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Search results 1 to 93 out of 93 for Snx9

0.035s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok []. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. Sorting nexin 9 (SNX9) is a well-characterised member of this group; it is has been suggested to be involved in the endocytic process as an accessory factor []. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain []. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin []. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity [].
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Soulet F
Year: 2005
Journal: Mol Biol Cell
Title: SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.
Volume: 16
Issue: 4
Pages: 2058-67
Publication
First Author: Lundmark R
Year: 2003
Journal: J Biol Chem
Title: Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components.
Volume: 278
Issue: 47
Pages: 46772-81
Publication
First Author: Lundmark R
Year: 2002
Journal: Biochem J
Title: The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2.
Volume: 362
Issue: Pt 3
Pages: 597-607
Protein
Organism: Mus musculus
Length: 410  
Fragment?: true
Protein
Organism: Mus musculus
Length: 595  
Fragment?: false
Protein
Organism: Mus musculus
Length: 595  
Fragment?: false
Protein
Organism: Mus musculus
Length: 595  
Fragment?: false
Publication
First Author: Ma MP
Year: 2012
Journal: J Cell Sci
Title: SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.
Volume: 125
Issue: Pt 18
Pages: 4372-82
Publication
First Author: Cullen PJ
Year: 2011
Journal: Nat Cell Biol
Title: Sorting nexins provide diversity for retromer-dependent trafficking events.
Volume: 14
Issue: 1
Pages: 29-37
Publication
First Author: Liu C
Year: 2016
Journal: Oncotarget
Title: Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice.
Volume: 7
Issue: 42
Pages: 68921-68932
Publication
First Author: Cao H
Year: 2013
Journal: PLoS One
Title: FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro.
Volume: 8
Issue: 2
Pages: e56516
Publication
First Author: MaCaulay SL
Year: 2003
Journal: Biochem J
Title: Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action.
Volume: 376
Issue: Pt 1
Pages: 123-34
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:4424036
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828370
Age: embryonic day 14.5
Image: euxassay_012283_07
Specimen Label: euxassay_012283_07
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4424036
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828370
Age: embryonic day 14.5
Image: euxassay_012283_19
Specimen Label: euxassay_012283_19
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4424036
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828370
Age: embryonic day 14.5
Image: euxassay_012283_07
Specimen Label: euxassay_012283_07
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4424036
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828370
Age: embryonic day 14.5
Image: euxassay_012283_19
Specimen Label: euxassay_012283_19
Detected: true
Specimen Num: 2
Publication    
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, similar to sorting nexin 9, clone MGC:6327 IMAGE:3257422, mRNA, complete cds
Pages: BC014814
Publication  
First Author: Nández R
Year: 2014
Journal: Elife
Title: A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.
Volume: 3
Pages: e02975
Publication
First Author: Schimenti JC
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated male mouse sterility but not transmission ratio distortion.
Volume: 102
Issue: 9
Pages: 3342-7
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: GemPharmatech
Year: 2020
Journal: website
Title: GemPharmatech website
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Allele
Name: sorting nexin 9; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Park J
Year: 2010
Journal: J Cell Sci
Title: SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane.
Volume: 123
Issue: Pt 10
Pages: 1742-50
Publication
First Author: Håberg K
Year: 2008
Journal: J Cell Sci
Title: SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking.
Volume: 121
Issue: Pt 9
Pages: 1495-505
Protein Domain
Type: Domain
Description: Sorting nexin 9 (SNX9) has been suggested to be involved in the endocytic process as an accessory factor []. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain []. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin []. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity [].SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNX9 also contains a BAR and a SH3 domain. This entry represents the SH3 domain of SNX9.
Protein Domain
Type: Domain
Description: Sorting nexin 9 (SNX9) has been suggested to be involved in the endocytic process as an accessory factor []. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain []. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin []. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity [].SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNX9 also contains a BAR and a SH3 domain. This entry represents the BAR domain of sorting nexin-9. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions [].
Protein Domain
Type: Domain
Description: Sorting nexin 9 (SNX9) has been suggested to be involved in the endocytic process as an accessory factor []. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain []. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin []. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity [].SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNX9 also contains a BAR and a SH3 domain. This entry represents the PX domain of sorting nexin-9. The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions [].
Publication
First Author: Wang Q
Year: 2008
Journal: Structure
Title: Structure and plasticity of Endophilin and Sorting Nexin 9.
Volume: 16
Issue: 10
Pages: 1574-87
Protein Domain
Type: Family
Description: Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok []. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. This entry represents SNX18, which acts as a membrane tubulator in AP (adaptor proteins)-1-positive endosomal trafficking []. It has a similar role to SNX9 in endocytic trafficking at the plasma membrane [].
Publication
First Author: He Q
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.
Volume: 114
Issue: 45
Pages: E9559-E9568
Publication
First Author: Badour K
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.
Volume: 104
Issue: 5
Pages: 1593-8
Publication
First Author: Posor Y
Year: 2013
Journal: Nature
Title: Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.
Volume: 499
Issue: 7457
Pages: 233-7
Publication
First Author: Frost A
Year: 2009
Journal: Cell
Title: The BAR domain superfamily: membrane-molding macromolecules.
Volume: 137
Issue: 2
Pages: 191-6
Publication
First Author: Wishart MJ
Year: 2001
Journal: Cell
Title: Phoxy lipids: revealing PX domains as phosphoinositide binding modules.
Volume: 105
Issue: 7
Pages: 817-20
Protein
Organism: Mus musculus
Length: 614  
Fragment?: false
Protein
Organism: Mus musculus
Length: 615  
Fragment?: false
Protein
Organism: Mus musculus
Length: 547  
Fragment?: false
Protein
Organism: Mus musculus
Length: 547  
Fragment?: false