Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Danio rerio |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Rattus norvegicus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Publication |
First Author: |
Silverman JL |
Year: |
2011 |
Journal: |
Brain Res |
Title: |
Sociability and motor functions in Shank1 mutant mice. |
Volume: |
1380 |
|
Pages: |
120-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao W |
Year: |
2015 |
Journal: |
Eur J Neurosci |
Title: |
Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons. |
Volume: |
41 |
Issue: |
8 |
Pages: |
1025-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sungur AÖ |
Year: |
2014 |
Journal: |
J Neurosci Methods |
Title: |
Repetitive behaviors in the Shank1 knockout mouse model for autism spectrum disorder: developmental aspects and effects of social context. |
Volume: |
234 |
|
Pages: |
92-100 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2167
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Wöhr M |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e20631 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hung AY |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. |
Volume: |
28 |
Issue: |
7 |
Pages: |
1697-708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sungur AÖ |
Year: |
2018 |
Journal: |
Front Mol Neurosci |
Title: |
Reduced Efficacy of d-Amphetamine and 3,4-Methylenedioxymethamphetamine in Inducing Hyperactivity in Mice Lacking the Postsynaptic Scaffolding Protein SHANK1. |
Volume: |
11 |
|
Pages: |
419 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uemura T |
Year: |
2004 |
Journal: |
Mol Cell Neurosci |
Title: |
Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. |
Volume: |
26 |
Issue: |
2 |
Pages: |
330-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schütt J |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. |
Volume: |
284 |
Issue: |
38 |
Pages: |
25479-87 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Stella SL Jr |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Association of shank 1A scaffolding protein with cone photoreceptor terminals in the mammalian retina. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e43463 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3641148 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754423 |
|
Stage: |
TS23 |
Assay Id: |
MGI:3641157 |
Age: |
embryonic day 15.0 |
|
|
Specimen Label: |
E15 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3641148 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754427 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3641157 |
Age: |
postnatal day 1 |
|
|
Specimen Label: |
P1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3641148 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3641157 |
Age: |
postnatal day 7 |
|
|
Specimen Label: |
P7 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3641148 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3641157 |
Age: |
postnatal day 15 |
|
|
Specimen Label: |
P15 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3641148 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3641157 |
Age: |
postnatal week 8 |
|
|
Specimen Label: |
8W |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3641151 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754427 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3641161 |
Age: |
postnatal day 1 |
|
|
Specimen Label: |
P1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3641151 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3641161 |
Age: |
postnatal day 15 |
|
|
Specimen Label: |
P15 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3641151 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-08-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3641161 |
Age: |
postnatal week 8 |
|
|
Specimen Label: |
8W |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Francke F |
Year: |
2005 |
Journal: |
Brain Res Mol Brain Res |
Title: |
Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain. |
Volume: |
139 |
Issue: |
1 |
Pages: |
31-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Filice F |
Year: |
2016 |
Journal: |
Mol Brain |
Title: |
Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism. |
Volume: |
9 |
|
Pages: |
10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang YH |
Year: |
2013 |
Journal: |
Neuron |
Title: |
Modeling autism by SHANK gene mutations in mice. |
Volume: |
78 |
Issue: |
1 |
Pages: |
8-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida T |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. |
Volume: |
31 |
Issue: |
38 |
Pages: |
13485-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakai Y |
Year: |
2011 |
Journal: |
Sci Transl Med |
Title: |
Protein interactome reveals converging molecular pathways among autism disorders. |
Volume: |
3 |
Issue: |
86 |
Pages: |
86ra49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uchino S |
Year: |
2006 |
Journal: |
J Neurochem |
Title: |
Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. |
Volume: |
97 |
Issue: |
4 |
Pages: |
1203-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mendus D |
Year: |
2014 |
Journal: |
Eur J Neurosci |
Title: |
Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear. |
Volume: |
39 |
Issue: |
8 |
Pages: |
1256-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berkel S |
Year: |
2018 |
Journal: |
Front Mol Neurosci |
Title: |
Sex Hormones Regulate SHANK Expression. |
Volume: |
11 |
|
Pages: |
337 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. |
Volume: |
21 |
Issue: |
3 |
Pages: |
666-678 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dani A |
Year: |
2010 |
Journal: |
Neuron |
Title: |
Superresolution imaging of chemical synapses in the brain. |
Volume: |
68 |
Issue: |
5 |
Pages: |
843-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang LC |
Year: |
2012 |
Journal: |
Neural Dev |
Title: |
Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea. |
Volume: |
7 |
|
Pages: |
38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Z |
Year: |
2020 |
Journal: |
eNeuro |
Title: |
The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development. |
Volume: |
7 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kazdoba TM |
Year: |
2016 |
Journal: |
Genes Brain Behav |
Title: |
Behavioral phenotypes of genetic mouse models of autism. |
Volume: |
15 |
Issue: |
1 |
Pages: |
7-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quesnel-Vallières M |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders. |
Volume: |
64 |
Issue: |
6 |
Pages: |
1023-1034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verpelli C |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. |
Volume: |
286 |
Issue: |
40 |
Pages: |
34839-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quesnel-Vallières M |
Year: |
2015 |
Journal: |
Genes Dev |
Title: |
Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. |
Volume: |
29 |
Issue: |
7 |
Pages: |
746-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sawallisch C |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. |
Volume: |
284 |
Issue: |
14 |
Pages: |
9225-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Farini D |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. |
Volume: |
31 |
Issue: |
9 |
Pages: |
107703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thuret S |
Year: |
2004 |
Journal: |
Mol Cell Neurosci |
Title: |
Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. |
Volume: |
25 |
Issue: |
3 |
Pages: |
394-405 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Rat to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gaudet P |
Year: |
2011 |
Journal: |
Brief Bioinform |
Title: |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Volume: |
12 |
Issue: |
5 |
Pages: |
449-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2014 |
Journal: |
RNA Biol |
Title: |
FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA. |
Volume: |
11 |
Issue: |
11 |
Pages: |
1364-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boeckers TM |
Year: |
2002 |
Journal: |
J Neurochem |
Title: |
ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease. |
Volume: |
81 |
Issue: |
5 |
Pages: |
903-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehlers MD |
Year: |
1999 |
Journal: |
Curr Biol |
Title: |
Synapse structure: glutamate receptors connected by the shanks. |
Volume: |
9 |
Issue: |
22 |
Pages: |
R848-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheng M |
Year: |
2000 |
Journal: |
J Cell Sci |
Title: |
The Shank family of scaffold proteins. |
Volume: |
113 ( Pt 11) |
|
Pages: |
1851-6 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Shank1, also called SSTRIP (Somatostatin receptor-interacting protein), is a brain-specific protein that plays a role in the construction of postsynaptic density (PSD) and the maturation of dendritic spines [, ]. Mice deficient in Shank1 show altered PSD composition, thinner PSDs, smaller dendritic spines, and weaker basal synaptic transmission, although synaptic plasticity is normal. They show increased anxiety and impaired fear memory, but also show better spatial learning [, , ]. A Shank protein carries scaffolding functions through multiple sites of protein-protein interaction in its domain architecture, including ankyrin (ANK) repeats, a long proline rich region, as well as SH3, PDZ, and SAM domains.This entry represents the SH3 domain of Shank1 which binds GRIP, a scaffold protein that binds AMPA receptors and Eph receptors/ligands []. |
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Publication |
First Author: |
Lilja J |
Year: |
2017 |
Journal: |
Nat Cell Biol |
Title: |
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. |
Volume: |
19 |
Issue: |
4 |
Pages: |
292-305 |
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Publication |
First Author: |
Pham E |
Year: |
2010 |
Journal: |
FEBS J |
Title: |
Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. |
Volume: |
277 |
Issue: |
14 |
Pages: |
3051-67 |
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Publication |
First Author: |
Lin CW |
Year: |
2014 |
Journal: |
Front Cell Neurosci |
Title: |
Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator. |
Volume: |
8 |
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Pages: |
87 |
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