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Search results 1 to 100 out of 1553 for Tnc

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0.044s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Tenascin-C (TNC or Tenascin) is an extracellular matrix glycoprotein with multiple functions during development and in the adult []. It is expressed in the developing embryo. In adults expression is constrained to sites with high cell turnover, such as stem cell niches and the central nervous system (CNS), in addition to regions which undergo significant tensile stress, such as tendons, ligaments and smooth muscle fibres. However, most healthy adult tissues exhibit negligible tenascin-C levels []. Its splice variants are highly expressed in cancer tissues []. Tenascin-C interacts with integrins, these interactions can mediate cell proliferation, cell motility, and cell survival [].Tenascins are extracellular matrix glycoproteins that act both as integrin ligands and as modifiers of fibronectin-integrin interactions to regulate cell adhesion, migration, proliferation and differentiation. Tenascins are usually composed of repeated epidermal growth factor (EGF)-like domains, fibronectin-type III (FNIII) domains and a C-terminal fibrinogen related domain (FReD) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 1564  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1564  
Fragment?: false
Publication
First Author: Zhang MZ
Year: 2018
Journal: Hypertension
Title: Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity.
Volume: 72
Issue: 5
Pages: 1172-1179
Publication
First Author: He W
Year: 2013
Journal: PLoS One
Title: Generation of a tenascin-C-CreER2 knockin mouse line for conditional DNA recombination in renal medullary interstitial cells.
Volume: 8
Issue: 11
Pages: e79839
Publication
First Author: Neelisetty S
Year: 2015
Journal: Kidney Int
Title: Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells.
Volume: 88
Issue: 3
Pages: 503-14
Publication
First Author: Fleming JT
Year: 2013
Journal: Dev Cell
Title: The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors.
Volume: 27
Issue: 3
Pages: 278-92
Publication
First Author: Morellini F
Year: 2006
Journal: Eur J Neurosci
Title: Enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength in tenascin-C-deficient mice.
Volume: 23
Issue: 5
Pages: 1255-68
Allele
Name: tenascin C; targeted mutation 1, Chuan-Ming Hao
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Genotype
Symbol: Tnc/Tnc<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tnc/Tnc<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Protein
Organism: Mus musculus
Length: 2110  
Fragment?: false
Protein
Organism: Mus musculus
Length: 832  
Fragment?: false
Protein
Organism: Mus musculus
Length: 56  
Fragment?: true
Publication
First Author: Adams JC
Year: 2015
Journal: Cell Adh Migr
Title: The evolution of tenascins and fibronectin.
Volume: 9
Issue: 1-2
Pages: 22-33
Publication  
First Author: Tucker RP
Year: 2015
Journal: Int J Biochem Cell Biol
Title: Tenascin-C: Its functions as an integrin ligand.
Volume: 65
Pages: 165-8
Publication
First Author: Giblin SP
Year: 2015
Journal: Cell Adh Migr
Title: Tenascin-C: Form versus function.
Volume: 9
Issue: 1-2
Pages: 48-82
Publication
First Author: Yoshida T
Year: 2015
Journal: Cell Adh Migr
Title: Tenascin-C and integrins in cancer.
Volume: 9
Issue: 1-2
Pages: 96-104
GXD Expression    
Probe: MGI:6185553
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191491
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Tnc
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6185553
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191491
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Tnc
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6185553
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191491
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Tnc
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6185553
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191491
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Tnc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6185553
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191491
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Tnc
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6185553
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191491
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Tnc
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6185553
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191491
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Tnc
Detected: true
Specimen Num: 7
Publication
First Author: Angel I
Year: 2020
Journal: Oncogene
Title: Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma.
Volume: 39
Issue: 46
Pages: 6990-7004
Publication  
First Author: Kimura T
Year: 2014
Journal: Sci Rep
Title: Tenascin C protects aorta from acute dissection in mice.
Volume: 4
Pages: 4051
Publication
First Author: Saupe F
Year: 2013
Journal: Cell Rep
Title: Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model.
Volume: 5
Issue: 2
Pages: 482-92
Publication
First Author: Gruber BL
Year: 2020
Journal: BMC Res Notes
Title: Tenascin-C expression controls the maturation of articular cartilage in mice.
Volume: 13
Issue: 1
Pages: 78
Publication  
First Author: Manrique-Castano D
Year: 2021
Journal: Brain Behav Immun
Title: Tenascin-C preserves microglia surveillance and restricts leukocyte and, more specifically, T cell infiltration of the ischemic brain.
Volume: 91
Pages: 639-648
Publication
First Author: Sumioka T
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Impaired angiogenic response in the cornea of mice lacking tenascin C.
Volume: 52
Issue: 5
Pages: 2462-7
Publication
First Author: Abbadi D
Year: 2018
Journal: Cardiovasc Res
Title: Local production of tenascin-C acts as a trigger for monocyte/macrophage recruitment that provokes cardiac dysfunction.
Volume: 114
Issue: 1
Pages: 123-137
Publication  
First Author: Stamenkovic V
Year: 2017
Journal: Behav Brain Res
Title: Enriched environment alters the behavioral profile of tenascin-C deficient mice.
Volume: 331
Pages: 241-253
Publication
First Author: Xie K
Year: 2013
Journal: Neurobiol Aging
Title: Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice.
Volume: 34
Issue: 10
Pages: 2389-98
Publication
First Author: Flück M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Mechano-regulated tenascin-C orchestrates muscle repair.
Volume: 105
Issue: 36
Pages: 13662-7
Publication
First Author: Roth-Kleiner M
Year: 2004
Journal: Am J Respir Cell Mol Biol
Title: Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture.
Volume: 30
Issue: 3
Pages: 360-6
Publication  
First Author: May M
Year: 2018
Journal: Biol Open
Title: Cell tracking in vitro reveals that the extracellular matrix glycoprotein Tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord.
Volume: 7
Issue: 7
Publication
First Author: Liu L
Year: 2018
Journal: Mol Neurobiol
Title: Deficiency of Tenascin-C Alleviates Neuronal Apoptosis and Neuroinflammation After Experimental Subarachnoid Hemorrhage in Mice.
Volume: 55
Issue: 11
Pages: 8346-8354
Publication
First Author: El-Karef A
Year: 2007
Journal: J Pathol
Title: Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice.
Volume: 211
Issue: 1
Pages: 86-94
Publication
First Author: de Chevigny A
Year: 2006
Journal: Mol Cell Neurosci
Title: Delayed onset of odor detection in neonatal mice lacking tenascin-C.
Volume: 32
Issue: 1-2
Pages: 174-86
Publication
First Author: Irintchev A
Year: 2005
Journal: Cereb Cortex
Title: Structural and functional aberrations in the cerebral cortex of tenascin-C deficient mice.
Volume: 15
Issue: 7
Pages: 950-62
Publication
First Author: Stamenkovic V
Year: 2017
Journal: Brain Struct Funct
Title: The extracellular matrix glycoprotein tenascin-C and matrix metalloproteinases modify cerebellar structural plasticity by exposure to an enriched environment.
Volume: 222
Issue: 1
Pages: 393-415
Publication
First Author: Shinohara Y
Year: 2014
Journal: Eur J Histochem
Title: Inhibition of fibrous adhesion formation in the temporomandibular joint of tenascin-C knockout mice.
Volume: 58
Issue: 4
Pages: 2337
Publication  
First Author: Dzyubenko E
Year: 2022
Journal: Matrix Biol
Title: Tenascin-C restricts reactive astrogliosis in the ischemic brain.
Volume: 110
Pages: 1-15
Publication
First Author: Kato H
Year: 2019
Journal: Liver Transpl
Title: Overproduction of Tenascin-C Driven by Lipid Accumulation in the Liver Aggravates Hepatic Ischemia/Reperfusion Injury in Steatotic Mice.
Volume: 25
Issue: 2
Pages: 288-301
Publication
First Author: Keller KE
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: The effects of tenascin C knockdown on trabecular meshwork outflow resistance.
Volume: 54
Issue: 8
Pages: 5613-23
Publication  
First Author: Haage V
Year: 2019
Journal: Brain Behav Immun
Title: Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1.
Volume: 81
Pages: 470-483
Publication
First Author: Ellis SL
Year: 2013
Journal: Exp Hematol
Title: The role of Tenascin C in the lymphoid progenitor cell niche.
Volume: 41
Issue: 12
Pages: 1050-61
Publication
First Author: Czopka T
Year: 2009
Journal: Glia
Title: Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway.
Volume: 57
Issue: 16
Pages: 1790-801
Publication
First Author: Guntinas-Lichius O
Year: 2005
Journal: Eur J Neurosci
Title: Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair.
Volume: 22
Issue: 9
Pages: 2171-9
Publication
First Author: Kubo Y
Year: 2020
Journal: Sci Rep
Title: Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy.
Volume: 10
Issue: 1
Pages: 9299
Publication  
First Author: Wiemann S
Year: 2020
Journal: Front Immunol
Title: Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model.
Volume: 11
Pages: 566279
Publication  
First Author: Wiemann S
Year: 2021
Journal: Front Neurosci
Title: Knock-Out of Tenascin-C Ameliorates Ischemia-Induced Rod-Photoreceptor Degeneration and Retinal Dysfunction.
Volume: 15
Pages: 642176
Publication
First Author: Matsumoto K
Year: 2002
Journal: Jpn J Cancer Res
Title: Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C.
Volume: 93
Issue: 9
Pages: 968-75
Publication
First Author: Gocheva V
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival.
Volume: 114
Issue: 28
Pages: E5625-E5634
Publication  
First Author: Bauch J
Year: 2022
Journal: Cells
Title: The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.
Volume: 11
Issue: 11
Publication
First Author: Becerril S
Year: 2018
Journal: Int J Obes (Lond)
Title: Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C.
Volume: 42
Issue: 8
Pages: 1458-1470
Publication
First Author: Treloar HB
Year: 2009
Journal: J Neurosci
Title: Tenascin-C is an inhibitory boundary molecule in the developing olfactory bulb.
Volume: 29
Issue: 30
Pages: 9405-16
Publication
First Author: Imanaka-Yoshida K
Year: 2003
Journal: Differentiation
Title: The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse.
Volume: 71
Issue: 4-5
Pages: 291-8
Publication
First Author: Karus M
Year: 2011
Journal: Development
Title: The extracellular matrix molecule tenascin C modulates expression levels and territories of key patterning genes during spinal cord astrocyte specification.
Volume: 138
Issue: 24
Pages: 5321-31
Publication
First Author: Besser M
Year: 2012
Journal: Dev Biol
Title: Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Müller glia by influencing growth factor responsiveness and the extracellular matrix compartment.
Volume: 369
Issue: 2
Pages: 163-76
Publication
First Author: Wang L
Year: 2013
Journal: Atherosclerosis
Title: Tenascin-C deficiency in apo E-/- mouse increases eotaxin levels: implications for atherosclerosis.
Volume: 227
Issue: 2
Pages: 267-74
Publication
First Author: Wang L
Year: 2012
Journal: Cardiovasc Pathol
Title: Deletion of tenascin-C gene exacerbates atherosclerosis and induces intraplaque hemorrhage in Apo-E-deficient mice.
Volume: 21
Issue: 5
Pages: 398-413
Publication
First Author: British Society of Audiology short papers meeting on experimental studies of hearing and deafness. Cambridge, United Kingdom, 22-23 September 1996. Kiernan BW
Year: 1997
Journal: Br J Audiol
Title: Analysis of the deaf mouse mutant, whirler.
Volume: 31
Issue: 2
Pages: 73-132 (84-5 Abstr.)
Publication  
First Author: Yonebayashi S
Year: 2021
Journal: Front Immunol
Title: Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C.
Volume: 12
Pages: 620541
Publication  
First Author: Deng J
Year: 2021
Journal: Front Cell Dev Biol
Title: Noggin Overexpression Impairs the Development of Muscles, Tendons, and Aponeurosis in Soft Palates by Disrupting BMP-Smad and Shh-Gli1 Signaling.
Volume: 9
Pages: 711334
Publication  
First Author: Ohki S
Year: 2020
Journal: Front Physiol
Title: Transforming Growth Factor-Beta and Sonic Hedgehog Signaling in Palatal Epithelium Regulate Tenascin-C Expression in Palatal Mesenchyme During Soft Palate Development.
Volume: 11
Pages: 532
Publication
First Author: Son EJ
Year: 2012
Journal: PLoS One
Title: Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.
Volume: 7
Issue: 7
Pages: e40735
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Saga Y
Year: 1991
Journal: Gene
Title: Murine tenascin: cDNA cloning, structure and temporal expression of isoforms.
Volume: 104
Issue: 2
Pages: 177-85
Publication
First Author: Weller A
Year: 1991
Journal: J Cell Biol
Title: Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis.
Volume: 112
Issue: 2
Pages: 355-62
Publication
First Author: Joester A
Year: 1999
Journal: J Biol Chem
Title: Evidence for combinatorial variability of tenascin-C isoforms and developmental regulation in the mouse central nervous system.
Volume: 274
Issue: 24
Pages: 17144-51
Publication
First Author: Nur R
Year: 2008
Journal: Nephron Exp Nephrol
Title: Implantation of dedifferentiated fat cells ameliorates habu snake venom-induced chronic renal dysfunction in tenascin-C-deficient mice.
Volume: 110
Issue: 3
Pages: e91-8
Publication
First Author: Kusakabe M
Year: 2001
Journal: J Comp Neurol
Title: Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene.
Volume: 430
Issue: 4
Pages: 485-500
Publication
First Author: Forsberg E
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Skin wounds and severed nerves heal normally in mice lacking tenascin-C.
Volume: 93
Issue: 13
Pages: 6594-9
Publication  
First Author: Sun Z
Year: 2019
Journal: Matrix Biol
Title: Tenascin-C increases lung metastasis by impacting blood vessel invasions.
Volume: 83
Pages: 26-47
Publication
First Author: Murdamoothoo D
Year: 2021
Journal: EMBO Mol Med
Title: Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression.
Volume: 13
Issue: 6
Pages: e13270
Publication  
First Author: Hendaoui I
Year: 2014
Journal: Matrix Biol
Title: Tenascin-C is required for normal Wnt/β-catenin signaling in the whisker follicle stem cell niche.
Volume: 40
Pages: 46-53