pages: 410-24
Publication
First Author: Liu X
Year: 2019
Journal: J Exp Med
Title: CtIP is essential for early B cell proliferation and development in mice.
Volume: 216
Issue: 7
Pages: 1648-1663
Publication
First Author: Makharashvili N
Year: 2014
Journal: Mol Cell
Title: Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.
Volume: 54
Issue: 6
Pages: 1022-33
Publication
First Author: McCarthy EE
Year: 2003
Journal: Mol Cell Biol
Title: Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability.
Volume: 23
Issue: 14
Pages: 5056-63
Publication
First Author: Chen PL
Year: 2005
Journal: Mol Cell Biol
Title: Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency.
Volume: 25
Issue: 9
Pages: 3535-42
Publication
First Author: Helmink BA
Year: 2011
Journal: Nature
Title: H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Volume: 469
Issue: 7329
Pages: 245-9
Publication  
First Author: Wang XS
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.
Volume: 118
Issue: 38
Publication
First Author: Polato F
Year: 2014
Journal: J Exp Med
Title: CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
Volume: 211
Issue: 6
Pages: 1027-36
Publication
First Author: Bothmer A
Year: 2013
Journal: J Exp Med
Title: Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
Volume: 210
Issue: 1
Pages: 115-23
Publication
First Author: Mohiuddin M
Year: 2019
Journal: Nucleic Acids Res
Title: CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.
Volume: 47
Issue: 6
Pages: 2966-2980
Publication  
First Author: Syed A
Year: 2018
Journal: Annu Rev Biochem
Title: The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
Volume: 87
Pages: 263-294
Publication
First Author: Chen L
Year: 2008
Journal: J Biol Chem
Title: Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.
Volume: 283
Issue: 12
Pages: 7713-20
Publication
First Author: Nakamura K
Year: 2012
Journal: Mol Cell Biol
Title: Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.
Volume: 32
Issue: 15
Pages: 2966-78
Publication
First Author: Snow JW
Year: 2009
Journal: J Biol Chem
Title: Translational isoforms of FOG1 regulate GATA1-interacting complexes.
Volume: 284
Issue: 43
Pages: 29310-9
Publication
First Author: Wang B
Year: 2012
Journal: Cell Biosci
Title: BRCA1 tumor suppressor network: focusing on its tail.
Volume: 2
Issue: 1
Pages: 6
Publication  
First Author: Kafer GR
Year: 2020
Journal: Front Cell Dev Biol
Title: A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.
Volume: 8
Pages: 416
Publication
First Author: Greig LC
Year: 2016
Journal: Neuron
Title: Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex.
Volume: 90
Issue: 2
Pages: 261-77
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 614  
Fragment?: false
UniProt Feature
Begin: 1
Description: DNA endonuclease RBBP8
Type: chain
End: 893
Allele  
Name: RBBP8 N-terminal like; wild type
Allele Type: Not Specified
Publication
First Author: Kaidi A
Year: 2010
Journal: Science
Title: Human SIRT6 promotes DNA end resection through CtIP deacetylation.
Volume: 329
Issue: 5997
Pages: 1348-53
Publication
First Author: Kaidi A
Year: 2019
Journal: Science
Title: Retraction.
Volume: 364
Issue: 6437
Pages: 247
Publication
First Author: Zhang Y
Year: 2011
Journal: Nat Struct Mol Biol
Title: An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway.
Volume: 18
Issue: 1
Pages: 80-4
Publication
First Author: Lee-Theilen M
Year: 2011
Journal: Nat Struct Mol Biol
Title: CtIP promotes microhomology-mediated alternative end joining during class-switch recombination.
Volume: 18
Issue: 1
Pages: 75-9
Protein
Organism: Mus musculus
Length: 26  
Fragment?: true
Allele
Name: RBBP8 N-terminal like; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus