Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family of proteins includes the mammalian transmembrane inner ear expressed protein. Its function is unknown []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitchem KL |
Year: |
2002 |
Journal: |
Hum Mol Genet |
Title: |
Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6. |
Volume: |
11 |
Issue: |
16 |
Pages: |
1887-98 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
153
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Park S |
Year: |
2013 |
Journal: |
Comp Med |
Title: |
tmie Is required for gentamicin uptake by the hair cells of mice. |
Volume: |
63 |
Issue: |
2 |
Pages: |
136-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao B |
Year: |
2014 |
Journal: |
Neuron |
Title: |
TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells. |
Volume: |
84 |
Issue: |
5 |
Pages: |
954-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunningham CL |
Year: |
2020 |
Journal: |
Neuron |
Title: |
TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells. |
Volume: |
107 |
Issue: |
1 |
Pages: |
126-143.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kane KL |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Spinner 2 Jackson, a new spontaneous mutation in the Tmie gene |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shin MJ |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Ectopic expression of tmie transgene induces various recovery levels of behavior and hearing ability in the circling mouse. |
Volume: |
374 |
Issue: |
1 |
Pages: |
17-21 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
153
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho KI |
Year: |
2006 |
Journal: |
Comp Med |
Title: |
The circling mouse (C57BL/6J-cir) has a 40-kilobase genomic deletion that includes the transmembrane inner ear (tmie) gene. |
Volume: |
56 |
Issue: |
6 |
Pages: |
476-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
DEOL MS |
Year: |
1962 |
Journal: |
J Hered |
Title: |
The spinner mouse. |
Volume: |
53 |
|
Pages: |
133-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu S |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products. |
Volume: |
117 |
Issue: |
39 |
Pages: |
24534-24544 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fettiplace R |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. |
Volume: |
119 |
Issue: |
41 |
Pages: |
e2210849119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hollander WF |
Year: |
1973 |
Journal: |
Mouse News Lett |
Title: |
sr and Tw are not alleles, and seem independent |
Volume: |
48 |
|
Pages: |
33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji YR |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2. |
Volume: |
13 |
Issue: |
1 |
Pages: |
6330 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Q |
Year: |
2024 |
Journal: |
Neuron |
Title: |
Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2022 |
Journal: |
Front Mol Neurosci |
Title: |
The Mechanotransduction Channel and Organic Cation Transporter Are Critical for Cisplatin Ototoxicity in Murine Hair Cells. |
Volume: |
15 |
|
Pages: |
835448 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vargas GA |
Year: |
1996 |
Journal: |
J Clin Invest |
Title: |
Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice. |
Volume: |
97 |
Issue: |
11 |
Pages: |
2426-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jones SM |
Year: |
2005 |
Journal: |
J Assoc Res Otolaryngol |
Title: |
A quantitative survey of gravity receptor function in mutant mouse strains. |
Volume: |
6 |
Issue: |
4 |
Pages: |
297-310 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee J |
Year: |
2021 |
Journal: |
Elife |
Title: |
Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Krey JF |
Year: |
2020 |
Journal: |
Curr Biol |
Title: |
Mechanotransduction-Dependent Control of Stereocilia Dimensions and Row Identity in Inner Hair Cells. |
Volume: |
30 |
Issue: |
3 |
Pages: |
442-454.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun S |
Year: |
2018 |
Journal: |
Cell |
Title: |
Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System. |
Volume: |
174 |
Issue: |
5 |
Pages: |
1247-1263.e15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang P |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
LOXHD1 is indispensable for maintaining TMC1 auditory mechanosensitive channels at the site of force transmission. |
Volume: |
15 |
Issue: |
1 |
Pages: |
7865 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fox S |
Year: |
1978 |
Journal: |
Mouse News Lett |
Title: |
sr |
Volume: |
58 |
|
Pages: |
50 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGrath J |
Year: |
2021 |
Journal: |
Curr Biol |
Title: |
Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin. |
Volume: |
31 |
Issue: |
6 |
Pages: |
1141-1153.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krey JF |
Year: |
2023 |
Journal: |
PLoS Biol |
Title: |
Control of stereocilia length during development of hair bundles. |
Volume: |
21 |
Issue: |
4 |
Pages: |
e3001964 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eicher EM |
Year: |
1978 |
Journal: |
Mouse News Lett |
Title: |
[Repeated epilation located on Chr 4.] |
Volume: |
58 |
|
Pages: |
50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunningham CL |
Year: |
2017 |
Journal: |
Elife |
Title: |
The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2022 |
Journal: |
Dev Cell |
Title: |
RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss. |
Volume: |
57 |
Issue: |
18 |
Pages: |
2204-2220.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Halford J |
Year: |
2022 |
Journal: |
Mol Biol Cell |
Title: |
Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips. |
Volume: |
33 |
Issue: |
4 |
Pages: |
br6 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Rosa A |
Year: |
2020 |
Journal: |
Amino Acids |
Title: |
Prenatal expression of D-aspartate oxidase causes early cerebral D-aspartate depletion and influences brain morphology and cognitive functions at adulthood. |
Volume: |
52 |
Issue: |
4 |
Pages: |
597-617 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
transmembrane inner ear; spinner |
Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, spontaneous mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, spontaneous mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tmie/Tmie |
Background: |
B6.B(CBA)-Tmie/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tmie/Tmie |
Background: |
C57BL/How-Tmie |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tmie/Tmie<+> cir/cir<+> |
Background: |
involves: C57BL/6J * C57BL/How * ICR |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung WH |
Year: |
2007 |
Journal: |
Acta Otolaryngol |
Title: |
Cochlear pathology of the circling mouse: a new mouse model of DFNB6. |
Volume: |
127 |
Issue: |
3 |
Pages: |
244-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|