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Search results 1 to 100 out of 319 for Wnk4

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0.037s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kahle KT
Year: 2003
Journal: Nat Genet
Title: WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
Volume: 35
Issue: 4
Pages: 372-6
Publication
First Author: Shibata S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
Volume: 110
Issue: 19
Pages: 7838-43
Publication
First Author: Yamauchi K
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice.
Volume: 332
Issue: 3
Pages: 750-5
Publication
First Author: Wilson FH
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.
Volume: 100
Issue: 2
Pages: 680-4
Publication
First Author: Yang CL
Year: 2007
Journal: J Clin Invest
Title: The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.
Volume: 117
Issue: 11
Pages: 3403-11
Publication
First Author: Ferdaus MZ
Year: 2019
Journal: Physiol Rep
Title: WNK4 limits distal calcium losses following acute furosemide treatment.
Volume: 7
Issue: 17
Pages: e14195
Publication
First Author: Yang SS
Year: 2010
Journal: Endocrinology
Title: Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice.
Volume: 151
Issue: 4
Pages: 1829-36
Publication      
First Author: Chen JC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: WNK4 kinase is a physiological intracellular chloride sensor.
Publication
First Author: Chu PY
Year: 2013
Journal: PLoS One
Title: SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.
Volume: 8
Issue: 9
Pages: e72969
Publication
First Author: Murillo-de-Ozores AR
Year: 2018
Journal: J Biol Chem
Title: C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity.
Volume: 293
Issue: 31
Pages: 12209-12221
Publication
First Author: Mori Y
Year: 2015
Journal: Biochem J
Title: Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.
Volume: 472
Issue: 1
Pages: 33-41
Publication
First Author: Kahle KT
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.
Volume: 101
Issue: 7
Pages: 2064-9
Publication
First Author: Yang YS
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Differential roles of WNK4 in regulation of NCC in vivo.
Volume: 314
Issue: 5
Pages: F999-F1007
Publication
First Author: Zhou B
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.
Volume: 302
Issue: 5
Pages: F533-9
Publication  
First Author: Takahashi D
Year: 2017
Journal: EBioMedicine
Title: WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.
Volume: 18
Pages: 118-127
Publication
First Author: Lalioti MD
Year: 2006
Journal: Nat Genet
Title: Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.
Volume: 38
Issue: 10
Pages: 1124-32
Publication  
First Author: Takahashi D
Year: 2014
Journal: Biosci Rep
Title: WNK4 is the major WNK positively regulating NCC in the mouse kidney.
Volume: 34
Issue: 3
Publication
First Author: Kasagi Y
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.
Volume: 487
Issue: 2
Pages: 368-374
Publication
First Author: Ring AM
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
Volume: 104
Issue: 10
Pages: 4020-4
Publication
First Author: Kahle KT
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
Volume: 101
Issue: 41
Pages: 14877-82
Publication
First Author: Susa K
Year: 2017
Journal: Biochem Biophys Res Commun
Title: WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.
Volume: 491
Issue: 3
Pages: 727-732
Publication
First Author: Susa K
Year: 2014
Journal: Hum Mol Genet
Title: Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.
Volume: 23
Issue: 19
Pages: 5052-60
Publication
First Author: Shibata S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.
Volume: 111
Issue: 43
Pages: 15556-61
Publication
First Author: Rozansky DJ
Year: 2009
Journal: J Clin Invest
Title: Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.
Volume: 119
Issue: 9
Pages: 2601-12
Publication
First Author: Subramanya AR
Year: 2009
Journal: J Biol Chem
Title: WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction.
Volume: 284
Issue: 27
Pages: 18471-80
Publication
First Author: Thomson MN
Year: 2020
Journal: Am J Physiol Renal Physiol
Title: WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia.
Volume: 318
Issue: 1
Pages: F216-F228
Publication
First Author: Wakabayashi M
Year: 2013
Journal: Cell Rep
Title: Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
Volume: 3
Issue: 3
Pages: 858-68
Publication
First Author: Ohta A
Year: 2009
Journal: Hum Mol Genet
Title: Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure.
Volume: 18
Issue: 20
Pages: 3978-86
Publication
First Author: Mukherjee A
Year: 2021
Journal: Am J Physiol Renal Physiol
Title: Roles of WNK4 and SPAK in K+-mediated dephosphorylation of the NaCl cotransporter.
Volume: 320
Issue: 5
Pages: F719-F733
Publication
First Author: Chiga M
Year: 2011
Journal: J Cell Sci
Title: Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.
Volume: 124
Issue: Pt 9
Pages: 1391-5
Publication
First Author: Ring AM
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.
Volume: 104
Issue: 10
Pages: 4025-9
Publication
First Author: Wu P
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.
Volume: 315
Issue: 2
Pages: F223-F230
Publication
First Author: Wilson FH
Year: 2001
Journal: Science
Title: Human hypertension caused by mutations in WNK kinases.
Volume: 293
Issue: 5532
Pages: 1107-12
Publication
First Author: Yang CL
Year: 2003
Journal: J Clin Invest
Title: WNK kinases regulate thiazide-sensitive Na-Cl cotransport.
Volume: 111
Issue: 7
Pages: 1039-45
Publication
First Author: Shibata S
Year: 2013
Journal: Cell Metab
Title: Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia.
Volume: 18
Issue: 5
Pages: 660-71
Publication
First Author: Terker AS
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo.
Volume: 315
Issue: 4
Pages: F781-F790
Publication
First Author: Castañeda-Bueno M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
Volume: 114
Issue: 5
Pages: E879-E886
Publication
First Author: Yang D
Year: 2011
Journal: J Clin Invest
Title: IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
Volume: 121
Issue: 3
Pages: 956-65
Publication
First Author: Zhang C
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.
Volume: 312
Issue: 4
Pages: F682-F688
Publication
First Author: Yang SS
Year: 2007
Journal: Cell Metab
Title: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.
Volume: 5
Issue: 5
Pages: 331-44
Publication
First Author: Park HW
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.
Volume: 108
Issue: 26
Pages: 10750-5
Publication
First Author: Chávez-Canales M
Year: 2014
Journal: Hypertension
Title: WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Volume: 64
Issue: 5
Pages: 1047-53
Publication
First Author: Dorwart MR
Year: 2007
Journal: J Physiol
Title: SLC26A9 is a Cl(-) channel regulated by the WNK kinases.
Volume: 584
Issue: Pt 1
Pages: 333-45
Publication
First Author: Chiga M
Year: 2008
Journal: Kidney Int
Title: Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.
Volume: 74
Issue: 11
Pages: 1403-9
Publication
First Author: Castañeda-Bueno M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.
Volume: 109
Issue: 20
Pages: 7929-34
Publication
First Author: Susa K
Year: 2012
Journal: Clin Exp Nephrol
Title: Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.
Volume: 16
Issue: 4
Pages: 530-8
Publication
First Author: Lee BH
Year: 2004
Journal: Mol Cell
Title: WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
Volume: 15
Issue: 5
Pages: 741-51
Publication
First Author: Melo Z
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
Volume: 305
Issue: 10
Pages: F1402-11
Publication
First Author: Rafael C
Year: 2018
Journal: Sci Rep
Title: Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4.
Volume: 8
Issue: 1
Pages: 3249
Publication
First Author: Castañeda-Bueno M
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved.
Volume: 306
Issue: 12
Pages: F1507-19
Publication  
First Author: Hung CM
Year: 2020
Journal: Biochem Pharmacol
Title: WNK4-SPAK modulates lipopolysaccharide-induced macrophage activation.
Volume: 171
Pages: 113738
Publication
First Author: Chung WY
Year: 2018
Journal: Mol Cell Biochem
Title: Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2.
Volume: 447
Issue: 1-2
Pages: 165-174
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Salzler HR
Year: 2007
Journal: Kidney Int
Title: Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus.
Volume: 72
Issue: 10
Pages: 1226-32
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_01
Specimen Label: euxassay_005023_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_02
Specimen Label: euxassay_005023_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_03
Specimen Label: euxassay_005023_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_03
Specimen Label: euxassay_005023_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_04
Specimen Label: euxassay_005023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_04
Specimen Label: euxassay_005023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1759623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_04
Specimen Label: euxassay_005023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1913123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_04
Specimen Label: euxassay_005023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1912923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_04
Specimen Label: euxassay_005023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1912723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_04
Specimen Label: euxassay_005023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1912523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_04
Specimen Label: euxassay_005023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1912323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_04
Specimen Label: euxassay_005023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_05
Specimen Label: euxassay_005023_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_05
Specimen Label: euxassay_005023_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1759623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_05
Specimen Label: euxassay_005023_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1912323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_05
Specimen Label: euxassay_005023_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1912523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_05
Specimen Label: euxassay_005023_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1912723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_05
Specimen Label: euxassay_005023_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1577287
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1912923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829222
Age: embryonic day 14.5
Image: euxassay_005023_05
Specimen Label: euxassay_005023_05
Detected: true
Specimen Num: 5