| First Author | Zhu Z | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 358 |
| Issue | 1 | Pages | 66-72 |
| PubMed ID | 17475214 | Mgi Jnum | J:122475 |
| Mgi Id | MGI:3714450 | Doi | 10.1016/j.bbrc.2007.04.096 |
| Citation | Zhu Z, et al. (2007) PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein. Biochem Biophys Res Commun 358(1):66-72 |
| abstractText | Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator. |
