|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 1150 for Tlr9

<< First    < Previous  |  Next >    Last >>
0.047s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Toll-like receptor 9 (TLR9) is a key component of innate and adaptive immunity [, ]. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides, which is more abundant in bacterial genomes or viral DNA compared to the vertebrate genomes [, , , ]. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR9 controls lymphocyte response to Helicobacter infection [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Anderson AE
Year: 2007
Journal: Eur J Immunol
Title: TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan.
Volume: 37
Issue: 6
Pages: 1548-61
Publication
First Author: Chuang TH
Year: 2002
Journal: J Leukoc Biol
Title: Toll-like receptor 9 mediates CpG-DNA signaling.
Volume: 71
Issue: 3
Pages: 538-44
Publication
First Author: Tabeta K
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
Volume: 101
Issue: 10
Pages: 3516-21
Publication
First Author: Bauer S
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition.
Volume: 98
Issue: 16
Pages: 9237-42
Publication
First Author: Takeshita F
Year: 2001
Journal: J Immunol
Title: Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.
Volume: 167
Issue: 7
Pages: 3555-8
Publication
First Author: Huang X
Year: 2010
Journal: Expert Opin Ther Targets
Title: Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses.
Volume: 14
Issue: 8
Pages: 787-96
Publication
First Author: Doyle SL
Year: 2007
Journal: J Biol Chem
Title: Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
Volume: 282
Issue: 51
Pages: 36953-60
Publication      
First Author: Xiao N
Year: 2008
Journal: MGI Direct Data Submission
Title: The CpG5 mutation of Tlr9 specifically impairs immune response to unmethylated CpG oligonucleotides
Protein
Organism: Mus musculus
Length: 1032  
Fragment?: false
Publication
First Author: Khan NS
Year: 2019
Journal: FASEB J
Title: CD82 controls CpG-dependent TLR9 signaling.
Volume: 33
Issue: 11
Pages: 12500-12514
Publication
First Author: Javmen A
Year: 2018
Journal: J Immunol
Title: Blocking TIR Domain Interactions in TLR9 Signaling.
Volume: 201
Issue: 3
Pages: 995-1006
Publication
First Author: Bhan U
Year: 2011
Journal: Am J Pathol
Title: Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent.
Volume: 179
Issue: 6
Pages: 2779-87
Publication
First Author: Babdor J
Year: 2017
Journal: Nat Immunol
Title: IRAP+ endosomes restrict TLR9 activation and signaling.
Volume: 18
Issue: 5
Pages: 509-518
Publication
First Author: Guggemoos S
Year: 2008
Journal: J Immunol
Title: TLR9 contributes to antiviral immunity during gammaherpesvirus infection.
Volume: 180
Issue: 1
Pages: 438-43
Publication
First Author: Calcaterra C
Year: 2008
Journal: J Immunol
Title: Critical role of TLR9 in acute graft-versus-host disease.
Volume: 181
Issue: 9
Pages: 6132-9
Publication  
First Author: Ashley SN
Year: 2019
Journal: Cell Immunol
Title: TLR9 signaling mediates adaptive immunity following systemic AAV gene therapy.
Volume: 346
Pages: 103997
Publication
First Author: Wu J
Year: 2014
Journal: Am J Pathol
Title: TLR9 agonist regulates angiogenesis and inhibits corneal neovascularization.
Volume: 184
Issue: 6
Pages: 1900-10
Publication
First Author: Park JE
Year: 2008
Journal: J Immunol
Title: Protein kinase D1: a new component in TLR9 signaling.
Volume: 181
Issue: 3
Pages: 2044-55
Publication
First Author: Lewis CJ
Year: 2010
Journal: J Immunol
Title: Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling.
Volume: 184
Issue: 7
Pages: 3789-800
Publication
First Author: Thaxton JE
Year: 2009
Journal: J Immunol
Title: TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes.
Volume: 183
Issue: 2
Pages: 1144-54
Publication
First Author: Xu L
Year: 2019
Journal: J Clin Invest
Title: TLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity.
Volume: 129
Issue: 9
Pages: 3657-3669
Publication
First Author: Butchi NB
Year: 2011
Journal: Am J Pathol
Title: TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNS.
Volume: 179
Issue: 2
Pages: 783-94
Publication
First Author: Avalos AM
Year: 2013
Journal: J Immunol
Title: Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice.
Volume: 190
Issue: 2
Pages: 695-702
Publication
First Author: Kalis C
Year: 2005
Journal: J Immunol
Title: Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.
Volume: 174
Issue: 7
Pages: 4295-300
Publication
First Author: Han SJ
Year: 2018
Journal: J Immunol
Title: Kidney Proximal Tubular TLR9 Exacerbates Ischemic Acute Kidney Injury.
Volume: 201
Issue: 3
Pages: 1073-1085
Publication      
First Author: Huang H
Year: 2010
Journal: MGI Direct Data Submission
Title: CpG11 is an allele of Tlr9 and causes Tlr9 signaling defects
Publication
First Author: Celhar T
Year: 2016
Journal: Int Immunol
Title: TLR7 and TLR9 ligands regulate antigen presentation by macrophages.
Volume: 28
Issue: 5
Pages: 223-32
Publication
First Author: Zambirinis CP
Year: 2015
Journal: J Exp Med
Title: TLR9 ligation in pancreatic stellate cells promotes tumorigenesis.
Volume: 212
Issue: 12
Pages: 2077-94
Publication
First Author: Liu Y
Year: 2020
Journal: Nature
Title: TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise.
Volume: 578
Issue: 7796
Pages: 605-609
Publication
First Author: Varga MG
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: TLR9 activation suppresses inflammation in response to Helicobacter pylori infection.
Volume: 311
Issue: 5
Pages: G852-G858
Publication
First Author: Thon JN
Year: 2012
Journal: J Cell Biol
Title: T granules in human platelets function in TLR9 organization and signaling.
Volume: 198
Issue: 4
Pages: 561-74
Publication
First Author: Kim D
Year: 2016
Journal: PLoS One
Title: Extracellular Release of CD11b by TLR9 Stimulation in Macrophages.
Volume: 11
Issue: 3
Pages: e0150677
Publication
First Author: Jegerlehner A
Year: 2007
Journal: J Immunol
Title: TLR9 signaling in B cells determines class switch recombination to IgG2a.
Volume: 178
Issue: 4
Pages: 2415-20
Publication  
First Author: Matsuda T
Year: 2015
Journal: Nat Commun
Title: TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Volume: 6
Pages: 6514
Publication  
First Author: Akilesh HM
Year: 2019
Journal: Science
Title: Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.
Volume: 363
Issue: 6423
Publication
First Author: Lima BHF
Year: 2019
Journal: Sci Rep
Title: Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.
Volume: 9
Issue: 1
Pages: 19085
Publication
First Author: Montes-Cobos E
Year: 2020
Journal: J Immunol
Title: Voltage-Gated Proton Channel Hv1 Controls TLR9 Activation in Plasmacytoid Dendritic Cells.
Volume: 205
Issue: 11
Pages: 3001-3010
Publication
First Author: Sørensen LN
Year: 2008
Journal: J Immunol
Title: TLR2 and TLR9 synergistically control herpes simplex virus infection in the brain.
Volume: 181
Issue: 12
Pages: 8604-12
Publication  
First Author: Rose WA 2nd
Year: 2012
Journal: Sci Rep
Title: TLR9 is important for protection against intestinal damage and for intestinal repair.
Volume: 2
Pages: 574
Publication
First Author: Gäbele E
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Role of TLR9 in hepatic stellate cells and experimental liver fibrosis.
Volume: 376
Issue: 2
Pages: 271-6
Publication
First Author: Yasuda K
Year: 2006
Journal: Eur J Immunol
Title: CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA.
Volume: 36
Issue: 2
Pages: 431-6
Publication
First Author: Lee J
Year: 2006
Journal: Nat Cell Biol
Title: Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells.
Volume: 8
Issue: 12
Pages: 1327-36
Publication
First Author: Sester DP
Year: 2006
Journal: J Immunol
Title: CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway.
Volume: 177
Issue: 7
Pages: 4473-80
Publication
First Author: Peter ME
Year: 2009
Journal: J Immunol
Title: Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation.
Volume: 182
Issue: 12
Pages: 7690-7
Publication
First Author: Li Y
Year: 2012
Journal: EMBO J
Title: DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature.
Volume: 31
Issue: 4
Pages: 919-31
Publication
First Author: Muhonen P
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Sequence and TLR9 independent increase of TRACP expression by antisense DNA and siRNA molecules.
Volume: 359
Issue: 4
Pages: 889-95
Publication
First Author: Wade MF
Year: 2018
Journal: J Immunol
Title: TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization.
Volume: 201
Issue: 8
Pages: 2232-2243
Publication
First Author: Gao C
Year: 2013
Journal: Cancer Res
Title: TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy.
Volume: 73
Issue: 24
Pages: 7211-21
Publication
First Author: Marta M
Year: 2008
Journal: Eur J Immunol
Title: Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis.
Volume: 38
Issue: 2
Pages: 565-75
Publication
First Author: Theiner G
Year: 2008
Journal: Mol Immunol
Title: TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.
Volume: 45
Issue: 1
Pages: 244-52
Publication
First Author: Li Y
Year: 2017
Journal: J Immunol
Title: TLR9 Regulates the NF-κB-NLRP3-IL-1β Pathway Negatively in Salmonella-Induced NKG2D-Mediated Intestinal Inflammation.
Volume: 199
Issue: 2
Pages: 761-773
Publication
First Author: Han SJ
Year: 2020
Journal: FASEB J
Title: Intestinal TLR9 deficiency exacerbates hepatic IR injury via altered intestinal inflammation and short-chain fatty acid synthesis.
Volume: 34
Issue: 9
Pages: 12083-12099
Publication
First Author: Bhan U
Year: 2007
Journal: J Immunol
Title: TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells.
Volume: 179
Issue: 6
Pages: 3937-46
Publication
First Author: Zhang Y
Year: 2010
Journal: Am J Pathol
Title: TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungs.
Volume: 177
Issue: 2
Pages: 754-65
Publication
First Author: Biswas C
Year: 2018
Journal: PLoS One
Title: Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling.
Volume: 13
Issue: 7
Pages: e0200913
Publication
First Author: Chinnery HR
Year: 2012
Journal: Am J Pathol
Title: TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation.
Volume: 180
Issue: 1
Pages: 209-20
Publication
First Author: Minns LA
Year: 2006
Journal: J Immunol
Title: TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondii.
Volume: 176
Issue: 12
Pages: 7589-97
Publication
First Author: Roda JM
Year: 2005
Journal: J Immunol
Title: CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells.
Volume: 175
Issue: 3
Pages: 1619-27
Publication
First Author: Guo Z
Year: 2005
Journal: J Immunol
Title: A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 gene.
Volume: 175
Issue: 11
Pages: 7407-18
Publication
First Author: Ito T
Year: 2007
Journal: Eur J Immunol
Title: TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response.
Volume: 37
Issue: 10
Pages: 2847-55
Publication  
First Author: Zhao CC
Year: 2020
Journal: Mol Immunol
Title: TLR9 mediates the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation.
Volume: 125
Pages: 24-31
Publication  
First Author: Hao L
Year: 2021
Journal: Front Pharmacol
Title: TLR9 Signaling Protects Alcohol-Induced Hepatic Oxidative Stress but Worsens Liver Inflammation in Mice.
Volume: 12
Pages: 709002
Publication  
First Author: Baptista BJA
Year: 2018
Journal: Front Immunol
Title: TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells.
Volume: 9
Pages: 2281
Publication
First Author: Lartigue A
Year: 2006
Journal: J Immunol
Title: Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus.
Volume: 177
Issue: 2
Pages: 1349-54
Publication
First Author: Eckl-Dorna J
Year: 2009
Journal: Blood
Title: BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation.
Volume: 113
Issue: 17
Pages: 3969-77
Publication
First Author: Latz E
Year: 2004
Journal: Nat Immunol
Title: TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Volume: 5
Issue: 2
Pages: 190-8
Publication
First Author: Kajita E
Year: 2006
Journal: Biochem Biophys Res Commun
Title: The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3.
Volume: 343
Issue: 2
Pages: 578-84
Publication
First Author: Tross D
Year: 2009
Journal: Mol Immunol
Title: Global changes in gene expression and synergistic interactions induced by TLR9 and TLR3.
Volume: 46
Issue: 13
Pages: 2557-64
Publication
First Author: Pratti JES
Year: 2019
Journal: PLoS Negl Trop Dis
Title: The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy.
Volume: 13
Issue: 2
Pages: e0007146
Publication
First Author: Maatouk L
Year: 2018
Journal: Nat Commun
Title: TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons.
Volume: 9
Issue: 1
Pages: 2450
Publication
First Author: Nickerson KM
Year: 2013
Journal: J Immunol
Title: Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1.
Volume: 190
Issue: 8
Pages: 3889-94
Publication
First Author: Guillerey C
Year: 2012
Journal: Blood
Title: Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice.
Volume: 120
Issue: 1
Pages: 90-9
Publication
First Author: Hisaeda H
Year: 2008
Journal: J Immunol
Title: Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.
Volume: 180
Issue: 4
Pages: 2496-503
Publication
First Author: Dosenovic P
Year: 2015
Journal: Immunol Cell Biol
Title: Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation.
Volume: 93
Issue: 2
Pages: 136-46
Publication
First Author: Liese J
Year: 2007
Journal: Eur J Immunol
Title: TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis.
Volume: 37
Issue: 12
Pages: 3424-34
Publication
First Author: Gowda NM
Year: 2012
Journal: J Immunol
Title: TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Volume: 188
Issue: 10
Pages: 5073-85
Publication
First Author: Foronjy RF
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice.
Volume: 311
Issue: 1
Pages: L154-66
Publication
First Author: Ito T
Year: 2009
Journal: J Clin Invest
Title: TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4.
Volume: 119
Issue: 1
Pages: 33-46
Publication
First Author: Bueno M
Year: 2019
Journal: PLoS One
Title: PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses.
Volume: 14
Issue: 6
Pages: e0218003
Publication
First Author: Ma Z
Year: 2006
Journal: J Immunol
Title: Modulation of autoimmunity by TLR9 in the chronic graft-vs-host model of systemic lupus erythematosus.
Volume: 177
Issue: 10
Pages: 7444-50
Publication
First Author: De Nardo D
Year: 2009
Journal: J Immunol
Title: Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.
Volume: 183
Issue: 12
Pages: 8110-8
Publication
First Author: Liu FY
Year: 2019
Journal: Cell Death Dis
Title: TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis.
Volume: 10
Issue: 7
Pages: 480
Publication  
First Author: Lyu AK
Year: 2019
Journal: Exp Gerontol
Title: Inhibition of TLR9 attenuates skeletal muscle fibrosis in aged sarcopenic mice via the p53/SIRT1 pathway.
Volume: 122
Pages: 25-33
Publication
First Author: Scharfe-Nugent A
Year: 2012
Journal: J Immunol
Title: TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia.
Volume: 188
Issue: 11
Pages: 5706-12
Publication
First Author: Dolina JS
Year: 2020
Journal: Cell Rep
Title: TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.
Volume: 31
Issue: 1
Pages: 107249
Publication
First Author: Puttur F
Year: 2016
Journal: Cell Rep
Title: Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling.
Volume: 17
Issue: 4
Pages: 1113-1127
Publication
First Author: Sato A
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells.
Volume: 103
Issue: 46
Pages: 17343-8
Publication
First Author: Prinz M
Year: 2006
Journal: J Clin Invest
Title: Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis.
Volume: 116
Issue: 2
Pages: 456-64
Publication
First Author: Bafica A
Year: 2005
Journal: J Exp Med
Title: TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.
Volume: 202
Issue: 12
Pages: 1715-24
Publication
First Author: Zhang Y
Year: 2010
Journal: J Immunol
Title: TLR9 blockade inhibits activation of diabetogenic CD8+ T cells and delays autoimmune diabetes.
Volume: 184
Issue: 10
Pages: 5645-53
Publication
First Author: Roh YS
Year: 2015
Journal: Am J Physiol Gastrointest Liver Physiol
Title: TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration.
Volume: 309
Issue: 1
Pages: G30-41
Publication
First Author: Zaks K
Year: 2006
Journal: J Immunol
Title: Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes.
Volume: 176
Issue: 12
Pages: 7335-45
Publication
First Author: Zucchini N
Year: 2008
Journal: J Immunol
Title: Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.
Volume: 180
Issue: 9
Pages: 5799-803
Publication
First Author: Nickerson KM
Year: 2010
Journal: J Immunol
Title: TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus.
Volume: 184
Issue: 4
Pages: 1840-8
Publication
First Author: Tai N
Year: 2013
Journal: J Immunol
Title: TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice.
Volume: 191
Issue: 6
Pages: 2926-37