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Search results 1 to 100 out of 611 for Ryr2

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Type Details Score
Gene
6262 | RYR2
Type: gene
Organism: human
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Gene
717179 | RYR2
Type: gene
Organism: macaque, rhesus
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Gene
key_19538 | RYR2
Type: gene
Organism: pig, domestic
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Gene
403615 | RYR2
Type: gene
Organism: dog, domestic
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Gene
457846 | RYR2
Type: gene
Organism: chimpanzee
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Gene
689560 | Ryr2
Type: gene
Organism: rat
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Gene
537376 | RYR2
Type: gene
Organism: cattle
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Gene
421508 | RYR2
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:99685 | Ryr2
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:7493396
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7493448
Age: postnatal adult
Image: 4K RyR2
Note: Very slight enhanced expression in outer epicardial region.
Specimen Label: 4K RyR2
Detected: true
Specimen Num: 1
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Publication
28389603 | J:243300
First Author: Lascano E
Year: 2017
Journal: Am J Physiol Heart Circ Physiol
Title: Impact of RyR2 potentiation on myocardial function.
Volume: 312
Issue: 6
Pages: H1105-H1109
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Publication
22511749 | J:212663
First Author: Respress JL
Year: 2012
Journal: Circ Res
Title: Role of RyR2 phosphorylation at S2814 during heart failure progression.
Volume: 110
Issue: 11
Pages: 1474-83
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Publication
30355031 | J:292074
First Author: Pan X
Year: 2018
Journal: Circ Res
Title: In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.
Volume: 123
Issue: 8
Pages: 953-963
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Publication
32683896 | J:293263
     
First Author: Campbell HM
Year: 2020
Journal: Circulation
Title: Loss of SPEG Inhibitory Phosphorylation of RyR2 Promotes Atrial Fibrillation.
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Publication
20080623 | J:156537
First Author: Fauconnier J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy.
Volume: 107
Issue: 4
Pages: 1559-64
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Publication
20615971 | J:272210
First Author: Sarma S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Volume: 107
Issue: 29
Pages: 13165-70
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Publication
15044459 | J:123988
First Author: Johnson JD
Year: 2004
Journal: J Biol Chem
Title: RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
Volume: 279
Issue: 23
Pages: 24794-802
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Publication
32966798 | J:311228
First Author: Yao J
Year: 2020
Journal: Cell Rep
Title: Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.
Volume: 32
Issue: 12
Pages: 108169
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Publication
27482086 | J:235432
First Author: Aiba I
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.
Volume: 113
Issue: 33
Pages: E4895-903
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Publication
16825580 | J:123665
First Author: Liu N
Year: 2006
Journal: Circ Res
Title: Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model.
Volume: 99
Issue: 3
Pages: 292-8
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Publication
25619687 | J:251313
First Author: Roussel J
Year: 2015
Journal: Biochim Biophys Acta
Title: Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase.
Volume: 1852
Issue: 5
Pages: 749-58
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Publication
26555638 | J:250725
First Author: Wang Q
Year: 2015
Journal: J Mol Cell Cardiol
Title: Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy.
Volume: 89
Issue: Pt B
Pages: 177-84
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Publication
20595652 | J:175031
First Author: Kang G
Year: 2010
Journal: Circ Res
Title: Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy.
Volume: 107
Issue: 4
Pages: 512-9
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Publication
24755079 | J:219452
First Author: Fukuda M
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes.
Volume: 448
Issue: 1
Pages: 1-7
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Publication
15024040 | J:105461
First Author: Ji G
Year: 2004
Journal: J Gen Physiol
Title: RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.
Volume: 123
Issue: 4
Pages: 377-86
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Publication
26695843 | J:291966
First Author: Mazzocchi G
Year: 2016
Journal: J Physiol
Title: Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814.
Volume: 594
Issue: 11
Pages: 3005-30
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Publication
22158709 | J:192706
First Author: Li N
Year: 2012
Journal: Circ Res
Title: Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.
Volume: 110
Issue: 3
Pages: 465-70
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Publication
23733959 | J:197381
First Author: Brunello L
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.
Volume: 110
Issue: 25
Pages: 10312-7
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Publication
34270372 | J:310401
First Author: Sadredini M
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation.
Volume: 321
Issue: 2
Pages: H446-H460
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Publication
16239587 | J:117512
First Author: Jiang D
Year: 2005
Journal: Circ Res
Title: Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death.
Volume: 97
Issue: 11
Pages: 1173-81
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Publication
29402414 | J:271671
First Author: Okuda S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy.
Volume: 496
Issue: 4
Pages: 1250-1256
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Allele
Ryr2<tm1.1Maya> | MGI:4442645
Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, Masafumi Yano
Allele Type: Targeted
Attribute String: Humanized sequence
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Protein
Q80ZZ5
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
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Publication
33536282 | J:302151
 
First Author: Sun B
Year: 2021
Journal: Sci Transl Med
Title: Cardiac ryanodine receptor calcium release deficiency syndrome.
Volume: 13
Issue: 579
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Publication
- | J:267529
     
First Author: Pontes R
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for arruda2.
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Publication
- | J:267530
     
First Author: Pontes R
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for arruda3.
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Publication
- | J:267528
     
First Author: Teixeira S
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Arruda.
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Publication
32641776 | J:302783
First Author: Bertan F
Year: 2020
Journal: Cell Death Differ
Title: Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability.
Volume: 27
Issue: 12
Pages: 3354-3373
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Publication
22867515 | J:191292
First Author: Min CK
Year: 2012
Journal: Biochem J
Title: Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca²+ transfer from the sarcoplasmic reticulum to the mitochondria in the heart.
Volume: 447
Issue: 3
Pages: 371-9
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Publication
21113126 | J:168729
First Author: Ziviani E
Year: 2011
Journal: EMBO J
Title: Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.
Volume: 30
Issue: 1
Pages: 194-204
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Publication
32669538 | J:292289
First Author: Mei L
Year: 2020
Journal: Nat Commun
Title: Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway.
Volume: 11
Issue: 1
Pages: 3527
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Publication
12837242 | J:107733
First Author: Wehrens XH
Year: 2003
Journal: Cell
Title: FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.
Volume: 113
Issue: 7
Pages: 829-40
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Publication
16672364 | J:110224
First Author: Lehnart SE
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.
Volume: 103
Issue: 20
Pages: 7906-10
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Publication
21098440 | J:179475
First Author: van Oort RJ
Year: 2010
Journal: Circulation
Title: Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Volume: 122
Issue: 25
Pages: 2669-79
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Publication
25093823 | J:223162
First Author: Chakraborty A
Year: 2014
Journal: PLoS One
Title: Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor.
Volume: 9
Issue: 8
Pages: e104338
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Publication
25775566 | J:220671
First Author: Zhao YT
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function.
Volume: 112
Issue: 13
Pages: E1669-77
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Publication
28096415 | J:240743
First Author: Lavorato M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges.
Volume: 114
Issue: 5
Pages: E849-E858
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Publication
26109063 | J:239358
First Author: Hiess F
Year: 2015
Journal: J Biol Chem
Title: Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes.
Volume: 290
Issue: 33
Pages: 20477-87
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Publication
29170159 | J:255692
First Author: Zhong X
Year: 2018
Journal: Biochem J
Title: Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans.
Volume: 475
Issue: 1
Pages: 169-183
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Publication
16873551 | J:111780
First Author: Kannankeril PJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.
Volume: 103
Issue: 32
Pages: 12179-84
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Publication
20009080 | J:296564
First Author: Mathur N
Year: 2009
Journal: Circ Arrhythm Electrophysiol
Title: Sudden infant death syndrome in mice with an inherited mutation in RyR2.
Volume: 2
Issue: 6
Pages: 677-85
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Publication
20157052 | J:281015
First Author: van Oort RJ
Year: 2010
Journal: Hypertension
Title: Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.
Volume: 55
Issue: 4
Pages: 932-8
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Publication
31167968 | J:308964
 
First Author: Nakamura Y
Year: 2019
Journal: JCI Insight
Title: Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia.
Volume: 4
Issue: 11
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Publication
15890976 | J:109683
First Author: Cerrone M
Year: 2005
Journal: Circ Res
Title: Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.
Volume: 96
Issue: 10
Pages: e77-82
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Publication
20966392 | J:178510
First Author: Kashimura T
Year: 2010
Journal: Circ Res
Title: In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves.
Volume: 107
Issue: 12
Pages: 1483-9
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Publication
20080988 | J:176105
First Author: Sedej S
Year: 2010
Journal: Cardiovasc Res
Title: Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Volume: 87
Issue: 1
Pages: 50-9
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Publication
19096022 | J:156428
First Author: Fernández-Velasco M
Year: 2009
Journal: Circ Res
Title: Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia.
Volume: 104
Issue: 2
Pages: 201-9, 12p following 209
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Publication
24315909 | J:320832
First Author: Sedej S
Year: 2014
Journal: J Am Coll Cardiol
Title: Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
Volume: 63
Issue: 15
Pages: 1569-79
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Publication
16407108 | J:105666
First Author: Wehrens XH
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Volume: 103
Issue: 3
Pages: 511-8
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Publication
21099118 | J:171860
First Author: Shan J
Year: 2010
Journal: J Clin Invest
Title: Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.
Volume: 120
Issue: 12
Pages: 4388-98
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Publication
21099115 | J:171862
First Author: Shan J
Year: 2010
Journal: J Clin Invest
Title: Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice.
Volume: 120
Issue: 12
Pages: 4375-87
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Publication
18483626 | J:137696
First Author: Lehnart SE
Year: 2008
Journal: J Clin Invest
Title: Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.
Volume: 118
Issue: 6
Pages: 2230-45
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Publication
27161030 | J:255475
First Author: Manotheepan R
Year: 2016
Journal: Cardiovasc Res
Title: Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.
Volume: 111
Issue: 3
Pages: 295-306
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Publication
38012000 | J:343249
 
First Author: Wegener JW
Year: 2024
Journal: Life Sci Alliance
Title: A dual-targeted drug inhibits cardiac ryanodine receptor Ca(2+) leak but activates SERCA2a Ca(2+) uptake.
Volume: 7
Issue: 2
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Publication
30209242 | J:266929
 
First Author: Mohamed BA
Year: 2018
Journal: Sci Transl Med
Title: Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.
Volume: 10
Issue: 458
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Publication
34955889 | J:319355
 
First Author: Wegener JW
Year: 2021
Journal: Front Physiol
Title: The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool.
Volume: 12
Pages: 777770
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Publication
25087098 | J:228787
First Author: Nishio H
Year: 2014
Journal: Leg Med (Tokyo)
Title: Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: a study using a knock-in mouse model.
Volume: 16
Issue: 6
Pages: 326-32
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Publication
23666671 | J:200958
First Author: Yamaguchi N
Year: 2013
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1.
Volume: 305
Issue: 1
Pages: H86-94
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Publication
18419777 | J:186379
First Author: Goddard CA
Year: 2008
Journal: Acta Physiol (Oxf)
Title: Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts.
Volume: 194
Issue: 2
Pages: 123-40
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Publication
24441828 | J:214434
First Author: Chen W
Year: 2014
Journal: Nat Med
Title: The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.
Volume: 20
Issue: 2
Pages: 184-92
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Publication
17363382 | J:151738
First Author: Hotta S
Year: 2007
Journal: J Physiol
Title: Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle.
Volume: 582
Issue: Pt 2
Pages: 489-506
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Publication
27582498 | J:248496
First Author: Zhong X
Year: 2016
Journal: Biochem J
Title: Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.
Volume: 473
Issue: 21
Pages: 3951-3964
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Publication
27422983 | J:328198
First Author: Becerra R
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart.
Volume: 311
Issue: 3
Pages: H713-24
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Publication
24186966 | J:223626
First Author: Yang Y
Year: 2014
Journal: Circ Res
Title: Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.
Volume: 114
Issue: 2
Pages: 295-306
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Publication
23836685 | J:214180
First Author: Arnáiz-Cot JJ
Year: 2013
Journal: J Physiol
Title: Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor.
Volume: 591
Issue: 17
Pages: 4287-99
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Publication
31028179 | J:300378
 
First Author: Salvage SC
Year: 2019
Journal: J Cell Sci
Title: Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse.
Volume: 132
Issue: 10
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Publication
12089338 | J:77723
First Author: Yang HT
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development.
Volume: 99
Issue: 14
Pages: 9225-30
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Publication
16249315 | J:104642
First Author: Fu JD
Year: 2006
Journal: FASEB J
Title: Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells.
Volume: 20
Issue: 1
Pages: 181-3
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Publication
17717301 | J:141342
First Author: Benkusky NA
Year: 2007
Journal: Circ Res
Title: Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor.
Volume: 101
Issue: 8
Pages: 819-29
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Publication
22302785 | J:212670
First Author: Zhang H
Year: 2012
Journal: Circ Res
Title: Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Volume: 110
Issue: 6
Pages: 831-40
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Publication
27623776 | J:248475
First Author: Tan Z
Year: 2016
Journal: Biochem J
Title: Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia.
Volume: 473
Issue: 22
Pages: 4159-4172
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Publication
26348911 | J:235844
First Author: Zhang J
Year: 2015
Journal: Biochem J
Title: Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure.
Volume: 470
Issue: 2
Pages: 233-42
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Publication
25389315 | J:340679
First Author: Chiang DY
Year: 2014
Journal: Circ Arrhythm Electrophysiol
Title: Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.
Volume: 7
Issue: 6
Pages: 1214-22
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Publication
14593104 | J:87557
First Author: Wang R
Year: 2004
Journal: J Biol Chem
Title: The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gating.
Volume: 279
Issue: 5
Pages: 3635-42
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Publication
12919952 | J:196115
First Author: George CH
Year: 2003
Journal: Circ Res
Title: Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes.
Volume: 93
Issue: 6
Pages: 531-40
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Publication
12324472 | J:222155
First Author: Liu Z
Year: 2002
Journal: J Biol Chem
Title: Three-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1.
Volume: 277
Issue: 48
Pages: 46712-9
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Publication
20427316 | J:222148
First Author: Liu Z
Year: 2010
Journal: J Cell Sci
Title: Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor.
Volume: 123
Issue: Pt 10
Pages: 1775-84
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Publication
11429443 | J:70263
First Author: Li P
Year: 2001
Journal: J Gen Physiol
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