| Type | MGI:General | Description | thioglycollate-elicited peritoneal macrophages produce more TNF alpha in response to LPS stimulation; Il-6 production is also significantly elevated Il-12 production is decreased in response to LPS stimulation in peritoneal macrophages splenocytes stimulated with LPS produce more TNF alpha compared to wild-type but Il-12 and IFN gamma production is attenuated with respect to wild-type mutant mice stimulated with LPS in vivo show 3.5-fold higher TNF alpha levels than wild-type at 1 hour and levels still increase at 2 hours; mice produce more Il-6 at 1 hour and this keeps increasing through 3 hours, while Il-10 levels increase and remain elevated throughout the experiment |
