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Search results 1 to 100 out of 967 for Trpv1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent ofvoltage-gated channels and comprises six putative transmembrane segments (S1-S6), intracellular N- and C-termini, and a pore-forming reentrant loop between S5 and S6 [].TRP channels represent a superfamily conserved from worms to humans that comprise seven subfamilies []: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin or long TRPs), TRPA (ankyrin, whose only member is Transient receptor potential cation channel subfamily A member 1, TrpA1), TRPP (polycystin), TRPML (mucolipin) and TRPN (Nomp-C homologues), which has a single member that can be found in worms, flies, and zebrafish. TRPs are classified essentially according to their primary amino acid sequence rather than selectivity or ligand affinity, due to their heterogeneous properties and complex regulation.TRP channels are involved in many physiological functions, ranging from pure sensory functions, such as pheromone signalling, taste transduction, nociception, and temperature sensation, over homeostatic functions, such as Ca2+ and Mg2+ reabsorption and osmoregulation, to many other motile functions, such as muscle contraction and vaso-motor control [].The TRPV (vanilloid) subfamily can be divided into two distinct groups. The first, which comprises TrpV1, TrpV2, TrpV3, and TrpV4, with nonselective cation conducting pores, has members which can be activated by temperature as well as chemical stimuli. They are involved in a range of functions including nociception, thermosensing and osmolarity sensing. The second group, which consists of TrpV5 and TrpV6, (also known as epithelial calcium channels 1 and 2), highly calcium selective, are involved in renal Ca2+ absorption/reabsorption [, ].TRPV1 was the first vanilloid receptor identified. It is a nonselective cation channel with a preference for calcium and is activated by noxious stimuli, heat, protons, pH 5.9, and various, mostly obnoxious, natural products []. TRPV1 is predominantly expressed in sensory neurons []and is believed to play a crucial role in temperature sensing and nociception [], qualifying therefore as a molecular target for pain treatment.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 531  
Fragment?: false
Publication
First Author: Phan TX
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Sex-dependent expression of TRPV1 in bladder arterioles.
Volume: 311
Issue: 5
Pages: F1063-F1073
Publication
First Author: Hanack C
Year: 2015
Journal: Cell
Title: GABA blocks pathological but not acute TRPV1 pain signals.
Volume: 160
Issue: 4
Pages: 759-70
Publication  
First Author: Basso L
Year: 2019
Journal: Sci Signal
Title: TRPV1 promotes opioid analgesia during inflammation.
Volume: 12
Issue: 575
Publication
First Author: Stemkowski P
Year: 2016
Journal: Cell Rep
Title: TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity.
Volume: 17
Issue: 11
Pages: 2901-2912
Publication
First Author: Lagerström MC
Year: 2010
Journal: Neuron
Title: VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.
Volume: 68
Issue: 3
Pages: 529-42
Publication
First Author: Lapointe TK
Year: 2015
Journal: Am J Physiol Gastrointest Liver Physiol
Title: TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.
Volume: 309
Issue: 2
Pages: G87-99
Publication
First Author: Cavanaugh DJ
Year: 2011
Journal: J Neurosci
Title: Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.
Volume: 31
Issue: 13
Pages: 5067-77
Publication  
First Author: Wang S
Year: 2019
Journal: Front Physiol
Title: TRPV1 and TRPV1-Expressing Nociceptors Mediate Orofacial Pain Behaviors in a Mouse Model of Orthodontic Tooth Movement.
Volume: 10
Pages: 1207
Publication  
First Author: Lakk M
Year: 2018
Journal: Front Cell Neurosci
Title: Polymodal TRPV1 and TRPV4 Sensors Colocalize but Do Not Functionally Interact in a Subpopulation of Mouse Retinal Ganglion Cells.
Volume: 12
Pages: 353
Publication
First Author: Caterina MJ
Year: 2000
Journal: Science
Title: Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
Volume: 288
Issue: 5464
Pages: 306-13
Publication
First Author: Mishra SK
Year: 2011
Journal: EMBO J
Title: TRPV1-lineage neurons are required for thermal sensation.
Volume: 30
Issue: 3
Pages: 582-93
Publication
First Author: Spencer NJ
Year: 2018
Journal: Am J Physiol Gastrointest Liver Physiol
Title: CGRPα within the Trpv1-Cre population contributes to visceral nociception.
Volume: 314
Issue: 2
Pages: G188-G200
Publication
First Author: Tränkner D
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways.
Volume: 111
Issue: 31
Pages: 11515-20
Publication
First Author: Black CJ
Year: 2020
Journal: Sci Rep
Title: Automated and rapid self-report of nociception in transgenic mice.
Volume: 10
Issue: 1
Pages: 13215
Publication
First Author: Rogoz K
Year: 2015
Journal: PLoS One
Title: VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents.
Volume: 10
Issue: 1
Pages: e0116568
Publication  
First Author: Hong J
Year: 2020
Journal: Neurosci Lett
Title: Identification of Cardiac Expression Pattern of Transient Receptor Potential Vanilloid Type 1 (TRPV1) Receptor using a Transgenic Reporter Mouse Model.
Volume: 737
Pages: 135320
Publication  
First Author: Wang S
Year: 2020
Journal: eNeuro
Title: Ablation of TRPV1+ Afferent Terminals by Capsaicin Mediates Long-Lasting Analgesia for Trigeminal Neuropathic Pain.
Volume: 7
Issue: 3
Publication
First Author: Jeong JH
Year: 2018
Journal: PLoS Biol
Title: Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake.
Volume: 16
Issue: 4
Pages: e2004399
Publication
First Author: Cobos EJ
Year: 2018
Journal: Cell Rep
Title: Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling.
Volume: 22
Issue: 5
Pages: 1301-1312
Publication
First Author: Smith-Edwards KM
Year: 2019
Journal: Gastroenterology
Title: Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice.
Volume: 157
Issue: 2
Pages: 522-536.e2
Publication
First Author: Xie AX
Year: 2022
Journal: PLoS One
Title: Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain.
Volume: 17
Issue: 1
Pages: e0262769
Publication
First Author: Cavanaugh DJ
Year: 2011
Journal: J Neurosci
Title: Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons.
Volume: 31
Issue: 28
Pages: 10119-27
Publication  
First Author: Stanford KR
Year: 2019
Journal: Brain Res
Title: Antimycin A-induced mitochondrial dysfunction activates vagal sensory neurons via ROS-dependent activation of TRPA1 and ROS-independent activation of TRPV1.
Volume: 1715
Pages: 94-105
Publication
First Author: Luo X
Year: 2021
Journal: Neuron
Title: IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.
Volume: 109
Issue: 17
Pages: 2691-2706.e5
Publication
First Author: Patil MJ
Year: 2018
Journal: PLoS One
Title: Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines.
Volume: 13
Issue: 6
Pages: e0198601
Publication
First Author: Saloman JL
Year: 2016
Journal: J Neurosci
Title: Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons.
Volume: 36
Issue: 42
Pages: 10769-10781
Publication    
First Author: López Soto EJ
Year: 2020
Journal: Elife
Title: Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function.
Volume: 9
Publication
First Author: Shamsi F
Year: 2021
Journal: Nat Metab
Title: Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes.
Volume: 3
Issue: 4
Pages: 485-495
Publication
First Author: Wang F
Year: 2018
Journal: Cell Rep
Title: Sensory Afferents Use Different Coding Strategies for Heat and Cold.
Volume: 23
Issue: 7
Pages: 2001-2013
Publication
First Author: Makadia PA
Year: 2018
Journal: J Neurosci
Title: Optogenetic Activation of Colon Epithelium of the Mouse Produces High-Frequency Bursting in Extrinsic Colon Afferents and Engages Visceromotor Responses.
Volume: 38
Issue: 25
Pages: 5788-5798
Publication  
First Author: DuBreuil DM
Year: 2021
Journal: Cell Rep Methods
Title: A high-content platform for physiological profiling and unbiased classification of individual neurons.
Volume: 1
Issue: 1
Publication
First Author: Eskilsson A
Year: 2021
Journal: J Neurosci
Title: Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP3 Receptors.
Volume: 41
Issue: 24
Pages: 5206-5218
Publication  
First Author: Kim SH
Year: 2022
Journal: eNeuro
Title: Mapping of the Sensory Innervation of the Mouse Lung by Specific Vagal and Dorsal Root Ganglion Neuronal Subsets.
Volume: 9
Issue: 2
Publication
First Author: Alvarez FJ
Year: 2004
Journal: J Comp Neurol
Title: Vesicular glutamate transporters in the spinal cord, with special reference to sensory primary afferent synapses.
Volume: 472
Issue: 3
Pages: 257-80
Publication
First Author: Davies AJ
Year: 2019
Journal: Cell
Title: Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury.
Volume: 176
Issue: 4
Pages: 716-728.e18
Publication  
First Author: Matsuwaki T
Year: 2017
Journal: Brain Behav Immun
Title: Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses.
Volume: 66
Pages: 165-176
Publication
First Author: Browne LE
Year: 2017
Journal: Cell Rep
Title: Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses.
Volume: 20
Issue: 1
Pages: 89-98
Publication  
First Author: Xu C
Year: 2021
Journal: J Exp Med
Title: Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage.
Volume: 218
Issue: 1
Publication
First Author: Ghitani N
Year: 2017
Journal: Neuron
Title: Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair Pull.
Volume: 95
Issue: 4
Pages: 944-954.e4
Publication
First Author: Corder G
Year: 2017
Journal: Nat Med
Title: Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
Volume: 23
Issue: 2
Pages: 164-173
Publication
First Author: Beaulieu-Laroche L
Year: 2020
Journal: Cell
Title: TACAN Is an Ion Channel Involved in Sensing Mechanical Pain.
Volume: 180
Issue: 5
Pages: 956-967.e17
Publication
First Author: Abdus-Saboor I
Year: 2019
Journal: Cell Rep
Title: Development of a Mouse Pain Scale Using Sub-second Behavioral Mapping and Statistical Modeling.
Volume: 28
Issue: 6
Pages: 1623-1634.e4
Publication
First Author: Eskilsson A
Year: 2014
Journal: J Neurosci
Title: Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis.
Volume: 34
Issue: 48
Pages: 15957-61
Publication  
First Author: Kim SH
Year: 2020
Journal: eNeuro
Title: Mapping of Sensory Nerve Subsets within the Vagal Ganglia and the Brainstem Using Reporter Mice for Pirt, TRPV1, 5-HT3, and Tac1 Expression.
Volume: 7
Issue: 2
Publication
First Author: Petitjean H
Year: 2019
Journal: Cell Rep
Title: Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons.
Volume: 28
Issue: 6
Pages: 1429-1438.e4
Publication
First Author: Wang K
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle.
Volume: 117
Issue: 10
Pages: 5402-5408
Publication  
First Author: Mailhot B
Year: 2020
Journal: J Exp Med
Title: Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases.
Volume: 217
Issue: 9
Publication
First Author: Solinski HJ
Year: 2019
Journal: Cell Rep
Title: Nppb Neurons Are Sensors of Mast Cell-Induced Itch.
Volume: 26
Issue: 13
Pages: 3561-3573.e4
Publication
First Author: Delvalle NM
Year: 2018
Journal: Cell Mol Gastroenterol Hepatol
Title: Communication Between Enteric Neurons, Glia, and Nociceptors Underlies the Effects of Tachykinins on Neuroinflammation.
Volume: 6
Issue: 3
Pages: 321-344
Publication
First Author: Pinho-Ribeiro FA
Year: 2018
Journal: Cell
Title: Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection.
Volume: 173
Issue: 5
Pages: 1083-1097.e22
Publication
First Author: Borgmann D
Year: 2021
Journal: Cell Metab
Title: Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism.
Volume: 33
Issue: 7
Pages: 1466-1482.e7
Publication
First Author: Klawonn AM
Year: 2021
Journal: Immunity
Title: Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons.
Volume: 54
Issue: 2
Pages: 225-234.e6
Publication
First Author: Mishra SK
Year: 2020
Journal: Cell Rep
Title: Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.
Volume: 31
Issue: 1
Pages: 107472
Publication
First Author: Angueira AR
Year: 2021
Journal: Nat Metab
Title: Defining the lineage of thermogenic perivascular adipose tissue.
Volume: 3
Issue: 4
Pages: 469-484
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: Trpv1
Protein
Organism: Mus musculus
Length: 839  
Fragment?: false
Publication
First Author: Roman K
Year: 2020
Journal: Prostate
Title: TRPV1 in experimental autoimmune prostatitis.
Volume: 80
Issue: 1
Pages: 28-37
Allele
Name: transient receptor potential cation channel, subfamily V, member 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
Publication
First Author: Tominaga M
Year: 1998
Journal: Neuron
Title: The cloned capsaicin receptor integrates multiple pain-producing stimuli.
Volume: 21
Issue: 3
Pages: 531-43
Publication
First Author: Caterina MJ
Year: 1997
Journal: Nature
Title: The capsaicin receptor: a heat-activated ion channel in the pain pathway.
Volume: 389
Issue: 6653
Pages: 816-24
Publication  
First Author: Jia YF
Year: 2015
Journal: Front Cell Neurosci
Title: Interference of TRPV1 function altered the susceptibility of PTZ-induced seizures.
Volume: 9
Pages: 20
Protein
Organism: Mus musculus
Length: 474  
Fragment?: true
Protein
Organism: Mus musculus
Length: 471  
Fragment?: false
Publication
First Author: Tian YH
Year: 2018
Journal: Sci Rep
Title: Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects.
Volume: 8
Issue: 1
Pages: 882
Publication
First Author: Poitras T
Year: 2019
Journal: Mol Neurobiol
Title: Selective Sensory Axon Reinnervation and TRPV1 Activation.
Volume: 56
Issue: 10
Pages: 7144-7158
Publication
First Author: Wang SE
Year: 2017
Journal: Cell Rep
Title: TRPV1 Regulates Stress Responses through HDAC2.
Volume: 19
Issue: 2
Pages: 401-412
Protein
Organism: Mus musculus
Length: 779  
Fragment?: false
Protein
Organism: Mus musculus
Length: 839  
Fragment?: false
Publication
First Author: Alter BJ
Year: 2008
Journal: Neuron
Title: Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity.
Volume: 57
Issue: 5
Pages: 629-31
Publication
First Author: Vriens J
Year: 2009
Journal: Mol Pharmacol
Title: Pharmacology of vanilloid transient receptor potential cation channels.
Volume: 75
Issue: 6
Pages: 1262-79
Publication  
First Author: Samanta A
Year: 2018
Journal: Subcell Biochem
Title: Transient Receptor Potential (TRP) Channels.
Volume: 87
Pages: 141-165
Publication
First Author: Sondermann JR
Year: 2019
Journal: Pain
Title: Vti1b promotes TRPV1 sensitization during inflammatory pain.
Volume: 160
Issue: 2
Pages: 508-527
Publication
First Author: Gaudet R
Year: 2008
Journal: J Physiol
Title: TRP channels entering the structural era.
Volume: 586
Issue: 15
Pages: 3565-75
Publication
First Author: Latorre R
Year: 2009
Journal: Q Rev Biophys
Title: Structure-functional intimacies of transient receptor potential channels.
Volume: 42
Issue: 3
Pages: 201-46
Publication
First Author: Gees M
Year: 2010
Journal: Cold Spring Harb Perspect Biol
Title: The role of transient receptor potential cation channels in Ca2+ signaling.
Volume: 2
Issue: 10
Pages: a003962
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Page AJ
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: The TRPV1 channel regulates glucose metabolism.
Volume: 317
Issue: 4
Pages: E667-E676
Publication
First Author: Zhong B
Year: 2019
Journal: In Vivo
Title: TRPV1 Mediates Glucose-induced Insulin Secretion Through Releasing Neuropeptides.
Volume: 33
Issue: 5
Pages: 1431-1437
Publication
First Author: Chung MK
Year: 2008
Journal: Nat Neurosci
Title: TRPV1 shows dynamic ionic selectivity during agonist stimulation.
Volume: 11
Issue: 5
Pages: 555-64
Publication
First Author: Christoph T
Year: 2008
Journal: Mol Cell Neurosci
Title: Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice.
Volume: 37
Issue: 3
Pages: 579-89
Publication  
First Author: McGrady NR
Year: 2020
Journal: Front Physiol
Title: TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma.
Volume: 11
Pages: 249
GXD Expression      
Probe: MGI:6185909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191514
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Trpv1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6185909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191514
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Trpv1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6185909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191514
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Trpv1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6185909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191514
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Trpv1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6185909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191514
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Trpv1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6185909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191514
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Trpv1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6185909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191514
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Trpv1
Detected: true
Specimen Num: 7
Publication
First Author: Lu J
Year: 2021
Journal: EMBO Rep
Title: TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease.
Volume: 22
Issue: 6
Pages: e52013
Publication
First Author: Gibson HE
Year: 2008
Journal: Neuron
Title: TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Volume: 57
Issue: 5
Pages: 746-59
Publication
First Author: Yin S
Year: 2013
Journal: J Clin Invest
Title: Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.
Volume: 123
Issue: 9
Pages: 3941-51