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Search results 1 to 85 out of 85 for Slc41a2

0.027s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Goytain A
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Functional characterization of the mouse [corrected] solute carrier, SLC41A2.
Volume: 330
Issue: 3
Pages: 701-5
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2813026
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3157126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2828126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3156626
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1794826
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2828726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1867626
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4422938
Assay Type: RNA in situ
Annotation Date: 2011-02-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:4888726
Age: embryonic day 14.5
Image: Table S1
Specimen Label: Table S1
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1795226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2800326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3128126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Specimen Num: 1
GXD Expression    
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2837026
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2834626
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5299060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1897626
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5543044
Age: embryonic day 17.5
Image: GUDMAP:14537
Specimen Label: GUDMAP:14537
Detected: true
Specimen Num: 1
Publication      
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
Publication
First Author: Willnow T
Year: 2005
Journal: Organogenesis
Title: The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.
Volume: 2
Issue: 2
Pages: 42-7
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Protein Domain
Type: Homologous_superfamily
Description: The SLC41 superfamily of divalent cation transporters includes MgtE (SLC41A1), SLC41A2 and SLC41A3. The prokaryote orthologue, MgtE, is a magnesium transporter []. MgtE consists of a C-terminal transmembrane domain and a N-terminal cytosolic domain, and adopts a homodimeric architecture in bateria []. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ [].This entry represents the integral membrane region of SLC41 transporter proteins. Bacterial family members have one copy of this region while archaeal and eukaryotic sequences have two. This suggests that the bacterial proteins may act as dimers.
Protein
Organism: Mus musculus
Length: 573  
Fragment?: false
Protein
Organism: Mus musculus
Length: 488  
Fragment?: false
Protein
Organism: Mus musculus
Length: 512  
Fragment?: false
Protein
Organism: Mus musculus
Length: 573  
Fragment?: false
Protein
Organism: Mus musculus
Length: 488  
Fragment?: false
Protein Domain
Type: Domain
Description: This entry represents the integral membrane region of SLC41 transporter proteins. SLC41 family of divalent cation transporters includes SLC41A1/2/3 from eukaryotes and MgtE from prokaryotes [, , , , ]. MgtE is the prokaryote homologue of SLC41A1 magnesium transporter which adopts a homodimeric architecture with five transmembrane domains in the C terminus and cytosolic N terminus domains [, ]. Bacterial family members have one copy of this region while archaeal and eukaryotic sequences have two. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ [].
Protein
Organism: Mus musculus
Length: 131  
Fragment?: true
Protein
Organism: Mus musculus
Length: 89  
Fragment?: true
Publication
First Author: Lin CH
Year: 2014
Journal: Parkinsonism Relat Disord
Title: Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function.
Volume: 20
Issue: 6
Pages: 600-3
Publication
First Author: Kolisek M
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Human gene SLC41A1 encodes for the Na+/Mg²+ exchanger.
Volume: 302
Issue: 1
Pages: C318-26
Publication  
First Author: Schweigel-Röntgen M
Year: 2014
Journal: Curr Top Membr
Title: SLC41 transporters--molecular identification and functional role.
Volume: 73
Pages: 383-410
Publication
First Author: Feeney KA
Year: 2016
Journal: Nature
Title: Daily magnesium fluxes regulate cellular timekeeping and energy balance.
Volume: 532
Issue: 7599
Pages: 375-9
Publication
First Author: Tsao YT
Year: 2017
Journal: Stem Cell Res Ther
Title: Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.
Volume: 8
Issue: 1
Pages: 39
Publication
First Author: Kolisek M
Year: 2013
Journal: Hypertens Pregnancy
Title: SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women.
Volume: 32
Issue: 4
Pages: 378-89
Protein Domain
Type: Family
Description: This entry includes the SLC41A family members mostly from eukaryotes and archaea. Some proteins are from bacteria. The SLC41A family of divalent cation transporters includes SLC41A1, SLC41A2 and SLC41A3 and MgtE [, , , ]. MgtE, the SLC41A1 orthologue found in prokaryotes, consists of a homodimer architecture with five transmembrane domains at the C terminus and the cytosolic domains at the N terminus. Structural and functional analyses showed MgtE conserved acidic side-chains play a key role as part of its selectivity filter [, ]. In humans, SLC41A1 is a Na+/Mg2+ ion exchanger that acts as a predominant Mg2+ efflux system at the plasma membrane. The transporter activity is driven by the inwardly directed electrochemical gradient for Na+ ions, thus directly depends on the extracellular Na+ ion concentration set by the Na+/K+ pump. In this way, it generates circadian cellular Mg2+ fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. This protein is located in the cell membrane [, ]. Its expression level has been linked to diverse disorders such as preeclampsia in pregnant woman, nephronophthisis, Parkinson's disease and bone mass loss. Hence, it has been suggested this protein might be a great therapeutic target [, , , ]. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ [].
Publication
First Author: Wabakken T
Year: 2003
Journal: Biochem Biophys Res Commun
Title: The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.
Volume: 306
Issue: 3
Pages: 718-24
Publication  
First Author: de Baaij JH
Year: 2016
Journal: Sci Rep
Title: Identification of SLC41A3 as a novel player in magnesium homeostasis.
Volume: 6
Pages: 28565
Publication
First Author: Jin F
Year: 2021
Journal: PLoS Biol
Title: The structure of MgtE in the absence of magnesium provides new insights into channel gating.
Volume: 19
Issue: 4
Pages: e3001231
Publication
First Author: Payandeh J
Year: 2013
Journal: Biochim Biophys Acta
Title: The structure and regulation of magnesium selective ion channels.
Volume: 1828
Issue: 11
Pages: 2778-92
Publication
First Author: Sahni J
Year: 2013
Journal: Mol Aspects Med
Title: The SLC41 family of MgtE-like magnesium transporters.
Volume: 34
Issue: 2-3
Pages: 620-8
Publication
First Author: Hattori M
Year: 2007
Journal: Nature
Title: Crystal structure of the MgtE Mg2+ transporter.
Volume: 448
Issue: 7157
Pages: 1072-5