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Search results 1 to 100 out of 354 for Rock1

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
6093 | ROCK1
Type: gene
Organism: human
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Gene
785911 | ROCK1
Type: gene
Organism: cattle
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Gene
373970 | ROCK1
Type: gene
Organism: chicken
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Gene
100329779 | rock1
Type: gene
Organism: zebrafish
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Gene
698223 | ROCK1
Type: gene
Organism: macaque, rhesus
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Gene
100496057 | rock1
Type: gene
Organism: frog, western clawed
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Gene
81762 | Rock1
Type: gene
Organism: rat
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Gene
455326 | ROCK1
Type: gene
Organism: chimpanzee
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Gene
480181 | ROCK1
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:107927 | Rock1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19276091 | J:149751
First Author: Lee DH
Year: 2009
Journal: J Biol Chem
Title: Targeted disruption of ROCK1 causes insulin resistance in vivo.
Volume: 284
Issue: 18
Pages: 11776-80
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Publication
18414683 | J:135152
First Author: Noma K
Year: 2008
Journal: J Clin Invest
Title: ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
Volume: 118
Issue: 5
Pages: 1632-44
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Publication
24326423 | J:208371
First Author: Lee SH
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance.
Volume: 306
Issue: 3
Pages: E332-43
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Publication
32507765 | J:345551
First Author: Wang J
Year: 2020
Journal: Aging (Albany NY)
Title: LncRNA SNHG7 promotes cardiac remodeling by upregulating ROCK1 via sponging miR-34-5p.
Volume: 12
Issue: 11
Pages: 10441-10456
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Publication
24595357 | J:214645
First Author: Surma M
Year: 2014
Journal: PLoS One
Title: ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment.
Volume: 9
Issue: 3
Pages: e90758
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Publication
31302146 | J:280274
 
First Author: Greathouse KM
Year: 2019
Journal: Behav Brain Res
Title: Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.
Volume: 373
Pages: 112083
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Publication
23885017 | J:203288
First Author: Huang H
Year: 2013
Journal: Endocrinology
Title: ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice.
Volume: 154
Issue: 10
Pages: 3660-70
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Publication
23877263 | J:207251
 
First Author: Gurkar AU
Year: 2013
Journal: Nat Commun
Title: Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.
Volume: 4
Pages: 2189
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Publication
16675849 | J:111469
First Author: Zhang YM
Year: 2006
Journal: FASEB J
Title: Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis.
Volume: 20
Issue: 7
Pages: 916-25
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Publication
18178218 | J:133756
First Author: Shi J
Year: 2008
Journal: J Mol Cell Cardiol
Title: Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy.
Volume: 44
Issue: 3
Pages: 551-60
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Publication
35303680 | J:323927
 
First Author: Penumatsa KC
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice.
Volume: 604
Pages: 137-143
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Publication
22889758 | J:191835
First Author: Vemula S
Year: 2012
Journal: Blood
Title: ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.
Volume: 120
Issue: 14
Pages: 2868-78
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Publication
18556458 | J:140261
First Author: Wang HW
Year: 2008
Journal: FASEB J
Title: Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
Volume: 22
Issue: 10
Pages: 3561-70
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Publication
27411515 | J:254132
 
First Author: Zhou X
Year: 2016
Journal: Sci Rep
Title: ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity.
Volume: 6
Pages: 29669
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Publication
22326220 | J:182287
First Author: Wang W
Year: 2012
Journal: Cell Metab
Title: Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells.
Volume: 15
Issue: 2
Pages: 186-200
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Publication
17005937 | J:135839
First Author: Fu P
Year: 2006
Journal: J Am Soc Nephrol
Title: Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice.
Volume: 17
Issue: 11
Pages: 3105-14
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Publication
20008297 | J:157776
First Author: Vemula S
Year: 2010
Journal: Blood
Title: ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
Volume: 115
Issue: 9
Pages: 1785-96
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Publication
26875770 | J:229535
First Author: Liu Y
Year: 2016
Journal: Exp Cell Res
Title: Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3.
Volume: 341
Issue: 2
Pages: 225-36
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Publication
23392171 | J:294294
 
First Author: Shi J
Year: 2013
Journal: Cell Death Dis
Title: Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.
Volume: 4
Pages: e483
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Publication
29211497 | J:274582
First Author: Knipe RS
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.
Volume: 58
Issue: 4
Pages: 471-481
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Publication
26943578 | J:315390
First Author: Kapur R
Year: 2016
Journal: Oncotarget
Title: ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.
Volume: 7
Issue: 13
Pages: 16936-47
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Publication
30196430 | J:268041
First Author: Greathouse KM
Year: 2018
Journal: Brain Struct Funct
Title: Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.
Volume: 223
Issue: 9
Pages: 4227-4241
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Publication
30826947 | J:326655
First Author: Yan J
Year: 2019
Journal: Neurosci Bull
Title: Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function.
Volume: 35
Issue: 4
Pages: 649-660
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Publication
29560126 | J:278809
First Author: Shi J
Year: 2018
Journal: Oncotarget
Title: Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity.
Volume: 9
Issue: 16
Pages: 12995-13008
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Publication
36497425 | J:332103
 
First Author: Naylor G
Year: 2022
Journal: Cancers (Basel)
Title: Immunogenic Death of Hepatocellular Carcinoma Cells in Mice Expressing Caspase-Resistant ROCK1 Is Not Replicated by ROCK Inhibitors.
Volume: 14
Issue: 23
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Publication
27246255 | J:234187
First Author: Henderson BW
Year: 2016
Journal: J Neurochem
Title: Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain.
Volume: 138
Issue: 4
Pages: 525-31
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Publication
29987023 | J:265781
First Author: Sunamura S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice.
Volume: 115
Issue: 30
Pages: E7129-E7138
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Publication
19014928 | J:143534
First Author: Kim JY
Year: 2009
Journal: Dev Biol
Title: Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development.
Volume: 325
Issue: 1
Pages: 273-80
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Publication
30848941 | J:294073
First Author: Shi J
Year: 2019
Journal: FASEB J
Title: Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging.
Volume: 33
Issue: 6
Pages: 7348-7362
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Publication
20133903 | J:170862
First Author: Bu DX
Year: 2010
Journal: Circ Res
Title: Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice.
Volume: 106
Issue: 6
Pages: 1040-51
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Publication
33871359 | J:304720
   
First Author: Julian L
Year: 2021
Journal: Elife
Title: Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression.
Volume: 10
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Publication
14962675 | J:88026
First Author: Dennehey BK
Year: 2004
Journal: Genomics
Title: Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution.
Volume: 83
Issue: 3
Pages: 493-501
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Publication
24358370 | J:209853
First Author: Dasgupta SK
Year: 2013
Journal: PLoS One
Title: Rho associated coiled-coil kinase-1 regulates collagen-induced phosphatidylserine exposure in platelets.
Volume: 8
Issue: 12
Pages: e84649
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Publication
35597365 | J:334687
First Author: Nagai Y
Year: 2022
Journal: Kidney Int
Title: Rho-associated, coiled-coil-containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism.
Volume: 102
Issue: 3
Pages: 536-545
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Publication
35265203 | J:321977
First Author: Li M
Year: 2022
Journal: Theranostics
Title: Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation.
Volume: 12
Issue: 5
Pages: 2133-2149
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Publication
31182644 | J:277741
 
First Author: Butler MB
Year: 2019
Journal: J Cell Sci
Title: Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure.
Volume: 132
Issue: 13
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Publication
22941110 | J:204885
First Author: Huang H
Year: 2012
Journal: Nat Neurosci
Title: Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.
Volume: 15
Issue: 10
Pages: 1391-8
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Publication
16260635 | J:116836
First Author: Rikitake Y
Year: 2005
Journal: Circulation
Title: Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Volume: 112
Issue: 19
Pages: 2959-65
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Publication
31914704 | J:299726
First Author: Wei L
Year: 2020
Journal: FASEB J
Title: ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice.
Volume: 34
Issue: 1
Pages: 474-493
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Publication
23250919 | J:210279
First Author: Yao L
Year: 2013
Journal: Cardiovasc Res
Title: Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.
Volume: 97
Issue: 3
Pages: 509-19
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Publication
26276827 | J:232886
First Author: Kasahara DI
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.
Volume: 309
Issue: 7
Pages: L736-46
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Publication
25774552 | J:222170
First Author: Luo J
Year: 2015
Journal: Endocrinology
Title: FSP-1 Impairs the Function of Endothelium Leading to Failure of Arteriovenous Grafts in Diabetic Mice.
Volume: 156
Issue: 6
Pages: 2200-10
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Publication
15464581 | J:94515
First Author: Zhao Z
Year: 2004
Journal: Dev Biol
Title: Rho-associated kinases play a role in endocardial cell differentiation and migration.
Volume: 275
Issue: 1
Pages: 183-91
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Publication
19201893 | J:144783
First Author: Mong PY
Year: 2009
Journal: J Immunol
Title: Activation of Rho kinase isoforms in lung endothelial cells during inflammation.
Volume: 182
Issue: 4
Pages: 2385-94
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Publication
21576392 | J:172646
First Author: Vega FM
Year: 2011
Journal: J Cell Biol
Title: RhoA and RhoC have distinct roles in migration and invasion by acting through different targets.
Volume: 193
Issue: 4
Pages: 655-65
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Publication
21732490 | J:190208
First Author: Leong SY
Year: 2011
Journal: Stem Cells
Title: The Rho kinase pathway regulates mouse adult neural precursor cell migration.
Volume: 29
Issue: 2
Pages: 332-43
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Publication
23946538 | J:203845
First Author: Laeno AM
Year: 2013
Journal: Biol Reprod
Title: Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst.
Volume: 89
Issue: 5
Pages: 122
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Publication
22186730 | J:311919
First Author: Daley WP
Year: 2012
Journal: Development
Title: ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.
Volume: 139
Issue: 2
Pages: 411-22
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Publication
26765561 | J:229442
 
First Author: Kümper S
Year: 2016
Journal: Elife
Title: Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Volume: 5
Pages: e12994
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Publication
23271052 | J:196433
First Author: Okamoto R
Year: 2013
Journal: FASEB J
Title: FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
Volume: 27
Issue: 4
Pages: 1439-49
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Publication
19456252 | J:186058
First Author: Whitlock NA
Year: 2009
Journal: J Ocul Pharmacol Ther
Title: Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK.
Volume: 25
Issue: 3
Pages: 187-94
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Publication
26054539 | J:290410
First Author: Peng H
Year: 2016
Journal: J Am Soc Nephrol
Title: CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation.
Volume: 27
Issue: 2
Pages: 509-19
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Publication
30226474 | J:270450
First Author: Huang H
Year: 2018
Journal: J Clin Invest
Title: Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition.
Volume: 128
Issue: 12
Pages: 5335-5350
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Publication
22278938 | J:183286
First Author: Yang X
Year: 2012
Journal: FASEB J
Title: Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.
Volume: 26
Issue: 5
Pages: 2105-16
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Publication
22798677 | J:189745
First Author: Gallo RM
Year: 2012
Journal: J Immunol
Title: Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.
Volume: 189
Issue: 4
Pages: 1689-98
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Publication
36509022 | J:334394
 
First Author: Li Y
Year: 2023
Journal: J Mol Cell Cardiol
Title: Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission.
Volume: 174
Pages: 115-132
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Publication
26040287 | J:232964
First Author: Escuin S
Year: 2015
Journal: J Cell Sci
Title: Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.
Volume: 128
Issue: 14
Pages: 2468-81
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Publication
15637299 | J:106431
First Author: Phillips HM
Year: 2005
Journal: Circ Res
Title: Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.
Volume: 96
Issue: 3
Pages: 292-9
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Publication
19923274 | J:158281
First Author: Ferrón SR
Year: 2009
Journal: J Neurosci
Title: Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis.
Volume: 29
Issue: 46
Pages: 14394-407
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Protein Coding Gene
MGP_CAROLIEiJ_G0021991 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024146 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024108 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024075 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024107 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023874 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023846 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023969 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023097 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018728 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022907 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15956119 | J:112242
First Author: Rikitake Y
Year: 2005
Journal: Circulation
Title: Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells.
Volume: 111
Issue: 24
Pages: 3261-8
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Publication
22798675 | J:189746
First Author: Mehrotra S
Year: 2012
Journal: J Immunol
Title: A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice.
Volume: 189
Issue: 4
Pages: 1627-38
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Publication
19406912 | J:167967
First Author: Haudek SB
Year: 2009
Journal: Cardiovasc Res
Title: Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation.
Volume: 83
Issue: 3
Pages: 511-8
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Publication
16862148 | J:116360
First Author: Ohta Y
Year: 2006
Journal: Nat Cell Biol
Title: FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.
Volume: 8
Issue: 8
Pages: 803-14
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Publication
22100295 | J:180374
First Author: Ichida M
Year: 2011
Journal: FEBS Lett
Title: Changes in cell migration of mesenchymal cells during osteogenic differentiation.
Volume: 585
Issue: 24
Pages: 4018-24
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Publication
23169653 | J:192326
First Author: Suprynowicz FA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells.
Volume: 109
Issue: 49
Pages: 20035-40
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Publication
22389400 | J:197695
First Author: Guolla L
Year: 2012
Journal: J Cell Sci
Title: Force transduction and strain dynamics in actin stress fibres in response to nanonewton forces.
Volume: 125
Issue: Pt 3
Pages: 603-13
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GXD Expression
GXD Expression
   
Probe: MGI:3053195
Assay Type: Western blot
Annotation Date: 2004-09-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3053200
Age: embryonic day 18.5
Image: 3
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3053195
Assay Type: Western blot
Annotation Date: 2004-09-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3053200
Age: embryonic day 18.5
Image: 3
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3053195
Assay Type: Western blot
Annotation Date: 2004-09-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3053200
Age: embryonic day 18.5
Image: 3
Specimen Label: -/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3804900
Assay Type: RT-PCR
Annotation Date: 2008-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1669615
Stage: TS15
Assay Id: MGI:3804902
Age: embryonic day 9.5
Image: 1
Specimen Label: 1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3804900
Assay Type: RT-PCR
Annotation Date: 2008-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1669617
Stage: TS17
Assay Id: MGI:3804902
Age: embryonic day 10.5
Image: 1
Specimen Label: 2
Detected: true
Specimen Num: 2
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