Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Not Specified |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Thy-1 membrane glycoprotein (also known as CD90) was identified as an activation-associated cell adhesion molecule on human dermal microvascular endothelial cells. Its cellular effects vary; however, it most often seems to affect cell-cell or cell-matrix interactions and cellular adhesion and migration [, ]. Thy-1 interacts with the leukocyte integrin Mac-1 and may play an important role in the regulation of leukocyte recruitment to sites of inflammation []. It also plays an important role in normal retinal development []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Simon PD |
Year: |
1999 |
Journal: |
Brain Res Dev Brain Res |
Title: |
Thy-1 is critical for normal retinal development. |
Volume: |
117 |
Issue: |
2 |
Pages: |
219-23 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Woeller CF |
Year: |
2015 |
Journal: |
FASEB J |
Title: |
Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn. |
Volume: |
29 |
Issue: |
3 |
Pages: |
920-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paine A |
Year: |
2018 |
Journal: |
FASEB J |
Title: |
Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice. |
Volume: |
32 |
Issue: |
6 |
Pages: |
3174-3183 |
|
•
•
•
•
•
|
Publication |
First Author: |
McCullough KM |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala. |
Volume: |
7 |
|
Pages: |
13149 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cohen PY |
Year: |
2009 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Thy1 up-regulates FasL expression in lung myofibroblasts via Src family kinases. |
Volume: |
40 |
Issue: |
2 |
Pages: |
231-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koren E |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis. |
Volume: |
13 |
Issue: |
1 |
Pages: |
4628 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
162
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
162
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
125
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wetzel A |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). |
Volume: |
172 |
Issue: |
6 |
Pages: |
3850-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leyton L |
Year: |
2014 |
Journal: |
Adv Neurobiol |
Title: |
Thy-1 modulates neurological cell-cell and cell-matrix interactions through multiple molecular interactions. |
Volume: |
8 |
|
Pages: |
3-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barker TH |
Year: |
2004 |
Journal: |
Exp Cell Res |
Title: |
Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity. |
Volume: |
295 |
Issue: |
2 |
Pages: |
488-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Itami S |
Year: |
2011 |
Journal: |
Biol Reprod |
Title: |
The roles of THY1 and integrin beta3 in cell adhesion during theca cell layer formation and the effect of follicle-stimulating hormone on THY1 and integrin beta3 localization in mouse ovarian follicles. |
Volume: |
84 |
Issue: |
5 |
Pages: |
986-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen SJ |
Year: |
2006 |
Journal: |
Immunol Lett |
Title: |
Kinetics of adaptive immunity to Haemophilus influenzae type b meningitis in transgenic mice: evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines. |
Volume: |
105 |
Issue: |
1 |
Pages: |
6-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gilman TL |
Year: |
2018 |
Journal: |
Neurobiol Learn Mem |
Title: |
Basolateral amygdala Thy1-expressing neurons facilitate the inhibition of contextual fear during consolidation, reconsolidation, and extinction. |
Volume: |
155 |
|
Pages: |
498-507 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marangoni RG |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma. |
Volume: |
7 |
Issue: |
19 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Schietinger A |
Year: |
2016 |
Journal: |
Immunity |
Title: |
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis. |
Volume: |
45 |
Issue: |
2 |
Pages: |
389-401 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tcyganov EN |
Year: |
2022 |
Journal: |
Cancer Cell |
Title: |
Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy. |
Volume: |
40 |
Issue: |
10 |
Pages: |
1173-1189.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Voehringer D |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. |
Volume: |
180 |
Issue: |
7 |
Pages: |
4742-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bracamonte-Baran W |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. |
Volume: |
114 |
Issue: |
5 |
Pages: |
1099-1104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ranheim EA |
Year: |
2004 |
Journal: |
Autoimmunity |
Title: |
Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgene. |
Volume: |
37 |
Issue: |
8 |
Pages: |
555-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Misumi I |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection. |
Volume: |
27 |
Issue: |
2 |
Pages: |
514-524.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wüthrich M |
Year: |
2012 |
Journal: |
Infect Immun |
Title: |
Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall. |
Volume: |
80 |
Issue: |
2 |
Pages: |
787-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaleski MB |
Year: |
1975 |
Journal: |
Immunogenetics |
Title: |
Immune response of mice to the Thy-1.1 antigen: effect of the Ir-5 alleles studies in 129/J and B10.129(6M) mice. |
Volume: |
2 |
|
Pages: |
241-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raff MC |
Year: |
1971 |
Journal: |
Transplant Rev |
Title: |
Surface antigenic markers for distinguishing T and B lymphocytes in mice. |
Volume: |
6 |
|
Pages: |
52-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
1999 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Experimental induction of retinal ganglion cell death in adult mice. |
Volume: |
40 |
Issue: |
5 |
Pages: |
1004-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andreata F |
Year: |
2024 |
Journal: |
Cell |
Title: |
Therapeutic potential of co-signaling receptor modulation in hepatitis B. |
Volume: |
187 |
Issue: |
15 |
Pages: |
4078-4094.e21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chakraborty P |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells. |
Volume: |
294 |
Issue: |
23 |
Pages: |
9198-9212 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi BK |
Year: |
2018 |
Journal: |
Eur J Immunol |
Title: |
RELT negatively regulates the early phase of the T-cell response in mice. |
Volume: |
48 |
Issue: |
10 |
Pages: |
1739-1749 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mammadli M |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity. |
Volume: |
24 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Jayant K |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Flexible Nanopipettes for Minimally Invasive Intracellular Electrophysiology In Vivo. |
Volume: |
26 |
Issue: |
1 |
Pages: |
266-278.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Epidermal Langerhans cells are not required for UV-induced immunosuppression. |
Volume: |
183 |
Issue: |
9 |
Pages: |
5548-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clarkson BD |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
CCR7 deficient inflammatory Dendritic Cells are retained in the Central Nervous System. |
Volume: |
7 |
|
Pages: |
42856 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu T |
Year: |
2023 |
Journal: |
Cell Insight |
Title: |
Cannabinoid receptor 2 signal promotes type 2 immunity in the lung. |
Volume: |
2 |
Issue: |
5 |
Pages: |
100124 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang W |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function. |
Volume: |
193 |
Issue: |
5 |
Pages: |
2267-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SY |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells. |
Volume: |
190 |
Issue: |
10 |
Pages: |
4991-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaleski M |
Year: |
1974 |
Journal: |
J Immunol |
Title: |
Immune response of mice to Thy-1. 1 antigen: genetic control by alleles at the Ir-5 locus loosely linked to the H-2 complex. |
Volume: |
113 |
Issue: |
4 |
Pages: |
1170-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
REIF AE |
Year: |
1964 |
Journal: |
J Exp Med |
Title: |
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. |
Volume: |
120 |
|
Pages: |
413-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reif AE |
Year: |
1966 |
Journal: |
Nature |
Title: |
Mouse thymic iso-antigens. |
Volume: |
209 |
Issue: |
5022 |
Pages: |
521-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen TT |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. |
Volume: |
202 |
Issue: |
7 |
Pages: |
955-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ulibarri MR |
Year: |
2024 |
Journal: |
Cell Rep |
Title: |
Epithelial organoid supports resident memory CD8 TÂ cell differentiation. |
Volume: |
43 |
Issue: |
8 |
Pages: |
114621 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan H |
Year: |
2023 |
Journal: |
iScience |
Title: |
The transcription factor IRF4 determines the anti-tumor immunity of CD8(+) TÂ cells. |
Volume: |
26 |
Issue: |
11 |
Pages: |
108087 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beziaud L |
Year: |
2023 |
Journal: |
Cell Stem Cell |
Title: |
IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy. |
Volume: |
30 |
Issue: |
6 |
Pages: |
818-831.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wüthrich M |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts. |
Volume: |
175 |
Issue: |
8 |
Pages: |
5288-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee J |
Year: |
2023 |
Journal: |
Cancer Discov |
Title: |
Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma. |
Volume: |
13 |
Issue: |
9 |
Pages: |
2090-2105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pauken KE |
Year: |
2013 |
Journal: |
Diabetes |
Title: |
PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes. |
Volume: |
62 |
Issue: |
8 |
Pages: |
2859-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uhl M |
Year: |
2009 |
Journal: |
Cell Death Differ |
Title: |
Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells. |
Volume: |
16 |
Issue: |
7 |
Pages: |
991-1005 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsu M |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells. |
Volume: |
10 |
Issue: |
1 |
Pages: |
229 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mandarano AH |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory TÂ cell development. |
Volume: |
42 |
Issue: |
2 |
Pages: |
112106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chatterjee S |
Year: |
2014 |
Journal: |
Cancer Res |
Title: |
Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors. |
Volume: |
74 |
Issue: |
21 |
Pages: |
6048-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jasnow AM |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Thy1-expressing neurons in the basolateral amygdala may mediate fear inhibition. |
Volume: |
33 |
Issue: |
25 |
Pages: |
10396-404 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klebanoff CA |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. |
Volume: |
210 |
Issue: |
10 |
Pages: |
1961-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riding RL |
Year: |
2021 |
Journal: |
Pigment Cell Melanoma Res |
Title: |
Type I interferon signaling limits viral vector priming of CD8(+) T cells during initiation of vitiligo and melanoma immunotherapy. |
Volume: |
34 |
Issue: |
4 |
Pages: |
683-695 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu Y |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms. |
Volume: |
190 |
Issue: |
4 |
Pages: |
1873-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nanjappa SG |
Year: |
2017 |
Journal: |
PLoS Pathog |
Title: |
Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells. |
Volume: |
13 |
Issue: |
5 |
Pages: |
e1006356 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wirasinha RC |
Year: |
2018 |
Journal: |
Immunol Cell Biol |
Title: |
GPR65 inhibits experimental autoimmune encephalomyelitis through CD4+ T cell independent mechanisms that include effects on iNKT cells. |
Volume: |
96 |
Issue: |
2 |
Pages: |
128-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gitlin AD |
Year: |
2016 |
Journal: |
Immunity |
Title: |
Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory. |
Volume: |
44 |
Issue: |
4 |
Pages: |
769-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brinkman CC |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Peripheral tissue homing receptors enable T cell entry into lymph nodes and affect the anatomical distribution of memory cells. |
Volume: |
191 |
Issue: |
5 |
Pages: |
2412-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bennion KB |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
CD8(+) T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB. |
Volume: |
15 |
Issue: |
1 |
Pages: |
5280 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogrodnik M |
Year: |
2019 |
Journal: |
Cell Metab |
Title: |
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. |
Volume: |
29 |
Issue: |
5 |
Pages: |
1061-1077.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dewals B |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
Control of Schistosoma mansoni egg-induced inflammation by IL-4-responsive CD4(+)CD25(-)CD103(+)Foxp3(-) cells is IL-10-dependent. |
Volume: |
40 |
Issue: |
10 |
Pages: |
2837-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bursch LS |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens. |
Volume: |
182 |
Issue: |
8 |
Pages: |
4657-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Divangahi M |
Year: |
2010 |
Journal: |
Nat Immunol |
Title: |
Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. |
Volume: |
11 |
Issue: |
8 |
Pages: |
751-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krieg C |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. |
Volume: |
107 |
Issue: |
26 |
Pages: |
11906-11 |
|
•
•
•
•
•
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