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Search results 1 to 100 out of 280 for Tlr5

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0.096s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. Toll-like receptors are classified into various types, depending on their primary sequence and types of ligands they recognise. TLR5 mediates detection of bacterial flagellins, both from from both Gram-positive and Gram-negative bacteria [, ]. TLR5 signaling acts via MYD88. In MyD88-dependent signaling, ligand binding to TLR triggers sequential recruitment of MyD88, members of IRAK (interleukin-1 receptora ssociated kinase) family and TRAF6, that results in nuclear factor (NF)-kB activation and induction of cytokine secretion and production of inflammatory cytokines including IL-8 and TNF-alpha. Genetic variation in TLR5 have been associated with systemic lupus erythematosus, an inflammatory and often febrile multisystemic disorder of connective tissue [].
Publication
First Author: Ivison SM
Year: 2007
Journal: J Immunol
Title: Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin.
Volume: 178
Issue: 9
Pages: 5735-43
Publication
First Author: Parkunan SM
Year: 2014
Journal: PLoS One
Title: Role of TLR5 and flagella in bacillus intraocular infection.
Volume: 9
Issue: 6
Pages: e100543
Publication
First Author: Vijay-Kumar M
Year: 2007
Journal: J Clin Invest
Title: Deletion of TLR5 results in spontaneous colitis in mice.
Volume: 117
Issue: 12
Pages: 3909-21
Publication  
First Author: Yiu JHC
Year: 2021
Journal: Front Cell Dev Biol
Title: TLR5 Supports Development of Placental Labyrinthine Zone in Mice.
Volume: 9
Pages: 711253
Publication
First Author: Hossain MS
Year: 2014
Journal: PLoS One
Title: Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice.
Volume: 9
Issue: 5
Pages: e96165
Publication
First Author: Hayashi F
Year: 2001
Journal: Nature
Title: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
Volume: 410
Issue: 6832
Pages: 1099-103
Publication
First Author: Hawn TR
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus.
Volume: 102
Issue: 30
Pages: 10593-7
Publication  
First Author: Holzapfel M
Year: 2020
Journal: Front Immunol
Title: Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.
Volume: 11
Pages: 2007
Publication
First Author: Letran SE
Year: 2011
Journal: Eur J Immunol
Title: TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.
Volume: 41
Issue: 1
Pages: 29-38
Publication
First Author: Ito H
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury.
Volume: 519
Issue: 1
Pages: 15-22
Publication
First Author: Saha S
Year: 2007
Journal: J Immunol
Title: Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.
Volume: 179
Issue: 2
Pages: 1147-54
Publication
First Author: Vijay-Kumar M
Year: 2010
Journal: Eur J Immunol
Title: TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin.
Volume: 40
Issue: 12
Pages: 3528-34
Publication    
First Author: Hussain S
Year: 2020
Journal: Elife
Title: TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.
Volume: 9
Publication
First Author: Shibata T
Year: 2012
Journal: Int Immunol
Title: PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.
Volume: 24
Issue: 10
Pages: 613-23
Publication  
First Author: Ellenbroek GH
Year: 2017
Journal: Sci Rep
Title: Leukocyte TLR5 deficiency inhibits atherosclerosis by reduced macrophage recruitment and defective T-cell responsiveness.
Volume: 7
Pages: 42688
Publication
First Author: Angers I
Year: 2006
Journal: Mamm Genome
Title: Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice.
Volume: 17
Issue: 5
Pages: 385-97
Publication
First Author: Janot L
Year: 2009
Journal: Eur J Immunol
Title: Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
Volume: 39
Issue: 6
Pages: 1587-96
Publication
First Author: Van Maele L
Year: 2010
Journal: J Immunol
Title: TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.
Volume: 185
Issue: 2
Pages: 1177-85
Publication
First Author: Bates JT
Year: 2011
Journal: J Immunol
Title: Enhanced antigen processing of flagellin fusion proteins promotes the antigen-specific CD8+ T cell response independently of TLR5 and MyD88.
Volume: 186
Issue: 11
Pages: 6255-62
Publication
First Author: Ali ASM
Year: 2017
Journal: Sci Rep
Title: Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent Urinary Tract Infection.
Volume: 7
Issue: 1
Pages: 11039
Protein
Organism: Mus musculus
Length: 859  
Fragment?: false
Protein
Organism: Mus musculus
Length: 859  
Fragment?: false
Protein
Organism: Mus musculus
Length: 873  
Fragment?: false
Protein
Organism: Mus musculus
Length: 853  
Fragment?: true
Protein
Organism: Mus musculus
Length: 859  
Fragment?: false
Publication
First Author: Kato K
Year: 2012
Journal: J Immunol
Title: Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88.
Volume: 188
Issue: 4
Pages: 2014-22
Publication
First Author: Sun Y
Year: 2010
Journal: J Immunol
Title: TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways.
Volume: 185
Issue: 7
Pages: 4272-83
Publication
First Author: Thakur BK
Year: 2016
Journal: Nucleic Acids Res
Title: Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms.
Volume: 44
Issue: 12
Pages: 5658-72
Publication
First Author: Letran SE
Year: 2011
Journal: J Immunol
Title: TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen.
Volume: 186
Issue: 9
Pages: 5406-12
Publication
First Author: Andersen-Nissen E
Year: 2007
Journal: J Immunol
Title: Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.
Volume: 178
Issue: 8
Pages: 4717-20
Publication
First Author: Mosquera MJ
Year: 2019
Journal: Sci Adv
Title: Immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome-mediated metabolic syndrome.
Volume: 5
Issue: 3
Pages: eaav9788
Publication
First Author: Oh JZ
Year: 2014
Journal: Immunity
Title: TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.
Volume: 41
Issue: 3
Pages: 478-492
Publication
First Author: Andersen-Nissen E
Year: 2007
Journal: J Exp Med
Title: A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.
Volume: 204
Issue: 2
Pages: 393-403
Publication
First Author: Jarchum I
Year: 2011
Journal: Infect Immun
Title: Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis.
Volume: 79
Issue: 4
Pages: 1498-503
Publication
First Author: Morris AE
Year: 2009
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia.
Volume: 297
Issue: 6
Pages: L1112-9
Publication
First Author: Hawn TR
Year: 2007
Journal: J Immunol
Title: Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.
Volume: 179
Issue: 10
Pages: 6981-7
Publication  
First Author: Birnie E
Year: 2019
Journal: Infect Immun
Title: Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis.
Volume: 87
Issue: 8
Publication
First Author: Liu Y
Year: 2015
Journal: Biochim Biophys Acta
Title: Toll-like receptor 5 deficiency attenuates interstitial cardiac fibrosis and dysfunction induced by pressure overload by inhibiting inflammation and the endothelial-mesenchymal transition.
Volume: 1852
Issue: 11
Pages: 2456-66
Publication
First Author: Carapau D
Year: 2013
Journal: Infect Immun
Title: Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin.
Volume: 81
Issue: 12
Pages: 4350-62
Publication
First Author: Flores-Langarica A
Year: 2012
Journal: J Immunol
Title: Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node.
Volume: 189
Issue: 12
Pages: 5745-54
Publication
First Author: Nempont C
Year: 2008
Journal: J Immunol
Title: Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.
Volume: 181
Issue: 3
Pages: 2036-43
Publication
First Author: Uematsu S
Year: 2006
Journal: Nat Immunol
Title: Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
Volume: 7
Issue: 8
Pages: 868-74
Publication
First Author: Han JH
Year: 2015
Journal: J Vet Sci
Title: Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice.
Volume: 16
Issue: 3
Pages: 281-7
Publication
First Author: Feng T
Year: 2012
Journal: PLoS One
Title: Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells.
Volume: 7
Issue: 4
Pages: e35918
Publication
First Author: Sebastiani G
Year: 2000
Journal: Genomics
Title: Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice.
Volume: 64
Issue: 3
Pages: 230-40
Publication
First Author: Mett V
Year: 2018
Journal: Oncogene
Title: Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy.
Volume: 37
Issue: 4
Pages: 439-449
Publication
First Author: Chassaing B
Year: 2018
Journal: PLoS One
Title: Mice harboring pathobiont-free microbiota do not develop intestinal inflammation that normally results from an innate immune deficiency.
Volume: 13
Issue: 4
Pages: e0195310
Publication
First Author: Burdelya LG
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist.
Volume: 110
Issue: 20
Pages: E1857-66
Publication
First Author: Cao Y
Year: 2017
Journal: J Leukoc Biol
Title: Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response.
Volume: 102
Issue: 3
Pages: 575-587
Publication
First Author: Yu FS
Year: 2010
Journal: J Immunol
Title: Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide.
Volume: 185
Issue: 2
Pages: 1142-9
Publication
First Author: Feuillet V
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria.
Volume: 103
Issue: 33
Pages: 12487-92
Publication
First Author: Cheng L
Year: 2016
Journal: Biol Reprod
Title: Toll-like Receptors 4 and 5 Cooperatively Initiate the Innate Immune Responses to Uropathogenic Escherichia coli Infection in Mouse Epididymal Epithelial Cells.
Volume: 94
Issue: 3
Pages: 58
Publication
First Author: Sanders CJ
Year: 2009
Journal: Eur J Immunol
Title: Induction of adaptive immunity by flagellin does not require robust activation of innate immunity.
Volume: 39
Issue: 2
Pages: 359-71
Publication
First Author: Xu ZZ
Year: 2015
Journal: Nat Med
Title: Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Volume: 21
Issue: 11
Pages: 1326-31
Publication
First Author: Lai MA
Year: 2013
Journal: PLoS One
Title: Innate immune detection of flagellin positively and negatively regulates salmonella infection.
Volume: 8
Issue: 8
Pages: e72047
Publication
First Author: Huh JW
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5.
Volume: 111
Issue: 19
Pages: 7072-7
Publication
First Author: Vijay-Kumar M
Year: 2008
Journal: J Immunol
Title: Flagellin treatment protects against chemicals, bacteria, viruses, and radiation.
Volume: 180
Issue: 12
Pages: 8280-5
Publication
First Author: Vijayan A
Year: 2020
Journal: J Immunol
Title: The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin.
Volume: 205
Issue: 10
Pages: 2873-2882
Publication
First Author: Rutkowski MR
Year: 2015
Journal: Cancer Cell
Title: Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.
Volume: 27
Issue: 1
Pages: 27-40
Publication
First Author: Fulde M
Year: 2018
Journal: Nature
Title: Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.
Volume: 560
Issue: 7719
Pages: 489-493
Publication
First Author: Ramphal R
Year: 2008
Journal: J Immunol
Title: Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin.
Volume: 181
Issue: 1
Pages: 586-92
Publication
First Author: Garaude J
Year: 2012
Journal: Sci Transl Med
Title: Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses.
Volume: 4
Issue: 120
Pages: 120ra16
Publication
First Author: Choi YJ
Year: 2010
Journal: J Biol Chem
Title: TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells.
Volume: 285
Issue: 48
Pages: 37570-8
Publication
First Author: Shu M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Inhibition of MAPK and NF-κB signaling pathways alleviate carbon tetrachloride (CCl4)-induced liver fibrosis in Toll-like receptor 5 (TLR5) deficiency mice.
Volume: 471
Issue: 1
Pages: 233-9
Publication
First Author: Ifuku M
Year: 2020
Journal: Acta Neuropathol Commun
Title: Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury.
Volume: 8
Issue: 1
Pages: 159
Publication
First Author: Anas AA
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism.
Volume: 311
Issue: 2
Pages: L219-28
Publication
First Author: Zhou Z
Year: 2020
Journal: Am J Pathol
Title: Toll-Like Receptor 5 Signaling Ameliorates Liver Fibrosis by Inducing Interferon β-Modulated IL-1 Receptor Antagonist in Mice.
Volume: 190
Issue: 3
Pages: 614-629
Publication
First Author: Riccioli A
Year: 2006
Journal: J Immunol
Title: Sertoli cells initiate testicular innate immune responses through TLR activation.
Volume: 177
Issue: 10
Pages: 7122-30
Publication
First Author: Floyd M
Year: 2016
Journal: PLoS Pathog
Title: Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa.
Volume: 12
Issue: 11
Pages: e1005987
Publication
First Author: West TE
Year: 2009
Journal: Infect Immun
Title: Toll-like receptor signaling in airborne Burkholderia thailandensis infection.
Volume: 77
Issue: 12
Pages: 5612-22
Publication
First Author: Kuo PJ
Year: 2019
Journal: PLoS One
Title: Metagenomic analysis of the effects of toll-like receptors on bacterial infection in the peritoneal cavity following cecum ligation and puncture in mice.
Volume: 14
Issue: 7
Pages: e0220398
Publication
First Author: Brackett CM
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.
Volume: 113
Issue: 7
Pages: E874-83
Publication
First Author: López-Yglesias AH
Year: 2014
Journal: J Immunol
Title: Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway.
Volume: 192
Issue: 4
Pages: 1587-96
Publication
First Author: Shin OS
Year: 2008
Journal: Infect Immun
Title: Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction.
Volume: 76
Issue: 6
Pages: 2341-51
Publication
First Author: Lim JS
Year: 2015
Journal: Aging Cell
Title: Flagellin-dependent TLR5/caveolin-1 as a promising immune activator in immunosenescence.
Volume: 14
Issue: 5
Pages: 907-15
Publication
First Author: Wu H
Year: 2008
Journal: Endocrinology
Title: Expression patterns and functions of toll-like receptors in mouse sertoli cells.
Volume: 149
Issue: 9
Pages: 4402-12
Publication
First Author: Menon BB
Year: 2015
Journal: Mucosal Immunol
Title: Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16.
Volume: 8
Issue: 5
Pages: 1000-8
Publication
First Author: Uematsu S
Year: 2008
Journal: Nat Immunol
Title: Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Volume: 9
Issue: 7
Pages: 769-76
Publication
First Author: Descamps D
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.
Volume: 109
Issue: 5
Pages: 1619-24
Publication
First Author: Metruccio MME
Year: 2017
Journal: Sci Rep
Title: Contributions of MyD88-dependent receptors and CD11c-positive cells to corneal epithelial barrier function against Pseudomonas aeruginosa.
Volume: 7
Issue: 1
Pages: 13829
Publication
First Author: Shi Z
Year: 2012
Journal: J Biol Chem
Title: Toll-like receptor 11 (TLR11) prevents Salmonella penetration into the murine Peyer patches.
Volume: 287
Issue: 52
Pages: 43417-23
Publication
First Author: Dupont A
Year: 2016
Journal: PLoS Pathog
Title: Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in Mice.
Volume: 12
Issue: 5
Pages: e1005616
Publication
First Author: Langlet C
Year: 2010
Journal: Eur J Immunol
Title: PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells.
Volume: 40
Issue: 2
Pages: 505-15
Publication
First Author: Rydström A
Year: 2009
Journal: Eur J Immunol
Title: Monocyte and neutrophil recruitment during oral Salmonella infection is driven by MyD88-derived chemokines.
Volume: 39
Issue: 11
Pages: 3019-30
Publication
First Author: Uchida T
Year: 2007
Journal: J Immunol
Title: Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists.
Volume: 178
Issue: 6
Pages: 3886-92
Publication
First Author: Schülke S
Year: 2014
Journal: PLoS One
Title: Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC.
Volume: 9
Issue: 2
Pages: e87822
Publication
First Author: Chassaing B
Year: 2014
Journal: Gastroenterology
Title: Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice.
Volume: 147
Issue: 6
Pages: 1363-77.e17
Publication  
First Author: Gao Y
Year: 2021
Journal: Int J Mol Sci
Title: YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes.
Volume: 22
Issue: 13
Publication
First Author: Lee LM
Year: 2016
Journal: PLoS One
Title: Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.
Volume: 11
Issue: 12
Pages: e0167693
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus