Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
NIS (product of the SLC5A5 gene) transports iodide (I-), and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer []. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis [, ]. Human NIS exists mainly as a dimer stabilized by a disulfide bridge []. This subgroup belongs to the solute carrier 5 (SLC5) transporter family. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Dohán O |
Year: |
2003 |
Journal: |
Endocr Rev |
Title: |
The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. |
Volume: |
24 |
Issue: |
1 |
Pages: |
48-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huc-Brandt S |
Year: |
2011 |
Journal: |
Biochim Biophys Acta |
Title: |
Characterisation of the purified human sodium/iodide symporter reveals that the protein is mainly present in a dimeric form and permits the detailed study of a native C-terminal fragment. |
Volume: |
1808 |
Issue: |
1 |
Pages: |
65-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kosugi S |
Year: |
1999 |
Journal: |
J Clin Endocrinol Metab |
Title: |
A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect. |
Volume: |
84 |
Issue: |
9 |
Pages: |
3248-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pohlenz J |
Year: |
1998 |
Journal: |
J Clin Invest |
Title: |
Congenital hypothyroidism due to mutations in the sodium/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3' splice site. |
Volume: |
101 |
Issue: |
5 |
Pages: |
1028-35 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
618
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
618
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferrandino G |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice. |
Volume: |
7 |
Issue: |
1 |
Pages: |
5329 |
|
•
•
•
•
•
|
Publication |
First Author: |
Afink GB |
Year: |
2010 |
Journal: |
Thyroid |
Title: |
Initial characterization of C16orf89, a novel thyroid-specific gene. |
Volume: |
20 |
Issue: |
7 |
Pages: |
811-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang HS |
Year: |
2024 |
Journal: |
Cell Mol Life Sci |
Title: |
GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. |
Volume: |
81 |
Issue: |
1 |
Pages: |
65 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Pinke LA |
Year: |
2001 |
Journal: |
Thyroid |
Title: |
Cloning of the mouse sodium iodide symporter. |
Volume: |
11 |
Issue: |
10 |
Pages: |
935-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dayem M |
Year: |
2008 |
Journal: |
J Endocrinol |
Title: |
Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization. |
Volume: |
197 |
Issue: |
1 |
Pages: |
95-109 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perron B |
Year: |
2001 |
Journal: |
J Endocrinol |
Title: |
Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. |
Volume: |
170 |
Issue: |
1 |
Pages: |
185-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Concilio SC |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS). |
Volume: |
15 |
Issue: |
2 |
Pages: |
e0229085 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6114167 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-02-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6114663 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
Cre-/0 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6114167 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-02-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6114663 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
Cre+/0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6114167 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-02-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6114663 |
Age: |
postnatal month 12 |
|
|
Specimen Label: |
Cre-/0 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6114167 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-02-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6114663 |
Age: |
postnatal month 12 |
|
|
Specimen Label: |
Cre+/0 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6114167 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-02-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6114693 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
Thyr-TRB<+/+> |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6114167 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-02-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6114693 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
Thyr-TRB<+/-> |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6114167 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-02-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6114693 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
Thyr-TRB<-/-> |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150283 |
Age: |
postnatal |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150283 |
Age: |
postnatal |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150289 |
Age: |
postnatal adult |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150289 |
Age: |
postnatal adult |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150289 |
Age: |
postnatal adult |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150289 |
Age: |
postnatal adult |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150295 |
Age: |
postnatal adult |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150295 |
Age: |
postnatal adult |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150295 |
Age: |
postnatal adult |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149782 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6150295 |
Age: |
postnatal adult |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7705246 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-07-31 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3599828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7705372 |
Age: |
postnatal day 23 |
Image: |
7 |
|
Specimen Label: |
Ctrl |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7705246 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-07-31 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3599828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7705372 |
Age: |
postnatal day 23 |
Image: |
7 |
|
Specimen Label: |
cKO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428438 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1804323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828254 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_019729_15 |
|
Specimen Label: |
euxassay_019729_15 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428438 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1804323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828254 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_019729_16 |
|
Specimen Label: |
euxassay_019729_16 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5286051 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-09-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706820 |
|
Stage: |
TS20 |
Assay Id: |
MGI:5286063 |
Age: |
embryonic day 12.5 |
|
Note: |
Data also shown in Table 2. |
Specimen Label: |
E12.5 Thyroid |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5286051 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-09-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5286063 |
Age: |
embryonic day 14.5 |
|
Note: |
Data also shown in Table 2. |
Specimen Label: |
E14.5 Thyroid |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5286051 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-09-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706825 |
Pattern: |
Not Specified |
Stage: |
TS25 |
Assay Id: |
MGI:5286063 |
Age: |
embryonic day 17.5 |
|
Note: |
Data also shown in Table 2. |
Specimen Label: |
E17.5 Thyroid |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149773 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2018-04-10 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:6150277 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
1A E14.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149773 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706823 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6150277 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
1A E15.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149773 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2018-04-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6150277 |
Age: |
postnatal |
|
Note: |
Expression was detected at the basal pole of thyrocytes. |
Specimen Label: |
3C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7720361 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-09-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706824 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:7720405 |
Age: |
embryonic day 16.5 |
Image: |
5B/C |
Note: |
Expressed in thyrocytes. |
Specimen Label: |
5B/C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7720361 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-09-26 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706824 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:7720405 |
Age: |
embryonic day 16.5 |
Image: |
5E/F |
Note: |
Expressed in thyrocytes. The positive surface area relative to the Nkx2-1-positive surface area was 69% lower than in wild type mice (see Fig 5G). |
Specimen Label: |
5E/F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5286051 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-09-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1685320 |
|
Stage: |
TS20 |
Assay Id: |
MGI:5286063 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
E12.5 Trachea |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5286051 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-09-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1685322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5286063 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
E14.5 Trachea |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5286051 |
Assay Type: |
RNA in situ |
Annotation Date: |
2011-09-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1685325 |
|
Stage: |
TS25 |
Assay Id: |
MGI:5286063 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
E17.5 Trachea |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692446 |
Age: |
postnatal adult |
Image: |
JAX_1371973 |
|
Specimen Label: |
JAX_1371973 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424007 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828253 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_012146_05 |
|
Specimen Label: |
euxassay_012146_05 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424007 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828253 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_012146_06 |
|
Specimen Label: |
euxassay_012146_06 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424007 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828253 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_012146_07 |
|
Specimen Label: |
euxassay_012146_07 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424007 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828253 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_012146_08 |
|
Specimen Label: |
euxassay_012146_08 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428438 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828254 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_019729_09 |
|
Specimen Label: |
euxassay_019729_09 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428438 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702123 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828254 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_019729_10 |
|
Specimen Label: |
euxassay_019729_10 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferrandino G |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. |
Volume: |
114 |
Issue: |
43 |
Pages: |
E9172-E9180 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaspari RR |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The paradoxical lean phenotype of hypothyroid mice is marked by increased adaptive thermogenesis in the skeletal muscle. |
Volume: |
117 |
Issue: |
36 |
Pages: |
22544-22551 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Felice M |
Year: |
2004 |
Journal: |
Endocrinology |
Title: |
Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases. |
Volume: |
145 |
Issue: |
9 |
Pages: |
4062-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Postiglione MP |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. |
Volume: |
99 |
Issue: |
24 |
Pages: |
15462-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Milenkovic M |
Year: |
2007 |
Journal: |
J Endocrinol |
Title: |
Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult. |
Volume: |
192 |
Issue: |
3 |
Pages: |
615-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Silberschmidt D |
Year: |
2011 |
Journal: |
BMC Dev Biol |
Title: |
In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. |
Volume: |
11 |
|
Pages: |
9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Didier-Mathon H |
Year: |
2023 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures. |
Volume: |
14 |
|
Pages: |
1286747 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carre A |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development. |
Volume: |
6 |
Issue: |
2 |
Pages: |
e16752 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frezzetti D |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
The microRNA-processing enzyme Dicer is essential for thyroid function. |
Volume: |
6 |
Issue: |
11 |
Pages: |
e27648 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marotta P |
Year: |
2014 |
Journal: |
Mol Cell Endocrinol |
Title: |
The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. |
Volume: |
396 |
Issue: |
1-2 |
Pages: |
26-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis. |
Volume: |
15 |
Issue: |
1 |
Pages: |
4108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Selmi-Ruby S |
Year: |
2014 |
Journal: |
Endocrinology |
Title: |
The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production. |
Volume: |
155 |
Issue: |
2 |
Pages: |
635-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stoupa A |
Year: |
2018 |
Journal: |
EMBO Mol Med |
Title: |
TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology. |
Volume: |
10 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Watson LA |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. |
Volume: |
123 |
Issue: |
5 |
Pages: |
2049-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hick AC |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. |
Volume: |
381 |
Issue: |
1 |
Pages: |
227-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt |
Year: |
2021 |
|
Title: |
Electronic Gene Ontology annotations created by ARBA machine learning models |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|