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Search results 1 to 100 out of 691 for Sin3a

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: Sin3a is a transcriptional repressor and a homologue of the SIN3 repressor from yeast. Sin3a associates with the strong repressive isoform of Mxi1, a helix-loop-helix leucone zipper that associates with Max to antagonize Myc oncogenic activities []. Unlike Mxi1 and Myc, expression of Sin3a does not vary during development []. Sin3a is a component of several complexes, including the REST-CoREST repressor complex [], the PER complex which maintains circadian rhythm []and the Sin3 HDAC complex []. Sin3a also interacts with FOXK1 to regulate cell cycle progression []. Sin3a has three PAH domains by which it interacts with HCFC1, REST and SAP30 [, ].
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Rao G
Year: 1996
Journal: Oncogene
Title: Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
Volume: 12
Issue: 5
Pages: 1165-72
Publication
First Author: Grimes JA
Year: 2000
Journal: J Biol Chem
Title: The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
Volume: 275
Issue: 13
Pages: 9461-7
Publication
First Author: Shi X
Year: 2012
Journal: Mol Cell Biochem
Title: Sin3 interacts with Foxk1 and regulates myogenic progenitors.
Volume: 366
Issue: 1-2
Pages: 251-8
Publication
First Author: Duong HA
Year: 2011
Journal: Science
Title: A molecular mechanism for circadian clock negative feedback.
Volume: 332
Issue: 6036
Pages: 1436-9
Publication
First Author: Laherty CD
Year: 1998
Journal: Mol Cell
Title: SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.
Volume: 2
Issue: 1
Pages: 33-42
GXD Expression
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:318653
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:6283036
Age: embryonic day 2.5
Image: 1B Sin3A 8-cell -/-
Note: Nuclear expression is less apparent than in wild type littermates.
Specimen Label: 1B Sin3A 8-cell -/-
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:6283036
Age: embryonic day 2.5
Image: 1B Sin3A 8-cell +/+
Note: Nuclear expression in wild type and heterozygous mutant embryos.
Specimen Label: 1B Sin3A 8-cell +/+
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Ubiquitous
Stage: TS04
Assay Id: MGI:6283036
Age: embryonic day 3.5
Image: 1B Sin3A Blastocyst +/+
Note: Ubiquitous expression in wild type and heterozygous mutant embryos.
Specimen Label: 1B Sin3A Blastocyst +/+
Detected: true
Specimen Num: 9
GXD Expression
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:6283036
Age: embryonic day 3.0
Image: 1B Sin3A 16-cell +/+
Note: Nuclear expression in wild type and heterozygous mutant embryos.
Specimen Label: 1B Sin3A 16-cell +/+
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:6283036
Age: embryonic day 1.0
Image: 1A Sin3A 2-cell +/+
Note: Authors report maternal expression in nuclei of wild type and homozygous mutant embryos.
Specimen Label: 1A Sin3A 2-cell +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Regionally restricted
Stage: TS04
Assay Id: MGI:6283036
Age: embryonic day 3.5
Image: 1B Sin3A Blastocyst -/-
Specimen Label: 1B Sin3A Blastocyst -/-
Specimen Num: 11
GXD Expression  
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:6283036
Age: embryonic day 3.0
Image: 1B Sin3A 16-cell -/-
Note: Authors state maternal protein has largely been depleted. No nuclear expression.
Specimen Label: 1B Sin3A 16-cell -/-
Specimen Num: 8
GXD Expression
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:6283036
Age: embryonic day 1.0
Image: 1A Sin3A 2-cell -/-
Note: Authors report maternal expression in nuclei of wild type and homozygous mutant embryos.
Specimen Label: 1A Sin3A 2-cell -/-
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus/domesticus
Length: 1274  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
Publication
First Author: Gallagher SJ
Year: 2013
Journal: Dev Biol
Title: Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia.
Volume: 373
Issue: 1
Pages: 83-94
Publication
First Author: Pellegrino J
Year: 2012
Journal: Dev Biol
Title: Chromatin associated Sin3A is essential for male germ cell lineage in the mouse.
Volume: 369
Issue: 2
Pages: 349-55
Publication
First Author: Viiri KM
Year: 2006
Journal: Nucleic Acids Res
Title: SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.
Volume: 34
Issue: 11
Pages: 3288-98
Publication
First Author: Bartolomé A
Year: 2022
Journal: Diabetes
Title: An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition.
Volume: 71
Issue: 11
Pages: 2395-2401
Publication  
First Author: Bridi M
Year: 2020
Journal: JCI Insight
Title: Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.
Volume: 5
Issue: 5
Publication
First Author: Witteveen JS
Year: 2016
Journal: Nat Genet
Title: Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity.
Volume: 48
Issue: 8
Pages: 877-87
Protein
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: true
Publication
First Author: Jimenez R
Year: 2015
Journal: Biol Reprod
Title: Maternal SIN3A regulates reprogramming of gene expression during mouse preimplantation development.
Volume: 93
Issue: 4
Pages: 89
Publication
First Author: Srivas S
Year: 2018
Journal: J Neurochem
Title: Transcriptional co-repressor SIN3A silencing rescues decline in memory consolidation during scopolamine-induced amnesia.
Volume: 145
Issue: 3
Pages: 204-216
Publication
First Author: Nascimento EM
Year: 2011
Journal: Nat Cell Biol
Title: The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
Volume: 13
Issue: 12
Pages: 1395-405
Publication
First Author: Zhang Y
Year: 2005
Journal: Nucleic Acids Res
Title: The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.
Volume: 33
Issue: 18
Pages: 6024-33
Publication
First Author: Yao C
Year: 2017
Journal: Development
Title: Sin3a regulates epithelial progenitor cell fate during lung development.
Volume: 144
Issue: 14
Pages: 2618-2628
GXD Expression  
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:6283036
Age: embryonic day 2.5
Note: Nuclear expression in wild type and heterozygous mutant embryos.
Specimen Label: Sin3A 8-cell +/- not shown
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Ubiquitous
Stage: TS04
Assay Id: MGI:6283036
Age: embryonic day 3.5
Note: Ubiquitous expression in wild type and heterozygous mutant embryos.
Specimen Label: Sin3A Blastocyst +/- not shown
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:6283033
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:6283036
Age: embryonic day 3.0
Note: Nuclear expression in wild type and heterozygous mutant embryos.
Specimen Label: Sin3A 16-cell +/- not shown
Detected: true
Specimen Num: 7
Publication
First Author: Fleischer TC
Year: 2003
Journal: Mol Cell Biol
Title: Identification and characterization of three new components of the mSin3A corepressor complex.
Volume: 23
Issue: 10
Pages: 3456-67
Publication
First Author: McDonel P
Year: 2012
Journal: Dev Biol
Title: Sin3a is essential for the genome integrity and viability of pluripotent cells.
Volume: 363
Issue: 1
Pages: 62-73
Publication
First Author: Payne CJ
Year: 2010
Journal: Stem Cells
Title: Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation.
Volume: 28
Issue: 8
Pages: 1424-34
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Halleck MS
Year: 1995
Journal: Genomics
Title: A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3.
Volume: 26
Issue: 2
Pages: 403-6
Publication
First Author: Mathur M
Year: 2001
Journal: Mol Cell Biol
Title: PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
Volume: 21
Issue: 7
Pages: 2298-311
Publication
First Author: Yang X
Year: 2020
Journal: Diabetes
Title: Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Volume: 69
Issue: 6
Pages: 1219-1231
Publication    
First Author: Nabeshima R
Year: 2018
Journal: Elife
Title: Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters.
Volume: 7
Publication
First Author: Lu P
Year: 2011
Journal: J Biol Chem
Title: The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.
Volume: 286
Issue: 20
Pages: 18311-9
Publication
First Author: Yochum GS
Year: 2001
Journal: Mol Cell Biol
Title: Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.
Volume: 21
Issue: 13
Pages: 4110-8
Publication  
First Author: Brown MA
Year: 2006
Journal: Mol Cancer
Title: Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.
Volume: 5
Pages: 26
Publication
First Author: Ma P
Year: 2015
Journal: Cell Rep
Title: A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes.
Volume: 13
Issue: 8
Pages: 1552-60
Publication
First Author: Williams K
Year: 2011
Journal: Nature
Title: TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.
Volume: 473
Issue: 7347
Pages: 343-8
Publication
First Author: Bowman CJ
Year: 2014
Journal: Nat Cell Biol
Title: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.
Volume: 16
Issue: 12
Pages: 1202-14
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Zhang X
Year: 2023
Journal: iScience
Title: Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription.
Volume: 26
Issue: 3
Pages: 106158
GXD Expression    
Probe: MGI:2655679
Assay Type: RNase protection
Annotation Date: 2003-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:2655722
Age: embryonic day 9.5
Image: 1
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2655679
Assay Type: RNase protection
Annotation Date: 2003-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:2655722
Age: embryonic day 9.5
Image: 1
Specimen Label: deltaORF/deltaORF
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3603583
Assay Type: RT-PCR
Annotation Date: 2005-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3603607
Age: embryonic day 1.0
Specimen Label: 2-cell
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3603583
Assay Type: RT-PCR
Annotation Date: 2005-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3603607
Age: embryonic day 2.5
Specimen Label: 8-cell
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3603583
Assay Type: RT-PCR
Annotation Date: 2005-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3603607
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3603583
Assay Type: RT-PCR
Annotation Date: 2005-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3603607
Age: embryonic day 3.5
Specimen Label: Pre-hatch Blastocyst
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3603583
Assay Type: RT-PCR
Annotation Date: 2005-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3603607
Age: embryonic day 4.0
Specimen Label: Hatch Blastocyst
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3603582
Assay Type: RT-PCR
Annotation Date: 2005-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3603619
Age: embryonic day 3.5
Specimen Label: Pre-hatch Blastocyst
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3603582
Assay Type: RT-PCR
Annotation Date: 2005-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3603619
Age: embryonic day 4.0
Specimen Label: Hatch Blastocyst
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6283055
Assay Type: RT-PCR
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160414
Stage: TS04
Assay Id: MGI:6283072
Age: embryonic day 3.5
Image: 4
Specimen Label: Sin3a+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6283055
Assay Type: RT-PCR
Annotation Date: 2019-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160414
Stage: TS04
Assay Id: MGI:6283072
Age: embryonic day 3.5
Image: 4
Specimen Label: Sin3a+/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6283055
Assay Type: RT-PCR
Annotation Date: 2019-03-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160414
Stage: TS04
Assay Id: MGI:6283072
Age: embryonic day 3.5
Image: 4
Specimen Label: Sin3a-/-
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6385572
Assay Type: RT-PCR
Annotation Date: 2020-01-21
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:6385573
Age: postnatal week 6
Specimen Label: GV
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6385572
Assay Type: RT-PCR
Annotation Date: 2020-01-21
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:6385573
Age: postnatal week 6
Specimen Label: MII
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6385572
Assay Type: RT-PCR
Annotation Date: 2020-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:6385573
Age: embryonic day 0.5
Specimen Label: 1C
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6385572
Assay Type: RT-PCR
Annotation Date: 2020-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:6385573
Age: embryonic day 1.0
Specimen Label: 2C
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6385572
Assay Type: RT-PCR
Annotation Date: 2020-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Stage: TS03
Assay Id: MGI:6385573
Age: embryonic day 2.5
Specimen Label: 8C
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6385572
Assay Type: RT-PCR
Annotation Date: 2020-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Stage: TS04
Assay Id: MGI:6385573
Age: embryonic day 3.5
Specimen Label: BL
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6385569
Assay Type: Western blot
Annotation Date: 2020-01-21
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:6385591
Age: postnatal week 6
Specimen Label: GV
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6385569
Assay Type: Western blot
Annotation Date: 2020-01-21
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:6385591
Age: postnatal week 6
Specimen Label: MII in vivo
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6385569
Assay Type: Western blot
Annotation Date: 2020-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:6385591
Age: embryonic day 0.5
Specimen Label: 1C
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6385569
Assay Type: Western blot
Annotation Date: 2020-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:6385591
Age: embryonic day 1.0
Specimen Label: 2C
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6385569
Assay Type: Western blot
Annotation Date: 2020-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Stage: TS03
Assay Id: MGI:6385591
Age: embryonic day 2.5
Specimen Label: 8C
Detected: true
Specimen Num: 7