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Search results 1 to 100 out of 720 for Traf3

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling []. It is a critical regulator of both innate and adaptive immune responses []. TRAF3 plays a role in the regulation of B-cell survival [], in the regulation of antiviral responses [], and in T-cell dependent immune responses []. It is required for normal antibody isotype switching from IgM to IgG []. Differences in the ubiquitination of TRAF3 are the key to the selective production of type I interferons versus proinflammatory cytokines [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Xu Y
Year: 1996
Journal: Immunity
Title: Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.
Volume: 5
Issue: 5
Pages: 407-15
Publication
First Author: Gardam S
Year: 2008
Journal: Immunity
Title: TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.
Volume: 28
Issue: 3
Pages: 391-401
Publication
First Author: Jabara HH
Year: 2009
Journal: Int Immunol
Title: TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.
Volume: 21
Issue: 4
Pages: 477-88
Publication
First Author: Oganesyan G
Year: 2006
Journal: Nature
Title: Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.
Volume: 439
Issue: 7073
Pages: 208-11
Publication
First Author: Tseng PH
Year: 2010
Journal: Nat Immunol
Title: Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
Volume: 11
Issue: 1
Pages: 70-5
Publication  
First Author: He JQ
Year: 2007
Journal: Adv Exp Med Biol
Title: TRAF3 and its biological function.
Volume: 597
Pages: 48-59
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Häcker H
Year: 2011
Journal: Nat Rev Immunol
Title: Expanding TRAF function: TRAF3 as a tri-faced immune regulator.
Volume: 11
Issue: 7
Pages: 457-68
Publication
First Author: Zhang R
Year: 2017
Journal: Sci Rep
Title: TRAF3 negatively regulates platelet activation and thrombosis.
Volume: 7
Issue: 1
Pages: 17112
Protein
Organism: Mus musculus
Length: 567  
Fragment?: false
Publication  
First Author: Mambetsariev N
Year: 2016
Journal: Sci Rep
Title: TRAF3 deficiency promotes metabolic reprogramming in B cells.
Volume: 6
Pages: 35349
Publication
First Author: Yi Z
Year: 2014
Journal: PLoS One
Title: TRAF3 regulates homeostasis of CD8+ central memory T cells.
Volume: 9
Issue: 7
Pages: e102120
Publication
First Author: Xiao Y
Year: 2013
Journal: Nat Med
Title: Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation.
Volume: 19
Issue: 5
Pages: 595-602
Publication  
First Author: Zhu Q
Year: 2020
Journal: J Exp Med
Title: TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
Volume: 217
Issue: 7
Publication  
First Author: Wang PX
Year: 2016
Journal: Nat Commun
Title: Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling.
Volume: 7
Pages: 10592
Publication
First Author: Xiu Y
Year: 2014
Journal: J Clin Invest
Title: Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation.
Volume: 124
Issue: 1
Pages: 297-310
Publication
First Author: Li J
Year: 2019
Journal: Nat Commun
Title: TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.
Volume: 10
Issue: 1
Pages: 2795
Publication
First Author: Wallis AM
Year: 2017
Journal: Sci Rep
Title: TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22.
Volume: 7
Issue: 1
Pages: 2081
Publication
First Author: Shen Y
Year: 2020
Journal: FASEB J
Title: TRAF3 promotes ROS production and pyroptosis by targeting ULK1 ubiquitination in macrophages.
Volume: 34
Issue: 5
Pages: 7144-7159
Publication
First Author: Panda S
Year: 2015
Journal: Immunity
Title: Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.
Volume: 43
Issue: 4
Pages: 647-59
Publication
First Author: Sun N
Year: 2020
Journal: Protein Cell
Title: TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Volume: 11
Issue: 12
Pages: 894-914
Publication
First Author: Li F
Year: 2018
Journal: J Clin Invest
Title: HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
Volume: 128
Issue: 9
Pages: 4148-4162
Publication
First Author: He JQ
Year: 2007
Journal: J Biol Chem
Title: Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway.
Volume: 282
Issue: 6
Pages: 3688-94
Publication
First Author: Zapata JM
Year: 2009
Journal: Blood
Title: Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer.
Volume: 113
Issue: 19
Pages: 4595-603
Publication
First Author: Häcker H
Year: 2006
Journal: Nature
Title: Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Volume: 439
Issue: 7073
Pages: 204-7
Publication
First Author: Lalani AI
Year: 2015
Journal: J Immunol
Title: Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice.
Volume: 194
Issue: 1
Pages: 334-48
Publication      
First Author: Arkee T
Year: 2021
Journal: J Immunol
Title: TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.
Publication
First Author: Saha SK
Year: 2006
Journal: EMBO J
Title: Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Volume: 25
Issue: 14
Pages: 3257-63
Publication
First Author: Chang JH
Year: 2014
Journal: J Exp Med
Title: TRAF3 regulates the effector function of regulatory T cells and humoral immune responses.
Volume: 211
Issue: 1
Pages: 137-51
Publication  
First Author: Liu J
Year: 2017
Journal: Sci Rep
Title: Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer.
Volume: 7
Pages: 40487
Publication
First Author: Chen Z
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity.
Volume: 308
Issue: 6
Pages: E460-9
Publication
First Author: Moore CR
Year: 2012
Journal: Leukemia
Title: Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice.
Volume: 26
Issue: 5
Pages: 1122-7
Publication
First Author: Jenkinson SR
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
Volume: 110
Issue: 52
Pages: 21107-12
Publication
First Author: Mambetsariev N
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Nuclear TRAF3 is a negative regulator of CREB in B cells.
Volume: 113
Issue: 4
Pages: 1032-7
Publication
First Author: Lin WW
Year: 2015
Journal: Sci Signal
Title: The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.
Volume: 8
Issue: 392
Pages: ra88
Publication
First Author: Vallabhapurapu S
Year: 2008
Journal: Nat Immunol
Title: Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Volume: 9
Issue: 12
Pages: 1364-70
Publication
First Author: Yi Z
Year: 2014
Journal: Nat Immunol
Title: The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
Volume: 15
Issue: 9
Pages: 866-74
Publication
First Author: Jabara H
Year: 2002
Journal: Immunity
Title: The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.
Volume: 17
Issue: 3
Pages: 265-76
Publication  
First Author: Liu Y
Year: 2021
Journal: Front Immunol
Title: Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes.
Volume: 12
Pages: 670338
Publication
First Author: Yao Z
Year: 2017
Journal: J Biol Chem
Title: RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors.
Volume: 292
Issue: 24
Pages: 10169-10179
Publication
First Author: Chen Z
Year: 2020
Journal: J Immunol
Title: TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy.
Volume: 205
Issue: 3
Pages: 830-841
Publication
First Author: Lin D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.
Volume: 112
Issue: 36
Pages: 11324-9
Protein
Organism: Mus musculus
Length: 542  
Fragment?: false
Protein
Organism: Mus musculus
Length: 542  
Fragment?: false
Protein
Organism: Mus musculus
Length: 97  
Fragment?: true
Publication
First Author: Zarnegar BJ
Year: 2008
Journal: Nat Immunol
Title: Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
Volume: 9
Issue: 12
Pages: 1371-8
Publication
First Author: Wang X
Year: 1996
Journal: Dev Biol
Title: A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.
Volume: 177
Issue: 1
Pages: 274-90
Publication
First Author: Kalantry S
Year: 2001
Journal: Nat Genet
Title: The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain.
Volume: 27
Issue: 4
Pages: 412-6
Publication
First Author: Tomihara-Newberger C
Year: 1998
Journal: Dev Biol
Title: The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives.
Volume: 204
Issue: 1
Pages: 34-54
Publication
First Author: Qian Y
Year: 2004
Journal: Immunity
Title: Act1, a negative regulator in CD40- and BAFF-mediated B cell survival.
Volume: 21
Issue: 4
Pages: 575-87
Publication
First Author: Matsushima Y
Year: 2010
Journal: J Immunol
Title: An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene.
Volume: 185
Issue: 4
Pages: 2340-9
Publication
First Author: Ma C
Year: 2017
Journal: EMBO Rep
Title: NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3.
Volume: 18
Issue: 4
Pages: 586-602
Publication
First Author: Jiang X
Year: 2015
Journal: Hypertension
Title: Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy.
Volume: 66
Issue: 2
Pages: 356-67
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Danio rerio
Publication
First Author: Zepp JA
Year: 2012
Journal: J Immunol
Title: Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes.
Volume: 189
Issue: 1
Pages: 33-7
Publication
First Author: Zhou Y
Year: 2016
Journal: Nat Immunol
Title: The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.
Volume: 17
Issue: 4
Pages: 397-405
Publication
First Author: Edwards SK
Year: 2014
Journal: Leuk Res
Title: Expression and function of a novel isoform of Sox5 in malignant B cells.
Volume: 38
Issue: 3
Pages: 393-401
Publication
First Author: Zhu S
Year: 2010
Journal: J Exp Med
Title: Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling.
Volume: 207
Issue: 12
Pages: 2647-62
Publication
First Author: Xie P
Year: 2011
Journal: J Immunol
Title: TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling.
Volume: 186
Issue: 1
Pages: 143-55
Publication
First Author: Yi Z
Year: 2013
Journal: J Exp Med
Title: TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.
Volume: 210
Issue: 6
Pages: 1079-86
Publication
First Author: Gu H
Year: 2015
Journal: Toxicol Sci
Title: The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells.
Volume: 144
Issue: 1
Pages: 186-96
Publication  
First Author: Lui PY
Year: 2016
Journal: Emerg Microbes Infect
Title: Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3.
Volume: 5
Pages: e39
Publication
First Author: Xie P
Year: 2004
Journal: J Immunol
Title: Roles of TNF receptor-associated factor 3 in signaling to B lymphocytes by carboxyl-terminal activating regions 1 and 2 of the EBV-encoded oncoprotein latent membrane protein 1.
Volume: 173
Issue: 9
Pages: 5546-55
Publication
First Author: Wang Y
Year: 2013
Journal: Immunity
Title: The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
Volume: 39
Issue: 1
Pages: 111-22
Publication
First Author: Xie P
Year: 2007
Journal: Immunity
Title: Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.
Volume: 27
Issue: 2
Pages: 253-67
Publication
First Author: Parvatiyar K
Year: 2018
Journal: Nat Commun
Title: A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling.
Volume: 9
Issue: 1
Pages: 2770
Publication
First Author: Hao D
Year: 2020
Journal: FASEB J
Title: SHP-1 suppresses the antiviral innate immune response by targeting TRAF3.
Volume: 34
Issue: 9
Pages: 12392-12405
Publication
First Author: Allen IC
Year: 2012
Journal: Immunity
Title: NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling.
Volume: 36
Issue: 5
Pages: 742-54
Publication
First Author: Xie P
Year: 2011
Journal: J Leukoc Biol
Title: Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes.
Volume: 90
Issue: 6
Pages: 1149-57
Publication
First Author: Gokhale S
Year: 2020
Journal: J Immunol
Title: Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes.
Volume: 204
Issue: 2
Pages: 459-471
Publication    
First Author: Whillock AL
Year: 2021
Journal: J Biol Chem
Title: TNF receptor-associated factor 3 restrains B cell receptor signaling in normal and malignant B cells.
Pages: 100465
Publication
First Author: Li H
Year: 2021
Journal: J Biol Chem
Title: Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR.
Volume: 297
Issue: 3
Pages: 101097
Publication  
First Author: Jin J
Year: 2015
Journal: Nat Commun
Title: Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages.
Volume: 6
Pages: 5930
Publication
First Author: Ohazama A
Year: 2003
Journal: Gene Expr Patterns
Title: Expression of TNF-receptor-associated factor genes in murine tooth development.
Volume: 3
Issue: 2
Pages: 127-9
Publication
First Author: Rub A
Year: 2009
Journal: Nat Immunol
Title: Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function.
Volume: 10
Issue: 3
Pages: 273-80
Publication
First Author: He JQ
Year: 2006
Journal: J Exp Med
Title: Rescue of TRAF3-null mice by p100 NF-kappa B deficiency.
Volume: 203
Issue: 11
Pages: 2413-8
Publication
First Author: Hu G
Year: 2020
Journal: Am J Pathol
Title: Tumor Necrosis Factor Receptor Associated Factor 3 Modulates Cartilage Degradation through Suppression of Interleukin 17 Signaling.
Volume: 190
Issue: 8
Pages: 1701-1712
Publication
First Author: Gao P
Year: 2021
Journal: Nat Commun
Title: E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
Volume: 12
Issue: 1
Pages: 1194
Publication
First Author: Hostager BS
Year: 2003
Journal: J Biol Chem
Title: Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling.
Volume: 278
Issue: 46
Pages: 45382-90
Publication
First Author: Woolaver RA
Year: 2018
Journal: J Immunol
Title: TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation.
Volume: 201
Issue: 11
Pages: 3421-3430
Publication
First Author: Zhong B
Year: 2013
Journal: Sci Signal
Title: Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3.
Volume: 6
Issue: 275
Pages: ra35
Publication
First Author: Wimmer N
Year: 2013
Journal: Mol Immunol
Title: Lymphotoxin-beta receptor signalling regulates cytokine expression via TRIM30α in a TRAF3-dependent manner.
Volume: 54
Issue: 1
Pages: 40-7
Publication
First Author: Neely RJ
Year: 2011
Journal: Oncogene
Title: The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK.
Volume: 30
Issue: 1
Pages: 87-96
Publication
First Author: Arch RH
Year: 1998
Journal: Mol Cell Biol
Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.
Volume: 18
Issue: 1
Pages: 558-65
Publication
First Author: Ha YJ
Year: 2004
Journal: J Immunol
Title: Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase.
Volume: 172
Issue: 1
Pages: 231-9
Publication
First Author: Hu H
Year: 2013
Journal: Nature
Title: OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3.
Volume: 494
Issue: 7437
Pages: 371-4
Publication
First Author: Perkins DJ
Year: 2013
Journal: PLoS Pathog
Title: Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production.
Volume: 9
Issue: 7
Pages: e1003479
Publication
First Author: Lin YC
Year: 2013
Journal: Sci Signal
Title: The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.
Volume: 6
Issue: 289
Pages: ra71