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Search results 1 to 100 out of 312 for Syne2

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0.059s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Nesprins (nuclear envelope spectrin-repeat proteins) are a family of giant spectrin-repeat containing proteins that act as versatile intracellular protein scaffolds []. They are characterised by a central extended spectrin-repeat (SR) and a C-terminal Klarsicht/ANC-1/Syne homology (KASH) domain that can associate with Sad1p/UNC-84 (SUN)-domain proteins of the inner nuclear membrane within the periplasmic space of the nuclear envelope (NE) []. Nesprin-1 and nesprin-2 also contain an N-terminal calponin homology (CH) domain that links to filamentous actin (F-actin) []. Full length Nesprin-1 and nesprin-2 are large multidomain proteins. Smaller N-terminally truncated isoforms lacking the CH domains localise to the inner nuclear membrane, while isoforms that lack the KASH domain have been shown to localise to other regions of cells, including focal adhesions [].This entry represents nesprin-2 from animals, including insects and vertebrates. Nesprin-1 and nesprin-2 are key components of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness []. They also regulate endothelial cell shape and migration []. Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1217  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1060  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2152  
Fragment?: true
Publication
First Author: Dawe HR
Year: 2009
Journal: J Cell Sci
Title: Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.
Volume: 122
Issue: Pt 15
Pages: 2716-26
Publication      
First Author: Chang B
Year: 2019
Journal: MGI Direct Data Submission
Title: Three cone photoreceptor function loss mutations in the Syne2 gene.
Publication
First Author: Maddox DM
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia.
Volume: 56
Issue: 6
Pages: 3776-87
Protein
Organism: Mus musculus/domesticus
Length: 6874  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 6870  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1666  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 899  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1644  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: true
Publication
First Author: Wang W
Year: 2012
Journal: Cell Res
Title: Structural insights into SUN-KASH complexes across the nuclear envelope.
Volume: 22
Issue: 10
Pages: 1440-52
Publication
First Author: Wilhelmsen K
Year: 2006
Journal: J Cell Sci
Title: KASH-domain proteins in nuclear migration, anchorage and other processes.
Volume: 119
Issue: Pt 24
Pages: 5021-9
Publication
First Author: Mellad JA
Year: 2011
Journal: Curr Opin Cell Biol
Title: Nesprins LINC the nucleus and cytoskeleton.
Volume: 23
Issue: 1
Pages: 47-54
Publication
First Author: Rajgor D
Year: 2012
Journal: PLoS One
Title: Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.
Volume: 7
Issue: 7
Pages: e40098
Publication
First Author: King SJ
Year: 2014
Journal: Cytoskeleton (Hoboken)
Title: Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.
Volume: 71
Issue: 7
Pages: 423-34
Publication
First Author: Zhang X
Year: 2007
Journal: Development
Title: Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.
Volume: 134
Issue: 5
Pages: 901-8
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lüke Y
Year: 2008
Journal: J Cell Sci
Title: Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin.
Volume: 121
Issue: 11
Pages: 1887-98
Publication  
First Author: Falk N
Year: 2019
Journal: Cells
Title: Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model.
Volume: 8
Issue: 10
Publication
First Author: Zhang Q
Year: 2005
Journal: J Cell Sci
Title: Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle.
Volume: 118
Issue: Pt 4
Pages: 673-87
Publication
First Author: Mroß C
Year: 2018
Journal: Nucleus
Title: Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice.
Volume: 9
Issue: 1
Pages: 503-515
GXD Expression    
Probe: MGI:7462591
Assay Type: RT-PCR
Annotation Date: 2023-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668319
Stage: TS19
Assay Id: MGI:7462653
Age: embryonic day 11.5
Image: S13
Specimen Label: FNP
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7462591
Assay Type: RT-PCR
Annotation Date: 2023-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736119
Stage: TS19
Assay Id: MGI:7462653
Age: embryonic day 11.5
Image: S13
Specimen Label: MxP
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7462591
Assay Type: RT-PCR
Annotation Date: 2023-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1735719
Stage: TS19
Assay Id: MGI:7462653
Age: embryonic day 11.5
Image: S13
Specimen Label: MdP
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal
Image: 1
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal
Image: 1
Specimen Label: Thymus
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal
Image: 1
Specimen Label: Heart
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal
Image: 1
Specimen Label: Liver
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal
Image: 1
Specimen Label: Spleen
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal
Image: 1
Specimen Label: Kidney
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal
Image: 1
Specimen Label: Small Intestine
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal
Image: 1
Specimen Label: Testis
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796226
Stage: TS26
Assay Id: MGI:7561483
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:7561477
Assay Type: RT-PCR
Annotation Date: 2023-11-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:7561483
Age: postnatal week 4
Image: 1
Specimen Label: 4 wk
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3516422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2019-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6274333
Age: embryonic day 14.5
Specimen Label: Table S1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Specimen Label: MH1367; Specimen C1573
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828556
Age: embryonic day 14.5
Image: euxassay_010927_04
Specimen Label: euxassay_010927_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828556
Age: embryonic day 14.5
Image: euxassay_010927_05
Specimen Label: euxassay_010927_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828556
Age: embryonic day 14.5
Image: euxassay_010927_06
Specimen Label: euxassay_010927_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828556
Age: embryonic day 14.5
Image: euxassay_010927_07
Specimen Label: euxassay_010927_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828556
Age: embryonic day 14.5
Image: euxassay_010927_12
Specimen Label: euxassay_010927_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828556
Age: embryonic day 14.5
Image: euxassay_010927_13
Specimen Label: euxassay_010927_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828556
Age: embryonic day 14.5
Image: euxassay_010927_14
Specimen Label: euxassay_010927_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4425756
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828556
Age: embryonic day 14.5
Image: euxassay_010927_15
Specimen Label: euxassay_010927_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Specimen Label: MH1367; Specimen C1573
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Note: Expression was weak in the corpus striatum (lateral ganglionic eminence).
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Specimen Label: MH1367; Specimen C1573
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Specimen Label: MH1367; Specimen C1573
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665922
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Specimen Label: MH1367; Specimen C1573
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1706822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1674822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Specimen Label: MH1367; Specimen C1573
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1738222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1654222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1777922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Image: MH1367; Specimen C1573
Specimen Label: MH1367; Specimen C1573
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724836
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684922
Stage: TS22
Assay Id: MGI:5421488
Age: embryonic day 14.5
Specimen Label: MH1367; Specimen C1573
Detected: false
Specimen Num: 1