| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharoyko VV |
| Year: |
2014 |
| Journal: |
Hum Mol Genet |
| Title: |
Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. |
| Volume: |
23 |
| Issue: |
21 |
| Pages: |
5733-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koeck T |
| Year: |
2011 |
| Journal: |
Cell Metab |
| Title: |
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
80-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee S |
| Year: |
2015 |
| Journal: |
Hum Mol Genet |
| Title: |
Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing. |
| Volume: |
24 |
| Issue: |
25 |
| Pages: |
7286-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guja KE |
| Year: |
2013 |
| Journal: |
Nucleic Acids Res |
| Title: |
Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1. |
| Volume: |
41 |
| Issue: |
16 |
| Pages: |
7947-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Metodiev MD |
| Year: |
2009 |
| Journal: |
Cell Metab |
| Title: |
Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome. |
| Volume: |
9 |
| Issue: |
4 |
| Pages: |
386-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rantanen A |
| Year: |
2003 |
| Journal: |
Mamm Genome |
| Title: |
Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
1-6 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3654357 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2006-09-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360422 |
|
| Stage: |
TS02 |
| Assay Id: |
MGI:3654434 |
| Age: |
embryonic day 1.5 |
| Image: |
4 |
|
| Specimen Label: |
2-cell |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3654357 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2006-09-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360443 |
|
| Stage: |
TS03 |
| Assay Id: |
MGI:3654434 |
| Age: |
embryonic day 2.5 |
| Image: |
4 |
|
| Specimen Label: |
8-cell |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3654357 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2006-09-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360453 |
|
| Stage: |
TS03 |
| Assay Id: |
MGI:3654434 |
| Age: |
embryonic day 3.0 |
| Image: |
4 |
|
| Specimen Label: |
Mor |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3654357 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2006-09-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:360464 |
|
| Stage: |
TS04 |
| Assay Id: |
MGI:3654434 |
| Age: |
embryonic day 3.5 |
| Image: |
4 |
|
| Specimen Label: |
Blasto |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3654357 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2006-09-13 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:3575528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3654434 |
| Age: |
postnatal |
| Image: |
4 |
|
| Specimen Label: |
Oocyte |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7738601 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-10-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:7750806 |
| Age: |
postnatal week 4 |
|
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7738601 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-10-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:7750806 |
| Age: |
postnatal week 4 |
|
|
| Specimen Label: |
Chd4 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7738601 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-10-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3586628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:7750843 |
| Age: |
postnatal week 4 |
|
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7738601 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-10-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3586628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:7750843 |
| Age: |
postnatal week 4 |
|
|
| Specimen Label: |
Chd4 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:905305 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-08-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7516943 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thundathil J |
| Year: |
2005 |
| Journal: |
Mol Reprod Dev |
| Title: |
Molecular control of mitochondrial function in preimplantation mouse embryos. |
| Volume: |
71 |
| Issue: |
4 |
| Pages: |
405-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Son JS |
| Year: |
2022 |
| Journal: |
EBioMedicine |
| Title: |
Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling. |
| Volume: |
76 |
|
| Pages: |
103842 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gómez-Del Arco P |
| Year: |
2016 |
| Journal: |
Cell Metab |
| Title: |
The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. |
| Volume: |
23 |
| Issue: |
5 |
| Pages: |
881-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pagliarini DJ |
| Year: |
2008 |
| Journal: |
Cell |
| Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
| Volume: |
134 |
| Issue: |
1 |
| Pages: |
112-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
MGC Data curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lennon G |
| Year: |
1999 |
| Journal: |
Database Download |
| Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Falkenberg M |
| Year: |
2002 |
| Journal: |
Nat Genet |
| Title: |
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |
| Volume: |
31 |
| Issue: |
3 |
| Pages: |
289-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cotney J |
| Year: |
2009 |
| Journal: |
Hum Mol Genet |
| Title: |
Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. |
| Volume: |
18 |
| Issue: |
14 |
| Pages: |
2670-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shutt TE |
| Year: |
2006 |
| Journal: |
Mol Biol Evol |
| Title: |
Homologs of mitochondrial transcription factor B, sparsely distributed within the eukaryotic radiation, are likely derived from the dimethyladenosine methyltransferase of the mitochondrial endosymbiont. |
| Volume: |
23 |
| Issue: |
6 |
| Pages: |
1169-79 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
rRNA methyltransferase-related mitochondrial transcription factors B1 (TFB1M) and B2 (TFB2M) perform unique, yet cooperative functions. In addition to being mitochondrial transcription factors, they can dimethylate two adjacent adenines in a stem-loop structure close to the 3' end of the small subunit rRNA, a modification that is highly conserved in nature [, ]. The primary function of TFB2 is mtDNA transcription and maintenance, which is independent of its rRNA methyltransferase activity, while that of TFB1M is mitochondrial rRNA methylation []. TFB1M and TFB2M. This family represents TFB2M. Compared to TFB1M, TFB2M activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang ZF |
| Year: |
2014 |
| Journal: |
Mol Cell Biol |
| Title: |
GABP transcription factor (nuclear respiratory factor 2) is required for mitochondrial biogenesis. |
| Volume: |
34 |
| Issue: |
17 |
| Pages: |
3194-201 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McKay SE |
| Year: |
2015 |
| Journal: |
Am J Pathol |
| Title: |
Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. |
| Volume: |
185 |
| Issue: |
12 |
| Pages: |
3132-40 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
396
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
396
 |
| Fragment?: |
false |
|
•
•
•
•
•
|