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Search results 1 to 100 out of 780 for Tsc2

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Hits by Strain

Type Details Score
Gene
7249 | TSC2
Type: gene
Organism: human
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Gene
100170546 | tsc2
Type: gene
Organism: frog, western clawed
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Gene
24855 | Tsc2
Type: gene
Organism: rat
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Gene
468086 | TSC2
Type: gene
Organism: chimpanzee
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Gene
479883 | TSC2
Type: gene
Organism: dog, domestic
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Gene
504985 | TSC2
Type: gene
Organism: cattle
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Gene
416552 | TSC2
Type: gene
Organism: chicken
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Gene
567524 | tsc2
Type: gene
Organism: zebrafish
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Gene
694965 | TSC2
Type: gene
Organism: macaque, rhesus
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HT Sample
TSC2
         
Organism Name: mouse, laboratory
Curation Status: Not curated (Transgenic sample)
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Protein Coding Gene
MGI:102548 | Tsc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
38107199 | J:350855
First Author: Riley VA
Year: 2023
Journal: iScience
Title: Tsc2 coordinates neuroprogenitor differentiation.
Volume: 26
Issue: 12
Pages: 108442
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Publication
41255962 | J:376445
 
First Author: McCoy C
Year: 2025
Journal: Front Mol Neurosci
Title: Focal postnatal deletion of Tsc2 causes epilepsy.
Volume: 18
Pages: 1686023
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Publication
35005118 | J:355132
First Author: Kumar P
Year: 2022
Journal: Genes Dis
Title: Tsc2 mutation induces renal tubular cell nonautonomous disease.
Volume: 9
Issue: 1
Pages: 187-200
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Publication
17245776 | J:121748
First Author: Hernandez O
Year: 2007
Journal: Genesis
Title: Generation of a conditional disruption of the Tsc2 gene.
Volume: 45
Issue: 2
Pages: 101-6
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Publication
36759189 | J:350824
 
First Author: Dusing M
Year: 2023
Journal: eNeuro
Title: Neurovascular Development in Pten and Tsc2 Mouse Mutants.
Volume: 10
Issue: 2
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Publication
36277492 | J:369587
 
First Author: Riley VA
Year: 2022
Journal: Front Mol Neurosci
Title: Tsc2 shapes olfactory bulb granule cell molecular and morphological characteristics.
Volume: 15
Pages: 970357
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Publication
33401933 | J:371896
First Author: Oeing CU
Year: 2021
Journal: Circ Res
Title: MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury.
Volume: 128
Issue: 5
Pages: 639-651
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Publication
30700906 | J:286196
First Author: Ranek MJ
Year: 2019
Journal: Nature
Title: PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Volume: 566
Issue: 7743
Pages: 264-269
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Publication
29509898 | J:261762
First Author: Og?rek B
Year: 2018
Journal: Hum Mol Genet
Title: TSC2 regulates microRNA biogenesis via mTORC1 and GSK3?.
Volume: 27
Issue: 9
Pages: 1654-1663
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Publication
26734657 | J:377856
First Author: Carson RP
Year: 2015
Journal: Ann Clin Transl Neurol
Title: Hypomyelination following deletion of Tsc2 in oligodendrocyte precursors.
Volume: 2
Issue: 12
Pages: 1041-54
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Publication
23604129 | J:309778
First Author: Guenther GG
Year: 2014
Journal: Oncogene
Title: Loss of TSC2 confers resistance to ceramide and nutrient deprivation.
Volume: 33
Issue: 14
Pages: 1776-87
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Publication
19357198 | J:149326
First Author: Pollizzi K
Year: 2009
Journal: Hum Mol Genet
Title: A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Volume: 18
Issue: 13
Pages: 2378-87
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Publication
8833243 | J:32010
First Author: Olsson PG
Year: 1996
Journal: Mamm Genome
Title: Expression and differential splicing of the mouse TSC2 homolog.
Volume: 7
Issue: 3
Pages: 212-5
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Publication
26868506 | J:236273
 
First Author: Demetriades C
Year: 2016
Journal: Nat Commun
Title: Lysosomal recruitment of TSC2 is a universal response to cellular stress.
Volume: 7
Pages: 10662
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Publication
22923640 | J:193437
First Author: Moir LM
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TSC2 modulates cell adhesion and migration via integrin-?1?1.
Volume: 303
Issue: 8
Pages: L703-10
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Publication
20145209 | J:260298
First Author: Kuo HP
Year: 2010
Journal: Sci Signal
Title: ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Volume: 3
Issue: 108
Pages: ra9
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Publication
28695825 | J:257092
   
First Author: Klover PJ
Year: 2017
Journal: Elife
Title: Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3.
Volume: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191517
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Tsc2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191517
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Tsc2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191517
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Tsc2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191517
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Tsc2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191517
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Tsc2
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191517
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Tsc2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191517
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Tsc2
Detected: true
Specimen Num: 7
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Publication
21613414 | J:175260
First Author: Buller CL
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: GLUT1 enhances mTOR activity independently of TSC2 and AMPK.
Volume: 301
Issue: 3
Pages: F588-96
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Publication
34253722 | J:307919
First Author: Alesi N
Year: 2021
Journal: Nat Commun
Title: TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Volume: 12
Issue: 1
Pages: 4245
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Publication
24591652 | J:213670
First Author: Riddle RC
Year: 2014
Journal: Mol Cell Biol
Title: Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis.
Volume: 34
Issue: 10
Pages: 1850-62
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Publication
21205090 | J:370710
First Author: Zhang D
Year: 2011
Journal: Cancer Sci
Title: Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice.
Volume: 102
Issue: 4
Pages: 720-7
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Publication
23359422 | J:195049
First Author: Fu C
Year: 2013
Journal: Genesis
Title: Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.
Volume: 51
Issue: 4
Pages: 284-92
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Publication
25613864 | J:220337
First Author: Rozas NS
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation.
Volume: 457
Issue: 4
Pages: 635-9
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Publication
35288456 | J:322886
 
First Author: Dunkerly-Eyring BL
Year: 2022
Journal: Life Sci Alliance
Title: Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt.
Volume: 5
Issue: 6
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Publication
36357396 | J:331095
First Author: Asrani K
Year: 2022
Journal: Nat Commun
Title: An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss.
Volume: 13
Issue: 1
Pages: 6808
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Publication
15851026 | J:120197
First Author: Ma L
Year: 2005
Journal: Cell
Title: Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Volume: 121
Issue: 2
Pages: 179-93
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Publication
20160076 | J:158578
First Author: Alexander A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Volume: 107
Issue: 9
Pages: 4153-8
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Publication
23749404 | J:203971
First Author: Mietzsch U
Year: 2013
Journal: J Comp Neurol
Title: Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants.
Volume: 521
Issue: 16
Pages: 3817-31
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Publication
21886784 | J:176342
First Author: Koyanagi M
Year: 2011
Journal: PLoS One
Title: Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.
Volume: 6
Issue: 8
Pages: e23238
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Publication
23820898 | J:221228
First Author: Prizant H
Year: 2013
Journal: Mol Endocrinol
Title: Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.
Volume: 27
Issue: 9
Pages: 1403-14
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Publication
26693177 | J:239993
 
First Author: Crowell B
Year: 2015
Journal: eNeuro
Title: Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).
Volume: 2
Issue: 6
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Publication
40939191 | J:376183
First Author: Cui G
Year: 2025
Journal: Cancer Res
Title: Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma.
Volume: 85
Issue: 24
Pages: 5049-5065
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Publication
36400753 | J:334189
First Author: Liu X
Year: 2022
Journal: Cell Death Dis
Title: Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice.
Volume: 13
Issue: 11
Pages: 972
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Publication
11741832 | J:73510
First Author: Nellist M
Year: 2001
Journal: Hum Mol Genet
Title: TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex.
Volume: 10
Issue: 25
Pages: 2889-98
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Publication
10827137 | J:62413
First Author: Pasumarthi KB
Year: 2000
Journal: Circ Res
Title: Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene.
Volume: 86
Issue: 10
Pages: 1069-77
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Publication
27542907 | J:250631
First Author: Garc?a-Aguilar A
Year: 2016
Journal: Biochim Biophys Acta
Title: TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy.
Volume: 1863
Issue: 11
Pages: 2658-2667
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Publication
40480230 | J:373020
First Author: Cormerais Y
Year: 2025
Journal: Dev Cell
Title: AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth.
Volume: 60
Issue: 19
Pages: 2544-2557.e7
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Publication
32781001 | J:301371
 
First Author: Iffland PH 2nd
Year: 2020
Journal: Exp Neurol
Title: Dynamic analysis of 4E-BP1 phosphorylation in neurons with Tsc2 or Depdc5 knockout.
Volume: 334
Pages: 113432
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Publication
27768862 | J:238741
First Author: Ren S
Year: 2016
Journal: Am J Pathol
Title: Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.
Volume: 186
Issue: 12
Pages: 3261-3272
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Publication
36586433 | J:339842
 
First Author: Brazill JM
Year: 2023
Journal: Mol Metab
Title: Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity.
Volume: 68
Pages: 101664
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Publication
23123587 | J:197492
 
First Author: Reith RM
Year: 2013
Journal: Neurobiol Dis
Title: Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex.
Volume: 51
Pages: 93-103
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Publication
31182472 | J:277323
 
First Author: Carlin D
Year: 2019
Journal: eNeuro
Title: Nociceptor Deletion of Tsc2 Enhances Axon Regeneration by Inducing a Conditioning Injury Response in Dorsal Root Ganglia.
Volume: 6
Issue: 3
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Publication
30508035 | J:277580
First Author: M A S
Year: 2019
Journal: Carcinogenesis
Title: Heterozygous Tsc2 (Tsc2+/-) mouse model to study induced renal cancer in response to ionizing radiation at low doses.
Volume: 40
Issue: 6
Pages: 782-790
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Publication
37788104 | J:343526
 
First Author: Patel CH
Year: 2023
Journal: JCI Insight
Title: TSC2 S1365A mutation potently regulates CD8+ T cell function and differentiation and improves adoptive cellular cancer therapy.
Volume: 8
Issue: 21
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Publication
32912901 | J:303713
First Author: Van Nostrand JL
Year: 2020
Journal: Genes Dev
Title: AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
Volume: 34
Issue: 19-20
Pages: 1330-1344
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Publication
10096549 | J:52464
First Author: Kobayashi T
Year: 1999
Journal: Cancer Res
Title: Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice.
Volume: 59
Issue: 6
Pages: 1206-11
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Publication
29766046 | J:266779
 
First Author: Carlin D
Year: 2018
Journal: eNeuro
Title: Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat.
Volume: 5
Issue: 2
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Publication
16027168 | J:100094
First Author: Ma L
Year: 2005
Journal: Genes Dev
Title: Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.
Volume: 19
Issue: 15
Pages: 1779-86
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Publication
17077083 | J:388360
First Author: Cao Y
Year: 2006
Journal: J Biol Chem
Title: Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.
Volume: 281
Issue: 52
Pages: 40242-51
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Publication
25189766 | J:317521
First Author: Kaneko-Tarui T
Year: 2014
Journal: Mol Hum Reprod
Title: Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in M?llerian duct mesenchyme-derived myometria.
Volume: 20
Issue: 11
Pages: 1126-34
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Publication
26837766 | J:235545
First Author: D'Armiento J
Year: 2016
Journal: Cancer Res
Title: Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation.
Volume: 76
Issue: 4
Pages: 844-54
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Publication
35275792 | J:373136
First Author: Wang Y
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa.
Volume: 119
Issue: 11
Pages: e2118479119
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Publication
19150975 | J:146159
First Author: Way SW
Year: 2009
Journal: Hum Mol Genet
Title: Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse.
Volume: 18
Issue: 7
Pages: 1252-65
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Publication
21062901 | J:167241
First Author: Zeng LH
Year: 2011
Journal: Hum Mol Genet
Title: Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.
Volume: 20
Issue: 3
Pages: 445-54
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Publication
31461347 | J:290697
First Author: Gewin LS
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney.
Volume: 317
Issue: 5
Pages: F1201-F1210
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Publication
12504590 | J:81245
First Author: Onda H
Year: 2002
Journal: Mol Cell Neurosci
Title: Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway.
Volume: 21
Issue: 4
Pages: 561-74
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Publication
18587048 | J:137850
First Author: Rachdi L
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.
Volume: 105
Issue: 27
Pages: 9250-5
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Publication
10944454 | J:64047
First Author: Yamashita Y
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model.
Volume: 275
Issue: 1
Pages: 134-40
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Publication
20616807 | J:186339
First Author: Kang YJ
Year: 2011
Journal: Cell Death Differ
Title: The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Volume: 18
Issue: 1
Pages: 133-44
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Publication
23732640 | J:214196
First Author: Jacobs BL
Year: 2013
Journal: J Physiol
Title: Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome.
Volume: 591
Issue: 18
Pages: 4611-20
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Publication
11438694 | J:70463
First Author: Kobayashi T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.
Volume: 98
Issue: 15
Pages: 8762-7
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Publication
21827857 | J:179850
First Author: Ch?vere-Torres I
Year: 2012
Journal: Neurobiol Dis
Title: Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin.
Volume: 45
Issue: 1
Pages: 156-64
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Publication
7558029 | J:27400
First Author: Xu L
Year: 1995
Journal: Genomics
Title: Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues.
Volume: 27
Issue: 3
Pages: 475-80
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Publication
24529379 | J:338164
First Author: Menon S
Year: 2014
Journal: Cell
Title: Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Volume: 156
Issue: 4
Pages: 771-85
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Publication
15576369 | J:96943
First Author: Govindarajan B
Year: 2005
Journal: J Biol Chem
Title: Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain.
Volume: 280
Issue: 7
Pages: 5870-4
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Publication
20038814 | J:156692
First Author: Ma J
Year: 2010
Journal: J Clin Invest
Title: Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade.
Volume: 120
Issue: 1
Pages: 103-14
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Publication
22198573 | J:182345
First Author: Ch?vere-Torres I
Year: 2012
Journal: Neurobiol Dis
Title: Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ?RG mouse model of tuberous sclerosis complex.
Volume: 45
Issue: 3
Pages: 1101-10
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Publication
19738049 | J:152687
First Author: Bhatia B
Year: 2009
Journal: Cancer Res
Title: Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.
Volume: 69
Issue: 18
Pages: 7224-34
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Publication
22752306 | J:187405
First Author: Yuan E
Year: 2012
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