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Search results 1 to 100 out of 290 for Scn10a

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0.067s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Chambers JC
Year: 2010
Journal: Nat Genet
Title: Genetic variation in SCN10A influences cardiac conduction.
Volume: 42
Issue: 2
Pages: 149-52
Publication
First Author: van den Boogaard M
Year: 2014
Journal: J Clin Invest
Title: A common genetic variant within SCN10A modulates cardiac SCN5A expression.
Volume: 124
Issue: 4
Pages: 1844-52
Publication
First Author: Yang T
Year: 2012
Journal: Circ Res
Title: Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.
Volume: 111
Issue: 3
Pages: 322-32
Publication
First Author: Verkerk AO
Year: 2012
Journal: Circ Res
Title: Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.
Volume: 111
Issue: 3
Pages: 333-43
Publication
First Author: Blasius AL
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.
Volume: 108
Issue: 48
Pages: 19413-8
Publication
First Author: Rannals MD
Year: 2016
Journal: Neuron
Title: Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1.
Volume: 90
Issue: 1
Pages: 43-55
GXD Expression      
Probe: MGI:6182845
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191256
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Scn10a
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6182845
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191256
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Scn10a
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:6182845
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191256
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Scn10a
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6182845
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191256
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Scn10a
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6182845
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191256
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Scn10a
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6182845
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191256
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Scn10a
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6182845
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191256
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Scn10a
Detected: true
Specimen Num: 7
Publication  
First Author: Chidiac C
Year: 2021
Journal: Front Pharmacol
Title: The Human SCN10A(G1662S) Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity.
Volume: 12
Pages: 780132
Publication
First Author: van den Boogaard M
Year: 2012
Journal: J Clin Invest
Title: Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.
Volume: 122
Issue: 7
Pages: 2519-30
Publication
First Author: Borgmann D
Year: 2021
Journal: Cell Metab
Title: Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism.
Volume: 33
Issue: 7
Pages: 1466-1482.e7
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Souslova VA
Year: 1997
Journal: Genomics
Title: Cloning and characterization of a mouse sensory neuron tetrodotoxin-resistant voltage-gated sodium channel gene, Scn10a.
Volume: 41
Issue: 2
Pages: 201-9
Publication
First Author: Huang S
Year: 2021
Journal: Cell
Title: Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential.
Volume: 184
Issue: 2
Pages: 441-459.e25
Publication
First Author: Filtjens J
Year: 2021
Journal: Nat Commun
Title: Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection.
Volume: 12
Issue: 1
Pages: 2936
Publication
First Author: Prazeres PHDM
Year: 2020
Journal: J Cell Mol Med
Title: Ablation of sensory nerves favours melanoma progression.
Volume: 24
Issue: 17
Pages: 9574-9589
Publication
First Author: Udit S
Year: 2017
Journal: Mol Metab
Title: Na(v)1.8 neurons are involved in limiting acute phase responses to dietary fat.
Volume: 6
Issue: 10
Pages: 1081-1091
Publication
First Author: Bullich-Vilarrubias C
Year: 2024
Journal: Commun Biol
Title: Nav1.8-expressing neurons control daily oscillations of food intake, body weight and gut microbiota in mice.
Volume: 7
Issue: 1
Pages: 219
Publication
First Author: Costa PAC
Year: 2021
Journal: Acta Neuropathol Commun
Title: Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression.
Volume: 9
Issue: 1
Pages: 183
Publication      
First Author: Usui K
Year: 2023
Journal: J Allergy Clin Immunol
Title: TRPV1-positive sensory nerves and neuropeptides are involved in epidermal barrier repair after tape stripping in mice.
Publication
First Author: Zhao J
Year: 2006
Journal: Genesis
Title: Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia.
Volume: 44
Issue: 8
Pages: 364-71
Publication
First Author: Gautron L
Year: 2011
Journal: J Comp Neurol
Title: Genetic tracing of Nav1.8-expressing vagal afferents in the mouse.
Volume: 519
Issue: 15
Pages: 3085-101
Publication
First Author: Serlin HK
Year: 2020
Journal: J Comp Neurol
Title: Abdominal vagotomy reveals majority of small intestinal mucosal afferents labeled in nav 1.8cre-rosa26tdTomato mice are vagal in origin.
Volume: 528
Issue: 5
Pages: 816-839
Publication  
First Author: Thakur M
Year: 2014
Journal: Front Mol Neurosci
Title: Defining the nociceptor transcriptome.
Volume: 7
Pages: 87
Publication
First Author: Mecum NE
Year: 2020
Journal: Sci Rep
Title: Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors.
Volume: 10
Issue: 1
Pages: 17225
Publication
First Author: Borah BJ
Year: 2021
Journal: iScience
Title: Nyquist-exceeding high voxel rate acquisition in mesoscopic multiphoton microscopy for full-field submicron resolution resolvability.
Volume: 24
Issue: 9
Pages: 103041
Publication
First Author: Persson AK
Year: 2013
Journal: J Neurosci
Title: Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury.
Volume: 33
Issue: 49
Pages: 19250-61
Publication
First Author: Daou I
Year: 2013
Journal: J Neurosci
Title: Remote optogenetic activation and sensitization of pain pathways in freely moving mice.
Volume: 33
Issue: 47
Pages: 18631-40
Publication
First Author: Mecum NE
Year: 2021
Journal: Invest Ophthalmol Vis Sci
Title: Optogenetic Inhibition of Nav1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain.
Volume: 62
Issue: 14
Pages: 15
Publication      
First Author: Megat S
Year: 2019
Journal: J Neurosci
Title: Differences between dorsal root and trigeminal ganglion nociceptors in mice revealed by translational profiling.
Publication
First Author: Lillis KV
Year: 2023
Journal: Sci Rep
Title: Nociceptors regulate osteoimmune transcriptomic response to infection.
Volume: 13
Issue: 1
Pages: 17601
Publication  
First Author: Daou I
Year: 2016
Journal: eNeuro
Title: Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain.
Volume: 3
Issue: 1
Publication
First Author: Bengel P
Year: 2021
Journal: Nat Commun
Title: Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure.
Volume: 12
Issue: 1
Pages: 6586
Publication
First Author: Akopian AN
Year: 1999
Journal: Nat Neurosci
Title: The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways.
Volume: 2
Issue: 6
Pages: 541-8
Publication
First Author: Renganathan M
Year: 2000
Journal: J Neurophysiol
Title: alpha-SNS produces the slow TTX-resistant sodium current in large cutaneous afferent DRG neurons.
Volume: 84
Issue: 2
Pages: 710-8
Publication
First Author: Zimmermann K
Year: 2007
Journal: Nature
Title: Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures.
Volume: 447
Issue: 7146
Pages: 855-8
Publication
First Author: Roza C
Year: 2003
Journal: J Physiol
Title: The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice.
Volume: 550
Issue: Pt 3
Pages: 921-6
Publication
First Author: Renganathan M
Year: 2001
Journal: J Neurophysiol
Title: Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons.
Volume: 86
Issue: 2
Pages: 629-40
Publication
First Author: Laird JM
Year: 2002
Journal: J Neurosci
Title: Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.
Volume: 22
Issue: 19
Pages: 8352-6
Publication  
First Author: Moldovan M
Year: 2016
Journal: Neurobiol Aging
Title: Aging-associated changes in motor axon voltage-gated Na(+) channel function in mice.
Volume: 39
Pages: 128-39
Publication
First Author: Kerr BJ
Year: 2001
Journal: Neuroreport
Title: A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain.
Volume: 12
Issue: 14
Pages: 3077-80
Publication  
First Author: Bengel P
Year: 2020
Journal: J Mol Cell Cardiol
Title: Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia.
Volume: 144
Pages: 35-46
Publication
First Author: Stirling LC
Year: 2005
Journal: Pain
Title: Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice.
Volume: 113
Issue: 1-2
Pages: 27-36
Publication
First Author: Garrison SR
Year: 2014
Journal: Pain
Title: A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons.
Volume: 155
Issue: 5
Pages: 896-905
Publication
First Author: Huang J
Year: 2013
Journal: J Neurosci
Title: Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons.
Volume: 33
Issue: 35
Pages: 14087-97
Publication    
First Author: Zhu J
Year: 2020
Journal: Elife
Title: Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis.
Volume: 9
GXD Expression      
Probe: MGI:3707870
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610525
Stage: TS25
Assay Id: MGI:3708955
Age: embryonic day 17.5
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3707870
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3708955
Age: postnatal day 1
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3707870
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3708955
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7258004
Assay Type: RT-PCR
Annotation Date: 2022-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3667828
Stage: TS28
Assay Id: MGI:7258094
Age: postnatal month 2
Image: 5
Specimen Label: Lrig1+/+;Lrig3+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7258004
Assay Type: RT-PCR
Annotation Date: 2022-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3667828
Stage: TS28
Assay Id: MGI:7258094
Age: postnatal month 2
Image: 5
Specimen Label: Lrig1+/-;Lrig3-/-
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_03
Specimen Label: euxassay_007406_03
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_05
Specimen Label: euxassay_007406_05
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_17
Specimen Label: euxassay_007406_17
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_18
Specimen Label: euxassay_007406_18
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_19
Specimen Label: euxassay_007406_19
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_05
Specimen Label: euxassay_007406_05
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_06
Specimen Label: euxassay_007406_06
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_07
Specimen Label: euxassay_007406_07
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_08
Specimen Label: euxassay_007406_08
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_09
Specimen Label: euxassay_007406_09
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_10
Specimen Label: euxassay_007406_10
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_12
Specimen Label: euxassay_007406_12
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_13
Specimen Label: euxassay_007406_13
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_14
Specimen Label: euxassay_007406_14
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4422473
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827900
Age: embryonic day 14.5
Image: euxassay_007406_15
Specimen Label: euxassay_007406_15
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:7484574
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484624
Age: postnatal adult
Specimen Label: 1c Nav1.8
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7484574
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484624
Age: postnatal adult
Specimen Label: 2c Nav1.8 Control
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7484574
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484624
Age: postnatal adult
Specimen Label: 2c Nav1.8 PN-ZB20KO
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7484590
Assay Type: RNA in situ
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484646
Age: postnatal adult
Specimen Label: S6 Nav1.8 Control
Detected: true
Specimen Num: 1