|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 91 out of 91 for Unc80

0.178s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
285175 | UNC80
Type: gene
Organism: human
•
•
•
•
•
Gene
779473 | unc80
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
488505 | UNC80
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
689991 | Unc80
Type: gene
Organism: rat
•
•
•
•
•
Gene
459911 | UNC80
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
536610 | UNC80
Type: gene
Organism: cattle
•
•
•
•
•
Gene
424003 | UNC80
Type: gene
Organism: chicken
•
•
•
•
•
Gene
100536734 | unc80
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
713007 | UNC80
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Coding Gene
MGI:2652882 | Unc80
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
32620897 | J:291847
First Author: Wie J
Year: 2020
Journal: Nat Commun
Title: Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
Volume: 11
Issue: 1
Pages: 3351
•
•
•
•
•
Publication
38892173 | J:349906
 
First Author: Chen HW
Year: 2024
Journal: Int J Mol Sci
Title: Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception.
Volume: 25
Issue: 11
•
•
•
•
•
Publication
21040849 | J:167858
First Author: Lu B
Year: 2010
Journal: Neuron
Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
Volume: 68
Issue: 3
Pages: 488-99
•
•
•
•
•
Publication
19092807 | J:145000
First Author: Lu B
Year: 2009
Journal: Nature
Title: Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
Volume: 457
Issue: 7230
Pages: 741-4
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0014225 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
ENSMUSG00200003972 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00195030084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00220034893 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00180031011 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00175000820 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_2652882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00215019685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSTCUG00005020594 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00210003085 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00185005057 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00205012455 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00230002026 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSUMUG00000002214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00190013847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSMUSG00225001276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSLUMG00010007345 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
ENSIUOG00005027712 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0027463 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
ENSMSPG00010017815 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
12477932 | J:82808
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
•
•
•
•
•
Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:384794
     
First Author: MGI and IMPC
Year: 2026
Journal: Database Release
Title: MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:389486
     
First Author: Mouse Genome Informatics and Ensembl Genome Database Project
Year: 2026
Journal: Database Release
Title: MGI Strain Genome Feature and Gene Model Load from Ensembl.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Protein
F6ZAB0
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR065547 | UNC-80
Type: Family
Description: UNC80 is a protein associated with the NALCN sodium channel complex. NALCN is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79, and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and is essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for the Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ].UNC80 is required for the activation of the NALCN channel by the neuropeptide substance P. NALCN activation is G-protein-independent but requires Src kinases: UNC80 binds Src kinases and recruits Src into the channel complex []. UNC80 is also required for the proper localisation of C. elegans NCA-1 and NCA-2, the homologues of the vertebrate cation leak channel NALCN [], and NCA-1 and UNC-80 regulate neuronal activity in C. elegans [].
•
•
•
•
•
Publication
19535918 | -
First Author: Wang H
Year: 2009
Journal: Channels (Austin)
Title: UNC80 functions as a scaffold for Src kinases in NALCN channel function.
Volume: 3
Issue: 3
Pages: 161-3
•
•
•
•
•
Publication
26708751 | J:231930
First Author: Stray-Pedersen A
Year: 2016
Journal: Am J Hum Genet
Title: Biallelic Mutations in UNC80 Cause Persistent Hypotonia, Encephalopathy, Growth Retardation, and Severe Intellectual Disability.
Volume: 98
Issue: 1
Pages: 202-9
•
•
•
•
•
Protein
I6L9J4
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
•
•
•
•
•
Protein
J9JI57
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
•
•
•
•
•
Protein
Q8BLN6
Organism: Mus musculus/domesticus
Length: 3326  
Fragment?: false
•
•
•
•
•
Protein
A0A1D5RLV3
Organism: Mus musculus/domesticus
Length: 3258  
Fragment?: false
•
•
•
•
•
Publication
17825559 | -
First Author: Jospin M
Year: 2007
Journal: Curr Biol
Title: UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
Volume: 17
Issue: 18
Pages: 1595-600
•
•
•
•
•
Publication
24904279 | -
 
First Author: Cochet-Bissuel M
Year: 2014
Journal: Front Cell Neurosci
Title: The sodium leak channel, NALCN, in health and disease.
Volume: 8
Pages: 132
•
•
•
•
•
Publication
31690562 | -
First Author: Zhou C
Year: 2020
Journal: G3 (Bethesda)
Title: The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate Caenorhabditis elegans Reversal Behavior.
Volume: 10
Issue: 1
Pages: 199-210
•
•
•
•
•
Publication
18336069 | -
First Author: Yeh E
Year: 2008
Journal: PLoS Biol
Title: A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
Volume: 6
Issue: 3
Pages: e55
•
•
•
•
•
Protein
J3QPJ0
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR024855 | UNC79
Type: Family
Description: The Protein unc-79 homolog is an auxiliary subunit of the NALCN sodium channel complex which is a voltage-gated ion channel responsible for the resting Na+ permeability that controls neuronal excitability [, ]. This complex is activated by neuropeptides substance P, neurotensin. In addition, the channel is inhibited by extracellular Ca2+ through the Ca2+-sensing receptor []. The human NALCN channelosome has been structurally characterised []. NALCN, UNC79 and UNC80 are essential, and mutations in human NALCN and UNC80 cause severe developmental and neurological disease. In the human NALCN channelosome structure UNC79 and UNC80 form an intertwined anti-parallel superhelical assembly, which docks intracellularly onto the NALCN-FAM155A pore-forming subcomplex () [].
•
•
•
•
•
Protein
J3QMH8
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
•
•
•
•
•
Publication
34929720 | -
First Author: Kschonsak M
Year: 2022
Journal: Nature
Title: Structural architecture of the human NALCN channelosome.
Volume: 603
Issue: 7899
Pages: 180-186
•
•
•
•
•
Protein Domain
IPR045852 | UNC80_central
Type: Domain
Description: This entry represents the central region of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex. Proteins containing this domain also include some uncharacterised proteins from fungi.UNC80 is a protein associated with the NALCN sodium channel complex. NALCN is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79, and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and is essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for the Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ].UNC80 is required for the activation of the NALCN channel by the neuropeptide substance P. NALCN activation is G-protein-independent but requires Src kinases: UNC80 binds Src kinases and recruits Src into the channel complex []. UNC80 is also required for the proper localisation of C. elegans NCA-1 and NCA-2, the homologues of the vertebrate cation leak channel NALCN [], and NCA-1 and UNC-80 regulate neuronal activity in C. elegans [].
•
•
•
•
•
Protein Domain
IPR046460 | UNC80_C
Type: Domain
Description: This entry represents the C-terminal domain of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex.UNC80 is a protein associated with the NALCN sodium channel complex. NALCN is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79, and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and is essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for the Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ].UNC80 is required for the activation of the NALCN channel by the neuropeptide substance P. NALCN activation is G-protein-independent but requires Src kinases: UNC80 binds Src kinases and recruits Src into the channel complex []. UNC80 is also required for the proper localisation of C. elegans NCA-1 and NCA-2, the homologues of the vertebrate cation leak channel NALCN [], and NCA-1 and UNC-80 regulate neuronal activity in C. elegans [].
•
•
•
•
•
Protein Domain
IPR060043 | HEAT_UNC79_C
Type: Domain
Description: This entry represents the C-terminal region of Protein unc-79 homolog from Homo sapiens and related proteins. In the Uncoordinated protein 79 (UNC79) from C.elegans, it spans nearly the entire length. This domain is composed of ��-helical HEAT repeats.The Protein unc-79 homolog is an auxiliary subunit of the NALCN sodium channel complex which is a voltage-gated ion channel responsible for the resting Na+ permeability that controls neuronal excitability [, ]. This complex is activated by neuropeptides substance P, neurotensin. In addition, the channel is inhibited by extracellular Ca2+ through the Ca2+-sensing receptor []. The human NALCN channelosome has been structurally characterised []. NALCN, UNC79 and UNC80 are essential, and mutations in human NALCN and UNC80 cause severe developmental and neurological disease. In the human NALCN channelosome structure UNC79 and UNC80 form an intertwined anti-parallel superhelical assembly, which docks intracellularly onto the NALCN-FAM155A pore-forming subcomplex () [].
•
•
•
•
•
Protein Domain
IPR031542 | UNC80_N
Type: Domain
Description: This entry represents the N-terminal domain of UNC80.UNC80 is a protein associated with the NALCN sodium channel complex. NALCN is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79, and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and is essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for the Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ].UNC80 is required for the activation of the NALCN channel by the neuropeptide substance P. NALCN activation is G-protein-independent but requires Src kinases: UNC80 binds Src kinases and recruits Src into the channel complex []. UNC80 is also required for the proper localisation of C. elegans NCA-1 and NCA-2, the homologues of the vertebrate cation leak channel NALCN [], and NCA-1 and UNC-80 regulate neuronal activity in C. elegans [].
•
•
•
•
•
Protein
E5CYJ9
Organism: Mus musculus/domesticus
Length: 2654  
Fragment?: false
•
•
•
•
•
Protein
G8JL63
Organism: Mus musculus/domesticus
Length: 2458  
Fragment?: false
•
•
•
•
•
Protein
J3QMK4
Organism: Mus musculus/domesticus
Length: 2654  
Fragment?: false
•
•
•
•
•
Protein
J3QP77
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
•
•
•
•
•
Protein
Q3UN20
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
•
•
•
•
•
Protein
Q0KK59
Organism: Mus musculus/domesticus
Length: 2596  
Fragment?: false
•
•
•
•
•
Protein
J3QNP0
Organism: Mus musculus/domesticus
Length: 2461  
Fragment?: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom