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Search results 1 to 100 out of 112 for Sec62

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0.048s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Protein Domain
Type: Family
Description: Members of the NSCC2 family have been sequenced from various yeast, fungal and animals species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 398  
Fragment?: false
Protein
Organism: Mus musculus
Length: 136  
Fragment?: true
Protein
Organism: Mus musculus
Length: 132  
Fragment?: true
Protein
Organism: Mus musculus
Length: 293  
Fragment?: true
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Lang S
Year: 2012
Journal: J Cell Sci
Title: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
Volume: 125
Issue: Pt 8
Pages: 1958-69
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Zheng B
Year: 2015
Journal: Mol Cell Proteomics
Title: Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis.
Volume: 14
Issue: 10
Pages: 2682-91
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication        
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
UniProt Feature
Begin: 1
Description: Translocation protein SEC62
Type: chain
End: 398
Publication
First Author: Sheehan BK
Year: 2021
Journal: iScience
Title: ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1.
Volume: 24
Issue: 4
Pages: 102315
Publication
First Author: Meyer HA
Year: 2000
Journal: J Biol Chem
Title: Mammalian Sec61 is associated with Sec62 and Sec63.
Volume: 275
Issue: 19
Pages: 14550-7
Allele    
Name: SEC62 homolog (S. cerevisiae); wild type
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap CSI590, BayGenomics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap RRA120, BayGenomics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST4792, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST4829, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST7089, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST11930, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST21718, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST36354, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST51037, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST60400, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST68616, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST75027, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST75029, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST76668, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST80790, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST328293, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST334369, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST366229, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap OST388584, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: SEC62 homolog (S. cerevisiae); endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap CD0061, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap E200G04, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap W038C03, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: SEC62 homolog (S. cerevisiae); gene trap IST14317B11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Sec62/Sec62
Background: C57BL/6NJ-Sec62/Mmjax
Zygosity: hm
Has Mutant Allele: true
Protein Domain
Type: Family
Description: Members of the NSCC2 family have been sequenced from various fungal and animal species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.This family of Sec62 proteins is restricted to the Ascomycota.
Publication
First Author: Young BP
Year: 2001
Journal: EMBO J
Title: Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.
Volume: 20
Issue: 1-2
Pages: 262-71
Publication
First Author: Skowronek MH
Year: 1999
Journal: Biol Chem
Title: Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog.
Volume: 380
Issue: 9
Pages: 1133-8
Publication
First Author: Davila S
Year: 2004
Journal: Nat Genet
Title: Mutations in SEC63 cause autosomal dominant polycystic liver disease.
Volume: 36
Issue: 6
Pages: 575-7
Protein Domain
Type: Family
Description: In Saccharomyces cerevisiae, Sec63 is a component of the Sec62/63 complex (includes Sec63p, Sec62p, Sec66p and Sec72p), which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex []. In humans, Sec63 is part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63. It is required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane [, ].Defects in SEC63 are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterised by the presence of multiple liver cysts of biliary epithelial origin [].
Publication
First Author: Lee J
Year: 2007
Journal: Mol Cell Proteomics
Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.
Volume: 6
Issue: 4
Pages: 669-76
Protein
Organism: Mus musculus
Length: 516  
Fragment?: true