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Search results 1 to 100 out of 302 for Vdac1

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0.038s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: VDAC-1 (outer mitochondrial membrane protein porin 1) is a voltage dependent anion channel that mediates the flow of metabolites and ions across the outer mitochondrial membrane. VDAC-1 appeares to be a pro-apoptotic protein through oligomerisation []. It is implicated in cell death induction for its ability to interact with BAX, a protein belonging to the BCL-2 protein family. BAX plays a role in apoptosis and mitochondrial function regulation via multiple protein-protein interactions with BCL-2, BAK, BID or other members of the family [, ]. Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Baines CP
Year: 2007
Journal: Nat Cell Biol
Title: Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.
Volume: 9
Issue: 5
Pages: 550-5
Publication  
First Author: Wang J
Year: 2022
Journal: Life Sci Alliance
Title: VDAC1 negatively regulates melanogenesis through the Ca(2+)-calcineurin-CRTC1-MITF pathway.
Volume: 5
Issue: 10
Publication
First Author: Ben-Hail D
Year: 2016
Journal: Biochim Biophys Acta
Title: VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis.
Volume: 1863
Issue: 7 Pt A
Pages: 1612-23
Publication
First Author: Ham SJ
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.
Volume: 117
Issue: 8
Pages: 4281-4291
Publication
First Author: Gatliff J
Year: 2014
Journal: Autophagy
Title: TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control.
Volume: 10
Issue: 12
Pages: 2279-96
Publication
First Author: Anflous-Pharayra K
Year: 2007
Journal: Biochim Biophys Acta
Title: VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles.
Volume: 1767
Issue: 2
Pages: 136-42
Publication  
First Author: Nowak G
Year: 2020
Journal: Biomolecules
Title: Deletion of VDAC1 Hinders Recovery of Mitochondrial and Renal Functions After Acute Kidney Injury.
Volume: 10
Issue: 4
Publication
First Author: Israelson A
Year: 2010
Journal: Neuron
Title: Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS.
Volume: 67
Issue: 4
Pages: 575-87
Publication
First Author: Arif T
Year: 2016
Journal: Biochim Biophys Acta
Title: Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in cancer cell differentiation.
Volume: 1857
Issue: 8
Pages: 1228-1242
Publication
First Author: Shoshan-Barmatz V
Year: 2009
Journal: Biochim Biophys Acta
Title: Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase.
Volume: 1787
Issue: 5
Pages: 421-30
Publication  
First Author: Zhou H
Year: 2023
Journal: Metabolism
Title: TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury.
Volume: 140
Pages: 155383
Publication
First Author: Ujwal R
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating.
Volume: 105
Issue: 46
Pages: 17742-7
Publication
First Author: Manczak M
Year: 2012
Journal: Hum Mol Genet
Title: Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.
Volume: 21
Issue: 23
Pages: 5131-46
Publication  
First Author: Fernandez-Echevarria C
Year: 2014
Journal: Neuroscience
Title: Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease.
Volume: 278
Pages: 354-66
Publication
First Author: Shoshan-Barmatz V
Year: 2010
Journal: Biochim Biophys Acta
Title: Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo.
Volume: 1797
Issue: 6-7
Pages: 1281-91
Publication  
First Author: Li X
Year: 2022
Journal: EBioMedicine
Title: DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease.
Volume: 76
Pages: 103859
Publication
First Author: Hiller S
Year: 2008
Journal: Science
Title: Solution structure of the integral human membrane protein VDAC-1 in detergent micelles.
Volume: 321
Issue: 5893
Pages: 1206-10
Publication
First Author: De Pinto V
Year: 2010
Journal: FEBS Lett
Title: Voltage-dependent anion-selective channel (VDAC) in the plasma membrane.
Volume: 584
Issue: 9
Pages: 1793-9
Publication
First Author: Shoshan-Barmatz V
Year: 2004
Journal: Biochim Biophys Acta
Title: Subcellular localization of VDAC in mitochondria and ER in the cerebellum.
Volume: 1657
Issue: 2-3
Pages: 105-14
Publication
First Author: Choudhary OP
Year: 2014
Journal: Nat Struct Mol Biol
Title: Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1.
Volume: 21
Issue: 7
Pages: 626-32
Publication
First Author: De Pinto V
Year: 2010
Journal: Biochim Biophys Acta
Title: Characterization of human VDAC isoforms: a peculiar function for VDAC3?
Volume: 1797
Issue: 6-7
Pages: 1268-75
Publication
First Author: Maurya SR
Year: 2014
Journal: PLoS One
Title: Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial β-barrel anion channel hVDAC-2.
Volume: 9
Issue: 3
Pages: e92183
Publication  
First Author: Martel C
Year: 2014
Journal: Mitochondrion
Title: VDAC phosphorylation, a lipid sensor influencing the cell fate.
Volume: 19 Pt A
Pages: 69-77
Publication
First Author: Vander Heiden MG
Year: 2001
Journal: J Biol Chem
Title: Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane.
Volume: 276
Issue: 22
Pages: 19414-9
Publication
First Author: Malia TJ
Year: 2007
Journal: Biochemistry
Title: NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL.
Volume: 46
Issue: 2
Pages: 514-25
Protein
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
GXD Expression
Probe: MGI:6850041
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-07
Strength: Present
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6850046
Age: postnatal adult
Image: 4C
Note: Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells.
Specimen Label: 4C
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6850041
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-07
Strength: Present
Sex: Male
Emaps: EMAPS:2965528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6850046
Age: postnatal adult
Image: 4C
Note: Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells.
Specimen Label: 4C
Detected: true
Specimen Num: 2
Publication
First Author: Guan K
Year: 2013
Journal: Mol Cell Biol
Title: MAVS regulates apoptotic cell death by decreasing K48-linked ubiquitination of voltage-dependent anion channel 1.
Volume: 33
Issue: 16
Pages: 3137-49
Publication
First Author: Wu S
Year: 1999
Journal: Biochim Biophys Acta
Title: Each mammalian mitochondrial outer membrane porin protein is dispensable: effects on cellular respiration.
Volume: 1452
Issue: 1
Pages: 68-78
Publication
First Author: Anflous K
Year: 2001
Journal: J Biol Chem
Title: Altered mitochondrial sensitivity for ADP and maintenance of creatine-stimulated respiration in oxidative striated muscles from VDAC1-deficient mice.
Volume: 276
Issue: 3
Pages: 1954-60
Publication
First Author: Chanda D
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
Volume: 120
Issue: 20
Pages: e2219644120
Publication
First Author: Sampson MJ
Year: 1997
Journal: J Biol Chem
Title: The murine voltage-dependent anion channel gene family. Conserved structure and function.
Volume: 272
Issue: 30
Pages: 18966-73
Publication
First Author: Tan W
Year: 2013
Journal: J Neurosci
Title: Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS.
Volume: 33
Issue: 28
Pages: 11588-98
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Huizing M
Year: 1996
Journal: Pediatr Res
Title: Deficiency of the voltage-dependent anion channel: a novel cause of mitochondriopathy.
Volume: 39
Issue: 5
Pages: 760-5
GXD Expression    
Probe: MGI:2665325
Assay Type: Western blot
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2665335
Age: postnatal day 2
Image: 2
Specimen Label: Liver +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2665325
Assay Type: Western blot
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2665335
Age: postnatal day 2
Image: 2
Specimen Label: Liver +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2665325
Assay Type: Western blot
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2665335
Age: postnatal day 2
Image: 2
Specimen Label: Liver +/+
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2665325
Assay Type: Western blot
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2665335
Age: postnatal day 2
Image: 2
Specimen Label: Liver +/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2665325
Assay Type: Western blot
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:2665335
Age: postnatal day 2
Image: 2
Specimen Label: Brain +/+
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2665325
Assay Type: Western blot
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:2665335
Age: postnatal day 2
Image: 2
Specimen Label: Brain +/-
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2665325
Assay Type: Western blot
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:2665335
Age: postnatal day 2
Image: 2
Specimen Label: Brain +/+
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2665325
Assay Type: Western blot
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:2665335
Age: postnatal day 2
Image: 2
Specimen Label: Brain +/-
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5471577
Age: embryonic day 12.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5471577
Age: embryonic day 12.5
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5471577
Age: embryonic day 12.5
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783827
Stage: TS27
Assay Id: MGI:5471607
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:5471607
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:5471607
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:5471607
Age: postnatal day 30
Specimen Label: P30
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:5471607
Age: postnatal day 90
Specimen Label: P90
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:5471637
Age: postnatal day 30
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5471327
Assay Type: Western blot
Annotation Date: 2013-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:5471637
Age: postnatal day 30
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6401152
Assay Type: Western blot
Annotation Date: 2020-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:6401202
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6401152
Assay Type: Western blot
Annotation Date: 2020-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:6401202
Age: postnatal
Specimen Label: +/I121N
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6761596
Assay Type: Western blot
Annotation Date: 2021-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:6763932
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6761596
Assay Type: Western blot
Annotation Date: 2021-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:6763932
Age: postnatal day 1
Image: 1
Specimen Label: P1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6761596
Assay Type: Western blot
Annotation Date: 2021-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6763932
Age: postnatal day 7
Image: 1
Specimen Label: P7
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6761596
Assay Type: Western blot
Annotation Date: 2021-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6763932
Age: postnatal day 30
Image: 1
Specimen Label: P30
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6761596
Assay Type: Western blot
Annotation Date: 2021-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6763932
Age: postnatal day 60
Image: 1
Specimen Label: P60
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6761596
Assay Type: Western blot
Annotation Date: 2021-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6763932
Age: postnatal day 150
Image: 1
Specimen Label: P150
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6761596
Assay Type: Western blot
Annotation Date: 2021-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6763932
Age: postnatal day 300
Image: 1
Specimen Label: P300
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:7284767
Assay Type: Western blot
Annotation Date: 2022-06-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:7284797
Age: postnatal adult
Image: 2
Specimen Label: Total
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7470894
Assay Type: Western blot
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7470901
Age: embryonic day 10.5
Image: S4
Specimen Label: Wild-type
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7470894
Assay Type: Western blot
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7470901
Age: embryonic day 10.5
Image: S4
Specimen Label: Dnmt3a-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7470894
Assay Type: Western blot
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7470903
Age: embryonic day 10.5
Image: S4
Specimen Label: Wild-type
Detected: true
Specimen Num: 1