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Search results 1 to 100 out of 191 for Wrn

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Type Details Score
Gene
7486 | WRN
Type: gene
Organism: human
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Gene
505061 | WRN
Type: gene
Organism: cattle
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Gene
569495 | wrn
Type: gene
Organism: zebrafish
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Gene
695678 | WRN
Type: gene
Organism: macaque, rhesus
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Gene
493997 | WRN
Type: gene
Organism: dog, domestic
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Gene
472732 | WRN
Type: gene
Organism: chimpanzee
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Gene
290805 | Wrn
Type: gene
Organism: rat
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Gene
422505 | WRN
Type: gene
Organism: chicken
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Gene
734043 | wrn
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:109635 | Wrn
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10871373 | J:62921
First Author: Huang S
Year: 2000
Journal: Nucleic Acids Res
Title: Characterization of the human and mouse WRN 3'-->5' exonuclease.
Volume: 28
Issue: 12
Pages: 2396-405
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Publication
22301954 | J:205393
First Author: Moser R
Year: 2012
Journal: Mol Cancer Res
Title: MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
Volume: 10
Issue: 4
Pages: 535-45
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Publication
10757812 | J:61567
First Author: Lombard DB
Year: 2000
Journal: Mol Cell Biol
Title: Mutations in the WRN gene in mice accelerate mortality in a p53-null background.
Volume: 20
Issue: 9
Pages: 3286-91
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Publication
33907225 | J:313779
First Author: Kang SM
Year: 2021
Journal: Sci Rep
Title: Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
Volume: 11
Issue: 1
Pages: 9122
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Publication
26447695 | J:243692
First Author: Aumailley L
Year: 2015
Journal: PLoS One
Title: Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Volume: 10
Issue: 10
Pages: e0140292
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Publication
11863428 | J:75032
First Author: Xue Y
Year: 2002
Journal: Biochemistry
Title: A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities.
Volume: 41
Issue: 9
Pages: 2901-12
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Publication
29452565 | J:273808
First Author: Aumailley L
Year: 2018
Journal: FASEB J
Title: Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein.
Volume: 32
Issue: 7
Pages: 3623-3640
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Gene
56897 | WRNIP1
Type: gene
Organism: human
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Protein
O35948
Organism: Mus musculus/domesticus
Length: 643  
Fragment?: false
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Publication
16330174 | J:106446
First Author: Massip L
Year: 2006
Journal: Exp Gerontol
Title: Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue.
Volume: 41
Issue: 2
Pages: 157-68
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Publication
16264192 | J:102524
First Author: Laud PR
Year: 2005
Journal: Genes Dev
Title: Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
Volume: 19
Issue: 21
Pages: 2560-70
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Publication
10782115 | J:61954
First Author: Shen JC
Year: 2000
Journal: Trends Genet
Title: The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
Volume: 16
Issue: 5
Pages: 213-20
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Publication
15743673 | J:97864
First Author: Chang S
Year: 2005
Journal: Int J Biochem Cell Biol
Title: A mouse model of Werner Syndrome: what can it tell us about aging and cancer?
Volume: 37
Issue: 5
Pages: 991-9
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Publication
18588880 | J:137828
First Author: Kahyo T
Year: 2008
Journal: FEBS Lett
Title: Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein.
Volume: 582
Issue: 17
Pages: 2479-83
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Publication
29494634 | J:258744
First Author: Aumailley L
Year: 2018
Journal: PLoS One
Title: Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.
Volume: 13
Issue: 3
Pages: e0193170
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Publication
26521679 | J:325816
 
First Author: Aumailley L
Year: 2015
Journal: Exp Gerontol
Title: Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.
Volume: 72
Pages: 192-203
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Publication
15235603 | J:91715
First Author: Chang S
Year: 2004
Journal: Nat Genet
Title: Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
Volume: 36
Issue: 8
Pages: 877-82
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Publication
9681877 | J:48529
First Author: Wu J
Year: 1998
Journal: Mech Ageing Dev
Title: Effect of age and apoptosis on the mouse homologue of the huWRN gene.
Volume: 103
Issue: 1
Pages: 27-44
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Publication
11301316 | J:69903
First Author: Kawabe Yi
Year: 2001
Journal: J Biol Chem
Title: A novel protein interacts with the Werner's syndrome gene product physically and functionally.
Volume: 276
Issue: 23
Pages: 20364-9
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Publication
10806190 | J:118820
First Author: Kawabe Y
Year: 2000
Journal: J Biol Chem
Title: Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.
Volume: 275
Issue: 28
Pages: 20963-6
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Publication
22753033 | J:199686
First Author: Kanagaraj R
Year: 2012
Journal: Nucleic Acids Res
Title: Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.
Volume: 40
Issue: 17
Pages: 8449-59
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Publication
12803543 | J:85650
First Author: Bachrati CZ
Year: 2003
Journal: Biochem J
Title: RecQ helicases: suppressors of tumorigenesis and premature aging.
Volume: 374
Issue: Pt 3
Pages: 577-606
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Publication
15367665 | J:93016
First Author: Du X
Year: 2004
Journal: Mol Cell Biol
Title: Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
Volume: 24
Issue: 19
Pages: 8437-46
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Publication
9789047 | J:48424
First Author: Lebel M
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.
Volume: 95
Issue: 22
Pages: 13097-102
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Publication
18028256 | J:214652
First Author: Pignolo RJ
Year: 2008
Journal: Aging Cell
Title: Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis.
Volume: 7
Issue: 1
Pages: 23-31
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Publication
16195394 | J:103920
First Author: Deschênes F
Year: 2005
Journal: Hum Mol Genet
Title: In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.
Volume: 14
Issue: 21
Pages: 3293-308
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Publication
12707040 | J:83068
First Author: Lebel M
Year: 2003
Journal: Am J Pathol
Title: Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
Volume: 162
Issue: 5
Pages: 1559-69
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Publication
12242664 | J:79056
First Author: Leder A
Year: 2002
Journal: Oncogene
Title: Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis.
Volume: 21
Issue: 43
Pages: 6657-68
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Publication
11420665 | J:69659
First Author: Suzuki T
Year: 2001
Journal: Oncogene
Title: Diverged nuclear localization of Werner helicase in human and mouse cells.
Volume: 20
Issue: 20
Pages: 2551-8
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Publication
12944467 | J:85464
First Author: Cheng WH
Year: 2003
Journal: Mol Cell Biol
Title: Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution.
Volume: 23
Issue: 18
Pages: 6385-95
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Publication
11756244 | J:73919
First Author: Lebel M
Year: 2002
Journal: Carcinogenesis
Title: Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.
Volume: 23
Issue: 1
Pages: 213-6
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Publication
11280729 | J:68488
First Author: Lebel M
Year: 2001
Journal: Cancer Res
Title: Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.
Volume: 61
Issue: 5
Pages: 1816-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0030961 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033520 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033500 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033208 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109635 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034012 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033186 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033429 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034031 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032247 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021430 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032079 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9143515 | J:39875
First Author: Imamura O
Year: 1997
Journal: Genomics
Title: Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization.
Volume: 41
Issue: 2
Pages: 298-300
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Publication
28119126 | J:249400
 
First Author: Rekik K
Year: 2017
Journal: Behav Brain Res
Title: Cognitive deficit in hippocampal-dependent tasks in Werner syndrome mouse model.
Volume: 323
Pages: 68-77
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Publication
24626990 | J:213181
First Author: Brennan TA
Year: 2014
Journal: Dis Model Mech
Title: Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis.
Volume: 7
Issue: 5
Pages: 583-92
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Publication
10757074 | J:61970
First Author: Oshima J
Year: 2000
Journal: In Vivo
Title: Comparative aspects of the Werner syndrome gene.
Volume: 14
Issue: 1
Pages: 165-72
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Publication
8602509 | J:46871
First Author: Yu CE
Year: 1996
Journal: Science
Title: Positional cloning of the Werner's syndrome gene.
Volume: 272
Issue: 5259
Pages: 258-62
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GXD Expression
GXD Expression
   
Probe: MGI:2675702
Assay Type: Northern blot
Annotation Date: 2003-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675709
Age: postnatal
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2675702
Assay Type: Northern blot
Annotation Date: 2003-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675709
Age: postnatal
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2675702
Assay Type: Northern blot
Annotation Date: 2003-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2675709
Age: postnatal
Image: 2
Specimen Label: -/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:2675700
Assay Type: RT-PCR
Annotation Date: 2003-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2675713
Age: postnatal
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2675700
Assay Type: RT-PCR
Annotation Date: 2003-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2675713
Age: postnatal
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2675700
Assay Type: RT-PCR
Annotation Date: 2003-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2675713
Age: postnatal
Image: 2
Specimen Label: -/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3526321
Assay Type: RNA in situ
Annotation Date: 2005-02-14
Strength: Present
Sex: Male
Emaps: EMAPS:1797321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3526379
Age: embryonic day 12.5
Note: Authors report epithelial expression.
Specimen Label: not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3526321
Assay Type: RNA in situ
Annotation Date: 2005-02-14
Strength: Absent
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:3526379
Age: embryonic day 12.5
Specimen Label: not shown
Detected: false
Specimen Num: 2
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Publication
23974989 | J:345735
First Author: Wang H
Year: 2013
Journal: J Mol Med (Berl)
Title: R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis.
Volume: 91
Issue: 12
Pages: 1421-9
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Publication
24608430 | J:218627
First Author: Chung L
Year: 2015
Journal: Oncogene
Title: The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.
Volume: 34
Issue: 7
Pages: 902-11
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Publication
22621437 | J:214714
First Author: Wang H
Year: 2012
Journal: Aging Cell
Title: Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging.
Volume: 11
Issue: 4
Pages: 704-13
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Publication
26195664 | J:227293
First Author: Drosopoulos WC
Year: 2015
Journal: J Cell Biol
Title: BLM helicase facilitates telomere replication during leading strand synthesis of telomeres.
Volume: 210
Issue: 2
Pages: 191-208
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Publication
25921537 | J:228364
First Author: Yu Q
Year: 2015
Journal: Cell Rep
Title: DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.
Volume: 11
Issue: 5
Pages: 785-797
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Publication
11087671 | J:66161
First Author: Dron M
Year: 2000
Journal: Genomics
Title: Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures.
Volume: 70
Issue: 1
Pages: 140-9
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Publication
16785251 | J:112037
First Author: Sebastiani G
Year: 2006
Journal: Hum Mol Genet
Title: Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice.
Volume: 15
Issue: 15
Pages: 2313-23
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Publication
14595844 | J:86589
First Author: McClive PJ
Year: 2003
Journal: Genesis
Title: Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.
Volume: 37
Issue: 2
Pages: 84-90
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Publication
25807483 | J:222159
First Author: Li Y
Year: 2015
Journal: Nature
Title: Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Volume: 521
Issue: 7553
Pages: 520-4
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Publication
- | J:175213
     
First Author: Lo C
Year: 2011
Journal: MGI Direct Data Submission (B2B/CvDC)
Title: Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC)
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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