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Search results 1 to 100 out of 156 for Ttc21b

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0.061s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Snedeker J
Year: 2019
Journal: PLoS Genet
Title: Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants.
Volume: 15
Issue: 11
Pages: e1008467
Publication  
First Author: Driver AM
Year: 2017
Journal: J Dev Biol
Title: Ttc21b Is Required in Bergmann Glia for Proper Granule Cell Radial Migration.
Volume: 5
Issue: 4
Publication
First Author: Stottmann RW
Year: 2009
Journal: Dev Biol
Title: Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain.
Volume: 335
Issue: 1
Pages: 166-78
Publication      
First Author: Zhang Z
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for plus-sized.
Publication
First Author: Jacobs DT
Year: 2016
Journal: Dis Model Mech
Title: Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome.
Volume: 9
Issue: 7
Pages: 789-98
Publication    
First Author: Brooks ER
Year: 2020
Journal: Elife
Title: Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure.
Volume: 9
Publication
First Author: Mukhopadhyay S
Year: 2010
Journal: Genes Dev
Title: TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
Volume: 24
Issue: 19
Pages: 2180-93
Publication
First Author: Snedeker J
Year: 2017
Journal: PLoS One
Title: Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development.
Volume: 12
Issue: 3
Pages: e0173258
Publication
First Author: Schock EN
Year: 2017
Journal: PLoS One
Title: A tissue-specific role for intraflagellar transport genes during craniofacial development.
Volume: 12
Issue: 3
Pages: e0174206
Publication
First Author: Tran PV
Year: 2008
Journal: Nat Genet
Title: THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.
Volume: 40
Issue: 4
Pages: 403-410
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:5603184
Assay Type: RNA in situ
Annotation Date: 2014-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5603194
Age: embryonic day 9.5
Image: 2D middle
Specimen Label: 2D middle
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5603184
Assay Type: RNA in situ
Annotation Date: 2014-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1606915
Pattern: Diffuse
Stage: TS15
Assay Id: MGI:5603194
Age: embryonic day 9.5
Image: 2D middle
Note: Expression was diffuse in the axial ectoderm around the neural tube.
Specimen Label: 2D middle
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:5603184
Assay Type: RNA in situ
Annotation Date: 2014-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3275315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5603194
Age: embryonic day 9.5
Image: 2D middle
Specimen Label: 2D middle
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5603184
Assay Type: RNA in situ
Annotation Date: 2014-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647015
Pattern: Widespread
Stage: TS15
Assay Id: MGI:5603194
Age: embryonic day 9.5
Image: 2D middle
Note: Expression was widespread in the neural epithelium all along the anterior-posterior axis.
Specimen Label: 2D middle
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:5603184
Assay Type: RNA in situ
Annotation Date: 2014-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5603194
Age: embryonic day 8.5
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5603184
Assay Type: RNA in situ
Annotation Date: 2014-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607313
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:5603194
Age: embryonic day 8.5
Image: 2A
Note: Expression was detected in the anterior neural ectoderm.
Specimen Label: 2A
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5603184
Assay Type: RNA in situ
Annotation Date: 2014-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1664015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5603194
Age: embryonic day 9.5
Image: 2C
Note: Expression was robust.
Specimen Label: 2C
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:5603184
Assay Type: RNA in situ
Annotation Date: 2014-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5603194
Age: embryonic day 9.5
Image: 2B
Note: Expression was robust.
Specimen Label: 2B
Detected: true
Specimen Num: 2
Publication
First Author: Wang W
Year: 2020
Journal: FASEB J
Title: Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.
Volume: 34
Issue: 5
Pages: 6369-6381
Publication  
First Author: Pottorf TS
Year: 2020
Journal: JCI Insight
Title: MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
Volume: 5
Issue: 2
Publication
First Author: Allard BA
Year: 2021
Journal: Cell Mol Life Sci
Title: Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis.
Volume: 78
Issue: 7
Pages: 3743-3762
Publication  
First Author: Bumann EE
Year: 2022
Journal: J Dev Biol
Title: Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial Bone.
Volume: 10
Issue: 2
Publication
First Author: Idowu J
Year: 2018
Journal: Sci Rep
Title: Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease.
Volume: 8
Issue: 1
Pages: 3340
Publication
First Author: Hong W
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation.
Volume: 415
Issue: 4
Pages: 650-5
Publication
First Author: Hou Y
Year: 2007
Journal: J Cell Biol
Title: Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella.
Volume: 176
Issue: 5
Pages: 653-65
Publication
First Author: Fu W
Year: 2016
Journal: Cell Rep
Title: Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Volume: 17
Issue: 6
Pages: 1505-1517
Publication
First Author: Tran PV
Year: 2014
Journal: J Am Soc Nephrol
Title: Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models.
Volume: 25
Issue: 10
Pages: 2201-12
Publication
First Author: Herron BJ
Year: 2002
Journal: Nat Genet
Title: Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.
Volume: 30
Issue: 2
Pages: 185-9
Publication
First Author: Patterson VL
Year: 2009
Journal: Hum Mol Genet
Title: Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.
Volume: 18
Issue: 10
Pages: 1719-39
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Davis EE
Year: 2011
Journal: Nat Genet
Title: TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.
Volume: 43
Issue: 3
Pages: 189-96
DO Term
DO Term
Protein Domain
Type: Family
Description: This entry includes tetratricopeptide repeat proteins 21A (TTC21A) and 21B (TTC21B), and other homologues with numerous tetratricopeptide repeats. TTC21B is a component of the IFT complex A (IFT-A), which is required for retrograde ciliary transport. Intraflagellar transport (IFT) is required for cilium assembly and trafficking within cilia []. Several diseases results from mutations in the TTC21B gene including nephronophthisis 12, short-rib thoracic dysplasia 4 with or without polydactyly, and Joubert syndrome 11 [].
Allele
Name: tetratricopeptide repeat domain 21B; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Strain
Attribute String: chemically induced mutation, coisogenic, mutant strain
Genotype
Symbol: Ttc21b/Ttc21b
Background: C57BL/6J-Ttc21b
Zygosity: hm
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory