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Search results 1 to 88 out of 88 for Wdr24

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
84219 | WDR24
Type: gene
Organism: human
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Gene
749852 | WDR24
Type: gene
Organism: chimpanzee
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Gene
507528 | WDR24
Type: gene
Organism: cattle
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Gene
416406 | WDR24
Type: gene
Organism: chicken
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Gene
406336 | wdr24
Type: gene
Organism: zebrafish
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Gene
697343 | WDR24
Type: gene
Organism: macaque, rhesus
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Gene
100216081 | wdr24
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR037590 | WDR24
Type: Family
Description: This entry represents GATOR complex protein WDR24, a component of the GATOR subcomplex GATOR2. GATOR2 is part of the amino acid-sensing branch of the TORC1 signaling pathway, activating mTORC1 by inhibition of the GATOR1 subcomplex. The GATOR2 complex consists of MIOS, SEC13, SEH1L, WDR24 and WDR59 []. WDR24 has a secondary role in the GATOR-independent promotion of lysosome acidity and regulation of autophagic flux [].This entry also includes the restriction of telomere capping protein 1 (Rtc1 or Sea2) from the budding yeast Saccharomyces cerevisiae. It is a component of the SEA complex, termed as GATOR in mammals, which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis [, ].
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Gene
360497 | Wdr24
Type: gene
Organism: rat
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Gene
479891 | WDR24
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:2446285 | Wdr24
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27166823 | -
First Author: Cai W
Year: 2016
Journal: PLoS Genet
Title: The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function.
Volume: 12
Issue: 5
Pages: e1006036
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Protein
Q8CFJ9
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: false
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Publication
36732624 | J:338167
First Author: Dai X
Year: 2023
Journal: Nat Metab
Title: AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation.
Volume: 5
Issue: 2
Pages: 265-276
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Publication
25934700 | -
First Author: Dokudovskaya S
Year: 2015
Journal: J Cell Sci
Title: SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.
Volume: 128
Issue: 12
Pages: 2219-28
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Publication
21454883 | -
First Author: Dokudovskaya S
Year: 2011
Journal: Mol Cell Proteomics
Title: A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.
Volume: 10
Issue: 6
Pages: M110.006478
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Publication
23723238 | -
First Author: Bar-Peled L
Year: 2013
Journal: Science
Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Volume: 340
Issue: 6136
Pages: 1100-6
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Publication
36528027 | J:332370
First Author: Jiang C
Year: 2023
Journal: Mol Cell
Title: Ring domains are essential for GATOR2-dependent mTORC1 activation.
Volume: 83
Issue: 1
Pages: 74-89.e9
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Publication
31915252 | J:285299
First Author: Kowalsky AH
Year: 2020
Journal: J Biol Chem
Title: The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
Volume: 295
Issue: 7
Pages: 1769-1780
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Protein Coding Gene
MGP_CAROLIEiJ_G0021253 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023371 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2446285 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023777 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022597 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023070 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023170 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023277 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023189 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022346 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022660 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023571 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022164 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372288
Note: kidney
Specimen Label: JAX_1372288
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1925228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372286
Specimen Label: JAX_1372286
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1672828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372283
Specimen Label: JAX_1372283
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:3283428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372284
Specimen Label: JAX_1372284
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1842628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372280
Specimen Label: JAX_1372280
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372287
Specimen Label: JAX_1372287
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372285
Specimen Label: JAX_1372285
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372282
Specimen Label: JAX_1372282
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3590528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372273
Specimen Label: JAX_1372273
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372277
Specimen Label: JAX_1372277
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372281
Specimen Label: JAX_1372281
Specimen Num: 7
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372275
Specimen Label: JAX_1372275
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372276
Specimen Label: JAX_1372276
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692728
Age: postnatal adult
Image: JAX_1372279
Specimen Label: JAX_1372279
Detected: true
Specimen Num: 5
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Publication
12477932 | J:82808
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: GATOR complex protein WDR24
Type: chain
End: 790
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Protein Domain
IPR037593 | MIOS/Sea4
Type: Family
Description: This entry includes the GATOR complex protein MIOS, a component of the GATOR subcomplex GATOR2. The GATOR2 complex consists of MIOS, SEC13, SEH1L, WDR24 and WDR59, and it activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex [].This entry also includes Sea4 from budding yeasts. Sea4 is a subunit of SEACAT, a subcomplex of the SEA complex. It inhibits the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1-Npr2-Npr3) subcomplex [].
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Protein
Q8BV62
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: true
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Publication
23716719 | -
First Author: Panchaud N
Year: 2013
Journal: Sci Signal
Title: Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.
Volume: 6
Issue: 277
Pages: ra42
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Protein
Q8VE19
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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