| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The TRPM subfamily of mammalian TRP channels includes TRPM3, which is a calcium-permeable nonselective cation channel []. TRPM3 is expressed by a variety of cells, including nociceptive neurons, pancreatic beta cells, and vascular smooth muscle cells []. TRPM3 channels are temperature sensitive and have been implicated in sensing noxious heat [, ]. They may also play a role of TRPM3 in renal Ca2+ homeostasis []. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brown RL |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
TRPM3 expression in mouse retina. |
| Volume: |
10 |
| Issue: |
2 |
| Pages: |
e0117615 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mulier M |
| Year: |
2020 |
| Journal: |
Elife |
| Title: |
Upregulation of TRPM3 in nociceptors innervating inflamed tissue. |
| Volume: |
9 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Straub I |
| Year: |
2013 |
| Journal: |
Mol Pharmacol |
| Title: |
Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. |
| Volume: |
84 |
| Issue: |
5 |
| Pages: |
736-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oberwinkler J |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Alternative splicing switches the divalent cation selectivity of TRPM3 channels. |
| Volume: |
280 |
| Issue: |
23 |
| Pages: |
22540-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dembla S |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aloi VD |
| Year: |
2023 |
| Journal: |
Pain |
| Title: |
TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain. |
| Volume: |
164 |
| Issue: |
9 |
| Pages: |
2060-2069 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xie MX |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
1401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vriens J |
| Year: |
2011 |
| Journal: |
Neuron |
| Title: |
TRPM3 is a nociceptor channel involved in the detection of noxious heat. |
| Volume: |
70 |
| Issue: |
3 |
| Pages: |
482-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vanneste M |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
TRPM3 Is Expressed in Afferent Bladder Neurons and Is Upregulated during Bladder Inflammation. |
| Volume: |
23 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kelemen B |
| Year: |
2021 |
| Journal: |
Biochem Pharmacol |
| Title: |
The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators. |
| Volume: |
183 |
|
| Pages: |
114310 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alonso-Carbajo L |
| Year: |
2019 |
| Journal: |
J Mol Cell Cardiol |
| Title: |
Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries. |
| Volume: |
129 |
|
| Pages: |
219-230 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Webster CM |
| Year: |
2020 |
| Journal: |
eNeuro |
| Title: |
The Impact of Steroid Activation of TRPM3 on Spontaneous Activity in the Developing Retina. |
| Volume: |
7 |
| Issue: |
2 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Su S |
| Year: |
2021 |
| Journal: |
J Neurosci |
| Title: |
TRPM3 Channels Play Roles in Heat Hypersensitivity and Spontaneous Pain after Nerve Injury. |
| Volume: |
41 |
| Issue: |
11 |
| Pages: |
2457-2474 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou Y |
| Year: |
2024 |
| Journal: |
Cells |
| Title: |
A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens. |
| Volume: |
13 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Held K |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. |
| Volume: |
112 |
| Issue: |
11 |
| Pages: |
E1363-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou Y |
| Year: |
2021 |
| Journal: |
FASEB J |
| Title: |
Mutation of the TRPM3 cation channel underlies progressive cataract development and lens calcification associated with pro-fibrotic and immune cell responses. |
| Volume: |
35 |
| Issue: |
2 |
| Pages: |
e21288 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oberwinkler J |
| Year: |
2014 |
| Journal: |
Handb Exp Pharmacol |
| Title: |
TRPM3. |
| Volume: |
222 |
|
| Pages: |
427-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grimm C |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Molecular and functional characterization of the melastatin-related cation channel TRPM3. |
| Volume: |
278 |
| Issue: |
24 |
| Pages: |
21493-501 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
793
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
737
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
142
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
369
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
234
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
262
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
461
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
369
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
783
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
958
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
848
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1719
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1691
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1721
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1337
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1697
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1744
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1689
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1719
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1734
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1707
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1579
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1701
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1722
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1579
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1716
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1718
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1732
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1719
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1732
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1707
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1709
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1711
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1721
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1731
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1692
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1709
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1719
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1689
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1699
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao C |
| Year: |
2023 |
| Journal: |
Neuron |
| Title: |
Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. |
| Volume: |
111 |
| Issue: |
1 |
| Pages: |
81-91.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duvoisin RM |
| Year: |
2017 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3. |
| Volume: |
58 |
| Issue: |
5 |
| Pages: |
2732-2738 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Siroky BJ |
| Year: |
2017 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. |
| Volume: |
312 |
| Issue: |
4 |
| Pages: |
F791-F805 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Becker A |
| Year: |
2020 |
| Journal: |
Cell Physiol Biochem |
| Title: |
Control of Insulin Release by Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels. |
| Volume: |
54 |
| Issue: |
6 |
| Pages: |
1115-1131 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alkhatib O |
| Year: |
2019 |
| Journal: |
J Neurosci |
| Title: |
Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits. |
| Volume: |
39 |
| Issue: |
40 |
| Pages: |
7840-7852 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deo M |
| Year: |
2006 |
| Journal: |
Dev Dyn |
| Title: |
Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides. |
| Volume: |
235 |
| Issue: |
9 |
| Pages: |
2538-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kleene SJ |
| Year: |
2019 |
| Journal: |
PLoS One |
| Title: |
The TRPP2-dependent channel of renal primary cilia also requires TRPM3. |
| Volume: |
14 |
| Issue: |
3 |
| Pages: |
e0214053 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xie Q |
| Year: |
2014 |
| Journal: |
Mol Vis |
| Title: |
Gene regulation by PAX6: structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204. |
| Volume: |
20 |
|
| Pages: |
270-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hughes S |
| Year: |
2012 |
| Journal: |
Eur J Neurosci |
| Title: |
Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception. |
| Volume: |
35 |
| Issue: |
1 |
| Pages: |
34-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shaham O |
| Year: |
2013 |
| Journal: |
PLoS Genet |
| Title: |
Pax6 regulates gene expression in the vertebrate lens through miR-204. |
| Volume: |
9 |
| Issue: |
3 |
| Pages: |
e1003357 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xie Q |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
e54507 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|