|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 181 for Sun1

<< First    < Previous  |  Next >    Last >>
0.022s

Categories

Hits by Strain

Hits by Category

Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: SUN domain-containing protein 1 is a nuclear inner membrane protein and a component of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [].SUN1 contains a conserved Sad1p/UNC-84 (SUN)-domain at its C terminus that can associate with Klarsicht/ANC-1/Syne homology (KASH)-domain proteins []. The structure of the LINC complex has been solved []. In mammals, SUN1 is widely expressed and can bind to all four Nesprins (KASH-domain containing proteins) []. Sun1 and KASH5 are essential factors which mediate meiotic resumption and spindle formation [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Luo Y
Year: 2016
Journal: Sci Rep
Title: Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes.
Volume: 6
Pages: 20408
Publication
First Author: Ding X
Year: 2007
Journal: Dev Cell
Title: SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.
Volume: 12
Issue: 6
Pages: 863-72
Publication
First Author: Lei K
Year: 2012
Journal: Curr Biol
Title: Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.
Volume: 22
Issue: 17
Pages: 1609-15
Publication
First Author: Lu W
Year: 2008
Journal: Biochim Biophys Acta
Title: Sun1 forms immobile macromolecular assemblies at the nuclear envelope.
Volume: 1783
Issue: 12
Pages: 2415-26
Publication
First Author: Wang JY
Year: 2015
Journal: Dis Model Mech
Title: Sun1 deficiency leads to cerebellar ataxia in mice.
Volume: 8
Issue: 8
Pages: 957-67
Publication
First Author: Haque F
Year: 2006
Journal: Mol Cell Biol
Title: SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.
Volume: 26
Issue: 10
Pages: 3738-51
Publication
First Author: Chi YH
Year: 2009
Journal: Development
Title: Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA.
Volume: 136
Issue: 6
Pages: 965-73
Publication    
First Author: Buglak DB
Year: 2023
Journal: Elife
Title: Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation.
Volume: 12
Publication    
First Author: Loo TH
Year: 2019
Journal: Elife
Title: The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity.
Volume: 8
Publication
First Author: Lei K
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.
Volume: 106
Issue: 25
Pages: 10207-12
Publication
First Author: Chen CY
Year: 2012
Journal: Cell
Title: Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies.
Volume: 149
Issue: 3
Pages: 565-77
Publication
First Author: Padmakumar VC
Year: 2005
Journal: J Cell Sci
Title: The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.
Volume: 118
Issue: Pt 15
Pages: 3419-30
Publication
First Author: Link J
Year: 2014
Journal: PLoS Genet
Title: Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.
Volume: 10
Issue: 2
Pages: e1004099
Protein
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: true
Publication
First Author: Sosa BA
Year: 2012
Journal: Cell
Title: LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.
Volume: 149
Issue: 5
Pages: 1035-47
Publication
First Author: Hieda M
Year: 2021
Journal: Sci Rep
Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
Volume: 11
Issue: 1
Pages: 5358
Protein
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
Publication
First Author: Liu W
Year: 2014
Journal: Dev Biol
Title: Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice.
Volume: 392
Issue: 1
Pages: 108-16
Publication
First Author: Wang W
Year: 2012
Journal: Cell Res
Title: Structural insights into SUN-KASH complexes across the nuclear envelope.
Volume: 22
Issue: 10
Pages: 1440-52
Publication
First Author: Wilhelmsen K
Year: 2006
Journal: J Cell Sci
Title: KASH-domain proteins in nuclear migration, anchorage and other processes.
Volume: 119
Issue: Pt 24
Pages: 5021-9
Publication
First Author: Horn HF
Year: 2013
Journal: J Clin Invest
Title: The LINC complex is essential for hearing.
Volume: 123
Issue: 2
Pages: 740-50
Publication
First Author: Ishiguro K
Year: 2014
Journal: Genes Dev
Title: Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.
Volume: 28
Issue: 6
Pages: 594-607
Publication
First Author: Stewart RM
Year: 2015
Journal: J Cell Biol
Title: Nuclear-cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions.
Volume: 209
Issue: 3
Pages: 403-18
Publication  
First Author: Feng Q
Year: 2018
Journal: J Cell Sci
Title: Mechanical forces on cellular organelles.
Volume: 131
Issue: 21
Publication
First Author: Yu J
Year: 2011
Journal: Hum Mol Genet
Title: KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
Volume: 20
Issue: 6
Pages: 1061-73
Publication
First Author: Zhang X
Year: 2009
Journal: Neuron
Title: SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
Volume: 64
Issue: 2
Pages: 173-87
Publication    
First Author: Carley E
Year: 2021
Journal: Elife
Title: The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation.
Volume: 10
Publication
First Author: Chen Y
Year: 2021
Journal: Nat Commun
Title: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Volume: 12
Issue: 1
Pages: 3176
Publication
First Author: Chai RJ
Year: 2021
Journal: Nat Commun
Title: Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy.
Volume: 12
Issue: 1
Pages: 4722
Publication  
First Author: Porter L
Year: 2020
Journal: Cells
Title: SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
Volume: 9
Issue: 1
Publication
First Author: Razafsky D
Year: 2012
Journal: PLoS One
Title: LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.
Volume: 7
Issue: 10
Pages: e47180
Publication
First Author: Viera A
Year: 2015
Journal: J Cell Sci
Title: CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.
Volume: 128
Issue: 1
Pages: 88-99
Publication
First Author: Ostlund C
Year: 2009
Journal: J Cell Sci
Title: Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins.
Volume: 122
Issue: Pt 22
Pages: 4099-108
Publication
First Author: Göb E
Year: 2010
Journal: PLoS One
Title: Mammalian sperm head formation involves different polarization of two novel LINC complexes.
Volume: 5
Issue: 8
Pages: e12072
Publication
First Author: Morimoto A
Year: 2012
Journal: J Cell Biol
Title: A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
Volume: 198
Issue: 2
Pages: 165-72
Publication
First Author: Wang Y
Year: 2019
Journal: Nat Commun
Title: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Volume: 10
Issue: 1
Pages: 564
Publication
First Author: Crisp M
Year: 2006
Journal: J Cell Biol
Title: Coupling of the nucleus and cytoplasm: role of the LINC complex.
Volume: 172
Issue: 1
Pages: 41-53
Publication
First Author: Haque F
Year: 2010
Journal: J Biol Chem
Title: Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.
Volume: 285
Issue: 5
Pages: 3487-98
Publication
First Author: Shibuya H
Year: 2015
Journal: Cell
Title: MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.
Volume: 163
Issue: 5
Pages: 1252-1266
Publication  
First Author: Daniel K
Year: 2014
Journal: BMC Cell Biol
Title: Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.
Volume: 15
Pages: 17
Publication
First Author: Shibuya H
Year: 2014
Journal: Nat Cell Biol
Title: The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.
Volume: 16
Issue: 2
Pages: 145-56
Publication
First Author: Zhang J
Year: 2017
Journal: Cell Rep
Title: Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement.
Volume: 21
Issue: 7
Pages: 1715-1726
Publication
First Author: Palmer N
Year: 2019
Journal: J Cell Biol
Title: CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I.
Volume: 218
Issue: 9
Pages: 2896-2918
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression
Probe: MGI:5636863
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1852126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5637335
Age: embryonic day 18.5
Image: S4A
Note: Expression is localized in the nuclear envelope.
Specimen Label: S4A
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5636863
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1852126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5637335
Age: embryonic day 18.5
Image: S4B
Note: Expression is localized in the nuclear envelope; no differences in localization between these mice and wild type were observed.
Specimen Label: S4B
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:5636863
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1852126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5637335
Age: embryonic day 18.5
Image: S4C
Note: Expression is localized in the nuclear envelope; no differences in localization between these mice and wild type were observed.
Specimen Label: S4C
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5636863
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1852126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5637335
Age: embryonic day 18.5
Image: S4D
Note: Expression is localized in the nuclear envelope; no differences in localization between these mice and wild type were observed.
Specimen Label: S4D
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:5636863
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1852126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5637335
Age: embryonic day 18.5
Image: S4E
Note: Expression is localized in the nuclear envelope; no differences in localization between these mice and wild type were observed.
Specimen Label: S4E
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:5636863
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-26
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5637335
Age: postnatal
Image: S2A
Specimen Label: S2A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5636863
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-26
Strength: Present
Sex: Male
Emaps: EMAPS:3148828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5637335
Age: postnatal
Image: S2A
Specimen Label: S2A
Detected: true
Specimen Num: 1
Publication
First Author: Kozono T
Year: 2018
Journal: J Biochem
Title: Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins.
Volume: 164
Issue: 4
Pages: 303-311
Publication
First Author: Horn HF
Year: 2013
Journal: J Cell Biol
Title: A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton.
Volume: 202
Issue: 7
Pages: 1023-39
Publication
First Author: Gimpel P
Year: 2017
Journal: Curr Biol
Title: Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
Volume: 27
Issue: 19
Pages: 2999-3009.e9
Publication
First Author: Lee CY
Year: 2015
Journal: Cell Rep
Title: Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes.
Volume: 11
Issue: 4
Pages: 551-63
Publication
First Author: Bray JD
Year: 2002
Journal: Genomics
Title: Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X.
Volume: 79
Issue: 6
Pages: 799-808
Publication
First Author: Boateng KA
Year: 2013
Journal: Dev Cell
Title: Homologous pairing preceding SPO11-mediated double-strand breaks in mice.
Volume: 24
Issue: 2
Pages: 196-205