| Primary Identifier | MGI:102463 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 18019 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in cartilage development; negative regulation of transcription by RNA polymerase II; and positive regulation of gene expression. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; myotube cell development; and positive regulation of myoblast fusion. Located in cytosol and nucleus. Part of chromatin; ribonucleoprotein complex; and transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; jaw; lung; and thymus primordium. Orthologous to human NFATC2 (nuclear factor of activated T cells 2). PHENOTYPE: Mutations in this locus cause altered immune system function such as decreased cytokine production by mast cells, increased Th2 responses after infection with a parasite but decreased Th1 responses after myobacterial infection, retarded thymic involutionand massive germinal center formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
