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Search results 1 to 100 out of 687 for Trpm8

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Type Details Score
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM8, which is a cold- and menthol-activated ion channel expressed in peripheral sensory neurons, where it plays a critical role in cold temperature detection []. TRPM8 is also found in the prostate and is up-regulated in prostate cancer and other malignancies [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:7388611
Assay Type: RNA in situ
Annotation Date: 2022-12-02
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3667828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7388631
Age: postnatal day 30
Image: 4D TRPM8 Tlx3 CKO
Note: Expression reduced by 45% compared to control.
Specimen Label: 4D TRPM8 Tlx3 CKO
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7388611
Assay Type: RNA in situ
Annotation Date: 2022-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3667827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7388631
Age: postnatal day 0
Image: 5A TRPM8 P0 Control
Specimen Label: 5A TRPM8 P0 Control
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:7388611
Assay Type: RNA in situ
Annotation Date: 2022-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3667828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7388631
Age: postnatal day 30
Image: 4D TRPM8 Control
Specimen Label: 4D TRPM8 Control
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7388611
Assay Type: RNA in situ
Annotation Date: 2022-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3667824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7388631
Age: embryonic day 16.5
Image: 5A TRPM8 E16.5 Control
Specimen Label: 5A TRPM8 E16.5 Control
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7388611
Assay Type: RNA in situ
Annotation Date: 2022-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3667824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7388631
Age: embryonic day 16.5
Image: 5A TRPM8 E16.5 Tlx3-/-
Note: Expression still detected at E16.5.
Specimen Label: 5A TRPM8 E16.5 Tlx3-/-
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:7388611
Assay Type: RNA in situ
Annotation Date: 2022-12-02
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:3667827
Pattern: Single cells
Stage: TS27
Assay Id: MGI:7388631
Age: postnatal day 0
Image: 5A TRPM8 P0 Tlx3-/-
Note: Expression greatly reduced at P0. Weak expression in neurons
Specimen Label: 5A TRPM8 P0 Tlx3-/-
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7484578
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484630
Age: postnatal adult
Specimen Label: 5d TRPM8
Detected: true
Specimen Num: 3
Publication  
First Author: Almaraz L
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM8.
Volume: 222
Pages: 547-79
Publication
First Author: Tsavaler L
Year: 2001
Journal: Cancer Res
Title: Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.
Volume: 61
Issue: 9
Pages: 3760-9
Publication
First Author: Colburn RW
Year: 2007
Journal: Neuron
Title: Attenuated cold sensitivity in TRPM8 null mice.
Volume: 54
Issue: 3
Pages: 379-86
Publication
First Author: Morenilla-Palao C
Year: 2009
Journal: J Biol Chem
Title: Lipid raft segregation modulates TRPM8 channel activity.
Volume: 284
Issue: 14
Pages: 9215-24
Publication
First Author: Ramachandran R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Volume: 110
Issue: 18
Pages: 7476-81
Protein
Organism: Mus musculus/domesticus
Length: 1104  
Fragment?: false
Publication
First Author: Dhaka A
Year: 2007
Journal: Neuron
Title: TRPM8 is required for cold sensation in mice.
Volume: 54
Issue: 3
Pages: 371-8
Publication
First Author: Ramos-Filho AC
Year: 2014
Journal: PLoS One
Title: Menthol inhibits detrusor contractility independently of TRPM8 activation.
Volume: 9
Issue: 11
Pages: e111616
Publication
First Author: Gkika D
Year: 2015
Journal: J Cell Biol
Title: TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.
Volume: 208
Issue: 1
Pages: 89-107
GXD Expression    
Probe: MGI:7484578
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484630
Age: postnatal adult
Specimen Label: 5a TRPM8 Control
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7484578
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-26
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484630
Age: postnatal adult
Note: Number of expressing neurons unaffected but expression level reduced compared with control
Specimen Label: 5a TRPM8 PN-ZB20KO
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7484587
Assay Type: RNA in situ
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484643
Age: postnatal adult
Specimen Label: 4 TRPM8 Control
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7484587
Assay Type: RNA in situ
Annotation Date: 2023-05-26
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484643
Age: postnatal adult
Note: Percentage of expressing neurons not significantly changed, but expression intensity weaker than control.
Specimen Label: 4 TRPM8 PN-ZB20KO
Detected: true
Specimen Num: 2
Publication
First Author: Arcas JM
Year: 2019
Journal: J Neurosci
Title: The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels.
Volume: 39
Issue: 6
Pages: 949-969
Publication
First Author: Klasen K
Year: 2012
Journal: Pflugers Arch
Title: The TRPM8 ion channel comprises direct Gq protein-activating capacity.
Volume: 463
Issue: 6
Pages: 779-97
Publication
First Author: McCoy DD
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Enhanced insulin clearance in mice lacking TRPM8 channels.
Volume: 305
Issue: 1
Pages: E78-88
Publication
First Author: Tajino K
Year: 2011
Journal: PLoS One
Title: Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling.
Volume: 6
Issue: 3
Pages: e17504
Publication
First Author: Zhang X
Year: 2012
Journal: Nat Cell Biol
Title: Direct inhibition of the cold-activated TRPM8 ion channel by Gαq.
Volume: 14
Issue: 8
Pages: 851-8
Publication  
First Author: Quallo T
Year: 2015
Journal: Nat Commun
Title: TRPM8 is a neuronal osmosensor that regulates eye blinking in mice.
Volume: 6
Pages: 7150
Publication
First Author: Cornejo VH
Year: 2020
Journal: Cell Rep
Title: Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing.
Volume: 30
Issue: 13
Pages: 4505-4517.e5
Publication
First Author: Bautista DM
Year: 2007
Journal: Nature
Title: The menthol receptor TRPM8 is the principal detector of environmental cold.
Volume: 448
Issue: 7150
Pages: 204-8
Publication
First Author: Ordás P
Year: 2021
Journal: J Comp Neurol
Title: Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits.
Volume: 529
Issue: 1
Pages: 234-256
Publication
First Author: Takashima Y
Year: 2010
Journal: Neuroscience
Title: The development of peripheral cold neural circuits based on TRPM8 expression.
Volume: 169
Issue: 2
Pages: 828-42
Publication
First Author: Chan H
Year: 2018
Journal: Oncotarget
Title: TRPM8 and RAAS-mediated hypertension is critical for cold-induced immunosuppression in mice.
Volume: 9
Issue: 16
Pages: 12781-12795
Publication
First Author: Michot B
Year: 2018
Journal: Sci Rep
Title: TRPM8 and TRPA1 do not contribute to dental pulp sensitivity to cold.
Volume: 8
Issue: 1
Pages: 13198
Publication
First Author: Dragoni I
Year: 2006
Journal: J Biol Chem
Title: The cold and menthol receptor TRPM8 contains a functionally important double cysteine motif.
Volume: 281
Issue: 49
Pages: 37353-60
Publication
First Author: Ran L
Year: 2023
Journal: Invest Ophthalmol Vis Sci
Title: Effect of TRPM8 Functional Loss on Corneal Epithelial Wound Healing in Mice.
Volume: 64
Issue: 1
Pages: 19
Publication
First Author: Moraes MN
Year: 2017
Journal: Biochim Biophys Acta
Title: Cold-sensing TRPM8 channel participates in circadian control of the brown adipose tissue.
Volume: 1864
Issue: 12
Pages: 2415-2427
Publication
First Author: Lelis Carvalho A
Year: 2021
Journal: PLoS One
Title: TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss.
Volume: 16
Issue: 6
Pages: e0231060
Publication  
First Author: Hernández-Ortego P
Year: 2022
Journal: Int J Mol Sci
Title: Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression.
Volume: 23
Issue: 24
Publication
First Author: Ota W
Year: 2019
Journal: Sci Rep
Title: Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior.
Volume: 9
Issue: 1
Pages: 3706
Publication
First Author: Ma S
Year: 2012
Journal: J Mol Cell Biol
Title: Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity.
Volume: 4
Issue: 2
Pages: 88-96
Publication
First Author: Brenner DS
Year: 2014
Journal: Pain
Title: A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.
Volume: 155
Issue: 10
Pages: 2124-33
Publication
First Author: Zhang X
Year: 2019
Journal: Cell Rep
Title: Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation.
Volume: 27
Issue: 12
Pages: 3672-3683.e4
Publication
First Author: Morenilla-Palao C
Year: 2014
Journal: Cell Rep
Title: Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.
Volume: 8
Issue: 5
Pages: 1571-82
Publication
First Author: Mueller-Tribbensee SM
Year: 2015
Journal: PLoS One
Title: Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
Volume: 10
Issue: 7
Pages: e0128242
Publication
First Author: Bidaux G
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner.
Volume: 112
Issue: 26
Pages: E3345-54
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Almeida MC
Year: 2012
Journal: J Neurosci
Title: Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.
Volume: 32
Issue: 6
Pages: 2086-99
Publication
First Author: Fujita T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins.
Volume: 495
Issue: 1
Pages: 935-940
Publication
First Author: Mohandass A
Year: 2020
Journal: FASEB J
Title: TRPM8 as the rapid testosterone signaling receptor: Implications in the regulation of dimorphic sexual and social behaviors.
Volume: 34
Issue: 8
Pages: 10887-10906
Publication
First Author: de Jong PR
Year: 2015
Journal: Mucosal Immunol
Title: TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP.
Volume: 8
Issue: 3
Pages: 491-504
Publication
First Author: Borowiec AS
Year: 2016
Journal: FASEB J
Title: Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.
Volume: 30
Issue: 9
Pages: 3155-70
Publication
First Author: Madrid R
Year: 2009
Journal: J Neurosci
Title: Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels.
Volume: 29
Issue: 10
Pages: 3120-31
Publication
First Author: Vanden Abeele F
Year: 2013
Journal: J Cell Sci
Title: Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia.
Volume: 126
Issue: Pt 19
Pages: 4479-89
Publication  
First Author: Huang D
Year: 2012
Journal: Mol Pain
Title: Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura.
Volume: 8
Pages: 66
Publication
First Author: Feketa VV
Year: 2013
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.
Volume: 305
Issue: 9
Pages: R1040-50
Publication
First Author: Pagano E
Year: 2023
Journal: Br J Pharmacol
Title: TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β-catenin signalling.
Volume: 180
Issue: 2
Pages: 235-251
Publication
First Author: Feng J
Year: 2023
Journal: Invest Ophthalmol Vis Sci
Title: Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea.
Volume: 64
Issue: 15
Pages: 24
Publication
First Author: Reimúndez A
Year: 2018
Journal: J Neurosci
Title: Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice.
Volume: 38
Issue: 15
Pages: 3643-3656
Publication  
First Author: Schecterson LC
Year: 2020
Journal: Mol Vis
Title: TRPV1, TRPA1, and TRPM8 are expressed in axon terminals in the cornea: TRPV1 axons contain CGRP and secretogranin II; TRPA1 axons contain secretogranin 3.
Volume: 26
Pages: 576-587
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Bouvier V
Year: 2018
Journal: J Invest Dermatol
Title: Merkel Cells Sense Cooling with TRPM8 Channels.
Volume: 138
Issue: 4
Pages: 946-956
Publication  
First Author: Kim YS
Year: 2015
Journal: Neuroscience
Title: Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse.
Volume: 303
Pages: 378-88
Publication
First Author: Kim YS
Year: 2014
Journal: PLoS One
Title: Central connectivity of transient receptor potential melastatin 8-expressing axons in the brain stem and spinal dorsal horn.
Volume: 9
Issue: 4
Pages: e94080
Publication
First Author: Knowlton WM
Year: 2013
Journal: J Neurosci
Title: A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia.
Volume: 33
Issue: 7
Pages: 2837-48
Publication  
First Author: Ongun S
Year: 2018
Journal: Commun Biol
Title: Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314.
Volume: 1
Pages: 53
Publication
First Author: Shapovalov G
Year: 2013
Journal: Cell Rep
Title: Opiates modulate thermosensation by internalizing cold receptor TRPM8.
Volume: 4
Issue: 3
Pages: 504-15
Publication
First Author: Matos-Cruz V
Year: 2017
Journal: Cell Rep
Title: Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters.
Volume: 21
Issue: 12
Pages: 3329-3337
Publication  
First Author: Horikawa R
Year: 2022
Journal: Neurosci Lett
Title: Effects of peripheral administration of lipopolysaccharide on chronic sickness responses in TRPM8-deficient mice.
Volume: 790
Pages: 136895
Publication
First Author: Khalil M
Year: 2016
Journal: Mucosal Immunol
Title: Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production.
Volume: 9
Issue: 6
Pages: 1500-1513
Publication
First Author: Gong K
Year: 2017
Journal: J Pain
Title: Sustained Morphine Administration Induces TRPM8-Dependent Cold Hyperalgesia.
Volume: 18
Issue: 2
Pages: 212-221
Publication
First Author: Robbins A
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents.
Volume: 53
Issue: 11
Pages: 7034-42
Publication  
First Author: Moriyama H
Year: 2021
Journal: Front Pharmacol
Title: Suppressive Effects of Transient Receptor Potential Melastatin 8 Agonist on Epileptiform Discharges and Epileptic Seizures.
Volume: 12
Pages: 766782
Publication  
First Author: Pezzoli M
Year: 2014
Journal: Sci Rep
Title: Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices.
Volume: 4
Pages: 6825
Publication
First Author: Beukema P
Year: 2018
Journal: J Comp Neurol
Title: TrpM8-mediated somatosensation in mouse neocortex.
Volume: 526
Issue: 9
Pages: 1444-1456
Publication
First Author: Dhaka A
Year: 2008
Journal: J Neurosci
Title: Visualizing cold spots: TRPM8-expressing sensory neurons and their projections.
Volume: 28
Issue: 3
Pages: 566-75
Publication  
First Author: Tsuneoka Y
Year: 2023
Journal: Neurosci Lett
Title: Characterization of TRPM8-expressing neurons in the adult mouse hypothalamus.
Volume: 814
Pages: 137463
Publication  
First Author: Moriyama H
Year: 2023
Journal: Front Pharmacol
Title: Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice.
Volume: 14
Pages: 1138673
Publication  
First Author: Li J
Year: 2024
Journal: J Neurosci
Title: Separation of Oral Cooling and Warming Requires TRPM8.
Volume: 44
Issue: 11
Publication
First Author: Caudle RM
Year: 2017
Journal: PLoS One
Title: Sex differences in mouse Transient Receptor Potential Cation Channel, Subfamily M, Member 8 expressing trigeminal ganglion neurons.
Volume: 12
Issue: 5
Pages: e0176753
Publication  
First Author: Tang Z
Year: 2013
Journal: Nat Commun
Title: Pirt functions as an endogenous regulator of TRPM8.
Volume: 4
Pages: 2179
Publication  
First Author: Ghosh D
Year: 2016
Journal: Nat Commun
Title: VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.
Volume: 7
Pages: 10489
Publication    
First Author: Janssens A
Year: 2016
Journal: Elife
Title: Definition of two agonist types at the mammalian cold-activated channel TRPM8.
Volume: 5
Publication
First Author: Gkika D
Year: 2020
Journal: FASEB J
Title: Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity.
Volume: 34
Issue: 6
Pages: 7483-7499
Publication
First Author: Vetter I
Year: 2013
Journal: J Neurosci
Title: Amplified cold transduction in native nociceptors by M-channel inhibition.
Volume: 33
Issue: 42
Pages: 16627-41
Publication
First Author: Mandadi S
Year: 2009
Journal: Neuroscience
Title: Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels.
Volume: 162
Issue: 4
Pages: 1377-97
Publication  
First Author: Memon T
Year: 2017
Journal: Neuroscience
Title: TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons.
Volume: 353
Pages: 76-86
Publication
First Author: Wang S
Year: 2017
Journal: EMBO Mol Med
Title: A clinical and mechanistic study of topical borneol-induced analgesia.
Volume: 9
Issue: 6
Pages: 802-815
Publication  
First Author: Lemon CH
Year: 2019
Journal: eNeuro
Title: The TRPA1 Ion Channel Contributes to Sensory-Guided Avoidance of Menthol in Mice.
Volume: 6
Issue: 6