|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 112 for Sec62

<< First    < Previous  |  Next >    Last >>
0.048s

Categories

Hits by Strain

Hits by Category

Type Details Score
Gene
7095 | SEC62
Type: gene
Organism: Homo sapiens
•
•
•
•
•
Gene
RGD:1308862 | Sec62
Type: gene
Organism: Rattus norvegicus
•
•
•
•
•
Gene
ZFIN:ZDB-GENE-050913-83 | sec62
Type: gene
Organism: Danio rerio
•
•
•
•
•
Gene
S000006015 | SEC62
Type: gene
Organism: Saccharomyces cerevisiae
•
•
•
•
•
Protein Domain
IPR004728 | Sec62
Type: Family
Description: Members of the NSCC2 family have been sequenced from various yeast, fungal and animals species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.
•
•
•
•
•
Protein Coding Gene
MGI:1916526 | Sec62
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein
Q8BU14
Organism: Mus musculus
Length: 398  
Fragment?: false
•
•
•
•
•
Protein
Q05DA2
Organism: Mus musculus
Length: 136  
Fragment?: true
•
•
•
•
•
Protein
Q9CRY0
Organism: Mus musculus
Length: 132  
Fragment?: true
•
•
•
•
•
Protein
Q8CIK3
Organism: Mus musculus
Length: 293  
Fragment?: true
•
•
•
•
•
Gene
106478967 | SEC62-AS1
Type: gene
Organism: Homo sapiens
•
•
•
•
•
Publication
22375059 | J:197701
First Author: Lang S
Year: 2012
Journal: J Cell Sci
Title: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
Volume: 125
Issue: Pt 8
Pages: 1958-69
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0024906 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0027127 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0027087 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0027056 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0027099 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0026841 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1916526 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0027545 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0026295 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0026819 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0026953 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0026921 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0027064 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0026941 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0027604 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0026028 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0026369 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0026351 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0025840 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
26199344 | J:318865
First Author: Zheng B
Year: 2015
Journal: Mol Cell Proteomics
Title: Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis.
Volume: 14
Issue: 10
Pages: 2682-91
•
•
•
•
•
Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
•
•
•
•
•
Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
21873635 | J:265628
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 1
Description: Translocation protein SEC62
Type: chain
End: 398
•
•
•
•
•
Publication
33870132 | J:316781
First Author: Sheehan BK
Year: 2021
Journal: iScience
Title: ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1.
Volume: 24
Issue: 4
Pages: 102315
•
•
•
•
•
Publication
10799540 | -
First Author: Meyer HA
Year: 2000
Journal: J Biol Chem
Title: Mammalian Sec61 is associated with Sec62 and Sec63.
Volume: 275
Issue: 19
Pages: 14550-7
•
•
•
•
•
Allele
Sec62<+> | MGI:3049901
   
Name: SEC62 homolog (S. cerevisiae); wild type
•
•
•
•
•
Allele
Sec62<Gt(CSI590)Byg> | MGI:3879425
 
Name: SEC62 homolog (S. cerevisiae); gene trap CSI590, BayGenomics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(RRA120)Byg> | MGI:4126333
 
Name: SEC62 homolog (S. cerevisiae); gene trap RRA120, BayGenomics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST4792)Lex> | MGI:4134069
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST4792, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST4829)Lex> | MGI:4134092
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST4829, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST7089)Lex> | MGI:4135416
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST7089, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST11930)Lex> | MGI:4138365
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST11930, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST21718)Lex> | MGI:4144743
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST21718, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST36354)Lex> | MGI:4154463
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST36354, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST51037)Lex> | MGI:4161831
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST51037, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST60400)Lex> | MGI:4167376
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST60400, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST68616)Lex> | MGI:4172745
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST68616, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST75027)Lex> | MGI:4174431
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST75027, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST75029)Lex> | MGI:4174433
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST75029, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST76668)Lex> | MGI:4174940
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST76668, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST80790)Lex> | MGI:4176681
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST80790, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST328293)Lex> | MGI:4282125
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST328293, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST334369)Lex> | MGI:4284057
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST334369, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST366229)Lex> | MGI:4295537
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST366229, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(OST388584)Lex> | MGI:4302373
 
Name: SEC62 homolog (S. cerevisiae); gene trap OST388584, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<em1(IMPC)J> | MGI:6188014
Name: SEC62 homolog (S. cerevisiae); endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Allele
Sec62<Gt(CD0061)Wtsi> | MGI:3864519
 
Name: SEC62 homolog (S. cerevisiae); gene trap CD0061, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(E200G04)Wrst> | MGI:3918269
 
Name: SEC62 homolog (S. cerevisiae); gene trap E200G04, German Gene Trap Consortium
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(W038C03)Wrst> | MGI:4336766
 
Name: SEC62 homolog (S. cerevisiae); gene trap W038C03, German Gene Trap Consortium
Allele Type: Gene trapped
•
•
•
•
•
Allele
Sec62<Gt(IST14317B11)Tigm> | MGI:5223439
 
Name: SEC62 homolog (S. cerevisiae); gene trap IST14317B11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Strain
MGI:6188017 | C57BL/6NJ-Sec62<em1(IMPC)J>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: Sec62/Sec62
Background: C57BL/6NJ-Sec62/Mmjax
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Protein Domain
IPR011553 | Sec62_asco
Type: Family
Description: Members of the NSCC2 family have been sequenced from various fungal and animal species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.This family of Sec62 proteins is restricted to the Ascomycota.
•
•
•
•
•
Publication
11226176 | -
First Author: Young BP
Year: 2001
Journal: EMBO J
Title: Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.
Volume: 20
Issue: 1-2
Pages: 262-71
•
•
•
•
•
Publication
10543453 | -
First Author: Skowronek MH
Year: 1999
Journal: Biol Chem
Title: Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog.
Volume: 380
Issue: 9
Pages: 1133-8
•
•
•
•
•
Publication
15133510 | -
First Author: Davila S
Year: 2004
Journal: Nat Genet
Title: Mutations in SEC63 cause autosomal dominant polycystic liver disease.
Volume: 36
Issue: 6
Pages: 575-7
•
•
•
•
•
Protein Domain
IPR027137 | Sec63
Type: Family
Description: In Saccharomyces cerevisiae, Sec63 is a component of the Sec62/63 complex (includes Sec63p, Sec62p, Sec66p and Sec72p), which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex []. In humans, Sec63 is part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63. It is required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane [, ].Defects in SEC63 are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterised by the presence of multiple liver cysts of biliary epithelial origin [].
•
•
•
•
•
Publication
17208939 | -
First Author: Lee J
Year: 2007
Journal: Mol Cell Proteomics
Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.
Volume: 6
Issue: 4
Pages: 669-76
•
•
•
•
•
Protein
Q8K2U5
Organism: Mus musculus
Length: 516  
Fragment?: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom