|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 121 for Smc5

<< First    < Previous  |  Next >    Last >>
0.038s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: SMC5 is a core component of the SMC5-SMC6 complex [, ], a complex involved in repair of DNA double-strand breaks by homologous recombination [, ]. In humans, the SMC5-SMC6 complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks []. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) []. SMC5 is required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 [].
Gene
Type: gene
Organism: Homo sapiens
Publication    
First Author: Cobbe N
Year: 2002
Journal: GenBank Submission
Title: Mus musculus mRNA for SMC5 protein
Pages: AJ534941
Publication
First Author: Behlke-Steinert S
Year: 2009
Journal: Cell Cycle
Title: SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.
Volume: 8
Issue: 14
Pages: 2211-8
Publication
First Author: Pryzhkova MV
Year: 2016
Journal: J Cell Sci
Title: Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.
Volume: 129
Issue: 8
Pages: 1619-34
Publication
First Author: Fousteri MI
Year: 2000
Journal: EMBO J
Title: A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein.
Volume: 19
Issue: 7
Pages: 1691-702
Publication
First Author: Zhao X
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.
Volume: 102
Issue: 13
Pages: 4777-82
Publication
First Author: Potts PR
Year: 2006
Journal: EMBO J
Title: Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.
Volume: 25
Issue: 14
Pages: 3377-88
Publication
First Author: Potts PR
Year: 2007
Journal: Nat Struct Mol Biol
Title: The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.
Volume: 14
Issue: 7
Pages: 581-90
Publication
First Author: Onoda F
Year: 2004
Journal: DNA Repair (Amst)
Title: SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae.
Volume: 3
Issue: 4
Pages: 429-39
Publication
First Author: Taylor EM
Year: 2008
Journal: Mol Cell Biol
Title: Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
Volume: 28
Issue: 4
Pages: 1197-206
Protein
Organism: Mus musculus
Length: 1101  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1011  
Fragment?: false
Publication
First Author: Hwang G
Year: 2018
Journal: Mol Biol Cell
Title: Depletion of SMC5/6 sensitizes male germ cells to DNA damage.
Volume: 29
Issue: 25
Pages: 3003-3016
Publication    
First Author: Atkins A
Year: 2020
Journal: Elife
Title: SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.
Volume: 9
Publication
First Author: Hwang G
Year: 2017
Journal: Development
Title: SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.
Volume: 144
Issue: 9
Pages: 1648-1660
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:6457039
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:6457075
Age: embryonic day 15.5
Specimen Label: Testis Fetal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6457039
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6457075
Age: postnatal adult
Specimen Label: Testis Adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6457039
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:6457075
Age: embryonic day 15.5
Specimen Label: Ovary Fetal
Detected: true
Specimen Num: 1
GXD Expression        
Probe: MGI:6457039
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:6457075
Age: postnatal adult
Specimen Label: Ovary Adult
Specimen Num: 2
GXD Expression  
Probe: MGI:6457055
Assay Type: RNA in situ
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:3575728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6457091
Age: postnatal adult
Note: Expression specifically in meiotic spermatocytes..
Specimen Label: 3 MLZ-452
Detected: true
Specimen Num: 1
Publication
First Author: Taylor EM
Year: 2001
Journal: Mol Biol Cell
Title: Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.
Volume: 12
Issue: 6
Pages: 1583-94
Publication
First Author: Brouwer AK
Year: 2009
Journal: Mol Biol Cell
Title: Telomeric DNA mediates de novo PML body formation.
Volume: 20
Issue: 22
Pages: 4804-15
Publication
First Author: Kogo H
Year: 2010
Journal: J Hum Genet
Title: Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans.
Volume: 55
Issue: 5
Pages: 293-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Palecek J
Year: 2006
Journal: J Biol Chem
Title: The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits.
Volume: 281
Issue: 48
Pages: 36952-9
Protein Domain
Type: Domain
Description: Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6 []. This entry represents the highly conserved C-terminal domain which interacts with the head domain of Smc5 [].
Protein Domain
Type: Domain
Description: The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homologyto the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 [].This entry represents the ATP-binding cassette domain of eukaryotic SMC3 proteins, which is found at the N terminus.
Protein Domain
Type: Domain
Description: The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 [].This entry represents the ATP-binding cassette domain of eukaryotic SMC4 proteins.
Protein
Organism: Mus musculus
Length: 202  
Fragment?: true
Protein
Organism: Mus musculus
Length: 375  
Fragment?: false
Protein
Organism: Mus musculus
Length: 381  
Fragment?: false
Publication
First Author: Andrews EA
Year: 2005
Journal: Mol Cell Biol
Title: Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.
Volume: 25
Issue: 1
Pages: 185-96
Publication
First Author: Potts PR
Year: 2005
Journal: Mol Cell Biol
Title: Human MMS21/NSE2 is a SUMO ligase required for DNA repair.
Volume: 25
Issue: 16
Pages: 7021-32
Publication
First Author: Huang L
Year: 2009
Journal: Plant J
Title: The Arabidopsis SUMO E3 ligase AtMMS21, a homologue of NSE2/MMS21, regulates cell proliferation in the root.
Volume: 60
Issue: 4
Pages: 666-78
Publication
First Author: Kliszczak M
Year: 2012
Journal: DNA Repair (Amst)
Title: SUMO ligase activity of vertebrate Mms21/Nse2 is required for efficient DNA repair but not for Smc5/6 complex stability.
Volume: 11
Issue: 10
Pages: 799-810
Publication
First Author: Stephan AK
Year: 2011
Journal: FEBS Lett
Title: The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.
Volume: 585
Issue: 18
Pages: 2907-13
Protein Domain
Type: Family
Description: This entry consists of the E3 SUMO-protein ligase Nse2 (also known as Mms21). Nse2 is an E3 SUMO-protein ligase component of the SMC5-SMC6 complex [, ]. Nse2 acts as an E3 ligase targeting several proteins for sumoylation and is required for efficient DNA repair and maintenance of genome stability [, , , ]. Nse2 and SMC5 may also be required for sister chromatid cohesion during prometaphase and mitotic progression; this role is apparently independent of SMC6 []. Nse2 is necessary for normal cell cycle progression in Arabidopsis, where Nse2 mutation results in abnormal root development [].
Publication
First Author: Pebernard S
Year: 2004
Journal: Mol Biol Cell
Title: Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.
Volume: 15
Issue: 11
Pages: 4866-76
Publication
First Author: Gómez R
Year: 2013
Journal: J Cell Sci
Title: Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis suggests functions in distinct chromosome processes.
Volume: 126
Issue: Pt 18
Pages: 4239-52
Protein
Organism: Mus musculus
Length: 337  
Fragment?: true
Protein
Organism: Mus musculus
Length: 284  
Fragment?: true
Protein
Organism: Mus musculus
Length: 451  
Fragment?: true