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Search results 1 to 100 out of 134 for Ro60

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4.387s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Reed JH
Year: 2013
Journal: J Immunol
Title: Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus.
Volume: 191
Issue: 1
Pages: 110-6
Publication
First Author: Wang D
Year: 1996
Journal: Mol Biol Rep
Title: Cloning and expression of mouse 60 kDa ribonucleoprotein SS-A/Ro.
Volume: 23
Issue: 3-4
Pages: 205-10
Publication
First Author: Scofield RH
Year: 1999
Journal: Arthritis Rheum
Title: Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse.
Volume: 42
Issue: 5
Pages: 1017-24
Publication
First Author: Lai CK
Year: 2011
Journal: Mol Biol Cell
Title: Functional characterization of putative cilia genes by high-content analysis.
Volume: 22
Issue: 7
Pages: 1104-19
Publication
First Author: Hung T
Year: 2015
Journal: Science
Title: The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.
Volume: 350
Issue: 6259
Pages: 455-9
Protein
Organism: Mus musculus
Length: 538  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Xue D
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.
Volume: 100
Issue: 13
Pages: 7503-8
Publication
First Author: Chen X
Year: 2003
Journal: Curr Biol
Title: The Ro autoantigen binds misfolded U2 small nuclear RNAs and assists mammalian cell survival after UV irradiation.
Volume: 13
Issue: 24
Pages: 2206-11
GXD Expression  
Probe: MGI:3065858
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603911
Pattern: Ubiquitous
Stage: TS11
Assay Id: MGI:3828805
Age: embryonic day 7.5
Image: E7.5
Specimen Label: E7.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3065858
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3828805
Age: embryonic day 8.5
Image: E8.5
Note: Expression is weak to non-existent.
Specimen Label: E8.5
Specimen Num: 2
Publication    
First Author: Kaufman KM
Year: 1999
Journal: GenBank Submission
Title: Mus musculus 60 kDa ribonucleoprotein SSA/Ro gene, complete cds
Pages: AF065398
Publication
First Author: Keech CL
Year: 1996
Journal: Clin Exp Immunol
Title: Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species.
Volume: 104
Issue: 2
Pages: 255-63
Publication
First Author: Fullerton J
Year: 2006
Journal: Behav Genet
Title: New approaches to the genetic analysis of neuroticism and anxiety.
Volume: 36
Issue: 1
Pages: 147-61
Publication
First Author: Yalcin B
Year: 2004
Journal: Nat Genet
Title: Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.
Volume: 36
Issue: 11
Pages: 1197-202
Publication
First Author: Al-Shami A
Year: 2010
Journal: PLoS One
Title: Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
Volume: 5
Issue: 10
Pages: e13654
Publication
First Author: Scekic-Zahirovic J
Year: 2016
Journal: EMBO J
Title: Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
Volume: 35
Issue: 10
Pages: 1077-97
Publication
First Author: Yang N
Year: 2022
Journal: J Dent Res
Title: Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.
Volume: 101
Issue: 2
Pages: 226-234
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication  
First Author: Tamplin OJ
Year: 2008
Journal: BMC Genomics
Title: Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Volume: 9
Pages: 511
Publication      
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: GemPharmatech
Year: 2020
Journal: website
Title: GemPharmatech website
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
UniProt Feature
Begin: 1
Description: RNA-binding protein Ro60
Type: chain
End: 538
Publication
First Author: Hogg JR
Year: 2007
Journal: Genes Dev
Title: Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control.
Volume: 21
Issue: 23
Pages: 3067-72
Protein Domain
Type: Family
Description: Proteins in this family contain a TROVE (Telomerase, Ro and Vault) domain and include RNA-binding protein RO60 (TROVE2), an RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs [, ].
Publication
First Author: Kaufman KM
Year: 2000
Journal: Genes Immun
Title: Characterization and genomic sequence of the murine 60 kD Ro gene.
Volume: 1
Issue: 4
Pages: 265-70
Allele
Name: Ro60, Y RNA binding protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Protein
Organism: Mus musculus
Length: 538  
Fragment?: false
Protein
Organism: Mus musculus
Length: 538  
Fragment?: false
Protein
Organism: Mus musculus
Length: 538  
Fragment?: false
SO Term
Publication
First Author: Laderach D
Year: 2003
Journal: J Autoimmun
Title: Concomitant early appearance of anti-ribonucleoprotein and anti-nucleosome antibodies in lupus prone mice.
Volume: 20
Issue: 2
Pages: 161-70
Publication
First Author: Kinoshita G
Year: 1999
Journal: Clin Exp Immunol
Title: Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice.
Volume: 115
Issue: 2
Pages: 268-74
Protein
Organism: Mus musculus
Length: 107  
Fragment?: false
Protein
Organism: Mus musculus
Length: 102  
Fragment?: false
Protein Domain
Type: Family
Description: Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome []. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor []. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation []. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis []. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and a RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif [].Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses [].
Protein Domain
Type: Homologous_superfamily
Description: The TROVE (Telomerase, Ro and Vault) domain is a module of ~300-500 residues that is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. It is also found in bacterial ribonucleoproteins suggesting an ancient origin of these ribonucleoproteins. It can be found associated with other domains, such as the VWFA domain, the TEP1 N-terminal domain, the NACHT-NTPase domain, and WD-40 repeats. This domain may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA [].The TROVE domain contains a few absolutely conserved residues. As none of these conserved residues are the polar type of amino acids found in active sites, it seems unlikely that this region has an enzymatic function [].Structurally, the TROVE domain consist of two superhelical sections arranged like a horse-shoe.
Protein Domain
Type: Domain
Description: The TROVE (Telomerase, Ro and Vault) domain is a module of ~300-500 residues that is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. It is also found in bacterial ribonucleoproteins suggesting an ancient origin of these ribonucleoproteins. It can be found associated with other domains, such as the VWFA domain, the TEP1 N-terminal domain, the NACHT-NTPase domain, and WD-40 repeats. This domain may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA [].The TROVE domain contains a few absolutely conserved residues. As none of these conserved residues are the polar type of amino acids found in active sites, it seems unlikely that this region has an enzymatic function [].
Publication  
First Author: Bateman A
Year: 2003
Journal: BMC Bioinformatics
Title: The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.
Volume: 4
Pages: 49
Publication
First Author: Lin-Marq N
Year: 1995
Journal: J Mol Biol
Title: A yeast RNA binding protein that resembles the human autoantigen La.
Volume: 245
Issue: 2
Pages: 81-5
Publication
First Author: Kenan DJ
Year: 2004
Journal: Nat Struct Mol Biol
Title: La gets its wings.
Volume: 11
Issue: 4
Pages: 303-5
Protein
Organism: Mus musculus
Length: 146  
Fragment?: false
Protein
Organism: Mus musculus
Length: 248  
Fragment?: false
Publication
First Author: Yoo CJ
Year: 1994
Journal: Mol Cell Biol
Title: La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth.
Volume: 14
Issue: 8
Pages: 5412-24
Protein Domain
Type: Domain
Description: Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome []. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor []. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation []. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis []. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and a RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif [].Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses [].This domain is found at the N terminus of La RNA-binding proteins as well as other proteins [].
Protein
Organism: Mus musculus
Length: 1072  
Fragment?: false
Protein
Organism: Mus musculus
Length: 288  
Fragment?: false
Protein
Organism: Mus musculus
Length: 215  
Fragment?: false