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Search results 1 to 100 out of 122 for Themis

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Hits by Strain

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Type Details Score
Gene
387357 | THEMIS
Type: gene
Organism: human
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Gene
555433 | themis
Type: gene
Organism: zebrafish
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Gene
711575 | THEMIS
Type: gene
Organism: macaque, rhesus
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Gene
100496964 | themis
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR039671 | THEMIS
Type: Family
Description: This entry includes THEMIS1/2/3 from animals. THEMIS1 and THEMIS2 are restricted to B and myeloid cells, and the more distantly related THEMIS3 is expressed in the large and small intestine. THEMIS is involved in the early TCR (T-cell antigen receptor) signal transduction and thymocyte selection []. It is recruited to LAT through GRB2 association and LAT phosphotyrosine GRB2 binding sites []. THEMIS contains CABIT modules that bind directly to the SHP-1 PTP (protein tyrosine phosphatase) domain and inhibit SHP-1 PTP activity by promoting or stabilizing oxidation of the catalytic cysteine [].
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Gene
484120 | THEMIS
Type: gene
Organism: dog, domestic
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Gene
498985 | Themis
Type: gene
Organism: rat
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Gene
462992 | THEMIS
Type: gene
Organism: chimpanzee
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Gene
540554 | THEMIS
Type: gene
Organism: cattle
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Gene
769224 | THEMIS
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:2443552 | Themis
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28250424 | J:258683
First Author: Choi S
Year: 2017
Journal: Nat Immunol
Title: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.
Volume: 18
Issue: 4
Pages: 433-441
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Protein
Q8BGW0
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: false
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Protein
E0CYT7
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
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Protein
E0CY68
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Publication
25700024 | -
 
First Author: Gascoigne NR
Year: 2015
Journal: Curr Opin Immunol
Title: THEMIS: a critical TCR signal regulator for ligand discrimination.
Volume: 33
Pages: 86-92
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Protein
Q9CU24
Organism: Mus musculus/domesticus
Length: 569  
Fragment?: false
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Protein
Q91YX0
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Publication
19597499 | J:151074
First Author: Fu G
Year: 2009
Journal: Nat Immunol
Title: Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.
Volume: 10
Issue: 8
Pages: 848-56
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Publication
19597497 | J:151076
First Author: Johnson AL
Year: 2009
Journal: Nat Immunol
Title: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Volume: 10
Issue: 8
Pages: 831-9
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Publication
24586531 | J:213434
First Author: Okada T
Year: 2014
Journal: PLoS One
Title: Differential function of Themis CABIT domains during T cell development.
Volume: 9
Issue: 2
Pages: e89115
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Publication
23460737 | J:194815
First Author: Paster W
Year: 2013
Journal: J Immunol
Title: GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Volume: 190
Issue: 7
Pages: 3749-56
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Publication
35857631 | J:339283
First Author: Yang C
Year: 2022
Journal: Sci Signal
Title: THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals.
Volume: 15
Issue: 742
Pages: eabl5343
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Publication
24226767 | J:207761
First Author: Fu G
Year: 2013
Journal: Nature
Title: Themis sets the signal threshold for positive and negative selection in T-cell development.
Volume: 504
Issue: 7480
Pages: 441-5
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Publication
38670234 | J:349065
     
First Author: Risemberg EL
Year: 2024
Journal: J Allergy Clin Immunol
Title: A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice.
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Publication
28877990 | J:251076
First Author: Garreau A
Year: 2017
Journal: J Immunol
Title: Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.
Volume: 199
Issue: 8
Pages: 2758-2766
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Publication
25452553 | J:223530
First Author: Torre S
Year: 2015
Journal: Infect Immun
Title: THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.
Volume: 83
Issue: 2
Pages: 759-68
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Publication
37739454 | J:341193
 
First Author: Gautam N
Year: 2023
Journal: Life Sci Alliance
Title: Themis controls T cell activation, effector functions, and metabolism of peripheral CD8(+) T cells.
Volume: 6
Issue: 12
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Publication
16084128 | J:102125
First Author: Themis M
Year: 2005
Journal: Mol Ther
Title: Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Volume: 12
Issue: 4
Pages: 763-71
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Publication
19620281 | J:152601
First Author: Kakugawa K
Year: 2009
Journal: Mol Cell Biol
Title: A novel gene essential for the development of single positive thymocytes.
Volume: 29
Issue: 18
Pages: 5128-35
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Publication
19597498 | J:151075
First Author: Lesourne R
Year: 2009
Journal: Nat Immunol
Title: Themis, a T cell-specific protein important for late thymocyte development.
Volume: 10
Issue: 8
Pages: 840-7
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Publication
19805304 | J:153235
First Author: Patrick MS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.
Volume: 106
Issue: 38
Pages: 16345-50
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Publication
- | J:272849
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Meteor.
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Publication
- | J:274716
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for six_flags.
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Publication
22561606 | J:186446
First Author: Wang D
Year: 2012
Journal: Nat Immunol
Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
Volume: 13
Issue: 6
Pages: 560-8
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Publication
31932808 | J:290690
First Author: Brzostek J
Year: 2020
Journal: Nat Immunol
Title: T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis.
Volume: 21
Issue: 2
Pages: 186-198
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Publication
37067793 | J:341962
 
First Author: Choi S
Year: 2023
Journal: J Exp Med
Title: GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1.
Volume: 220
Issue: 7
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Publication
31316154 | J:284764
First Author: Lyu J
Year: 2019
Journal: Cell Mol Immunol
Title: Thymic-specific regulation of TCR signaling by Tespa1.
Volume: 16
Issue: 12
Pages: 897-907
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Publication
30413615 | J:269303
First Author: Mehta M
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Themis-associated phosphatase activity controls signaling in T cell development.
Volume: 115
Issue: 48
Pages: E11331-E11340
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Publication
25535246 | J:217866
First Author: Paster W
Year: 2015
Journal: EMBO J
Title: A THEMIS:SHP1 complex promotes T-cell survival.
Volume: 34
Issue: 3
Pages: 393-409
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Protein Coding Gene
MGP_CAROLIEiJ_G0015203 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017107 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016867 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2443552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017505 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016446 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016841 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016946 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016941 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017023 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016971 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017541 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023825 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016012 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
24935457 | J:318795
First Author: Zvezdova E
Year: 2014
Journal: Immunol Cell Biol
Title: In vivo functional mapping of the conserved protein domains within murine Themis1.
Volume: 92
Issue: 8
Pages: 721-8
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Publication
- | J:254834
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for cloudies
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Publication
- | J:211400
     
First Author: Wang KW
Year: 2014
Journal: MGI Direct Data Submission
Title: Direct data submission for currant
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Publication
- | J:236691
     
First Author: Zeng M
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for death_valley
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Eye
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Brain
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Thymus
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Lung
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Liver
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Lymph node
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Bone marow
Detected: false
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Specimen Label: Kidney
Detected: false
Specimen Num: 9
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Publication
22732588 | J:189787
First Author: Lesourne R
Year: 2012
Journal: J Immunol
Title: Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
Volume: 189
Issue: 3
Pages: 1154-61
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Publication
32513716 | J:294360
First Author: Matson CA
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation.
Volume: 117
Issue: 25
Pages: 14342-14353
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein THEMIS
Type: chain
End: 636
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Publication
27188442 | J:259331
First Author: Zvezdova E
Year: 2016
Journal: Sci Signal
Title: Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Volume: 9
Issue: 428
Pages: ra51
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Publication
31591574 | J:282407
First Author: Voisinne G
Year: 2019
Journal: Nat Immunol
Title: Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.
Volume: 20
Issue: 11
Pages: 1530-1541
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Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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