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Search results 1 to 100 out of 105 for Spink5

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
11005 | SPINK5
Type: gene
Organism: human
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Gene
361319 | Spink5
Type: gene
Organism: rat
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Gene
478055 | SPINK5
Type: gene
Organism: dog, domestic
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Gene
462173 | SPINK5
Type: gene
Organism: chimpanzee
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Gene
526637 | SPINK5
Type: gene
Organism: cattle
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Gene
416235 | SPINK5
Type: gene
Organism: chicken
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Gene
709424 | SPINK5
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1919682 | Spink5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15780751 | J:97540
First Author: Galliano MF
Year: 2005
Journal: Genomics
Title: Characterization and expression analysis of the Spink5 gene, the mouse ortholog of the defective gene in Netherton syndrome.
Volume: 85
Issue: 4
Pages: 483-92
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Publication
38316920 | J:357366
First Author: Petrova E
Year: 2024
Journal: Commun Biol
Title: Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways.
Volume: 7
Issue: 1
Pages: 152
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Publication
15466487 | J:93050
First Author: Yang T
Year: 2004
Journal: Genes Dev
Title: Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice.
Volume: 18
Issue: 19
Pages: 2354-8
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Publication
15590704 | J:95549
First Author: Hewett DR
Year: 2005
Journal: Hum Mol Genet
Title: Lethal, neonatal ichthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome.
Volume: 14
Issue: 2
Pages: 335-46
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Publication
17676051 | J:125090
First Author: Yamasaki K
Year: 2007
Journal: Nat Med
Title: Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea.
Volume: 13
Issue: 8
Pages: 975-80
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Publication
32442469 | J:300922
First Author: Zingkou E
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Cathelicidin represents a new target for manipulation of skin inflammation in Netherton syndrome.
Volume: 1866
Issue: 10
Pages: 165831
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Publication
26390218 | J:228907
First Author: Furio L
Year: 2015
Journal: PLoS Genet
Title: KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome.
Volume: 11
Issue: 9
Pages: e1005389
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Publication
20703245 | J:180855
First Author: Briot A
Year: 2010
Journal: J Invest Dermatol
Title: Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model.
Volume: 130
Issue: 12
Pages: 2736-42
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Protein Coding Gene
MGP_CAROLIEiJ_G0022237 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024390 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024124 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1919682 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024093 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024189 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024220 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024848 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023342 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023661 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018970 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023147 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15619623 | J:96435
First Author: Descargues P
Year: 2005
Journal: Nat Genet
Title: Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity.
Volume: 37
Issue: 1
Pages: 56-65
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Publication
36516271 | J:335297
First Author: Chavarria-Smith J
Year: 2022
Journal: Sci Transl Med
Title: Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Volume: 14
Issue: 675
Pages: eabp9159
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Publication
- | J:183755
   
First Author: Beutler B
Year: 2012
Journal: MGI Direct Data Submission
Title: Direct Data Submission
Volume: v
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Publication
17596512 | J:128293
First Author: Deraison C
Year: 2007
Journal: Mol Biol Cell
Title: LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction.
Volume: 18
Issue: 9
Pages: 3607-19
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GXD Expression
GXD Expression
     
Probe: MGI:3711685
Assay Type: RT-PCR
Annotation Date: 2007-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639223
Stage: TS23
Assay Id: MGI:3711799
Age: embryonic day 15.5
Specimen Label: E15.5 wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3711685
Assay Type: RT-PCR
Annotation Date: 2007-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639224
Stage: TS24
Assay Id: MGI:3711799
Age: embryonic day 16.5
Specimen Label: E16.5 wt
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3711685
Assay Type: RT-PCR
Annotation Date: 2007-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639224
Stage: TS24
Assay Id: MGI:3711799
Age: embryonic day 16.5
Specimen Label: E16.5 Klf4-/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7484222
Assay Type: RT-PCR
Annotation Date: 2023-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639227
Stage: TS27
Assay Id: MGI:7484305
Age: postnatal newborn
Image: 1
Specimen Label: wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7484222
Assay Type: RT-PCR
Annotation Date: 2023-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3639227
Stage: TS27
Assay Id: MGI:7484305
Age: postnatal newborn
Image: 1
Specimen Label: A135X/A135X
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7484222
Assay Type: RT-PCR
Annotation Date: 2023-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639227
Stage: TS27
Assay Id: MGI:7484306
Age: postnatal newborn
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7484222
Assay Type: RT-PCR
Annotation Date: 2023-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3639227
Stage: TS27
Assay Id: MGI:7484306
Age: postnatal newborn
Image: 2
Specimen Label: A135X/A135X
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7484222
Assay Type: RT-PCR
Annotation Date: 2023-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3639227
Stage: TS27
Assay Id: MGI:7484306
Age: postnatal newborn
Image: 2
Specimen Label: Klk5-/-; A135X/A135X
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7484222
Assay Type: RT-PCR
Annotation Date: 2023-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3639227
Stage: TS27
Assay Id: MGI:7484306
Age: postnatal newborn
Image: 2
Specimen Label: Klk7-/-; A135X/A135X
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7484222
Assay Type: RT-PCR
Annotation Date: 2023-05-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3639227
Stage: TS27
Assay Id: MGI:7484306
Age: postnatal newborn
Image: 2
Specimen Label: Klk5-/-; Klk7-/-; A135X/A135X
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7484222
Assay Type: RT-PCR
Annotation Date: 2023-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639227
Stage: TS27
Assay Id: MGI:7484306
Age: postnatal newborn
Image: 2
Specimen Label: Klk5-/-; Klk7-/-
Detected: true
Specimen Num: 6
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Publication
31255470 | J:289877
First Author: Zingkou E
Year: 2019
Journal: J Dermatol Sci
Title: A proinflammatory role of KLK6 protease in Netherton syndrome.
Volume: 95
Issue: 1
Pages: 28-35
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Publication
35487308 | J:331721
First Author: Jackman JK
Year: 2022
Journal: J Allergy Clin Immunol
Title: Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
Volume: 150
Issue: 4
Pages: 972-978.e7
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Publication
17012259 | J:129736
First Author: Yamasaki K
Year: 2006
Journal: FASEB J
Title: Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin.
Volume: 20
Issue: 12
Pages: 2068-80
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Publication
20179351 | J:158765
First Author: Bonnart C
Year: 2010
Journal: J Clin Invest
Title: Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
Volume: 120
Issue: 3
Pages: 871-82
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Publication
24473265 | J:208441
First Author: Bautista DM
Year: 2014
Journal: Nat Neurosci
Title: Why we scratch an itch: the molecules, cells and circuits of itch.
Volume: 17
Issue: 2
Pages: 175-82
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Publication
19414552 | J:148493
First Author: Briot A
Year: 2009
Journal: J Exp Med
Title: Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome.
Volume: 206
Issue: 5
Pages: 1135-47
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Publication
28095415 | J:238698
First Author: Kasparek P
Year: 2017
Journal: PLoS Genet
Title: KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
Volume: 13
Issue: 1
Pages: e1006566
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Publication
17130451 | J:118301
First Author: Patel S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition.
Volume: 103
Issue: 49
Pages: 18668-73
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q5K5D4
Organism: Mus musculus/domesticus
Length: 1017  
Fragment?: false
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HT Experiment
GSE224674 | Transcriptome profiling of lesional skin from neonate Spink5 constitutive knock-out mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Spink5<em1Smoc> | MGI:7292564
Name: serine peptidase inhibitor, Kazal type 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6476369 | C57BL/6JSmoc-Spink5<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Spink5<tm1Drh> | MGI:3527214
Name: serine peptidase inhibitor, Kazal type 5; targeted mutation 1, Duncan R Hewett
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Spink5<tm1Hov> | MGI:3573756
Name: serine peptidase inhibitor, Kazal type 5; targeted mutation 1, Alain Hovnanian
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Spink5<Tn(Pgk2-sb10,sb-Tyr)1498Ove> | MGI:5286986
 
Name: serine peptidase inhibitor, Kazal type 5; transposon insertion 1498, Paul A Overbeek
Allele Type: Transposon induced
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Allele
Spink5<m1Btlr> | MGI:5319218
 
Name: serine peptidase inhibitor, Kazal type 5; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
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Allele
Tg(IVL-KLK5)#Hov | MGI:5583016
Name: transgene insertion, Alain Hovnanian
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Transgene
MGI:5583015 | Tg(IVL-KLK5)#Hov
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Spink5/Spink5
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spink5/Spink5
Background: involves: 129P2/OlaHsd * FVB
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spink5/Spink5
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: F2rl1/F2rl1 Spink5/Spink5
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spink5/Spink5
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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