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Search results 1 to 100 out of 223 for Slx4

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Hits by Category

Type Details Score
Gene
84464 | SLX4
Type: gene
Organism: human
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Gene
512193 | SLX4
Type: gene
Organism: cattle
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Gene
705887 | SLX4
Type: gene
Organism: macaque, rhesus
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Gene
100379741 | slx4
Type: gene
Organism: frog, western clawed
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Gene
416665 | SLX4
Type: gene
Organism: chicken
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Gene
100538153 | slx4
Type: gene
Organism: zebrafish
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Gene
302953 | Slx4
Type: gene
Organism: rat
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Gene
479867 | SLX4
Type: gene
Organism: dog, domestic
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Gene
453866 | SLX4
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:106299 | Slx4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23994477 | J:202845
First Author: Wilson JS
Year: 2013
Journal: Cell Rep
Title: Localization-dependent and -independent roles of SLX4 in regulating telomeres.
Volume: 4
Issue: 5
Pages: 853-60
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Publication
24726326 | J:213612
First Author: Hodskinson MR
Year: 2014
Journal: Mol Cell
Title: Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.
Volume: 54
Issue: 3
Pages: 472-84
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Publication
24794496 | J:214661
First Author: Lachaud C
Year: 2014
Journal: J Cell Sci
Title: Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia.
Volume: 127
Issue: Pt 13
Pages: 2811-7
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Gene
128710 | SLX4IP
Type: gene
Organism: human
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Publication
- | J:236683
     
First Author: Chen Z
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for slim
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Publication
21240276 | J:168567
First Author: Crossan GP
Year: 2011
Journal: Nat Genet
Title: Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Volume: 43
Issue: 2
Pages: 147-52
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Publication
24076219 | J:204996
First Author: Castor D
Year: 2013
Journal: Mol Cell
Title: Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.
Volume: 52
Issue: 2
Pages: 221-33
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Protein Coding Gene
MGP_CAROLIEiJ_G0020395 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_106299 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022873 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022291 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022289 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022885 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021767 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016103 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021290 | -
Type: protein_coding_gene
Organism: Mus spretus
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Protein
Q8BRX3
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
Q8C949
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Publication
21655083 | J:173448
First Author: Holloway JK
Year: 2011
Journal: PLoS Genet
Title: Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.
Volume: 7
Issue: 6
Pages: e1002094
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Publication
22922648 | J:188123
First Author: Garaycoechea JI
Year: 2012
Journal: Nature
Title: Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.
Volume: 489
Issue: 7417
Pages: 571-5
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Publication
26980188 | J:232403
First Author: Lachaud C
Year: 2016
Journal: Genes Dev
Title: Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice.
Volume: 30
Issue: 6
Pages: 639-44
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Publication
26980189 | J:232402
First Author: Thongthip S
Year: 2016
Journal: Genes Dev
Title: Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.
Volume: 30
Issue: 6
Pages: 645-59
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Publication
22579284 | J:222674
First Author: Vannier JB
Year: 2012
Journal: Cell
Title: RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.
Volume: 149
Issue: 4
Pages: 795-806
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Publication
23468651 | J:195191
First Author: Lyndaker AM
Year: 2013
Journal: PLoS Genet
Title: Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.
Volume: 9
Issue: 2
Pages: e1003320
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Publication
21240275 | -
First Author: Kim Y
Year: 2011
Journal: Nat Genet
Title: Mutations of the SLX4 gene in Fanconi anemia.
Volume: 43
Issue: 2
Pages: 142-6
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Publication
27760317 | J:240753
First Author: Alavattam KG
Year: 2016
Journal: Cell Rep
Title: Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Volume: 17
Issue: 4
Pages: 1141-1157
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Publication
25538220 | J:218236
First Author: Perez-Oliva AB
Year: 2015
Journal: EMBO J
Title: USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.
Volume: 34
Issue: 3
Pages: 326-43
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Protein
Q69ZA3
Organism: Mus musculus/domesticus
Length: 1379  
Fragment?: true
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
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Publication
9371744 | J:44483
First Author: Brady KP
Year: 1997
Journal: Genome Res
Title: Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Volume: 7
Issue: 11
Pages: 1085-93
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Protein
Q6P1D7
Organism: Mus musculus/domesticus
Length: 1565  
Fragment?: false
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Gene
499895 | Slx4ip
Type: gene
Organism: rat
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Gene
748063 | SLX4IP
Type: gene
Organism: chimpanzee
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Gene
100682892 | SLX4IP
Type: gene
Organism: dog, domestic
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Gene
100848905 | SLX4IP
Type: gene
Organism: cattle
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Gene
416738 | SLX4IP
Type: gene
Organism: chicken
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Gene
393383 | slx4ip
Type: gene
Organism: zebrafish
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Gene
718563 | SLX4IP
Type: gene
Organism: macaque, rhesus
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Gene
100038267 | slx4ip
Type: gene
Organism: frog, western clawed
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Publication
19596236 | -
First Author: Fekairi S
Year: 2009
Journal: Cell
Title: Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
Volume: 138
Issue: 1
Pages: 78-89
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Publication
19595721 | -
First Author: Muñoz IM
Year: 2009
Journal: Mol Cell
Title: Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
Volume: 35
Issue: 1
Pages: 116-27
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Publication
21240277 | -
First Author: Stoepker C
Year: 2011
Journal: Nat Genet
Title: SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.
Volume: 43
Issue: 2
Pages: 138-41
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Protein Domain
IPR018574 | Structure-sp_endonuc_su_Slx4
Type: Family
Description: The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 is a regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination [, ]. The SLX1-SLX4 complex has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs) [, ]. Defects in SLX4 are the cause of Fanconi anemia complementation group P (FANCP), which is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia [, ].
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UniProt Feature
UniProt Feature
Begin: 1
Description: Structure-specific endonuclease subunit SLX4
Type: chain
End: 1565
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Protein Coding Gene
MGI:1921493 | Slx4ip
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Slx4<em1Smoc> | MGI:7292464
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae); endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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